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Safety and efficacy of a docetaxel-5FU-oxaliplatin regimen with or without trastuzumab in neoadjuvant treatment of localized gastric or gastroesophageal junction cancer: A retrospective study

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World Journal of Gastrointestinal Oncology 2019年第8期11卷 634-641页

作者： Valeria Basso David Orry jean fraisse Julie Vincent Audrey Hennequin Leila Bengrine Francois Ghiringhelli Department of Surgery Centre Georges Francois LeclercDijon 21000France Department of Medical Oncology Centre Georges Francois LeclercDijon 21000France

BACKGROUND Triplet chemotherapy,with docetaxel-5FU-oxaliplatin FLOT regimen recently became the standard perioperative treatment for localized gastric cancer(GC).An adapted regimen called TeFOX was recently tested in metastatic setting and gave promising *** To determine safety and efficacy of TeFOX perioperative *** This monocentric retrospective study aims to test efficacy and safety of the perioperative TeFOX regimen given alone or in combination with trastuzumab in patients with localized *** consist in docetaxel(50 mg/m^2)with oxaliplatin 85 mg/m^2 and and leucovorin(400mg/m^2^)5 FU bolus(400mg/m^2)on day 1,followed by continuous infusion of 5FU for 46h(2400mg/m^2)every 2 *** Thirty-three consecutive patients were included in this retrospective *** patients have a gastroesophageal junction cancer and 11 have a *** follow-up of surviving patients was 32 mo.R0 resection was obtained in 30(91)*** patients(36)had a pathological complete response and 8(24)patients a nearly complete pathological *** OS and PFS were not reached at data base *** have observed 6 metastatic relapses and 1 localized *** relapse was observed in patients with pathological complete *** most common grade 3-4 adverse events were peripheral neuropathy(21)and asthenia(20).CONCLUSION TeFOX regimen could be safely administrated in perioperative treatment of localized *** and the FLOT regimen have comparable efficacy and safety profiles.

关键词： Gastric cancer Neoadjuvant chemotherapy TeFOX Retrospective study

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Caffeoyl Derivatives: Major Antioxidant Compounds of Some Wild Herbs of the <i>Asteraceae</i>Family

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Food and Nutrition Sciences 2011年第3期2卷 181-192页

作者： Didier fraisse Catherine Felgines Odile Texier jean-Louis Lamaison 不详

The polyphenolic composition and antioxidant activity of the aerial parts of 18 medicinal or food plants of the As- teraceae family were studied. Five main caffeoyl derivatives were determined individually by HPLC and compared with levels determined by colorimetry for total dihydroxycinnamic derivatives and total phenolics. The aim of this study was to assess the contribution of these constituents to the antioxidant activity of the herbs determined by DPPH radical scavenging tests. Significant correlations were found between total phenolic (R2 = 0.8904), total dihydroxycinnamic derivative (R2 = 0.8529) and total caffeoyl derivative (R2 = 0.7172) concentrations and the DPPH-scavenging ability of all herbs. The antioxidant activity of the main constituents, including chicoric acid (EC50 = 8.24 μmol/l) or 3,5- dicaffeoylquinic acid (EC50 = 7.62 μmol/l), was very high compared to vitamin C (EC50 = 15.66 μmol/l). Thus, for each species, antioxidant activity mainly involves the major caffeoyl derivatives. The contribution to antioxidant activity were assessed as 48.92% for 3,5-dicaffeoylquinic acid in Tanacetum parthenium (30.08 g/kg), and 68.96% for chicoric acid in Taraxacum officinale (34.08 g/kg). The main caffeoyl derivatives among polyphenols can be considered as the major antioxidant compounds of the studied Asteraceae herbs.

关键词： Plants Asteraceae Caffeoyl Derivatives Antioxidant

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