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Crosstalk between PKA and PKG controls host cell egress of Toxoplasma gondii

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Crosstalk between PKA and PKG controls host cell egress of T...

Ecthyma Gangrenosum about a Case at the Centre Hospitalier Roi Baudoin de Guédiawaye in Senegal

第五届全国人畜共患病学术研讨会

作者：贾永根 jean-baptiste Marq Mathieu Brochet Dominique Soldati-Favre 瑞士日内瓦大学医学研究中心微生物和分子医学部 Department of Microbiology and Molecular Medicine CMUUniversity of Geneva

Protein kinase A controls various key cellular processes in all *** activity is regulated by fluctuating levels of cyclic adenosine monophosphate(cAMP)via the binding of this second messenger to the PKA regulatory subunit(PKAr)leading to the release of the catalytic subunit(PKAc).Toxoplasma gondii encode three PKAc genes and we show here that the inactive holoenzyme of PKAc in anchored to the inner membrane complex(IMC)of the parasite,via a dual

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Open Journal of Pediatrics 2022年第4期12卷 652-656页

作者： jean baptiste Niokhor Diouf Hadja Mariama Barry Louis Philippe Sarr Ndèye Diama Ba Pediatric Department Centre Hospitalier Roi Baudouin de Guédiawaye Guédiawaye Senegal Saint Christopher Iba Mar Diop School of Medicine-Pharmacy-Dental Dakar Senegal

Background and Aim: Ecthyma gangrenosum (EG) is a rare necrotic skin infection caused by Pseudomonas aeruginosa occurring on healthy skin mainly, but not exclusively, in immunocompromised patients. We report the case of EG of unusual presentation in a 12-month-old infant. Case Presentation: This was a 12-month-old male infant who was referred from a peripheral structure for the treatment of facial swelling associated with fever. In his antenatal and intra nasal history, there was a notion of hospitalization for 15 days for early neonatal infection and a delay in psychomotor development. The admission examination showed the fair general condition, hyperthermia at 39°C, tachycardia at 136 beats/minute, and polypnea at 48 cycles/minute. The weight-for-height index with a z-score of 3DS was also found. The dermatological examination at the entrance found an extensive brownish inflammatory tense infiltrated plaque taking the mandibular, submental, retro-auricular occipital regions rapidly evolving towards necrosis, a significant swelling predominant on the upper right eyelid preventing the opening of the associated eyes to mouth ulceration. Biological abnormalities were predominantly neutrophilic leukocytosis, elevated CRP, and elevated muscle enzymes. Microbiological examination of skin samples had isolated Pseudomonas aeruginosa. He had received antibiotic therapy, and a necrosectomy under general anesthesia. The evolution was favorable and he was discharged from the hospital on D26 of hospitalization. Conclusion: This observation is rare due to its location, its early onset, and non-neutropenic background.

关键词： Ecthyma Gangrenosum Pseudomonas aeruginosa Infant

Mid-infrared Ⅲ-Ⅴ semiconductor lasers epitaxially grown on Si substrates

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Light(Science & Applications) 2022年第7期11卷 1366-1378页

作者： Eric Tournié Laura Monge Bartolome Marta Rio Calvo Zeineb Loghmari Daniel A.Díaz-Thomas Roland Teissier Alexei N.Baranov Laurent Cerutti jean-baptiste Rodriguez IES University of MontpellierCNRS34000 MontpellierFrance

There is currently much activity toward the integration of mid-infrared semiconductor lasers on Si substrates for developing a variety of smart,compact,sensors based on Si-photonics integrated *** review this rapidly-evolving research field,focusing on the epitaxial integration of antimonide lasers,the only technology covering the whole mid-to-far-infrared spectral *** explain how a dedicated molecular-beam epitaxy strategy allows for achieving high-performance GaSb-based diode lasers,InAs/AlSb quantum cascade lasers,and InAs/GaInSb interband cascade lasers by direct growth on on-axis(001)Si substrates,whereas GaAs-on-Si or GaSb-on-Si layers grown by metal-organic vapor phase epitaxy in large capability epitaxy tools are suitable templates for antimonide laser *** also show that etching the facets of antimonide lasers grown on Si is a viable approach in view of photonic integrated ***,this review shows that while diode lasers are sensitive to residual crystal defects,the quantum cascade and interband cascade lasers grown on Si exhibit performances comparable to those of similar devices grown on their native substrates,due to their particular band structures and radiative recombination *** device lifetimes have been extrapolated for interband cascade ***,routes to be further explored are also presented.

关键词： epitaxial quantum template

Epidemiologic Transition and Heart Failure in Black African Adults

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World Journal of Cardiovascular Diseases 2017年第10期7卷 358-366页

作者： Djinguin Ben Justin Koffi Loa Ambroise Gnaba Iklo Coulibaly Bamba Kamagaté jean baptiste Anzouan-Kacou Félix Houphouet Boigny University Abidjan Cote d’Ivoire National Police Hospital Abidjan Cote d’Ivoire Institute of Cardiology Abidjan Cote d’Ivoire Alassane Ouattara University Bouake Cote d’Ivoire

The objective of this study is to report clinical, electrocardiographic, and echocardiographic data on heart failure for the evaluation of its cardiovascular risk factors and causes at the Institute of Cardiology of Abidjan and the National Police Hospital. Patients and Methods: The 12-month prospective study included 989 patients who were diagnosed with heart failure at the Institute of Cardiology of Abidjan and the Heart Department of the National Police Hospital in Cote d’Ivoire. Results: The mean age of the patients was 55 ± 12 years. Patients ≤ 50 years, aged 50 and 70 years, and ≥ 70 years were 42%, 60%, and 18%, respectively. The major cardiovascular risk factors were high blood pression (60%), smoking (19%), type 2 diabetes (11%), and hypercholesterolemia (8%). The status of 11% of HIV positive patients were ignored upon admission to the Heart Hospitals. Severe kidney failure (25%) was found in all hypertensive patients. Atrial fibrillation patients and sinus rhythm subjects were 20% and 80%, respectively. The average duration of QRS was 102 ± 24 ms. 20% of patients had a complete left bundle branch block. The mean of the left ventricular ejection fraction (LVEF) was 35.8% ± 13%. The LVEF was? ≤ 45% in 57% of cases and ≤ 30% in 30% of cases. The identified causes of heart failure were ischemic heart disease (60%), hypertensive heart disease (20%), and rheumatic valvulopathy (12%). Among the patients with ischemic heart disease, 80% were infarction. The coronarography and the myocardial revascularization were performed in 50% of cases. The primitive cardiomyopathy was diagnosed in 15% of cases. The average follow-up was 12.6 ± 8 months. 18% of patients died, 14% of whom deceased within 1 year after the initial diagnosis and 5% of death occurred in 19 months following the first symptoms of heart failure. The end stage of heart failure (13%) was the most frequent cause of death followed by the sudden death (5%) and the terminal kidney failure (2%). The patients

关键词： Epidemiologic Transition Heart Failure Institute of Cardiology of Abidjan National Police Hospital Black African

Initial Treatment of Knee Dislocation at Yopougon Teaching Hospital/Abidjan, Ivory Coast

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Open Journal of Orthopedics 2016年第11期6卷 337-343页

作者： Traoré Alidou Kouassi Kouamé jean Eric Kouassi Aya Adelaïde Natacha Mbende Alban Slim Sie Essoh jean baptiste Bamba Insa Lambin Yves Trauma and Orthopaedics Department Yopougon Teaching Hospital Abidjan Ivory Coast Trauma and Orthopaedics Department Bouak&eacute Teaching Hospital Bouak&eacute Ivory Coast Neurosurgery Unit Yopougon Teaching Hospital Abidjan Ivory Coast

Knee dislocation is a serious and rare injury. Its rarity and the variety of injuries that result from it mean that there is no adequate management that is universally accepted. The aim of this study was to evaluate our emergency care strategy for these injuries. Materials and methodology: This was a retrospective study conducted from January 1992 to December 2004 on nine cases of knee dislocation. It consisted of six men and three women. The average age of these subjects was 35, ranging from 15 to 50 years. The causes for these injuries included: public road accidents (n = 4), household accidents (n = 3), a sporting accident and a dislocation that occurred following a fight. The dislocations were anteromedial (n = 4), posterolateral (n = 2), posterior (n = 2) and anterior (n = 1). Associated injuries were sore joint (n = 2), contusion of the common peroneal nerve (n = 1) and vascular injury (n = 1). An angiography was performed on one patient for a vascular injury and an Elecmyography (EMG) for a common peroneal nerve injury. Closed reduction was used for eight patients and open reduction for one patient. Results: Five knees were stable with normal range of motion and some residual pain. Four patients had knee instability;two anterior, one anteroposterior and one lateral. In three of these patients, the CT arthrography/arthro-scan confirmed central pivot damage, with meniscal damage in two of them. The four patients were referred to a knee surgeon in a private practice. The post-operational effects were minimal in vascular injury. The EMG performed for the common peroneal nerve detected a nerve contusion. Conclusion: Our emergency care strategy remains closed reduction. This therapeutic management is consistent, at least in the first 15 days, with the literature.

关键词： Knee Dislocation Initial Management Instability

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醉心贵族的小市民 1

1956年

作者：（法）莫里哀（jean baptiste Poquelin Moliere）邓琳译

醉心贵族的小市民

ISBN: (数字)10018·5091

ISBN: (纸本)10018·5091

醉心贵族的小市民

关键词：戏剧学科:剧本地点:法国年代:近代

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心病者

Vitamin D Status and the Determinants of Preeclampsia in Pregnant Women in Goma (Democratic Republic of the Congo)

1955年

作者：（法）莫里哀（jean baptiste Poquelin Moliere）邓琳译

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Open Journal of Obstetrics and Gynecology 2020年第6期10卷 820-835页

作者： Kabuyanga Kabuseba Richard Balungwe Sifa Marcelline Elongi Moyene jean-Pierre Lundimu Tugirimana Pierrot Kalenga Muenze Kayamba Prosper Kakoma Sakatolo Zambeze jean-baptiste Department of Gynecology-Obstetrics University of Goma Goma DR Congo Department of Gynecology-Obstetrics Evangelical University in Africa Bukavu DR Congo Department of Gynecology-Obstetrics General Hospital of Kinshasa Kinshasa DR Congo Department of Laboratory & Basic Sciences University of Goma Goma DR Congo Department of Gynecology-Obstetrics and School of Public Health University of Lubumbashi Lubumbashi DR Congo

Background: Preeclampsia (PE) is a common condition, causing maternal and perinatal morbidity and mortality worldwide. In the absence of fully satisfactory treatment, screening remains one of the pillars of management. Low vitamin D status has been identified as a risk factor for PE. But, data on vitamin D status and risk factors for PE in the Democratic Republic of the Congo (DRC) is scanty. The aim of this study is to determine the level of Vitamin D and risk factors in preeclamptic patients in our environment. Methods: To fill this gap, we conducted a multicenter incident case control study on 190 pregnant women, 95 cases and 95 controls, receiving care from seven hospitals in Goma, in the eastern DRC, from April 1 to December 31, 2019. Socioeconomic, diet habits, clinical data, urinalysis and serum 25-hydroxy

关键词： Democratic Republic of the Congo Vitamin D Deficiency Preeclampsia Determinants

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回溯时间的诞生

新发现 2020年第3期 26-45页

作者： jean-baptiste Veyrieras 王隽(编译) 不详

人类从未想过,能给宇宙诞生史倒片,将这部大电影倒回至大爆炸之后的10^-32秒!在这短短的一瞬,时空出现了停滞,没有过去,没有未来。突然,时空震颤,时间开始流动,将原初能量转化为夸克-胶子等离子体,原子、恒星、行星相继诞生,一个不可逆... 详细信息

人类从未想过,能给宇宙诞生史倒片,将这部大电影倒回至大爆炸之后的10^-32秒!在这短短的一瞬,时空出现了停滞,没有过去,没有未来。突然,时空震颤,时间开始流动,将原初能量转化为夸克-胶子等离子体,原子、恒星、行星相继诞生,一个不可逆转的过程就此开启……如今,科学家在实验室中成功还原了宇宙诞生后的瞬间,人类对宇宙时间的探索就此有了新的进展。

关键词：能量转化夸克-胶子等离子体宇宙诞生实验室时空不可逆转