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Characteristics of patients with Wilson disease in the United States: An insurance claims database study

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World Journal of Hepatology 2024年第5期16卷 791-799页

作者： Thomas Daniel-Robin Pradeep Kumar Bernard Benichou jean-Philippe Combal Vivet Therapeutics Paris 75008France Clarivate Noida 201301Uttar PradeshIndia

BACKGROUND Wilson disease(WD)is a progressive,potentially fatal degenerative disease affecting the liver and central nervous *** its low prevalence,collecting data on large cohorts of patients with WD is *** insur-ance claims databases provide powerful tools to collect retrospective data on large numbers of patients with rare *** To describe patients with WD in the United States,their treatment and clinical outcome,using a large insurance claims *** This retrospective,longitudinal study was performed in the Clarivate Real-World Data Product *** patients with≥2 claims associated with an Interna-tional Classification of diseases 10(ICD-10)diagnostic code for WD(E83.01)between 2016 and 2021 were included and followed until death or study *** were divided into two groups by whether or not they were documented to have received a specific treatment for *** manifestations,hospital-isations,liver transplantation and death were *** Overall,5376 patients with an ICD-10 diagnostic code for WD were *** mean age at inclusion was 41.2 years and 52.0%were men.A specific WD treatment was documented for 885 patients(15.1%),although the number of patients taking zinc salts may be underestimated due to over the counter *** inclusion,the mean age of patients with a documented treatment was 36.6±17.8 years vs 42.2±19.6 years in those without a documented *** follow-up,273 patients(5.1%)*** with the American general population,the standardised mortality ratio was *** proportion of patients with a documented WD-specific treatment who died during follow-up was 4.0%and the mean age at death 52.7 *** Patients treated for WD in the United States had an excess early mortality compared with the American *** findings indicate that there is a significant unmet need for effective treatment for WD in the United States.

关键词： Wilson disease Mortality Treatment Copper chelators Zinc acetate United States

From Control Theory to Gravitational Waves

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Advances in Pure Mathematics 2024年第2期14卷 49-100页

作者： jean-Francois Pommaret CERMICS Ecole des Ponts Paris Tech Paris France

When D:ξ→η is a linear ordinary differential (OD) or partial differential (PD) operator, a “direct problem” is to find the generating compatibility conditions (CC) in the form of an operator D1:η→ξ such that Dξ = η implies D1η = 0. When D is involutive, the procedure provides successive first-order involutive operators D1,...,Dn when the ground manifold has dimension n. Conversely, when D1 is given, a much more difficult “inverse problem” is to look for an operator D:ξ→η having the generating CC D1η = 0. If this is possible, that is when the differential module defined by D1 is “torsion-free”, that is when there does not exist any observable quantity which is a sum of derivatives of η that could be a solution of an autonomous OD or PD equation for itself, one shall say that the operator D1 is parametrized by D. The parametrization is said to be “minimum” if the differential module defined by D does not contain a free differential submodule. The systematic use of the adjoint of a differential operator provides a constructive test with five steps using double differential duality. We prove and illustrate through many explicit examples the fact that a control system is controllable if and only if it can be parametrized. Accordingly, the controllability of any OD or PD control system is a “built in” property not depending on the choice of the input and output variables among the system variables. In the OD case and when D1 is formally surjective, controllability just amounts to the formal injectivity of ad(D1), even in the variable coefficients case, a result still not acknowledged by the control community. Among other applications, the parametrization of the Cauchy stress operator in arbitrary dimension n has attracted many famous scientists (G. B. Airy in 1863 for n = 2, J. C. Maxwell in 1870, E. Beltrami in 1892 for n = 3, and A. Einstein in 1915 for n = 4).

关键词： differential Operator differential Sequence Killing Operator Riemann Operator Bianchi Operator Cauchy Operator Control Theory Controllability Elasticity General Relativity

Astral Actions on Allais’ Pendulum Apparently Inexplicable by Classical Factors: A Point of the Situation

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Journal of Modern Physics 2024年第9期15卷 1375-1408页

作者： jean-Bernard Deloly Independant Researcher Epinay sur Orge France

1) The observation by Allais of the precession of pendulums from 1954 to 1960 highlighted regularities of astral origin an in-depth analysis of which showed that, apparently, no classical phenomenon can explain them. These regularities were diurnal waves whose periods are characteristic of astral influence (the main ones being 24 h and 24 h 50 min), annual and semi-annual components, and a multi-annual component of approximately 6 years, an influence of Jupiter being a very good candidate to explain it. 2) Allais had experimentally established that all these astral influences were expressed globally on the pendulum by an action tending to call back its plane of oscillation towards a direction variable in time, and which ovalized its trajectory. In 2019 the observation of 2 pendulums in Horodnic (Romania), thanks to the use of an automatic alidade, made it possible to identify the main mechanism that, very probably, acted on the pendulum to achieve this result. This perturbation model, called “linear anisotropy”, is characterized by its “coefficient of anisotropy” η, and by the azimuth of its “direction of anisotropy”. The composition of 2 linear anisotropies is always a linear anisotropy. 3) In the search for the phenomena which could be at the origin of all what precedes, the fact that they must create an ovalization immediately eliminates some of them. 4) We have calculated the values of η corresponding to the 24 h and 24 h 50 min waves both for the observations in Horodnic and the Allais observations. The order of magnitude (some 10−7) is effectively the same in both cases. 5) Mathematically, the regularities discovered may result of a new force field but also, as Allais proposes, from the creation, under the astral influences, of a local anisotropy of the medium in which the pendulum oscillates. In the first case the length of the pendulum is involved, in the second one not. The data available do not make it possible to decide. 6) The joint exploitation, in mech

关键词： Allais Effect Pendulum Lunisolar Influence Jupiter Influence Lunar and Solar Eclipses Syzygies Sunspots Solar Cycles

The Njiki’s Fundamental Theorem-Definition on Fractions in the Mathematical Set ℚ and by Extension in ℝ and ℂ, for the Purpose of Leading to the Construction of Some Algebraic Structures as Its Theoretical Applications and for the Practical Ones

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American Journal of Computational Mathematics 2024年第3期14卷 358-379页

作者： jean Claude Njiki Independent Researcher Yaound Cameroon

The purpose of the research in the NJIKI’s fundamental THEOREM-DEFINITION on fractions in the mathematical set ℚand by extension in ℝand ℂand in order to construct some algebraic structures is about the proved EXISTENCE and the DEFINITION by NJIKI of two INNOVATIVE, IMPORTANT and TEACHABLE operations of addition or additive operations, in ℚ, marked ⊕and +α,β, and taken as VECTORIAL, TRIANGULAR, of THREE or PROPORTIONAL operations and in order to make THEM not be different from the RATIONAL ONE, +, but to bring much more and new information on fractions, and, by extension in ℝand ℂ. And the very NJIKI’s fundamental THEOREM-DEFINITION having many APPLICATIONS in the everyday life of the HUMAN BEINGS and without talking about computer sciences, henceforth being supplied with very interesting new ALGORITHMS. And as for the work done in the research, it will be waiting for its extension to be done after publication and along with the research results concerned.

关键词： Operations of Addition Additive Operations in ℚ Laws in ℚ THEOREM-DEFINITION External Multiplication

Structural Setting of the South-West Cameroon Using Satellite Potential Field Derived from SGG-UGM-2 Gravity Data

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Journal of Geoscience and Environment Protection 2024年第8期12卷 43-61页

作者： jean Aimé Mono Basical Science Department Advanced Technical Teacher Training School University of Douala Douala Cameroon

This study aims to improve knowledge of the structure of southwest Cameroon based on the analysis and interpretation of gravity data derived from the SGG-UGM-2 model. A residual anomaly map was first calculated from the Bouguer anomaly map, which is strongly affected by a regional gradient. The residual anomaly map generated provides information on the variation in subsurface density, but does not provide sufficient information, hence the interest in using filtering with the aim of highlighting the structures affecting the area of south-west Cameroon. Three interpretation methods were used: vertical gradient, horizontal gradient coupled with upward continuation and Euler deconvolution. The application of these treatments enabled us to map a large number of gravimetric lineaments materializing density discontinuities. These lineaments are organized along main preferential directions: NW-SE, NNE-SSW, ENE-WSW and secondary directions: NNW-SSE, NE-SW, NS and E-W. Euler solutions indicate depths of up to 7337 m. Thanks to the results of this research, significant information has been acquired, contributing to a deeper understanding of the structural composition of the study area. The resulting structural map vividly illustrates the major tectonic events that shaped the geological framework of the study area. It also serves as a guide for prospecting subsurface resources (water and hydrocarbons). .

关键词： SGG-UGM-2 Model Horizontal Gradient Bouguer Anomalies Potential Field Data

Risk factors for running-related injuries:An umbrella systematic review

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Journal of Sport and Health Science 2024年第6期13卷 793-804页

作者： Clara Knierim Correia jean Marlon Machado Fabio Hech Dominski Marcelo Peduzzi de Castro Heiliane de Brito Fontana Caroline Ruschel College of Health and Sport Science State University of the Santa CatarinaFlorianopolis 88080-350Brazil Fisiolab Institut Florianopolis 88015-310Brazil Biological Sciences Centre Federal University of Santa CatarinaFlorianopolis 88040-900Brazil

Purpose:This umbrella systematic review(SR) of SRs and meta-analysis seeks to comprehensively synthesize existing literature to identify and consolidate the diverse range of risk factors contributing to running-related injuries(RRIs).Methods:Systematic searches were conducted on June 28,2023,across Web of Science,SPORTdiscus,Scopus,PubMed,and Cochrane *** included SRs,whether accompanied by meta-analyses or not,that focused on investigating risk factors for RRIs within observational *** methodological quality of the SRs was evaluated using the Assessing the Methodological Quality of Systematic Reviews Ⅱ.To assess the extent of overlap across reviews,the corrected covered area metric was ***:From 1509 records retrieved,13 SRs were *** degree of overlap between SRs was low(4%),and quality varied from critically low(n=8) to low(n=5).Two hundred seven outcomes assessed in 148 primary studies were identified as being associated with the occurrence of *** effect sizes of the associations for which risk measures were reported(n=131) were classified as large(n=30,23%),medium(n=38,29%),small(n=48,37%) or no effect(n=15,11%).Running/training characteristics,health and lifestyle factors,along with morphological and biomechanical aspects,exhibit large effect sizes in increasing the risk for ***:Drawing from the outcomes of the low-quality SRs and associations with large effect sizes,our findings indicate that running/training characteristics and health and lifestyle factors,as well as morphological and biomechanical aspects,are all implicated in elevating the risk of RRIs,emphasizing the multifactorial basis of injury incidence in *** the low quality and heterogeneity of SR,individual findings warrant cautious interpretation.

关键词： Umbrella review Runners Injury Risk factor

Pd_(20)Pt_(20)Cu_(20)Ni_(20)P_(20)高熵金属玻璃的热稳定性和热塑成形性

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稀有金属材料与工程 2024年第1期53卷 1-7页

作者： Cardinal Sandrine Pelletier jean-Marc Kato Hidemi 里昂大学里昂国立应用科学学院法国里昂F-69621 东北大学金属材料研究所日本仙台980-8577

采用差示扫描量热法、X射线衍射和热力学分析研究了Pd_(20)Pt_(20)Cu_(20)Ni_(20)P_(20)高熵金属玻璃(HEMG)的热稳定性和热力学性能。结果表明,与其他经典贵金属基金属玻璃相比,Pd_(20)Pt_(20)Cu_(20)Ni_(20)P_(20)HEMG具有相当的性能... 详细信息

采用差示扫描量热法、X射线衍射和热力学分析研究了Pd_(20)Pt_(20)Cu_(20)Ni_(20)P_(20)高熵金属玻璃(HEMG)的热稳定性和热力学性能。结果表明,与其他经典贵金属基金属玻璃相比,Pd_(20)Pt_(20)Cu_(20)Ni_(20)P_(20)HEMG具有相当的性能和鲜明的特点。

关键词：高熵合金金属玻璃热塑性成形结晶

Matrix Assisted Laser Desorption Ionization Time of Flight(MALdi-TOF)-Mass Spectrometry and^(13)C-NMR-Identified New Compounds in Paraberlinia bifoliolata(Ekop-Beli)Bark Tannins

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Journal of Renewable Materials 2024年第3期12卷 553-568页

作者： Liliane Nga Benoit Ndiwe Achille Bernard Biwolé Antonio Pizzi jean Jalin Eyinga Biwole Joseph Zobo Mfomo Laboratory of Forest Resources and Wood Valorization Training Unit in Engineering SciencesPost Graduate School of Fundamental and Applied SciencesUniversity of DoualaP.O.Box 1872DoualaCameroun Laboratory of Mechanics Training Unit in Engineering SciencesPost Graduate School of Fundamental and Applied SciencesUniversity of DoualaP.O.Box 2701DoualaCameroun Laboratory of Studies and Research on Wood Material(LERMAB) University of LorraineNancyFrance

Extracts of plant origin,particularly tannins,are attracting growing interest for the sustainable development of materials in the industrial *** discovery of new tannins is therefore *** aim of this work was to contribute to the understanding of the properties of Paraberlinia bifoliolata tannin by Matrix Assisted Laser Desorption Ionization Time of Flight Mass Spectroscopy MALdi-TOF/MS and Carbon 13 Nuclear Magnetic Resonance(13C NMR).The chemical composition of tannin extracted from Paraberlinia bifoliolata bark was determined,as was the mechanical strength of the resin hardened with Acacia nilotica *** by successive water extraction was 35%.MALdi-TOF/MS analysis revealed the presence of three new compounds in this tannin,previously unknown in this family of *** are 3-hydroxyproline acid,N-methyl-4-hydroxypipecolic acid and N-methyl-5-dihydroxypipecolic *** identification of the above molecules means that this tannin can be used for industrial applications,as a resin in the manufacture of particleboard and in the formulation of green corrosion *** information is reinforced by 13C NMR spectrometry,which indicates the presence of several polyflavonoid units,confirming the condensed nature of the *** analysis of the resin formed by the purified tannin of Paraberlinia bifoliolata to which a vegetal biohardener has been added provided a Modulus of Elasticity(MOE)value of 4840 MPa at 150℃,confirming its possible use as a binder resin in the manufacture of wood panels as well as for the formulation of a corrosion inhibitor.

关键词： Tannin Paraberlinia bifoliolata Central African wood species MALdi-TOF/MS 13C NMR bark extracts thermomechanical behaviour wood-binder

Bridging Continents,Shaping Futures

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China Today 2024年第10期73卷 20-21页

作者： jean-CHRISTOPHE DESLARZES Board of the Adecco Group

The combined strengths of China and Europe can build a workforce that is well-prepared for the future and capable of driving economic *** highly anticipated China-Europe Talent Forum 2024 provides us with an invaluable platform to discuss and enhance the strong ties between China and Europe,focusing on the future of talent *** relationship between China and Europe has long been marked by mutual respect and a deep commitment to collaboration in various sectors,including trade,technology,education,and culture.

关键词： mutual driving education