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Evaluation of the Preventive and Therapeutic Activities of <i>Tridax procumbens</i>against Hyperglycemia and Hyperlipidemia Induced in Wistar Rats

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Pharmacology & Pharmacy 2021年第7期12卷 127-140页

作者： jean-Baptiste Amagbegnon Omédine Koukoui Pascal C. Agbangnan Santorin Seton Mansouratou Betira Sedami Medegan Laura Loko Victorin Dougnon Luc Djogbenou Alphonse Sezan Laboratory of Animal Physiology Cellular Signalisation and Pharmacology University of Sciences Technologies Engineering and Mathematics Dassa Zoume Benin Laboratory of Study and Research in Applied Chemistry Unity of Research and Molecular Interactions (URIM/LERCA/UAC) Cotonou Benin Medicinal and Organic Chemistry Laboratory Faculty of Health Sciences Cotonou Benin Laboratory of Applied Entomology University of Sciences Technologies Engineering and Mathematics Dassa Zoume Benin Research Unit in Applied Microbiology and Pharmacology of Natural Substances Research Laboratory for Applied Biology Polytechnic School of Abomey-Calavi University of Abomey-Calavi Abomey-Calavi Benin Laboratory of Infectious Vector Borne Diseases Regional Institute of Public Health University of Abomey-Calavi Abomey-Calavi Benin Laboratory of Biomembranes and Cellular Signalisation University of Abomey-Calavi Cotonou Benin

From the Asteraceaes family, Tridax procumbens is a wild species frequently found in fields, meadows and roadsides. It is traditionally used to treat yellow fever, typhoid fever, high blood pressure and diabetes. In this work we used the hydro-ethanolic extract of the leaves and stems of the plant and also the fractions of this extract to determine the preventive and therapeutic activities of the plant against obesity, hyperglycemia and hyperlipidemia. The yields of the fractions obtained by decantation of the hydro-ethanolic extract are respectively 0.160% with hexane, 0.073% with dichloromethane, 0.09% with diethyl ether and 0.150% with ethyl acetate. Hyperglycemia and hyperlipidemia were induced in the rats submitted to a fatty and sweet diet for 28 days. Our results showed a significant increase in glycemia, weight and triglyceride level in rats that were subjected to the diet. On the other hand, the rats treated with the dose of 500 mg/kg of body weight of Tridax procumbens extract during the induction showed a reduction in weight gain and an absence of increase in blood sugar and triglyceride levels. The ethyl acetate fraction of Tridax procumbens extract administered to fatty and hyperglycemic rats at 50 mg/kg of body weight for 14 days did not induce change in the blood sugar and triglycerides level of fatty and hyperglycemic rats. If it seems obvious that the extract of Tridax procumbens prevents hyperglycemia and hyperlipidemia, the ethyl acetate fraction does not seem to have a therapeutic effect.

关键词： Tridax procumbens Prevention Treatment Hyperglycemia Hyperlipidemia

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Influence of Some Physico-Chemical Exposure Factors on the Carbocysteine Content of an Opened Pharmaceutical Product

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American Journal of Analytical Chemistry 2022年第12期13卷 495-505页

作者： jean-Kisito Kouame Mariette Desiree Yehe Carine Nina Able Vincent De Paul Ovi Hervé Tazoh Broh Claude Bérenger Ngalemo Ngantchouko Gildas Komenan Gbassi National Public Health Laboratory (NPHL) Food Control Service Abidjan Ivory Coast Department of Analytical Sciences and Public Health UFR Pharmaceutical and Biological Sciences Félix Houphou&euml t Boigny University Abidjan Ivory Coast

The aim of this study was to investigate the stability of Carbocysteine (CBC) contained in a reference substance (RS) and in a sample of opened RHINATHIOL® 5% syrup (RNTL 5%) under the effect of some physicochemical parameters (temperature, light, time, pH, bile salts). The developed method was linear, precise and accurate according to USP 38. The co-efficient of determination R2 for linearity was 0.9993. The respective RSD of intra-day and inter-day between days (1st, 2nd and 3rd day) were respectively 0.338% and the interval from 0.05% to 0.387%. The average recovery rate ranged from 98.490% to 100.450%. The detection and quantification limits were 0.0001 mg/mL and 0.001 mg/mL respectively. The method was applied to four samples of opened syrup containing CBC and the CBC content in these samples was found to be in accordance with USP 38. The CBC content in the opened sample of RNTL 5% was obtained by UV-visible spectrophotometry at 217 nm and was 4.887 g/100mL. The study of the influence of physico-chemical factors on the content of CBC in RS and RNTL 5% showed that the evolution of CBC contents in each drug matrix remained dependent on pH and temperature. However, these levels remained stable in the presence of light.

关键词： Influence Physico-Chemistry Content Carbocysteine Stability

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基于个人辅助Agent的E-Learning教学平台研究

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时代教育 2010年第6期 94-95+99+303页

作者：陈可佳 BARTHèS jean-Paul TRIGANO Philippe 南京邮电大学计算机学院 Université de Technologie de Compiègne

在人工智能领域,辅助agent是一种能够帮助用户解决工作环境中特定任务的认知agent。本文将个人辅助agent应用于e-learning环境中,提出了一种具有记忆能力的辅助agent模型——MemoPELA,目的在于帮助学生和教师进行更好的教学活动。

关键词：辅助agent E-learning 教育教学

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Inter-Observer Variability in the Detection and Interpretation of Chest X-Ray Anomalies in Adults in an Endemic Tuberculosis Area

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Open Journal of Medical Imaging 2015年第3期5卷 143-149页

作者： Boniface Moifo Eric Walter Pefura-Yone Georges Nguefack-Tsague Marie Laure Gharingam jean Roger Moulion Tapouh André-Pascal Kengne Samuel Nko’o Amvene Faculty of Medicine and Biomedical Sciences (FMBS) The University of Yaoundé I Yaoundé Cameroon Department of Radiology and Radiation Oncology FMBS Yaoundé Cameroon Department of Internal Medicine and Specialties’ FMBS Yaoundé Cameroon Service of Pneumology A Jamot Hospital of Yaoundé Yaoundé Cameroon Department of Public Health FMBS Yaoundé Cameroon South African Medical Research Council & University of Cape Town Cape Town South Africa

Purpose: To assess the inter-observer agreement in reading adults chest radiographs (CXR) and determine the effectiveness of observers in radiographic diagnosis of pulmonary tuberculosis (PTB) in a tuberculosis endemic area. Methods: A quasi-observational study was conducted in the Pneumology Department of Yaounde Jamot Hospital (Cameroon) from January to March 2014. This included six observers (two chest physicians, two radiologists, two end-training residents in medical imaging) and 47 frontal CXRs (4 of diffuse interstitial lung disease, 6 normal, 7 of lung cancers, 7 of bacterial pneumonia, 23 of PTB). The sample size was calculated on the basis of an expected 0.47 Kappa with a spread of 0.13 (α = 5%, CI = 95%) for six observers and five diagnostic items. The analysis of concordance was focused on the detection of nodules, cavitary lesions, pleural effusion, adenomegaly and diagnosis of PTB and lung cancer. These intervals of kappa coefficient were considered: discordance (0.81). Results: The average score for the detection of caverns was the highest (58.3%) followed by that of the correct diagnosis of tuberculosis (49.3%). Pneumologists had the highest proportions of correct diagnosis of tuberculosis (69.6% and 73.9%) and better inter-observer agreement (k = 0.71) for PTB diagnosis. Observers were more in agreement for the detection of nodules (0.32 - 0.74), adenomegalies (0.43 - 0.69), and for the diagnosis of cancer (0.22 - 1) than for the diagnosis of tuberculosis (0.19 - 0.71). Disagreements were more frequent for the detection of pleural effusions (-0.08 - 0.73). Conclusion: The inter-observer agreement varies with the type of lesions and diagnosis. Pneumologists were most effective for the diagnosis of pulmonary tuberculosis. Observers were more in agreement for the detection of nodules and the diagnosis of cancer than for the diagnosis of pulmonary tuberculosis.

关键词： Inter-Observer Variability Concordance Pulmonary Tuberculosis Nodules Caverns Lung Cancer Chest Radiography Kappa

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Haemorrhoidal Disease in Cotonou: Epidemiological, Clinical and Anuscopic Aspects

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Open Journal of Gastroenterology 2015年第7期5卷 77-82页

作者： jean Sehonou Finangnon Armand Wanvoegbe Aboudou Raimi Kpossou Kouessi Anthelme Agbodande Roméo Dah-Bolinon Angèle Azon-Kouanou Marcel Zannou Fabien Houngbe Unit of Internal Medicine in the National Teaching Hospital“HKM” CotonouBenin Internal Medicine Unit Departmental Hospital of Oueme Plateau of Porto-NovoPorto-NovoBenin Unit of Hepato-Gastroenterology of the Hospital Menontin CotonouBenin

The haemorrhoidal disease is a very common disorder in proctology. It is favoured by many factors. Although benign, its treatment is difficult. Our aim is to study the epidemiological, clinical and anuscopic of haemorrhoidal disease. This was a cross sectional, descriptive and prospective study covering a three-month period from 06 January 2014 to 10 April 2014. It involved patients seen in gastroenterology consultation in internal medicine of the National Teaching Hospital of Cotonou and in the digestive diseases Unit of the Hospital of Menontin. We recorded 182 patients including 57 cases of haemorrhoidal disease, a prevalence of 31.3%. The sex ratio was 1.10. The average age was 43 years with extremes of 18 and 88 years. Anal events were dominated by rectal bleeding (54.4%) with a predominance of internal haemorrhoidal disease (87.7%). Stage 2 evolution of the disease was the most represented (65.4%). Haemorrhoidal disease is a common disorder seen mainly in actively producing people (young adult) with a male predominance.

关键词： Haemorrhoidal Disease Anal Event Cotonou

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Bilateral Gravidic Gigantomastia at the Gynecological and Obstetrical Clinic of Dantec: A Case Report

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Open Journal of Obstetrics and Gynecology 2022年第9期12卷 993-998页

作者： Ibrahim Rahadat Astou Coly Niassy Ibrahima Sitor Sarr Aissatou Sankharé Mouhamed Yahya Dede Alioune Ndiaye Dia Moussa Diallo Marie-Édouard Faye jean-Charles Moreau Gynecological and Obstetrical Clinic Le Dantec University Hospital Dakar Senegal General Surgery Le Dantec University Hospital Dakar Senegal Anatomic Pathology Laboratory Le Dantec University Hospital Dakar Senegal

The consequence of a monstrous and diffuse evolution of the usual epithelial hyperplasia of pregnancy, gravidic gigantomastia is a disabling pathology. Rarely, it poses a problem for management and its etiology is still undetermined. In spite of a benign condition, it is nonetheless a serious one because of the complications associated with excessive growth, the weight of the mammary gland and the compromise of breastfeeding function (through destruction of the nipple-areolar plate and surgery). We report a case of bilateral gravidic gigantomastia in a 31-year-old woman to discuss the diagnostic and therapeutic aspects.

关键词： Gigantomastia Pregnancy Breast Volume Hypertrophy Mastectomy Black Woman Macromastia Gravidic

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基于地震“哼鸣”的全球面波层析成像

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国际地震动态 2009年第12期30卷 13-15页

作者： Kiwamu Nishida jean-Paul Montagner Hitoshi Kawakatsu 左玉玲 Earthquake Research Institute University of Tokyo Institut de Physique du Globe de Paris 中国地震局地球物理研究所

基于地震的全球面波层析成像技术的发展对于探测地球深部动力学状态起着至关紧要的作用。人们很自然地认为只有大地震才会产生类似探测所需要的穿入地球深部的长周期地震波。然而,由海洋和/或大气扰动随机产生的地震"哼鸣"的发现,即地... 详细信息

基于地震的全球面波层析成像技术的发展对于探测地球深部动力学状态起着至关紧要的作用。人们很自然地认为只有大地震才会产生类似探测所需要的穿入地球深部的长周期地震波。然而,由海洋和/或大气扰动随机产生的地震"哼鸣"的发现,即地球背景自由振荡,提供了一种可供选择的方法。我们在此呈现的是利用地震"哼鸣"而非天然地震进行上地幔地震层析成像的结果。在100～400s周期,Rayleigh波的相速度异常可通过下述方式测得,即对观测得到的54个遍布全球的地震台站中每两个台站间的互相关函数进行模拟,然后对这些异常进行反演,以获取上地幔三维S波速度结构。此方法为探测具有大气和/或海洋的类地行星——特别是火星的三维内部结构提供了一种新的途径。

关键词：层析成像技术地震波球面波三维S波速度结构 Rayleigh波地球深部地震层析成像大气扰动

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Natural Regeneration of Marker Species of the Tropical Dense Humid Ecosystems in the Loukaya Peri-Urban Forest, Brazzaville-Congo

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Open Journal of Ecology 2020年第10期10卷 664-687页

作者： Victor Kimpouni jean de Dieu Nzila Oracle Clément Tondo Bafouiri Ntsoni Ghislain Bileri-Bakala Josérald Chaîph Mamboueni Charmes Maïdet Massamba-Makanda école Normale Supérieure Université Marien Ngouabi Brazzaville Congo Institut National de Recherche Forestière (IRF) Brazzaville Congo

The study aimed at evaluating the natural regeneration of some characteristic species in the Loukaya peri-urban forest was carried out in Brazzaville, over three surveys of one hectare each. The botanical inventory of the 23 species monitored covers the subjects of 2 ≤ d0.20 1.30 ≥ 10 cm. The study shows 1255 individuals of which 68.27% are 2 ≤ d0.20 < 10 cm. While being tropophilic and mesophilic, this ecosystem is pauciflorous and paucispecific. The phytoecological data show that this formation, which is a link in the African dense humid forest, presents values far below those known elsewhere;while being faithful to the forests of the Cataractes Plateau. As for the rate of natural regeneration, this index is greater than or equal to 100 for 69.56% of the taxa. Sarcochores and heliophytes are the taxa that best support this natural regeneration. This high rate of regeneration would be correlated with the high level of anthropization, whose large canopy gaps are accompanied by a flow of light conducive to the installation of seedlings.

关键词： Congo Biodiversity Index Peri-Urban Forest Phytoecology Natural Regeneration

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Lumbar Paraspinal Hemangiopericytoma, An Unusual Location: Surgery with Preoperative Embolization

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World Journal of Neuroscience 2021年第2期11卷 108-115页

作者： Habib Abdoul Karim Ouiminga Aminath Kelani Denléwendé Sylvain Zabsonre Anatole jean Innocent Ouedraogo Desire Harouna Sankara Mengyou Li Omar Salia Souleymane Ouattara Hongbo Wang Department of Orthopedic Traumatology and Neurosurgery Tengandogo Teaching Hospital Center Ouagadougou Burkina Faso Department of Neurosurgery Niamey Teaching Hospital Center Niamey Niger Department of Neurosurgery Yalgado Ouedraogo Teaching Hospital Center Ouagadougou Burkina Faso Department of Neuroradiology Ouagadougou Medical Imaging Center Ouagadougou Burkina Faso Department of Neurosurgery Liaocheng People’s Hospital Liaocheng China Department of Pathology CHU Tengandogo Ouagadougou Burkina Faso Department of Orthopedic Zaozhuang Municipal Hospital Zaozhuang China

Background: Lumbar paraspinal hemangiopericytoma is rare. The hemorrhagic nature of the tumor causes problems of hemostasis and makes the resection delicate. We report a rare case of lumbar paraspinal hemangiopericytoma managed with preoperative embolization. Clinical Case: It is about a woman of 31 years, admitted for a large left lumbar paraspinal mass that evolved for 6 years. The clinical exam showed an asymmetry of the left paraspinal muscle. The mass painless was extended from the lumbar region. The neurological exam was normal. MRI showed the left large paraspinal mass tissue. It was extended from lumbar vertebrae, L1 to L4, and measured 100 × 50 × 50 mm. It was an iso-intense signal on T1-weighted with strong enhancement after gadolinium. It was hypervascular and supplied by left intercostal T12, L1, and L2 pedicles. The complete exclusion of the hyper-vascular left paraspinal tumor was obtained after selective embolization of the artery left L1 of the pedicle of the intercostal left L1 and trunks intercostal T12 and L2 left. The total resection of a mass encapsulated was performed. The operative outcome was good. The histology concluded to a hemangiopericytoma. No chemotherapy or radiotherapy was prescribed. After 5 years, the patient was asymptomatic. MRI control confirmed tumor resection with a residue at the level of the left intervertebral foramen L1 - L2. Conclusion: Lumbar paraspinal hemangiopericytoma is an extremely rare tumor. Selective preoperative embolization is recommended before the resection of large tumors to reduce vascular supply. A follow-up extended for these patients is necessary, given the frequency of recurrences.

关键词： Hemangiopericytoma Embolization Spine Surgery

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Synthesis, Structural Characterization and Antimicrobial Activity of a Novel Cobalt(II) Complex Based on 3-Methyl-1-Phenyl-4-(2-Thienoyl)-Pyrazol-5-One

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Journal of Modern Physics 2023年第8期14卷 109-126页

作者： Emeline Sorelle Mefouegang Claudelle Sybilline Anensong Djadock Golngar Djimassingar Gabriel Tchuente Kamsu Donald Raoul Tchuifon Tchuifon Alain Charly Tagne Kuate Dirk Bockfeld jean Ngoune Research Unit of Noxious Chemistry and Environmental Engineering Department of Chemistry Faculty of Science University of Dschang Dschang Cameroon Department of Fundamental Sciences Mongo Polytechnique University Institute (IUPM) Mongo Chad Research Unit of Microbiology and Antimicrobial Substances Department of Biochemistry Faculty of Science University of Dschang Dschang Cameroon Department of Process Engineering Laboratory of Energy Materials Modeling and Method National Higher Polytechnic School of Douala University of Douala Douala Cameroon Institute of Inorganic and Analytical Chemistry Technical University of Braunschweig Braunschweig Germany

New cobalt(II) complex, [Co(O2C15H11N2S)2(OH2)2]∙2H2O (1∙2H2O), has been synthesized upon reaction of cobalt chloride hexahydrate (Co(Cl)2∙6H2O) with 3-methyl-1-Phenyl-4-(2-thienoyl)-pyrazol-5-one (referred as HL) in ethanol at room temperature. Single crystal X-ray diffraction (XRD), spectroscopic methods, and microelemental analyses were used to characterize 1∙2H2O. Compound 1∙2H2O crystallizes in the orthorhombic crystal system with a Pbca space group and with the cobalt atom being pseudo-octahedral coordinated. The broth microdilution technique was used to screen the free ligand (HL) and the complex (1∙2H2O) for antimicrobial activities. HL has a low activity (MIC > 100 μg/mL) on all microorganisms, whereas compound 1∙2H2O displayed moderate activity (10 ∙2H2O exhibited bactericidal and fungicidal activity respectively on all the bacteria and yeasts tested. These findings reveal that the antimicrobial activity of HL was enhanced upon coordination to Co(II) ion against all microorganisms (bacteria and fungus).

关键词： Cobalt Acylpyrazolone X-Ray Diffraction Antimicrobial Activity 3-Methyl-1-Phenyl-4-(2-Thienoyl)-Pyrazol-5-One

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