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Virtual brain twins: from basic neuroscience to clinical use

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National Science Review 2024年第5期11卷 72-86页

作者： Huifang E.Wang paul Triebkorn Martin Breyton Borana Dollomaja jean-Didier Lemarechal Spase Petkoski Pierpaolo Sorrentino Damien Depannemaecker Meysam Hashemi Viktor K.Jirsa Aix Marseille Université Institut National de la Santéet de la Recherche Médicale Institut de Neurosciences des Systèmes(INS) UMR1106 Service de Pharmacologie Clinique et Pharmacosurveillance AP–HM

Virtual brain twins are personalized, generative and adaptive brain models based on data from an individual's brain for scientific and clinical use. After a description of the key elements of virtual brain twins,we present the standard model for personalized whole-brain network models. The personalization is accomplished using a subject's brain imaging data by three means:(1) assemble cortical and subcortical areas in the subject-specific brain space;(2) directly map connectivity into the brain models, which can be generalized to other parameters; and(3) estimate relevant parameters through model inversion, typically using probabilistic machine learning. We present the use of personalized whole-brain network models in healthy ageing and five clinical diseases: epilepsy, Alzheimer's disease, multiple sclerosis, Parkinson's disease and psychiatric disorders. Specifically, we introduce spatial masks for relevant parameters and demonstrate their use based on the physiological and pathophysiological hypotheses. Finally, we pinpoint the key challenges and future directions.

关键词： virtual brain twin personalized modeling inference neuroscience brain disorder

Leaf habit differentiation explains trait tradeoffs across savanna woody plants

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Forest Ecosystems 2024年第3期11卷 287-295页

作者： Yangsiding Wang Da Yang German vargas G. Guangyou Hao Jennifer S.Powers Yan Ke Qin Wang Yunbing Zhang Jiaolin Zhang CAS Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMenglaYunnan 666303China University of Chinese Academy of Sciences Beijing 100049China School of Biological Sciences University of UtahSalt Lake CityUT 84112USA CAS Key Laboratory of Forest Ecology and Management Institute of Applied EcologyChinese Academy of SciencesShenyang 110016China Department of Ecology Evolution and BehaviorUniversity of MinnesotaSt PaulMN 55108USA

Identifying how leaf habit subdivisions link to the fast–slow and avoidance–tolerance trait tradeoffs can provide new insight into divergence in ecophysiological strategies among plant functional groups. Here, we tested a hypothesis that the differentiation across deciduous, semi-deciduous and evergreen woody species contributes to physiological trait tradeoffs in a dry-hot valley savanna. We investigated 11 photosynthetic, morphological and hydraulic traits of 24 species including 8 deciduous, 10 semi-deciduous and 6 evergreen species. Deciduous species were grouped in the fast and avoidance side associated with high values of maximum photosynthetic rates,stomatal conductance and leaf size, while evergreen species were grouped in the slow and tolerance side associated with high photosynthetic water use efficiency, leaf mass per area, sapwood density, Huber value, leaf water potential at turgor loss point and water potential causing 50% loss of stem hydraulic conductance. Semideciduous species generally had intermediate trait values and represented different physiological characteristics when compared to deciduous and evergreen species. The physiological trait tradeoffs showed a close linkage to the differentiation of these three leaf habits. Our findings clearly reveal trait tradeoffs related to fast–slow and avoidance–tolerance strategies among diverse savanna plants, suggesting a syndrome in multiple ecophysiology strategies across different leaf habits.

关键词： Dry-hot habitat Gas exchange Hydraulics Phenology Tolerance Valley savanna

Fuzzy Henstock-Kurzweil Triple Integral on a Type 1 Quasi-Fuzzy Parallelepipedal Domain

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Journal of Applied Mathematics and Physics 2024年第3期12卷 897-911页

作者： Kumwimba Seya Didier Kasongo Ntambwe Dany Panga Lutanda Grégoire Mayuke Katshongo jean paul Lunda Ngoy jean Pierre Département de Mathématiques et Informatique Faculté des Sciences Université de Lubumbashi Lubumbashi Democratic Republic of the Congo

In this article, we propose by using the Hausdorff distance Simpson’s rule for the triple integral of a fuzzy-valued function and the error bound of this method, one of the variables of which is fuzzy. In addition, thin δ-fine partitions are introduced. The integration domain is a quasi-fuzzy parallelipiped. A numerical example is presented in order to show the application and the significance of the method.

关键词： Fuzzy-Valued Function Hausdorff Distance Quasi-Fuzzy Parallelipiped Henstock Integral

Fatty Acid Composition of Hazelnut Kernel Oil from Coula edulis Collected in the Republic of Congo

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Food and Nutrition Sciences 2024年第4期15卷 290-297页

作者： Josiane Enzonga Yoca jean paul Latran Ossoko Yves Okandza Michel Didace Mvoula Tsieri Laboratoire de Contrô le et Qualit&#233 des Aliments de l&#8217Ecole Nationale Sup&#233rieure d&#8217Agronomie et de Foresterie Universit&#233 Marien NGOUABI Brazzaville Congo Université Denis Sassou NGUESSO Brazzaville Congo

Coula edulis is non-timber forest product (NTFP) used in Africa for its hazelnuts, which contain edible seeds with a demonstrated nutritional potential. However, there have been very few scientific studies of this species in the Republic of Congo. Thus, the aim of the current study was therefore to determine the fatty acid composition of the oil extracted from Coula edulis hazelnut seeds collected at random in the Republic of Congo. The oil was extracted using the Soxhlet method and its fatty acid composition was determined by gas chromatography. The extracted oil from Coula edulis hazelnut kernels is rich in monounsaturated fatty acids (95.28%), particularly oleic acid (94.5%), which classifies it as an oleic oil and gives it interesting nutritional and therapeutic properties. On the other hand, saturated fatty acids (4.15%) and polyunsaturated fatty acids (0.35%) are not well represented. Its low poly-unsaturated fatty acid content makes it more stable when stored at room temperature.

关键词： Coula edulis Fatty Acids Oil Seeds Hazelnuts Republic of Congo NTFP

Uncovering the Challenges of Faecal Sludge Management in Benin’s Urban Hubs: The Cases of Abomey-Calavi and Natitingou

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Journal of Environmental Protection 2024年第7期15卷 767-780页

作者： Nikita Topanou Blaise Agbatchi Gouvidé jean Gbaguidi Jacques Fatombi Fidèle paul Tchobo Kaba Laboratory of Chemical Research and Application (LaKReCA) Department of Chemistry Faculty of Science and Technology of Natitingou University of Abomey Natitingou Bnin Laboratory of Study and Research in Applied Chemistry Polytechnic School of Abomey-Calavi University of Abomey-Calavi (LERCA/EPAC/UAC) Cotonou Bnin

The issue of faecal sludge management in developing countries remains a significant challenge due to the indiscriminate discharge of sludge into the environment. This practice generates more environmental problems than it solves. This study aims to assess the management of household faecal sludge in the communes of Abomey-Calavi and Natitingou, Benin, in order to optimise the best storage conditions for subsequent more effective treatment. To this end, a sociological survey was conducted among households in Abomey-Calavi and Natitingou, as well as among manual emptiers. The results of our studies revealed that two types of latrines are used in households. 20.55% of households use traditional latrines, while 59.83% use ordinary latrines. 7.97% of households use both types of latrine. Moreover, the depth of the latrines varies from 2.5 m to 7 m in Abomey-Calavi and from 2.5 m to 8 m in Natitingou. Among households with a latrine, 28.26% empty their pit at least once, while 71.74% have never emptied it. The emptying cost varies between 35,000 FCFA and 90,000 FCFA. The mixing of faecal sludge with solid waste, including plastic materials, makes emptying difficult due to the obstruction of the vacuum pump. The results obtained will serve as a reliable database to facilitate decision-making in the context of faecal sludge management.

关键词： Management Faecal Sludge Valorization Benin

Dosage Formula in Anesthesia for Manual Intrauterine Aspiration Post-Abortion in Resource-Limited Settings

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Pharmacology & Pharmacy 2024年第4期15卷 71-80页

作者： Serge Ibula Rivain Iteke Berthe Barhayiga Doddie Tsansya Roger Cishugi jean Jacques Kalongo Sandra Sagboze jean paul Cikwanine Dieudonné Sengeyi ISTM/Bukavu Anesthesia-Resuscitation Section CIMAC Hospital Center in Goma Goma The Democratic Republic of the Congo Department of Anesthesia-Resuscitation University of Lubumbashi Lubumbashi The Democratic Republic of the Congo Department of Anesthesia-Resuscitation University of Kinshasa Kinshasa The Democratic Republic of the Congo Department of Gyneco-Obstetrics University of Kinshasa Kinshasa The Democratic Republic of the Congo Anesthesia-Resuscitation Department Panzi Hospital Bukavu The Democratic Republic of the Congo

Setting: Provincial General Reference Hospital of Bukavu, General Reference Hospital of Panzi, General Reference Hospital of Ciriri, General Reference Hospital of Nyatende and Biopharm Hospital Center. Objective: Contribute to the improvement of the anesthetic ECP of patients benefiting from MVA for incomplete abortion, Describe the methodology used for adoption of the dosage formula in Anesthesia for MVA, present the mathematical demonstration leading to the dosage formula in anesthesia for MVA. Materials and Methods: Our study was descriptive by mathematical demonstration of obtaining the equilibrium constant of the dosage formula of bipuvacaine 0.1% and Fentanyl 50 µg% adapted to the weight and specific size of patients treated anesthetically in MVA cases for incomplete abortion. We also carried out an operational research by first determining the interval where our equilibrium constant is included and secondly by means of the ends of the intervals found correlated to the ends of intervals of possible weights and sizes in the being normal human female of childbearing age to arrive at the real numerical value of the equilibrium constant of the BUKAVU Dosage Formula in the case of anesthesia for MVA during the management of incomplete abortions. Results: TWO-STAGE OPERATIONAL RESEARCH: • Determination of the interval where the equilibrium constant x = −0.95 x x by crossing the means between the extremes of volumes of anesthetic drugs giving a satisfactory sensory block without hemodynamic disturbance and the extremes of normal weight and height for women of childbearing age. We ended up with X = 0.37. Conclusion: At the end of our study which had the general objectives of contributing to the improvement of the anesthetic PEC of patients receiving MVA for incomplete abortion and specific objectives of describing the methodology used for adoption of the dosage formula in Anesthesia for MVA and present the mathematical demonstration which resulted in the dosage formul

关键词： Dosage Anesthesia Intrauterine Aspiration DR Congo

Experimental Assessment of the Thermal Performance of Two Corrugated Metal Roofs

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Open Journal of Applied Sciences 2024年第9期14卷 2374-2392页

作者： Kouamé jean-Louis Kouakou Ekoun paul Magloire Koffi Bi Tra Désiré Zinla Prosper Gbaha Laboratoire des Procds Industriels de Synthse de lEnvironnement et des Energies Nouvelles Institut National Polytechnique Felix Houphout-Boigny Yamoussoukro Cte dIvoire

This experimental study is a contribution to the search for solutions to reduce indoor heat gain through sheet metal roofing in hot weather. It has evaluated the thermal impact of two different sheet metal roofs inside of two identical test buildings in sunny weather and cloudy weather conditions. Test building 1 has a single sheet corrugated roof and the building 2 is covered with roof made from top to bottom with corrugated sheet metal, a 12 mm thick serpentine copper tube in which water is circulated, a sheet of aluminium foil acting as a heat reflector, a 4 cm thick polystyrene panel and a 1.5 cm thick plywood. A maximum reduction of 15.1˚C in the temperature of the inner face of the test Building 2 roof was obtained comparatively to the temperature of the inner face of the test Building 1 roof consisting of a single sheet of metal at the warmest hours. In addition, the simple corrugated sheet metal roof of the test building generates high and varied temperatures inside the building. Whereas the proposed heat recovery roof favours low and relatively uniform temperatures inside the building. The proposed sheet metal roof construction technique is very effective in reducing the heat gain through the roof considerably;thus improving the thermal comfort inside sheet metal roofed dwellings. Hot water has been produced by recovering heat from the metal sheet of the roof of test building 2. The temperature of the hot water produced reached of 39˚C. This study could be also an alternative for the reduction of energy consumption due to the use of mechanical means for cooling of sheet metal roofed houses and the reduction of the use of fossil fuels for domestic hot water production.

关键词： Metal Roof Corrugated Time Lag Decrement Factor

Pleomorphic leiomyosarcoma of the maxilla with metastasis to the colon:A case report

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World Journal of Gastrointestinal Endoscopy 2024年第6期16卷 361-367页

作者： Asma Alnajjar Abdulrahman Alfadda Abdullah Mohammad Alqaraawi Bader Alajlan jean paul Atallah Hussah Fahad AlHussaini Section of Gastroenterology Department of MedicineKing Faisal Specialist Hospital&Research CentreRiyadh 11211Saudi Arabia Department of Oncology King Faisal Specialist Hospital&Research CentreRiyadh 11211Saudi Arabia Department of Pathology King Faisal Specialist Hospital&Research CentreRiyadh 11211Saudi Arabia

BACKGROUND Pleomorphic leiomyosarcomas make up around 8.6%of all *** behave aggressively and often have poor *** can affect the gastrointestinal tract and *** date,pleomorphic leiomyosarcoma involving the mesocolon have been reported in nine *** SUMMARY The patient was a 44-year-old man with a history of pleomorphic leiomyosarcoma of the left maxilla with metastasis to the lung and *** most recent positron emission tomography-computed tomography(PET-CT)scan showed uptake in the ascending and transverse colons.A colonoscopy revealed a 5.0 cm×3.5 cm×3.0 cm pedunculated polyp in the ascending *** polyp was removed using hot snare polypectomy technique and retrieved with *** examination of the polyp showed a metastatic pleomorphic *** Uptake(s)on PET-CT in a patient with pleomorphic leiomyosarcoma should raise suspicion for metastasis.

关键词： Pleomorphic leiomyosarcoma Colon polyp Hot snare polypectomy Maxillary Spindle cell tumor Case report

Targeted therapy for capillary-venous malformations

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Signal Transduction and Targeted Therapy 2024年第7期9卷 3024-3039页

作者： Lola Zerbib Sophia Ladraa Antoine Fraissenon Charles Bayard Marina Firpion Quitterie Venot Sanela Protic Clément Hoguin Amandine Thomas Sylvie Fraitag jean-paul Duong Sophie Kaltenbach Estelle Balducci Coline Lefevre Patrick Villarese Vahid Asnafi Christine Broissand Nicolas Goudin Ivan Nemazanyy Gwennhael Autret Bertrand Tavitian Christophe Legendre Nadia Arzouk Veronique Minard-Colin Caroline Chopinet Michael Dussiot Denise MAdams Tristan Mirault Laurent Guibaud paul Isenring Guillaume Canaud UniversitéParis Cité ParisFrance INSERM U1151 Institut Necker-Enfants MaladesParisFrance Service d’Imagerie Pédiatrique Hôpital Femme-Mère-EnfantHCLBronFrance CREATIS UMR 5220 Villeurbanne 69100France Service de Radiologie Mère-Enfant Hôpital NordSaint EtienneFrance Service d’Anatomie pathologique Hôpital Necker-Enfants MaladesAP-HPParisFrance Laboratoire d’Oncohématologie Hôpital Necker-Enfants MaladesAP-HPParisFrance Pharmacie Hôpital Necker-Enfants MaladesAP-HPParisFrance Necker Bio-Image Analysis INSERM US24/CNRS UMS 3633ParisFrance Platform for Metabolic Analyses Structure Fédérative de Recherche NeckerINSERM US24/CNRS UMS 3633ParisFrance Plateforme Imageries du Vivant Universitéde ParisPARCCINSERMParisFrance Service de Néphrologie Transplantation AdultesHôpital Necker-Enfants MaladesAP-HPParisFrance Service de Transplantation Hôpital La PitiéSalpétrièreAP-HPParisFrance Department of Pediatric and Adolescent Oncology INSERM 1015Gustave RoussyUniversitéParis-SaclayVillejuifFrance Service de Physiologie&Explorations Fonctionnelles Cardiovasculaires CHU de LilleLille 59000France INSERM U1163 Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutic ImplicationsLaboratoire d’Excellence GR-ExParisFrance Division of Oncology Comprehensive Vascular Anomalies ProgramChildren’s Hospital of PhiladelphiaPhiladelphiaPAUSA Service de Médecine Vasculaire hôpital Européen Georges-PompidouParisFrance Nephrology Research Group L’Hôtel-Dieu de Québec Research CenterDepartment of MedicineFaculty of MedicineLaval UniversityQuebecQC G1R2J6Canada Unitéde médecine translationnelle et thérapies ciblées Hôpital Necker-Enfants MaladesAP-HPParisFrance CNRS UMR8253 Institut Necker-Enfants MaladesParisFrance

Sporadic venous malformations are genetic conditions primarily caused by somatic gain-of-function mutation of PIK3CA or TEK,an endothelial transmembrane receptor signaling through *** malformations are associated with pain,bleedings,thrombosis,pulmonary embolism,esthetic deformities and,in severe cases,life-threatening *** authorized medical treatment exists for patients with venous ***,we created a genetic mouse model of PIK3CA-related capillary venous malformations that replicates patient *** showed that these malformations only partially signal through AKT *** compared the efficacy of different drugs,including rapamycin,a mTORC1 inhibitor,miransertib,an AKT inhibitor and alpelisib,a PI3Kαinhibitor at improving the lesions seen in the mouse *** demonstrated the effectiveness of alpelisib in preventing vascular malformations’occurrence,improving the already established ones,and prolonging *** these findings,we were authorized to treat 25 patients with alpelisib,including 7 children displaying PIK3CA(n=16)or TEK(n=9)-related capillary venous malformations resistant to usual therapies including sirolimus,debulking surgical procedures or percutaneous *** assessed the volume of vascular malformations using magnetic resonance imaging(MRI)for each *** demonstrated improvement in all 25 *** malformations previously considered intractable were reduced and clinical symptoms were *** showed a decrease of 33.4%and 27.8%in the median volume of PIK3CA and TEK malformations respectively,over 6 months on *** conclusion,this study supports PI3Kαinhibition as a promising therapeutic strategy in patients with PIK3CA or TEK-related capillary venous malformations.

关键词： PIK3CA malformations venous