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Massive abdominal muscle atrophy during prolonged mechanical ventilation: Implications for tracheostomy removal

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Journal of Intensive Medicine 2024年第1期4卷 133-135页

作者： Pascal Beuret Florian Michelin Audrey Tientcheu Laurane Chalvet Benedicte Philippon-Jouve jean-charles Chakarian Xavier Fabre Service de Réanimation et Soins continus Centre Hospitalier de RoanneRoanneFrance

Introduction Maintaining the functional integrity of respiratory muscles is crucial for critically ill patients to be weaned from mechanical ventilation and decannulated if *** of the diaphragm is frequent in patients under mechanical ventilation and has been associated with a longer duration of weaning.[1,2]Studies on expiratory muscles are *** recent studies demonstrated the feasibility and reproducibility of ultrasound in measuring the thickness of abdominal muscles,[3,4]with one study showing abdominal muscle atrophy in 22%of mechanically ventilated critically ill patients during the first week of mechanical ventilation.[4]

关键词： critically mechanical abdominal

An Active Inrush Current Limiter Based on SCR Phase Shift Control for EV Charging Systems

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Journal of Energy and Power Engineering 2016年第4期10卷 247-257页

作者： Cedric Reymond Sebastien Jacques Ghafour Benabdelaziz jean-charles lebunetel Application and System Engineering STMicroelectronics Tours SAS Tours 3 7000 France Research Group on Materials Microelectronics Acoustics & Nanotechnology University of Tours Tours 37200 France

This article gives an overview of the main passive solutions and active techniques, based on AC switches to limit inrush currents in medium power AC-DC converters (up to 3.7 kW) for electric vehicle charging systems. In particular, a strategy, based on SCR (silicon controlled rectifier) phase, shift control in a mixed rectifier bridge with diodes and thyristors, is proposed. The challenge is to help designers optimize the triggering delay of SCRs to both limit the peak value of inrush current spikes and optimize the charge duration of the DC-link capacitor. A mathematical model (Mathcad engineering tool) has been defined to point out, the interest of a variable triggering delay to control SCRs to meet the expectations described previously. Experimental measurements using an industrial evaluation board of the AC-DC converter demonstrate the robustness of the method.

关键词：可控硅触发充电系统电动汽车相移控制励磁涌流 AC-DC变换器限制器中等功率

Phytochemical Screening, Study of Acute Toxicity and Hypoglycemic and Antihyperglycemic Activities of Silver Nanoparticles from Guibourtia tessmannii (Harms) J. Leonard (Caesalpiniaceae)

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Open Journal of Applied Sciences 2024年第1期14卷 118-130页

作者： Ngoulé charles Christian Eya’ane Meva François Sone Enone Bertin Ngo Nyobe Biwole Caroline Tankeu Séverin Elisée Songue Pascal Nguene jean Pierre Etame-Loe Gisèle Department of Pharmaceutical Sciences Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon Department of Biology of Plant Organisms Faculty of Sciences University of Douala Douala Cameroon

According to the World Health Organization, diabetes affects approximately 347 million people worldwide. Its management is not within the reach of all social classes, therefore medicinal plants are still the first resort for many populations in Africa. The biological material used in this study was the trunk bark of Guibourtia tessmannii. 50 g of trunk bark powder were decocted in 500 ml of distilled water for 5 minutes were carried out. The method used for the synthesis of silver nanoparticles (AgNps) was an organometallic bio-reduction of silver nitrate salts mediated by various secondary metabolites contained in the plant extract. The study of the toxicity acute was conducted according to guideline 423 of the OECD protocol. The pharmacological activities were each carried out with 28 female rats divided into 7 groups of four rats. It was a question for the hypoglycemic activity of administering various doses of silver nanoparticles and other substances to the rats thirty minutes after the carbohydrate intake and for the anti-hyperglycemic activity of administering the same substances to the rats thirty minutes before the carbohydrate intake. The extraction yield was 8.76%. Only the alkaloid test was negative. After acute toxicity study, the LD50 was greater than 2000 mg/kg. Blood sugar tests revealed that glibenclamide 5 mg/kg, which is the reference molecule, lowered blood sugar more than the other treatments applied in the other batches. It was followed by treatment with silver nanoparticles at a dose of 400 μg/kg in both tests. It was therefore concluded that silver nanoparticles from G. tessmannii are good for the formulation of improved traditional medicines and bring up their afficacity .

关键词： Guibourtia tessmannii Nanoparticles Hypoglycemia Anti-Hyperglycemia

Targeted therapy for capillary-venous malformations

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Signal Transduction and Targeted Therapy 2024年第7期9卷 3024-3039页

作者： Lola Zerbib Sophia Ladraa Antoine Fraissenon charles Bayard Marina Firpion Quitterie Venot Sanela Protic Clément Hoguin Amandine Thomas Sylvie Fraitag jean-Paul Duong Sophie Kaltenbach Estelle Balducci Coline Lefevre Patrick Villarese Vahid Asnafi Christine Broissand Nicolas Goudin Ivan Nemazanyy Gwennhael Autret Bertrand Tavitian Christophe Legendre Nadia Arzouk Veronique Minard-Colin Caroline Chopinet Michael Dussiot Denise MAdams Tristan Mirault Laurent Guibaud Paul Isenring Guillaume Canaud UniversitéParis Cité ParisFrance INSERM U1151 Institut Necker-Enfants MaladesParisFrance Service d’Imagerie Pédiatrique Hôpital Femme-Mère-EnfantHCLBronFrance CREATIS UMR 5220 Villeurbanne 69100France Service de Radiologie Mère-Enfant Hôpital NordSaint EtienneFrance Service d’Anatomie pathologique Hôpital Necker-Enfants MaladesAP-HPParisFrance Laboratoire d’Oncohématologie Hôpital Necker-Enfants MaladesAP-HPParisFrance Pharmacie Hôpital Necker-Enfants MaladesAP-HPParisFrance Necker Bio-Image Analysis INSERM US24/CNRS UMS 3633ParisFrance Platform for Metabolic Analyses Structure Fédérative de Recherche NeckerINSERM US24/CNRS UMS 3633ParisFrance Plateforme Imageries du Vivant Universitéde ParisPARCCINSERMParisFrance Service de Néphrologie Transplantation AdultesHôpital Necker-Enfants MaladesAP-HPParisFrance Service de Transplantation Hôpital La PitiéSalpétrièreAP-HPParisFrance Department of Pediatric and Adolescent Oncology INSERM 1015Gustave RoussyUniversitéParis-SaclayVillejuifFrance Service de Physiologie&Explorations Fonctionnelles Cardiovasculaires CHU de LilleLille 59000France INSERM U1163 Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutic ImplicationsLaboratoire d’Excellence GR-ExParisFrance Division of Oncology Comprehensive Vascular Anomalies ProgramChildren’s Hospital of PhiladelphiaPhiladelphiaPAUSA Service de Médecine Vasculaire hôpital Européen Georges-PompidouParisFrance Nephrology Research Group L’Hôtel-Dieu de Québec Research CenterDepartment of MedicineFaculty of MedicineLaval UniversityQuebecQC G1R2J6Canada Unitéde médecine translationnelle et thérapies ciblées Hôpital Necker-Enfants MaladesAP-HPParisFrance CNRS UMR8253 Institut Necker-Enfants MaladesParisFrance

Sporadic venous malformations are genetic conditions primarily caused by somatic gain-of-function mutation of PIK3CA or TEK,an endothelial transmembrane receptor signaling through *** malformations are associated with pain,bleedings,thrombosis,pulmonary embolism,esthetic deformities and,in severe cases,life-threatening *** authorized medical treatment exists for patients with venous ***,we created a genetic mouse model of PIK3CA-related capillary venous malformations that replicates patient *** showed that these malformations only partially signal through AKT *** compared the efficacy of different drugs,including rapamycin,a mTORC1 inhibitor,miransertib,an AKT inhibitor and alpelisib,a PI3Kαinhibitor at improving the lesions seen in the mouse *** demonstrated the effectiveness of alpelisib in preventing vascular malformations’occurrence,improving the already established ones,and prolonging *** these findings,we were authorized to treat 25 patients with alpelisib,including 7 children displaying PIK3CA(n=16)or TEK(n=9)-related capillary venous malformations resistant to usual therapies including sirolimus,debulking surgical procedures or percutaneous *** assessed the volume of vascular malformations using magnetic resonance imaging(MRI)for each *** demonstrated improvement in all 25 *** malformations previously considered intractable were reduced and clinical symptoms were *** showed a decrease of 33.4%and 27.8%in the median volume of PIK3CA and TEK malformations respectively,over 6 months on *** conclusion,this study supports PI3Kαinhibition as a promising therapeutic strategy in patients with PIK3CA or TEK-related capillary venous malformations.

关键词： PIK3CA malformations venous

Data-driven Bayesian model-based prediction of fatigue crack nucleation in Ni-based superalloys

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npj Computational Materials 2022年第1期8卷 354-368页

作者： Maxwell Pinz George Weber jean charles Stinville Tresa Pollock Somnath Ghosh Civil&Systems Engineering Johns Hopkins UniversityBaltimoreMD21218USA Materials Department University of CaliforniaSanta BarbaraCA93106USA Departments of Civil&Systems Engineering Mechanical Engineeringand Materials Science&EngineeringJohns Hopkins UniversityBaltimoreMD21218USA

This paper develops a Bayesian inference-based probabilistic crack nucleation model for the Ni-based superalloy René88DT under fatigue loading.A data-driven,machine learning approach is developed,identifying underlying mechanisms driving crack *** experimental set of fatigue-loaded microstructures is characterized near crack nucleation sites using scanning electron microscopy and electron backscatter diffraction images for correlating the grain morphology and crystallography to the location of crack nucleation sites.A concurrent multiscale model,embedding experimental polycrystalline microstructural representative volume elements(RVEs)in a homogenized material,is developed for fatigue *** RVE domain is modeled by a crystal plasticity finite element *** anisotropic continuum plasticity model,obtained by homogenization of the crystal plasticity model,is used for the exterior domain.A Bayesian classification method is introduced to optimally select informative state variable predictors of crack *** this principal set of state variables,a simple scalar crack nucleation indicator is formulated.

关键词： crack fatigue superalloy

Molecular mechanisms of liver carcinogenesis related to metabolic syndrome

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Hepatoma Research 2022年第1期8卷 22-34页

作者： Claudia Campani jean-charles Nault Team of Functional Genomics of Solid Tumors Centre de Recherche des CordeliersSorbonne UniversitéInsermUniversitéde ParisParis F-75006France Equipe labellisée Ligue Nationale Contre le Cancer Labex OncoImmunologyParis F-75006France Department of Experimental and Clinical Medicine University of FlorenceFlorence 50139Italy Service d’hépatologie Hôpital AvicenneHôpitaux Universitaires Paris-Seine-Saint-DenisAssistance-Publique Hôpitaux de ParisBobigny 93000France Unitéde Formation et de Recherche SantéMédecine et Biologie Humaine UniversitéParis 13Communautéd’Universités et Etablissements Sorbonne Paris CitéBobigny 93000France

Global prevalence of non-alcoholic fatty liver disease(NAFLD)and of NAFLD-hepatocellular carcinoma(HCC)is estimated to grow in the next *** burden of NAFLD and the evidence that NAFLD-HCC arises also in noncirrhotic patients,explain the urgent need of a better characterization of the molecular mechanisms involved in NAFLD *** and diabetes cause a chronic inflammatory state which favors changes in serum cytokines and adipokines,an increase in oxidative stress,DNA damage,and the activation of multiple signaling pathways involved in cell ***,a role in promoting NAFLD-HCC has been highlighted in the innate and adaptive immune system,dysbiosis,and alterations in bile acids *** dietary,genetic,or combined mouse models have been used to study nonalcoholic steatohepatitis(NASH)development and its progression to HCC,but models that fully recapitulate the biological and prognostic features of human NASH are still *** humans,four single nucleotide polymorphisms(PNPLA3,TM6SF2,GCKR,and MBOAT7)have been linked to the development of both NASH and HCC in cirrhotic and non-cirrhotic patients,whereas HSD17B13 polymorphism has a protective *** addition,higher rates of somatic ACVR2A mutations and a novel mutational signature have been recently discovered in NASH-HCC *** knowledge of the molecular pathogenesis of NAFLD-HCC will be helpful to personalized screening programs and allow for primary and secondary chemopreventive treatments for NAFLD patients who are more likely to progress to HCC.

关键词： Hepatocellular carcinoma mouse model genetic predisposition cirrhosis non-alcoholic fatty liver disease immune system

Evaluation of the Efficacy of Essential Oil Extracts in the Control of Termites (Isoptera: Termitidae) in Cashew Orchards in Badikaha (Côte d’Ivoire)

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Advances in Entomology 2024年第2期12卷 93-104页

作者： Adama Coulibaly Magloire Yves Minhibo charles Konan Kouakou Sylvain Bi Tra Djata Sanogo Lassina Fondio Mudde Barnabas National Agricultural Research Center (CNRA) Korhogo Regional Division Lataha Research Station Cashew Mango Papaya Program Abidjan C&#244te d&#8217Ivoire Agricultural Production Improvement Laboratory Jean Lorougnon Gu&#233d&#233 University Daloa C&#244te d&#8217Ivoire Ngetta Zonal Agricultural Research and Development Institute National Agricultural Research Organization (NARO) Lira Uganda

Cashew tree has gradually moved from a purely ecological aspect to a socio-economic one, due to the marketing of its nuts. But production per area, estimated at between 424 and 547 kg/ha, remains low, in contrast to India (2nd largest producer) and Vietnam (3rd largest producer), whose yields range from 1000 to 1500 and 2000 to 2500 kg/ha respectively. This low yield is due to a number of factors, among which insect pests are the most damaging. Among these insects, termites are considered to be one of the main pests of cashew trees. The general objective of this study is to contribute to termite management through the use of bioinsecticides, an alternative to the use of chemicals in cashew orchards. Five (5) biological products were tested: Limocide, Carapa oil, Neem oil, Kitana and Kaskara. Among them, two products proved effective, with a mortality rate of over 50%. These were Limocide, whose LC50 was obtained in 24 h at a dose of 3.6 g/ml and 3.1 g/ml , giving a mortality rate of 57.66% ± 4.04% and 51.33 ± 2.08 respectively , and Carapa, at a dose of 4.5 g/ml, with an estimated mortality rate of 52.33% ± 1.52%. Such results have demonstrated the potential application of Limocide and Carapa biopesticides to sustainably control termites in cashew orchards of Côte d’Ivoire.

关键词： Termite Pest Organic Products Cashew Tree Côte d’Ivoire

Investigations on MBSE modelling and dynamic performance assessment of an electrical trimmable horizontal stabilizer actuator

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Chinese Journal of Aeronautics 2023年第11期36卷 417-433页

作者： Wensen ZHANG Jian FU jean-charles MARÉ Haolin MA Tianxiang XIA Yongling FU Jiangao ZHAO School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191China INSA–Institut Clément Ader(CNRS UMR 5312) Toulouse 31400France Nanjing Engineer Institute of Aircraft System Jincheng AVICNanjing 211100China

With the development of power-by-wire technology for more electric aircraft,the electromechanical actuator(EMA)has the advantages to replace the conventional hydraulic servo actuator in some aerospace flight *** hydraulically powered trimmable horizontal stabilizer actuation(THSA)system is nowadays developed to be electrically *** their safety-criticality,no-back mechanism and redundant load paths are utilized to meet the flight control ***,rare literatures have introduced these functions and addressed the virtual prototyping activities from system-level point of *** paper proposed such a model of a THSA system with dual electric power sources and fault-tolerant mechanical load *** nonlinear effects of components are considered with realism,and system-level simulation test is conducted to support the model-based system engineering(MBSE)*** models are developed with a power view instead of a pure signal *** on the friction effect and compliance effect with backlash or preload,some improved and novel approaches are adopted for these crucial components and validated via experimental ***,the implemented systemlevel model enables injection of crucial ***,the simulation of the proposed model shows that it is an efficient resource to investigate the actuator’s dynamic performance,to virtually prove that the actuator meets the fail/safe constraint,and to demonstrate the soundness of the fault monitoring functions.

关键词： Electro-mechanical actuator Flight control Mechanical load path Modelling No-back mechanism

Best practices for model-based and simulation-aided engineering of power transmission and motion control systems

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Chinese Journal of Aeronautics 2019年第1期32卷 186-199页

作者： jean-charles MARE Institut Clément Ader (CNRS UMR 5312)

This paper deals with the modelling and simulation of aircraft systems, in particular for power transmission and control. It is intended to review, propose and disseminate best practices for making model-based/simulation-aided engineering more efficient at any phase of the system life cycle. The proposals are aimed at creating value, not only by increasing the performance of the product under study but also by shortening the time to market, capitalizing knowledge, mitigating risks and facilitating concurrent engineering. The needs associated with the engineering activities are firstly identified to define a set of requirements for the models. Then, these requirements are used to drive the considerations leading to model development, focusing in particular on the process,modelled physical effects, modelling level, model architecting and concurrent engineering. The third part deals with the model implementation, giving special consideration to the different types of models, causalities, parameterization, implementation and verification. Each part is illustrated by examples related to safety critical actuators.

关键词： Actuator Aerospace Architecture Causality Modelling Motion control Power transmission Simulation