检索结果-南通市图书馆

维普期刊数据库

Petrography of alluvial sands as a past and present environmental indicator:Case of the Loire River(France)

在线全文

学校读者我要写书评

暂无评论

International Journal of Sediment Research 2013年第3期28卷 285-303页

作者： jean-jacques MACAIRE Isabelle GAY-OVEJERO Michel BACCHI Constantin COCIRTA Luc PATRYL Stéphane RODRIGUES University Franqois-Rabelais of Tours University Francois-Rabelais of Tours SARL RIVE 4. Commissariat a l'Energie Atomique-CEA DAMDIF

Four sample sets of the Upper and Middle Loire river sands were analyzed in order to study the impact of natural and anthropogenic factors on their petrographic composition in space(on an 800 km stretch) and *** was determined by modal analysis of three sand-size fractions using a polarizing optical microscope and calculated for each sample("standard sand" = Sst).The watershed is composed mainly of endogenic(Massif Central) and sedimentary(southern Parisian Basin) rocks.B-set sands collected in channels for different water flows in 1996 show that Sst compositions vary by only 5%.Present-day sands in the Upper Loire and Middle Loire have very high petrographic immaturity comparing to others worldwide fluvial sands,although bio-climatic conditions favor sand maturation by source-rock weathering in the *** shows the strong impact of the Massif Central on sediment yield due to relief rejuvenation as a consequence of the formation of the Alps during the *** sands stored during the Weichselian and the Holocene in the Middle Loire floodplain,although partly weathered since their deposition,show higher inputs from the endogenic rocks of the Massif Central than present-day *** can be explained by Weichselian periglacial conditions and the development of crop farming since the Neolithic,which favored mechanical erosion,particularly in the Massif Central which is characterized by a cold,humid climate and steep *** upstream-downstream change in the composition of presently deposited sand is low in the diked *** shows however that basalt and some heavy mineral grains are vulnerable to abrasion during transport and indicates a marked sediment yield from ancient sediment stored in the *** is in line with the high incision of the river bed over the last 150 years partly due to dam construction and aggregate mining.

关键词： Fluvial sand Sand petrography Sediment source Tectonics impact Human impact Loire river

Effect of preoperative renin-angiotensin system blockade on vasoplegia after cardiac surgery:A systematic review with metaanalysis

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Cardiology 2022年第4期14卷 250-259页

作者： jean jacques Noubiap Brice Nouthe Ying Tung Sia Marco Spaziano Centre for Heart Rhythm Disorders The University of AdelaideAdelaide 5000South AustraliaAustralia Department of Medicine University of British ColumbiaVancouver V6T 1W5Canada Department of Medicine Regional Trois-Rivières Hospital(CIUSSS-MCQ)Trois-Rivières 5000Canada Department of Cardiology McGill University Health CentreMontréal QC H4A 3J1Canada

BACKGROUND Vasoplegia is a common complication of cardiac surgery but its causal relationship with preoperative use of renin angiotensin system(RAS)blockers[angiotensin converting enzyme inhibitors(ACEIs)and angiotensin receptor blockers(ARB)]is still *** To update and summarize data on the effect of preoperative use of RAS blockers on incident *** All published studies from MEDLINE,EMBASE,and Web of Science providing relevant data through January 13,2021 were identified.A random-effects metaanalysis method was used to pool estimates,and post-cardiac surgery shock was differentiated from *** Ten studies reporting on a pooled population of 15672 patients(none looking at ARBs exclusively)were included in the *** were case-control *** of ACEIs was associated with an increased risk of vasoplegia[pooled adjusted odds ratio(Aor)of 2.06,95%CI:1.45-2.93]and increased inotropic/vasopressor support requirement(pooled aOR 1.19,95%CI:1.10-1.29).Post-cardiac surgery shock was increased in the presence of left ventricular dysfunction(pooled aOR 2.32,95%CI:1.60-3.36;I249%)but not increased by the use of beta blockers(pooled aOR 0.78,95%CI:0.36-1.69;I277%).Two randomized control trials(RCTs),not eligible for the meta-analysis,did not show an association between continuation of RAS blockers and *** Preoperative continuation of ACEIs is associated with an increased need for inotropic support postoperatively and with an increased risk of vasoplegia in observational studies but not in *** absence of a consensus definition of vasoplegia should lead to the use of perioperative cardiovascular monitoring when designing RCTs to better understand this discrepancy.

关键词： Vasoplegia Cardiac surgery Coronary artery bypass graft Angiotensin converting enzyme inhibitors

What lessons can be learned from y T cell-based cancer immunotherapy trials？

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2013年第1期10卷 35-41页

作者： jean-jacques Fournie Helene Sicard Mary Poupot Christine Bezombes Amandine Blanc Franqois-Romagne Loic Ysebaert Guy Laurent INSERM UMR1037-Cancer ResearchCenter of Toulouse Toulouse France University of Toulouse Toulouse France ERL 5294 CNRS BP3028 Hospital Purpan ToulouseFrAnce lnnate Pharma Marseilles France and Department of Hematology Hospital Purpan Toulouse France

During the last several years, research has produced a significant amount of knowledge concerning the characteristics of human 76 T lymphocytes. Findings regarding the immune functions of these cells, particularly their natural killer cell-like lyric activity against tumor cells, have raised expectations for the therapeutic applications of these cells for cancer. Pharmaceutical companies have produced selective agonists for these lymphocytes, and several teams have launched clinical trials of y8 T cell-based cancer therapies. The findings from these studies include hematological malignancies （follicular lymphoma, multiple myeloma, acute and chronic myeloid leukemia）, as well as solid tumors （renal cell, breast and prostate carcinomas）, consisting of samples from more than 250 patients from Europe, Japan and the United States. The results of these pioneering studies are now available, and this short review summarizes the lessons learned and the role of y6 T cell-based strategies in the current landscape of cancer immunotherapies.

关键词： cancer cell therapy gamma-delta lymphocytes immunotherapy lymphoma trials

Antibacterial, Anti-Inflammatory and Antioxidant Activities of an ACAZY Herbal Formula Used in Traditional Medicine to Treat Respiratory Infections

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Natural Science 2024年第9期16卷 131-145页

作者： Mohamed Bonewendé Belemlilga Bagora Bayala Abdoul Gilchrist Laurent Boly Madinatou Annick Ouédraogo Alida Raissa Boina Boubacar Yaro Florentina Badea Camélia Diguti Moumouni Koala Denise P. Ilboudo Charles Bavouma Sombié Pascal Nadembega jean-Marie Compaoré Paul Darga Mahoukèdè Théodora Zohoncon Moussa Ouédraogo Aristide Traore Noufou Ouédraogo Florentina Matei Rasmane Semdé Sylvin Ouédraogo jacques Simporé Innocent Pierre Guissou Laboratoire de Recherche-Dveloppement de Phytomdicaments et Mdicaments (LR-D/PM) Institut de Recherche en Sciences de la Sant (IRSS) Centre National de la Recherche Scientifique et Technologique (CNRST) Ouagadougou Burkina Faso Centre de Recherche Biomolculaire Pietro Annigoni (CERBA) Ouagadougou Burkina Faso Laboratoire de Biologie Molculaire et de Gntique (LABIOGENE) Universit Joseph KI-ZERBO Ouagadougou Burkina Faso Ecole Normale Suprieure Koudougou Burkina Faso Laboratoire de Dveloppement du Mdicament (LADME) Centre de Formation de Recherche et dExpertises en Sciences du Mdicament (CEA-CFOREM) cole Doctorale Sciences de la Sant (ED2S) Universit Joseph KI-ZERBO Burkina Faso Laboratoire de Microbiologie Applique Universit des Sciences Agronomiques et de Mdecine Vtrinaire (UASMV) de Bucarest en Roumanie Bucharest Romania Dpartement de la mdecine traditionnelle Ministre de la Sant et de lHygine Publique Ouagadougou Burkina Faso Universit Saint Thomas dAquin (USTA) Ouagadougou Burkina Faso

ACAZY is a plant formula used in traditional medicine in Burkina Faso to treat respiratory infections. After phytochemical analysis, this study evaluated extracts’ anti-inflammatory, antioxidant and antibacterial properties from the ACAZY recipe. Three extractions, an aqueous macerate (AM), an aqueous decoction (AD) and an hydroethanolic macerate (HEM) of the ACAZY recipe powder were carried out. Phytochemical screening of the extracts was carried out using high-performance thin-layer chromatography (HPTLC) and the determination of phenolic compounds. The anti-inflammatory potential was assessed in vitro using pro-inflammatory enzyme inhibition tests. 2,2-Diphenyl-1-picrylhydrazyl (DPPH) and Ferric-reducing antioxidant power (FRAP) antioxidant properties were also determined. The antibacterial activity was evaluated on Staphylococcus aureus and Streptococcus pneumoniae strains. Phytochemical analysis revealed the presence of flavonoids, saponins, tannins, anthracenosids, sterols and triterpenes in the extracts. The extracts inhibited pro-inflammatory enzymes by more than 40% at only 100 µg/mL. The extracts also showed potent antibacterial activity with a minimum inhibitory concentration 1 mg/mL on Staphylococcus aureus and 2 mg/mL on Streptococcus pneumoniae. The extracts in the ACAZY formula have shown anti-inflammatory and antioxidant properties in vitro. The AD also showed an antibacterial activity. This justifies its use in traditional medicine to treat acute respiratory infections.

关键词： ACAZY Anti-Inflammatory Antioxidant Antibacterial In Vitro

Self-activation of Vγ9Vδ2 T cells by exogenous phosphoantigens involves TCR and butyrophilins

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2021年第8期18卷 1861-1870页

作者： ChloéLaplagne Laetitia Ligat Juliet Foote Frederic Lopez jean-jacques Fournié Camille Laurent Salvatore Valitutti Mary Poupot Inserm UMR1037 Centre de Recherches en Cancérologie de ToulouseToulouseFrance UniversitéToulouse III Paul-Sabatier ToulouseFrance ERL 5294 CNRS ToulouseFrance IUCT-O ToulouseFrance

The high cytotoxic activity of Vγ9Vδ2 T lymphocytes against tumor cells makes them useful candidates in anticancer ***,the molecular mechanism of their activation by phosphoantigens(PAgs)is not completely *** studies have depicted the mechanism of Vγ9Vδ2 T-cell activation by PAg-sensed accessory cells,such as immune presenting cells or tumor *** this study,we demonstrated that pure resting Vγ9Vδ2 T lymphocytes can self-activate through exogenous PAgs,involving their TCR and the butyrophilins BTN3A1 and *** is the first time that these three molecules,concurrently expressed at the plasma membrane of Vγ9Vδ2 T cells,have been shown to be involved together on the same and unique T cell during PAg ***,the use of probucol to stimulate the inhibition of this self-activation prompted us to propose that ABCA-1 could be implicated in the transfer of exogenous PAgs inside Vγ9Vδ2 T cells before activating them through membrane clusters formed byγ9TCR,BTN3A1 and *** self-activation of Vγ9Vδ2 T cells,which leads to self-killing,can therefore participate in the failure ofγδT cell-based therapies with exogenous PAgs and should be taken into account.

关键词： Vγ9Vδ2 T cells Phosphoantigen Butyrophilins T-cell receptor

Synthesis of P,N-2,2'-biphenyl derivatives with central chirality

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2010年第9期53卷 1907-1913页

作者： jean Ludovic POULIQUEN Michael BLANCHET Jérme LASNE Marie-Claire ROUDEN jacques Laboratoire de Chimie Moléculaire et Thioorganique UMR 6507 CNRS-ENSICAEN & Université de Caen-Basse Normandie6 Boulevard du Maréchal Juin14050 CaenInstitut Normand de Chimie MoléculaireMédicinale et Macromoléculaire(INC3M)

Enantiopure 2-(dicyclohexylphosphino)-1,1'-biphenyl derivatives substituted in the 2'-position by a chiral amino group were *** the compound bearing an acyclic chiral chain,the key step was a Suzuki coupling between bromobenzeneboronic acid and N-Boc-iodoaniline whereas an aromatic nucleophilic substitution allowed the introduction of a chiral pyrrolidine in the 2'-position of the biphenyl *** efficiency of the P,N-biphenyl pyrrolidine derivatives as ligands in Pd-catalyzed arylaminations compares well with that of DavePhos ligand.

关键词： 3-aminopyrrolidines Suzuki coupling biphenyls chiral ligand arylamination

维普期刊数据库

Prevalence and correlates of depressive symptoms in adult patients with pulmonary tuberculosis in the Southwest Region of Cameroon

在线全文

学校读者我要写书评

暂无评论

Infectious Diseases of Poverty 2016年第1期5卷 432-439页

作者： Jules Kehbila Cyril Jabea Ekabe Leopold Ndemnge Aminde jean jacques NNoubiap Peter Nde Fon Gottlieb Lobe Monekosso Department of Medicine Faculty of Health SciencesUniversity of BueaBueaCameroon Clinical Research Education Networking and ConsultancyBP 3480 DoualaCameroon School of Public Health Faculty of Medicine and Biomedical SciencesUniversity of QueenslandBrisbaneAustralia Department of Medicine Groote Schuur Hospital and University of Cape TownCape TownSouth Africa Medical Diagnostic Center YaoundéCameroon Department of Public Health and Hygiene Faculty of Health SciencesUniversity of BueaBueaCameroon Department of Medicine Faculty of Health SciencesUniversity of Buea and Global Health Dialogue FoundationBueaCameroon

Background:Tuberculosis(TB)remains a global health challenge and depression is a significant contributor to the global burden of *** evidence suggests that there is an association between depressive symptoms and TB,lower adherence to treatment,and increased morbidity and ***,there is paucity of data regarding these associations in *** study aimed to determine the prevalence and correlates of depression in adult patients with pulmonary TB(PTB)in the Southwest Region of ***:A hospital-based cross-sectional study involving 265 patients with PTB was conducted from 2nd January to 31st March 2015 in the Limbe Regional Hospital and the Kumba District *** was diagnosed using the standard nine-item Patient Health Questionnaire,and classified as none,mild or *** regressions were used to investigate correlates of depression in these ***:Of the 265 patients(mean age 36.9±10 years)studied,136(51.3%)were *** prevalence of depression was 61.1%(95%CI:55.1–66.8),with a significant proportion(36.6%)having mild *** logistic regression analysis showed that being female(aOR=3.0,95%CI(1.7–5.5),P0.05),being on retreatment for TB(aOR=11.2,95%CI:5.2–31.1,P<0.001),having discontinued treatment(aOR=8.2,95%CI:1.1–23.3,P<0.05)and having a HIV/TB co-infection(aOR=2.5,95%CI:1.2–6.5,P<0.001)were factors associated with having a higher chance of being ***:Our study suggests that there is a high prevalence of depression among PTB patients,with more than one in two patients *** care for TB patients involving mental health practitioners is highly encouraged,especially for high-risk groups.

关键词： Prevalence Correlates Depression Pulmonary tuberculosis Cameroon

Elective operation after acute complicated diverticulitis:Is it still mandatory?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第25期20卷 8166-8172页

作者： Valérie Bridoux Marlène Antor Lilian Schwarz Julien Cahais Haitham Khalil Francis Michot jean-jacques Tuech Department of Digestive Surgery Rouen University Hospital

AIM: To investigate recurrence rates, patterns and complications after nonoperatively managed complicated diverticulitis (CD).

关键词： Diverticulosis Diverticular abscess Hinchey classification Percutaneous drainage Recurrent diverticulitis

SYNTHESIS OF CONDUCTIVE POLYANILINE VIA OXIDATION BY MnO_2

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2004年第3期22卷 269-277页

作者：生瑜 Christian Carrotc jacques Guilletc Institute of Materials Science and Engineering East China University of Science and Technology Shanghai 20023 China Laboratoire de Rheologie des Matieres Plastiques FRE CNRS 2396 Universite Jean Monnet 42023 St-Etienne Cedex 2 France

A unique process of chemical oxidation polymerization of aniline using manganese dioxide (MnO2) as the oxidizing agent in an aqueous medium is described. The reaction between aniline and MnO2 follows a mechanism by which the organic monomer is oxidized while the metal oxide undergoes reductive dissolution. The effects of the amount of oxidizing agent and aniline, pH and temperature of the reactive system, type of acid on the yield and conductivity of polyaniline are discussed. The resulting polyaniline was characterized by IR and UV-Vis spectrometry. Polyaniline with a conductivity of 12.5 S/cm was obtained using 0.033 mol of aniline oxidized by 0.023 mol MnO2 in the presence of 100 mL of 2.7 mol/L HCl at 25degreesC for 4 h.

关键词： conducting polymers heteroatom-containing polymers manganese oxide oxidation polymerization polyaniline

维普期刊数据库