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Evaluation of the Safety and Efficacy of Extracts from the Leaves of Five Plants Used for the Treatment of Arterial Hypertension in Benin

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Pharmacology & Pharmacy 2022年第10期13卷 355-367页

作者： Omédine Koukoui Santorin Seton Mansouratou Betira jean baptiste amagbegnon Fidèle Sonounameto Eudoxie Assou Alphonse Sezan Laboratory of Animal Physiology Cellular Signaling and Pharmacology ENSBBA/UNSTIM Dassa Zoumè Benin Laboratory of Pharmacology and Improved Traditional Medicines FAST/University of Abomey-Calavi Godomey Benin

Cardiovascular diseases (CVD) are nowadays real health problems in the world. High blood pressure is one of the most important risk factors for CVD and is affecting more and more people in Benin. The objective of our work is to evaluate the safety and the efficacy of the leaves of five plants used for the treatment of hypertension in Benin. Acute toxicity was evaluated on wistar rats which orally administered a single dose of 2000 mg/kg of body weight of hydro-ethanolic extract of the leaves of Phyllanthus amarus Schumach. & Thonn., Persea americana MILL., Ipomoaea fistulosa Mart. ex Choisy., Heliotropium indicum L., Schrankia leptocarpa DC., and were monitored over a period of 14 days. Subacute toxicity was evaluated on rats which received a daily dose of 200 mg/kg of body weight of the plant leaf extract over a period of 28 days. Plant efficacy was assessed by measuring potassium in plant leaves. Administration of the single dose of the extract did not cause any deaths in rats;the weight of the rats varied depending on the extracts administered. Concerning the subacute treatment, the levels of aspartate amino transaminases (AST) and Alanine amino transaminases (AST) did not vary significantly after the 28 days of treatment with the different extracts. On the other hand, a significant increase in serum creatinine was observed in rats treated with extracts of Phyllanthus amarus. The leaves of Heliotropium indicum, Ipomoaea fistulosa and Phyllanthus amarus contain the highest levels of potassium. Among the five plants studied, only the leaves of Phyllanthus amarus seem to induce renal toxicity. Extracts from the leaves of Heliotropium indicum, Ipomoaea fistulosa might be the most effective in inducing hypotensive activity and do not show toxicity.

关键词： Hypertension Plant Extracts Toxicity Efficacy Potassium

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Evaluation of the Preventive and Therapeutic Activities of <i>Tridax procumbens</i>against Hyperglycemia and Hyperlipidemia Induced in Wistar Rats

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Pharmacology & Pharmacy 2021年第7期12卷 127-140页

作者： jean-baptiste amagbegnon Omédine Koukoui Pascal C. Agbangnan Santorin Seton Mansouratou Betira Sedami Medegan Laura Loko Victorin Dougnon Luc Djogbenou Alphonse Sezan Laboratory of Animal Physiology Cellular Signalisation and Pharmacology University of Sciences Technologies Engineering and Mathematics Dassa Zoume Benin Laboratory of Study and Research in Applied Chemistry Unity of Research and Molecular Interactions (URIM/LERCA/UAC) Cotonou Benin Medicinal and Organic Chemistry Laboratory Faculty of Health Sciences Cotonou Benin Laboratory of Applied Entomology University of Sciences Technologies Engineering and Mathematics Dassa Zoume Benin Research Unit in Applied Microbiology and Pharmacology of Natural Substances Research Laboratory for Applied Biology Polytechnic School of Abomey-Calavi University of Abomey-Calavi Abomey-Calavi Benin Laboratory of Infectious Vector Borne Diseases Regional Institute of Public Health University of Abomey-Calavi Abomey-Calavi Benin Laboratory of Biomembranes and Cellular Signalisation University of Abomey-Calavi Cotonou Benin

From the Asteraceaes family, Tridax procumbens is a wild species frequently found in fields, meadows and roadsides. It is traditionally used to treat yellow fever, typhoid fever, high blood pressure and diabetes. In this work we used the hydro-ethanolic extract of the leaves and stems of the plant and also the fractions of this extract to determine the preventive and therapeutic activities of the plant against obesity, hyperglycemia and hyperlipidemia. The yields of the fractions obtained by decantation of the hydro-ethanolic extract are respectively 0.160% with hexane, 0.073% with dichloromethane, 0.09% with diethyl ether and 0.150% with ethyl acetate. Hyperglycemia and hyperlipidemia were induced in the rats submitted to a fatty and sweet diet for 28 days. Our results showed a significant increase in glycemia, weight and triglyceride level in rats that were subjected to the diet. On the other hand, the rats treated with the dose of 500 mg/kg of body weight of Tridax procumbens extract during the induction showed a reduction in weight gain and an absence of increase in blood sugar and triglyceride levels. The ethyl acetate fraction of Tridax procumbens extract administered to fatty and hyperglycemic rats at 50 mg/kg of body weight for 14 days did not induce change in the blood sugar and triglycerides level of fatty and hyperglycemic rats. If it seems obvious that the extract of Tridax procumbens prevents hyperglycemia and hyperlipidemia, the ethyl acetate fraction does not seem to have a therapeutic effect.

关键词： Tridax procumbens Prevention Treatment Hyperglycemia Hyperlipidemia

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Analysis of Cardiovascular Risk Factors in Hypertensive Farmers and Non-Farmers in the Zou Region of Central Benin

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Journal of Biosciences and Medicines 2023年第12期11卷 362-375页

作者： Fidele Sonounameto Marcelin Agbo Colette Azandjeme Santorin Seton Mansouratou Betira jean-baptiste amagbegnon Fresnel Cachon Maximin Senou Casmir Akpovi Alphonse Sezan Camille Dossou Lamine Baba-Moussa Joachim Gbenou Omedine Koukoui Laboratory of Research in Medical and Pharmaceutic Biotechnology (LaRBiMeP) Research Unit of Animal Physiology Cell Signaling and Pharmacology (U-PASCPharm) ENSBBA/UNSTIM Dassa-Zoumé Benin Department of Health Promotion IRSP/UAC Ouidah Benin Laboratory of Research in Medical and Pharmaceutic Biotechnology (LaRBiMeP) Unit of Experimental and Clinical Biology (U-BEC) ENSBBA/UNSTIM Dassa-Zoumé Benin Laboratory of Applied Biology Research Research Unit on Non-Communicable Diseases and Cancer EPAC/UAC Cotonou Benin Laboratory of Pharmacology and Improved Traditional Medicines Department of Animal Physiology FAST/UAC Cotonou Benin Laboratory of Molecular Biology and Typing in Microbiology Department of Biochemistry and Cell Biology FAST/UAC Abomey Calavi Benin Laboratory of Pharmacognosy and Essential Oils FAST/UAC Cotonou Benin

The heavy use of chemicals, pesticides, cosmetics and plastic packaging coincides with a resurgence of cardiovascular disease, in particular hypertension, which is affecting younger and younger populations. The aim of this study was to analyze the cardiovascular risk factors in hypertensive farmers compared with hypertensive non farmers. This was a prospective case-control study that included 239 hypertensive farmers and non farmers aged 25 to 65 with blood pressure ≥ 140 mmHg and 90 mmHg. Hypertensive farmers (101) represented 42.25% of the population versus hypertensive non farmers (138) 57.74%. The median ages were 47 ± 11.3 years for farmers and 51.45 ± 9.77 years for non farmers. Biochemical analysisand screening for major cardiovascular disease risk factors such as metabolic syndrome were performed. Metabolic syndrome was defined according to the new definition of the International Diabetes Federation. Our results revealed higher blood glucose levels in farmers (47.77%) than in non farmers (27.20%) (p = 0.0132). Dyslipidemia was more frequent in non farmerswith high level of LDL cholesterol and total cholesterol. Farmers presented a high level of tryglycerides. The prevalence of obesity was higher in non farmers 51 (36.96%) than farmers 18 (17.82%). The prevalence of metabolic syndrome was 106 (44.35%) in our study population. There was not an important difference between farmers (39.60%) and non farmers (47.82%). However, the variation of metabolic syndrome according to age and sex showed a higher prevalence in young male farmers aged 25 to 45 whereas non farmers presented an increasing prevalence of metabolic syndrome according to age and the absence of metabolic syndrome between age 25 and 35. Our results showed that the cardiovascular risk appeared early in young farmers compared with non farmers suggesting a possible role of pesticides in the onset of this risk.

关键词： Chemicals Farmers Metabolic Syndrome Hypertension

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Impact of Genomics and in Silico Related Technologies in the Drug Discovery Process

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Chinese Journal of Chemistry 2003年第10期21卷 1241-1246页

作者： LEATUTE jean-baptiste DepartmentofValorizationandIndustrialRelationships Paris7University2PlaceJussieu75005ParisFrance

In order to evaluate to what extent will genomics and in silico related technologies improve overall drug discovery process, we analyzed three studies comparing cost, time and attrition rate at each step of the dr... 详细信息

关键词： in silico drug discovery bioinformatics chemoinformatics drug design functional and structural genomics virtual screening

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Dry reforming of methane on doped Ni nanoparticles:Featureassisted optimizations and ranking of doping metals for direct activations of CH_(4) and CO_(2)

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Nano Research 2022年第10期15卷 9670-9682页

作者： Shiru Lin jean-baptiste Tristan Yang Wang Junwei Lucas Bao Department of Chemistry Boston CollegeChestnut HillMassachusetts 02467USA Department of Computer Science Boston CollegeChestnut HillMassachusetts 02467USA

As a vital energy resource and raw material for many industrial products,syngas(CO and H_(2))is of great *** reforming of methane(DRM)is an important approach to producing syngas(with a hydrogen-to-carbon-monoxide ratio of 1:1 in principle)from methane and carbon dioxide,with a lower operational cost as compared to other reforming ***,many pure metallic catalysts used in DRM face deactivation issues due to coke formation or sintering of the metal particles.A systematic search for highly efficient metallic catalysts,which reduce the reaction barriers for the rate-determining steps and resist carbon deposition,is urgently *** is a typical low-cost transition metal for activating the C–H bond in *** this work,we applied a two-step workflow to search for nickel-based bimetallic catalysts with doping metals M(M-Ni)by combining density functional theory(DFT)calculations and machine learning(ML).We focus on the two critical steps in DRM—CH_(4) and CO_(2) direct *** used DFT and slab models for the Ni(111)facet to explore the relevant reaction pathways and constructed a data set containing structural and energetic information for representative M-Ni *** used this dataset to train ML models with chemical-knowledge-based features and predicted CH_(4) and CO_(2) dissociation energies and barriers,which revealed the composition–activity relationships of the bimetallic *** also used these models to rank the predicted catalytic performance of candidate systems to demonstrate the applicability of ML for catalyst *** emphasized that ML ranking models would be more valuable than regression models in high-throughput ***,we used our trained model to screen 12 unexplored M-Ni systems and showed that the DFT-computed energies and barriers are very close to the ML-predicted values for top candidates,validating the robustness of the trained model.

关键词： Ni-based bimetallic catalysts dry reforming of methane syngas production CH_(4)and CO_(2)direct activations ranking model

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Formation mechanisms of sub-micron pharmaceutical composite particles derived from far-and near-field Raman microscopy

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Journal of Pharmaceutical Analysis 2021年第4期11卷 480-489页

作者： Jakob Hübner jean-baptiste Coty Yan Busby Denis Spitzer Nanomateriaux pour Les Systemes Sous Sollicitations Extr^emes(NS3E) ISL-CNRS-UNISTRA UMR 3208French-German Research Institute of Saint-Louis5Rue Du General CassagnouB.P.7003468301Saint-LouisFrance Spinofrin SAS 20 Bis Rue Danjou92100BoulogneBillancourtFrance

Surface enhanced Raman spectroscopy(SERS) and confocal Raman microscopy are applied to investigate the structure and the molecular arrangement of sub-micron furosemide and polyvinylpyrrolidone(furosemide/PVP) particles produced by spray flash evaporation(SFE). Morphology, size and crystallinity of furosemide/PVP particles are analyzed by scanning electron microscopy(SEM) and X-ray powder diffraction(XRPD). Far-field Raman spectra and confocal far-field Raman maps of furosemide/PVP particles are interpreted based on the far-field Raman spectra of pure furosemide and PVP *** far-field Raman microscopy shows that furosemide/PVP particles feature an intermixture of furosemide and PVP molecules at the sub-micron scale. SERS and surface-enhanced confocal Raman microscopy(SECo RM) are performed on furosemide, PVP and furosemide/PVP composite particles sputtered with silver(40 nm). SERS and SECo RM maps reveal that furosemide/PVP particle surfaces mainly consist of PVP molecules. The combination of surface and bulk sensitive analyses reveal that furosemide/PVP sub-micron particles are formed by the agglomeration of primary furosemide nanocrystals embedded in a thin PVP matrix. Interestingly, both far-field Raman microscopy and SECo RM provide molecular information on a statistically-relevant amount of sub-micron particles in a single microscopic map;this combination is thus an effective and time-saving tool for investigating organic sub-micron composites.

关键词： SERS Confocal Raman microscopy Surface characterization Sub-micron particles Pharmaceutic composites

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Belt and Road Initiative ＆ Investment in Sustainable Development Field from China

Belt and Road Initiative ＆ Investment in Sustainable Develo...

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作者： jean-baptiste Blondaux 上海交通大学

学位级别：硕士

The principal aimed of this study was to show a correlation of Belt and Road Initiative and sustainable development for future years and additionally,tends to explain by which process,strategy Belt and Road Initiative works on to improve their *** master thesis methodology was based on qualitative research with four experts that gives their advice and opinions on the problematic during interview *** meet those experts in specific forums such as the forum of “Education for the Belt and Road Initiative,Our Shared Dream” The 8th International Educational Forum on the 03/04/2019 or at the Shanghai Expat Services Conferences on Green Technology in *** also complete our answer with quantitative research made by an online survey with 200 answers and also by two case analyses with one focusing on a BRI failure in Myanmar with a view to learning from past errors and the other case highlight a formula developed by researchers that shows the evolution of sustainable development score through Belt and Road Initiative,which could be interesting to implement as an official *** to our research,average sustainability through Belt and Road Initiative is low,but in constant positive ***,we could affirm a positive correlation between BRI and the SD field for future *** than that,from our quantitative research that has been done via an online survey with 200 answers,people trust and have faith in the ability of such a project to positively correlate with a sustainable development *** master thesis also highlights the desire of Chinese and Western European countries to financially involved themselves if the sustainable conditions are respected which represents a new pathway for the financial worlds to attract *** the other hand,this study is reinforced by qualitative research made by interviews with professional experts’ link to BRI and – or,sustainable development *** the case analysis and qualitative researc

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Diallel analyses of soluble sugar content in cowpea (Vigna unguiculata ***.)

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The Crop Journal 2017年第6期5卷 553-559页

作者： Maina Antoine Nassourou Tchiagam jean baptiste Noubissié Yanou Nicolas Njintang Joseph Martin Bell Department of Biological Sciences Faculty of Science University of Ngaoundéré P.O. Box 454 Ngaoundéré Cameroon Department of Food Science and Nutrition ENSAI University of Ngaoundéré P.O. Box 455 Ngaoundéré Cameroon Genetics and Plant Breeding Unit Department of Plant Biology Faculty of Science University of Yaoundé I P.O. Box 812 Yaoundé Cameroon

The content of soluble sugar in cowpea(Vigna unguiculata L. Walp.) seeds is important for their acceptability to consumers. The objective of this study was to evaluate the genetic control of soluble sugar content in cowpea using diallel analysis. For this purpose,half-diallel crosses were made among seven diverse parents. The amount of total soluble sugar was estimated by the phenol sulfuric acid reagent method and reducing sugar were measured by the DNS(3,5-dinitrosalicylic acid) reagent method. The total soluble sugar ranged from 11.12(VYA) to 40.79 mg g^(-1)(IT93 K-693-2) with a mean of 22.31 mg g^(-1).Reducing soluble sugar showed a mean value of 9.11 mg g^(-1) and ranged from 13.61(TVx3236) to 4.98 mg g^(-1)(Lori niebe). Diallel analysis showed that both additive and non-additive gene effects were significant in the genetic control of these traits. However,dominance variance was greater than additive variance for soluble sugar. The traits were controlled mainly by an overdominance model, suggesting the advantage of delaying selection to later generations. Soluble sugar content was found to be highly heritable, with broad-sense heritability ranging from 0.987 to 0.976. Narrow-sense heritability ranged from0.154 to 0.422 and revealed the lower importance of additive variance. Parents and F_1 hybrids differed significantly on the basis of their general and specific combining abilities,respectively. Recessive alleles had positive effects on total soluble sugar and reducing soluble sugar. These results could help cowpea breeders improve the acceptability of cowpea seeds and cowpea-based foods by appropriate selection.

关键词： Cowpea Genetic improvement Diallel analysis Soluble sugar

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Twinning-induced plasticity(TWIP)effect in multi-phase metastable beta Zr-Nb alloys

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Journal of Materials Science & Technology 2023年第8期139卷 120-125页

作者： Junhui Tang Ahmed Zorgati jean-baptiste Philippe Vermaut Frédéric Prim Fan Sun PSL Research University Chimie ParisTechCNRS-UMR8247Institut de Recherche de Chimie ParisParis 75005France Sorbonne University Ecole PolytechniquePalaiseau 91128France Gaillard Paris-Saclay University Commissariatàl’Energie AtomiqueService d’Etude des Matériaux IrradiésGif-Sur-Yvette 911191France PSL Research University Chimie ParisTechCNRS-UMR8247Institut de Recherche de Chimie ParisParis 75005France Sorbonne UniversityUPMC University ParisUFR926Paris 75005France

During the last decades,a large amount of scientific works had been devoted toβ-type Zr and Ti alloys for biomedical applica-tions due to their high strength,good corrosion resistance,low magnetic susceptibility and ... 详细信息

关键词： alloys corrosion resistance

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Reciprocal interactions between gut microbiota and autophagy

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World Journal of Gastroenterology 2021年第48期27卷 8283-8301页

作者： Pierre Lapaquette jean-baptiste Bizeau Niyazi Acar Marie-Agnès Bringer UMR PAM A 02.102 University Bourgogne Franche-ComtéAgrosup DijonDijon 21000France Eye and Nutrition Research Group Centre des Sciences du Goût et de l'AlimentationAgroSup DijonCNRSINRAEUniversitéBourgogne Franche-ComtéDijon 21000France

A symbiotic relationship has set up between the gut microbiota and its host in the course of evolution,forming an interkingdom *** gut offers a favorable ecological niche for microbial communities,with the whole body and external factors(e.g.,diet or medications)contributing to modulating this ***,the gut microbiota is important for maintaining health by acting not only on the gut mucosa but also on other ***,failure in one or another of these two partners can lead to the breakdown in their symbiotic equilibrium and contribute to disease onset and/or *** microbial and host processes are devoted to facing up the stress that could alter the symbiosis,ensuring the resilience of the *** these processes,autophagy is a host catabolic process integrating a wide range of stress in order to maintain cell survival and *** cytoprotective mechanism,which is ubiquitous and operates at basal level in all tissues,can be rapidly down-or upregulated at the transcriptional,post-transcriptional,or post-translational levels,to respond to various stress *** of its sensitivity to all,metabolic-,immune-,and microbial-derived stimuli,autophagy is at the crossroad of the dialogue between changes occurring in the gut microbiota and the host *** this review,we first delineate the modulation of host autophagy by the gut microbiota locally in the gut and in peripheral ***,we describe the autophagy-related mechanisms affecting the gut *** conclude this review with the current challenges and an outlook toward the future interventions aiming at modulating host autophagy by targeting the gut microbiota.

关键词： Gut microbiota Autophagy Probiotic Brain Liver Muscle

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