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Multi-level virtual prototyping of electromechanical actuation system for more electric aircraft

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Chinese Journal of Aeronautics 2018年第5期31卷 892-913页

作者： Jian FU jean-charles MARE Liming YU Yongling FU School of Mechanical Engineering and Automation Beihang University Institut Clement Ader (CNRS UMR 5312) INSA-Toulouse Flying College Beihang University

Electromechanical actuators（EMAs） are becoming increasingly attractive in the field of more electric aircraft because of their outstanding benefits, which include reduced fuel burn and maintenance cost, enhanced system flexibility, and improved management of fault detection and isolation. However, electromechanical actuation raises specific issues when being used for safetycritical aerospace applications like flight controls： huge reflected inertia to load, jamming-type failure, and increase of backlash with service due to wear and local dissipation of heat losses for thermal balance. This study proposes an incremental approach for virtual prototyping of EMAs. It is driven by a model-based system engineering process in order to enable simulation-aided *** practices supported by Bond graph formalism are suggested to develop a model＇s structure efficiently and to make the model ready for use（or extension） by addressing the above mentioned issues. Physical effects are progressively introduced, and the realism of lumped-parameter models is increased step-by-step. In particular, multi-level component models are architected to ensure continuity between engineering activities. The models are implemented in the AMESim simulation environment, and simulation responses are given to illustrate how they can be used for preliminary sizing, control design, thermal balance verification, and faults to failure analysis. The proposed best practices intend to provide engineers with fast, reusable, and efficient means to assess performance virtually and enhance maturity, performance, and robustness.

关键词： Bond graph Electromechanical actuator Flight control Model-based system engi-neering More electric aircraft Power-by-wire

Layered double hydroxide nanosheets via solvothermal delamination

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Journal of Energy Chemistry 2019年第8期28卷 88-94,I0004页

作者： Katarina Cermelj Kanittika Ruengkajorn jean-charles Buffet Dermot O’Hare Chemistry Research Laboratory Department of Chemistry University of Oxford

A new solvothermal post-synthesis treatment for preparing high aspect ratio magnesium aluminium layered double hydroxides(Mg Al–LDHs) has been developed. Treating laurate-intercalated Mg Al–LDHs in pure ethanol in an autoclave for 48 h at 150 °C was found to produce delaminated MgA l–LDH nanosheets with a thickness of ~2.6 nm and an aspect ratio of ~105. It is proposed that the high pressure solvothermal process promotes the insertion of ethanol molecules into the LDH interlayer space, thereby facilitating delamination. This new post-synthesis treatment provides the opportunity for a facile, large scale route to highly delaminated high aspect ratio LDHs, which might be of interest towards novel nanomaterials for energy conversion and storage.

关键词： Layered double hydroxide Hydrophobicity Aspect ratio Solvothermal treatment Delamination

Differences in egg hatching time between cyclical and obligate parthenogenetic lineages of aphids

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Insect Science 2019年第1期26卷 135-141页

作者： charles-Antoine Dedryver Joel Bonhomme jean-Francois Le Gallic jean-Christophe Simon Unite Mixte de Recherche IGEPP 1349 INRAIAgrocampus OuestlUniversite Rennes 1Le Rheu cedexFrance

Many aphid species exhibit a variation in reproductive mode which is influenced by winter climate regimes,with cyclical parthenogenetic (CP)lines dominating in cold winter areas (because they produce cold-resistant eggs)and obligate parthenogenetic (OP) ones in mild winter regions (because of their parthenogenetic overwintering).Genetic studies on several aphid species have shown that the OP trait can be transmitted during sexual events involving the 2 types of *** genetic system could be considered as a local safeguarding mechanism for OP alleles in case severe frost would have killed all parthenogenetically overwintering ***,this strategy would only be efficient in restoring local polymorphism in breeding systems if the newly hatched OP recombinants remain competitive over their CP *** this study we compared egg hatching sequences of CP and OP F1 clones from several crosses obtained for 2 cereal aphid species,Sitobion avenae (constant 5℃,8 h of light)and Rhopalosiphum padi (winter outdoor conditions).For ***,we obtained F1 offspring from 6 crosses, involving 4 clones while in *** F1 were obtained from 11 crosses involving 14 clones. We showed that in both species proportions of OP clones were higher in the first half of the progeny relative to the second *** addition,F1 OP clones hatched in the mean about a week earlier than their CP sibs,which gives them a demographic advantage at the start of the growth *** then discussed the consequences of this fitness advantage for the maintenance and spread of the OP trait in aphid populations.

关键词： asexuality diapauses genetic variation insects overwintering strategies reproductive mode

Molecular Determinants of Prognosis in Hepatocellular Carcinoma

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Journal of Clinical and Translational Hepatology 2014年第1期2卷 31-36页

作者： jean-charles Nault Inserm UMR-1162 Génomique fonctionnelle des Tumeurs solides IUH Paris France Université Paris Descartes Labex Immuno-Oncology Sorbonne Paris Cité Faculté de Médecine Paris France Service d'Hépatologie H(o)pital Jean Verdier AP-HPBondy and Université Paris 13 Bobigny France

Hepatocellular carcinoma is one of the leading causes of death by cancer *** of hepatocellular carcinoma is determined by characteristics of the tumor and the surrounding cirrhotic *** molecular signatures reflecting tumor biology and derived from tumor analyses predict early tumor recurrence and *** contrast,molecular signatures from cirrhotic non-tumor samples are enriched in immunity/inflammation related genes and could predict late tumor ***,combination of clinical,pathological,and molecular features may refine prognosis prediction in these ***,molecular signatures from both tumor and non-tumor tissues will be helpful in the future to guide treatments in different clinical settings.

关键词： Hepatocellular carcinoma Molecular signature Prognosis Microarray Cirrhosis Liver resection

Data-driven Bayesian model-based prediction of fatigue crack nucleation in Ni-based superalloys

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npj Computational Materials 2022年第1期8卷 354-368页

作者： Maxwell Pinz George Weber jean charles Stinville Tresa Pollock Somnath Ghosh Civil&Systems Engineering Johns Hopkins UniversityBaltimoreMD21218USA Materials Department University of CaliforniaSanta BarbaraCA93106USA Departments of Civil&Systems Engineering Mechanical Engineeringand Materials Science&EngineeringJohns Hopkins UniversityBaltimoreMD21218USA

This paper develops a Bayesian inference-based probabilistic crack nucleation model for the Ni-based superalloy René88DT under fatigue loading.A data-driven,machine learning approach is developed,identifying underlying mechanisms driving crack *** experimental set of fatigue-loaded microstructures is characterized near crack nucleation sites using scanning electron microscopy and electron backscatter diffraction images for correlating the grain morphology and crystallography to the location of crack nucleation sites.A concurrent multiscale model,embedding experimental polycrystalline microstructural representative volume elements(RVEs)in a homogenized material,is developed for fatigue *** RVE domain is modeled by a crystal plasticity finite element *** anisotropic continuum plasticity model,obtained by homogenization of the crystal plasticity model,is used for the exterior domain.A Bayesian classification method is introduced to optimally select informative state variable predictors of crack *** this principal set of state variables,a simple scalar crack nucleation indicator is formulated.

关键词： crack fatigue superalloy

Cabozantinib and the moving field of systemic treatments in advanced hepatocellular carcinoma

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Hepatobiliary Surgery and Nutrition 2019年第1期8卷 53-55页

作者： Manon Allaire jean charles Nault Service d’hépato-gastroentérologie et de nutrition CHU Cote de NacreCaenFrance UMR 1149 Centre de Recherche sur l’inflammationFacultéde Médecine BichatParisFrance Service d’hépatologie CHU de jean VerdierBondyFrance UMR 1162 Génomique Fonctionnelle des Tumeurs SolidesInstitut National de la Santéet de la Recherche MédicaleParisFrance

Most of patients with hepatocellular carcinoma(HCC),are diagnosed at an advanced-stage explaining the poor prognosis of this cancer with a median survival without treatment around 8 months(1-3).Currently,two systemic multi-kinase inhibitors with anti-proliferative and antiangiogenic effects are available as first line treatments in advanced *** first one,Sorafenib,was the only available systemic treatment available during one decade and was associated with an improvement of overall survival of around 3 months compared to placebo(4,5).The second one,lenvatinib,showed a similar median overall survival compared to Sorafenib in a non-inferiority phase-3 trial(6).No second line was available during several years due to toxicity or absence of efficacy of the different drugs tested in multicentric phase 3 randomized controlled trials.

关键词： hepatocellular treatment drugs

Molecular mechanisms of liver carcinogenesis related to metabolic syndrome

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Hepatoma Research 2022年第1期8卷 22-34页

作者： Claudia Campani jean-charles Nault Team of Functional Genomics of Solid Tumors Centre de Recherche des CordeliersSorbonne UniversitéInsermUniversitéde ParisParis F-75006France Equipe labellisée Ligue Nationale Contre le Cancer Labex OncoImmunologyParis F-75006France Department of Experimental and Clinical Medicine University of FlorenceFlorence 50139Italy Service d’hépatologie Hôpital AvicenneHôpitaux Universitaires Paris-Seine-Saint-DenisAssistance-Publique Hôpitaux de ParisBobigny 93000France Unitéde Formation et de Recherche SantéMédecine et Biologie Humaine UniversitéParis 13Communautéd’Universités et Etablissements Sorbonne Paris CitéBobigny 93000France

Global prevalence of non-alcoholic fatty liver disease(NAFLD)and of NAFLD-hepatocellular carcinoma(HCC)is estimated to grow in the next *** burden of NAFLD and the evidence that NAFLD-HCC arises also in noncirrhotic patients,explain the urgent need of a better characterization of the molecular mechanisms involved in NAFLD *** and diabetes cause a chronic inflammatory state which favors changes in serum cytokines and adipokines,an increase in oxidative stress,DNA damage,and the activation of multiple signaling pathways involved in cell ***,a role in promoting NAFLD-HCC has been highlighted in the innate and adaptive immune system,dysbiosis,and alterations in bile acids *** dietary,genetic,or combined mouse models have been used to study nonalcoholic steatohepatitis(NASH)development and its progression to HCC,but models that fully recapitulate the biological and prognostic features of human NASH are still *** humans,four single nucleotide polymorphisms(PNPLA3,TM6SF2,GCKR,and MBOAT7)have been linked to the development of both NASH and HCC in cirrhotic and non-cirrhotic patients,whereas HSD17B13 polymorphism has a protective *** addition,higher rates of somatic ACVR2A mutations and a novel mutational signature have been recently discovered in NASH-HCC *** knowledge of the molecular pathogenesis of NAFLD-HCC will be helpful to personalized screening programs and allow for primary and secondary chemopreventive treatments for NAFLD patients who are more likely to progress to HCC.

关键词： Hepatocellular carcinoma mouse model genetic predisposition cirrhosis non-alcoholic fatty liver disease immune system

Systemic treatment of hepatocellular carcinoma:the times they are a-changin’

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Hepatobiliary Surgery and Nutrition 2021年第6期10卷 893-895页

作者： Claudia Campani jean-charles Nault Centre de Recherche des Cordeliers Sorbonne UniversitéInsermUniversitéde ParisTeam“Functional Genomics of Solid Tumors”ParisFrance Equipe labellisée Ligue Nationale Contre le Cancer Labex OncoImmunologyParisFrance Department of Experimental and Clinical Medicine University of FlorenceFlorenceItaly Service d’Hépatologie Hôpital AvicenneHôpitaux Universitaires Paris-Seine-Saint-DenisAssistance-Publique Hôpitaux de ParisBobignyFrance Unitéde Formation et de Recherche SantéMédecine et Biologie Humaine UniversitéParis 13Communautéd’Universités et Etablissements Sorbonne Paris CitéParisFrance

For a decade,sorafenib remained the only drug approved for the treatment of advanced hepatocellular carcinoma(HCC)due to the failure of several phase III trials in which alternative angiogenesis inhibitors were tested(1).In recent years,the field of systemic treatments of HCC has evolved quickly and a recent position paper of the European Association for the Study of the Liver has well described the current advances in the systemic treatment of advanced HCC as well as the unmet needs in the field(1).First,lenvatinib was approved as an alternative to sorafenib in the first-line setting,and,thus,regorafenib,cabozantinib and ramucirumab as second-line treatments for patients who progressed on sorafenib(1).

关键词： hepatocellular treatment Liver

Investigations on MBSE modelling and dynamic performance assessment of an electrical trimmable horizontal stabilizer actuator

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Chinese Journal of Aeronautics 2023年第11期36卷 417-433页

作者： Wensen ZHANG Jian FU jean-charles MARÉ Haolin MA Tianxiang XIA Yongling FU Jiangao ZHAO School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191China INSA–Institut Clément Ader(CNRS UMR 5312) Toulouse 31400France Nanjing Engineer Institute of Aircraft System Jincheng AVICNanjing 211100China

With the development of power-by-wire technology for more electric aircraft,the electromechanical actuator(EMA)has the advantages to replace the conventional hydraulic servo actuator in some aerospace flight *** hydraulically powered trimmable horizontal stabilizer actuation(THSA)system is nowadays developed to be electrically *** their safety-criticality,no-back mechanism and redundant load paths are utilized to meet the flight control ***,rare literatures have introduced these functions and addressed the virtual prototyping activities from system-level point of *** paper proposed such a model of a THSA system with dual electric power sources and fault-tolerant mechanical load *** nonlinear effects of components are considered with realism,and system-level simulation test is conducted to support the model-based system engineering(MBSE)*** models are developed with a power view instead of a pure signal *** on the friction effect and compliance effect with backlash or preload,some improved and novel approaches are adopted for these crucial components and validated via experimental ***,the implemented systemlevel model enables injection of crucial ***,the simulation of the proposed model shows that it is an efficient resource to investigate the actuator’s dynamic performance,to virtually prove that the actuator meets the fail/safe constraint,and to demonstrate the soundness of the fault monitoring functions.

关键词： Electro-mechanical actuator Flight control Mechanical load path Modelling No-back mechanism