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Evaluation of SON’OR^(█),a Medical Device for Provoked Otoacoustic Emissions and Brainstem Evoked Response Audiometry Made in Cameroon

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Journal of Biomedical Science and Engineering 2017年第8期10卷 376-389页

作者： jean Espoir E.Vokwely jean valentin f.fokouo Guy Merlin Ngounou Dalil Asmaou Esthelle G.Minka Ngom Martin Kom Richard L.Njock G.Bengono Alexis Ndjolo Otorhinolaryngology Service Centre Hospitalier d’EssosYaoundeCameroon Regional Hospital Bertoua BertouaCameroon National Advanced School of Engineering YaoundeCameroon BENDO Company YaoundeCameroon General Hospital YaoundeCameroon General Hospital DoualaCameroon Laquintinie Hospital DoualaCameroon Cameroon Society of Otolaryngology and Head and Neck Surgery YaoundeCameroon Chantal Biya International Research Center YaoundeCameroon

Background: There is a huge gap in the audiological care in Africa by comparison with Western countries. Its main reason is the prohibitive cost of the medical devices used to screen or diagnose patients. A Cameroonian team tackled this problem by developing a medical device (SON’OR©) which integrates a new instrumentation amplifier structure dedicated to perform otoacoustic emissions (OAE) and brainstem evoked response audiometry (BERA). The major technical challenges to perform OAE and BERA are the synchronization and the amplification of signals of very low amplitude. In this work, we emphasize on the general criteria necessary and indispensable to achieve an optimal amplification. The application of a novel instrumentation amplifier structure characterized by its optimized noise factor in the case of BERA and OEA emissions provides simulations and experimental results fully in line with forecasts. The design of SON’OR©is based on general techniques of electronic instrumentation to which we associated the new instrumentation amplifier structure. Objective: To report the clinical evaluation of SON’OR©as a screening and diagnostic tool. Methods: We conducted a cross sectional comparative study in Centre Hospitalier d’Essos in Yaoundé. We tested SON’OR©on two sets of subjects, one for OAE with OTODYNAMICS Echoport ILO 292-II as gold standard and the other for BERA with NEUROSOfT NEURO AUDIO©as gold standard. Each patient was tested with both devices and then we studied the inter device differences and calculated the sensitivity, specificity, positive predictive value and negative predictive value for each test. Results: We got 52 subjects for OEA and 51 for BERA testing. Sex ratio was 1 woman for 2 men in both groups. Mean age was 24.86(SD = 10.53) and 26.33 (10.55) for OAE and BERA groups respectively. SON’OR©had good performances, showing sensitivity of 92.85%/95%, specificity of 96.77%/90.47%, positive predictive value of 95.21%/93.4

关键词： SON’OR^(█) Brainstem Evoked Response Audiometry Otoacoustic Emissions Cameroon Neonatal Hearing Screening

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Guest editorial: Special Issue on Science of Wear

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friction 2018年第3期6卷 243-244页

作者： Yonggang MENG valentin L.POPOV jean-fran?ois MOLINARI State Key Laboratory of Tribology Tsinghua University Institute of Mechanics Technische Universit?t Berlin Civil Engineering Department Materials Science Department école Polytechnique Fédérale de Lausanne

Among the basic tribological phenomena of contact,adhesion, friction, lubrication and wear, wear remains the least scientifically understood. At the same time,wear remains one of the most important tribological phenom... 详细信息

关键词：摩擦学工艺优化可持续发展摩擦理论

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Gross Tumour of Minor Salivary Glands in HIV Sero-Positive Patient

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International Journal of Clinical Medicine 2012年第3期3卷 220-222页

作者： jean valentin fokouo fogha Gisele Alenda Ngulefac Esthelle Genevieve Stephanie Minka Ngom Vincent fonyam Louis Richard Njock Douala General Hospital Douala Cameroon.

Tumours of minor salivary glands are rare. We report the case of a 58-year-old HIV positive woman with a palatal adenocarcinoma evolving for 15 years, followed by a literature review. The case enlightens on the delete... 详细信息

关键词： Adenocarcinoma Minor Salivary Glands HIV

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Lymphoma of the Nasopharynx in an HIV Sero-Positive Patient in the General Hospital of Douala

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International Journal of Clinical Medicine 2012年第2期3卷 156-157页

作者： Gisele Alenda Ngulefac jean valentin fokouo fogha Esthelle Genevieve Stephanie Minka Ngom Vincent fonyam Louis Richard Njock ENT-HNS General Hospital of Douala Douala Cameroon.

Humman immunodeficiency virus (HIV) infection is associated with opportunistic cancers notably Non-Hodgkin lymphoma (NHL). Generally the response to chemotherapy or radiation therapy is satisfactory but requires nursing measures to protect these patients from superinfection to which they are highly predisposed by the double immunosuppression. We report the case of a 54 year-old known HIV sero-positive female with lymphoma of the nasopharynx who presented lately and died of septic shock despite the favorable evolution of the tumor on treatment.

关键词： HIV Infection Non-Hodgkin Lymphoma Double Immunosuppression

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A 3D Numerical Study of LO_2/GH_2 Supercritical Combustion in the ONERA-Mascotte Test-rig Configuration

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Journal of Thermal Science 2016年第1期25卷 97-108页

作者： Abdelkrim Benmansour Abdelkrim Liazid Pierre-Olivier Logerais jean-félix Durastanti Laboratory LTE ENP-OranBP 1523 El Mnaouer 31000Oran Algeria Universite de Paris-Est CERTESIUT de Senartrue Georges Charpak77567 LieusaintFrance

Cryogenic propellants LOx/H2 are used at very high pressure in rocket engine combustion. The description of the combustion process in such application is very complex due essentially to the supercritical regime. Ideal gas law becomes invalid. In order to try to capture the average characteristics of this combustion process, numerical computations are performed using a model based on a one-phase multi-component approach. Such work requires fluid properties and a correct definition of the mixture behavior generally described by cubic equations of state with appropriated thermodynamic relations validated against the NIST data. In this study we consider an alternative way to get the effect of real gas by testing the volume-weighted-mixing-law with association of the component transport properties using directly the NIST library data fitting including the supercritical regime range. The numerical simulations are carried out using 3D RANS approach associated with two tested turbulence models, the standard k-Epsilon model and the realizable k-Epsilon one. The combustion model is also associated with two chemical reaction mechanisms. The first one is a one-step generic chemical reaction and the second one is a two-step chemical reaction. The obtained results like temperature profiles, recirculation zones, visible flame lengths and distributions of OH species are discussed.

关键词： Rocket engine non-premixed combustion supercritical regime H2-O2 flame transport properties

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Artificial light at night decreases the pupillary light response of dark-adapted toads to bright light

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Integrative Zoology 2023年第5期18卷 867-875页

作者： jean SECONDI Madeleine f.SCRIBA Nathalie MONDY Thierry LENGAGNE Univ Lyon UniversitéClaude Bernard Lyon 1CNRSENTPEVilleurbanneFrance facultédes Sciences Universitéd’AngersAngersFrance

Artificial light at night(ALAN)is expanding *** physiological effects have been reported in animals,but we still know little about the consequences for the visual *** pupil contributes to control incoming light onto the *** increases in light intensity evokes the pupil light reflex(PLR).Intrinsically photosensitive retinal ganglion cells(ipRGC)affect PLR and melatonin expression,which largely regulate circadian rhythms and PLR *** receive inputs from various photoreptors with different peak sensitivities implying that PLR could be altered by a broad range of light *** predicted ALAN to enhance *** to our prediction,dark-adapted cane toads Rhinella marina,exposed to ALAN(5 lx)for 12 days,exhibited a lower PLR than controls and individuals exposed to 0.04 lx,even after 1 h in bright *** cannot conclude whether ALAN induced a larger pupil size in dark-adapted toads or a slower initial ***,the response was triggered by a light source with an emission peak(590 nm)well above the sensitivity peak of melanopsin,the main photoreceptor involved in ***,ALAN alters the capacity of toads to regulate the incoming light in the eye at night,which may reduce the performance of visually guided behaviors,and increase mortality by predators or road kills at *** first study emphasizes the need to focus on the effect of ALAN on the vision of nocturnal organisms to better understand how this sensory system is altered and anticipate the consequences for organisms.

关键词： amphibian anuran light pollution pupillary light reflex vision

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Phase coexistence properties of liquid mercury:a simulation study

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Rare Metals 2006年第5期25卷 567-571页

作者： jean-Louis Bretonnet jean-Marc Bomont Laboratoire de Physique des Milieux Denses Université Paul Verlaine1bd F.D.Arago57078 MetzCedex 3France

The thermophysical properties of expanded liquid mercury have been investigated along the liquid-vapor coexistence curve by using Monte Carlo and Molecular Dynamic simulations. for the purpose, an empirical state dependent interatomic potential for the region of dense metallic liquid is used, while the state dependence is not necessary near the cliffcal point. In order to test the validity of this potential, we determine the surface layering and the sound velocity, two properties very sensitive to the choice of the potential. Our results are in quite good agreement with other theoretical results and to the experimental data available in the literature.

关键词： mercury simulation phase coexistence liquid state

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What is artificial meat and what does it mean for the future of the meat industry?

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Journal of Integrative Agriculture 2015年第2期14卷 255-263页

作者： Sarah P f Bonny Graham E Gardner David W Pethick jean-franois Hocquette School of Veterinary and Life Sciences Murdoch UniversityMurdoch W.A. 6150 Australia INRA UMR1213 Recherches sur les HerbivoresSaint-Genès Champanelle F-63122 France Clermont Université Vet Agro Sup UMR1213 Recherches sur les HerbivoresSaint-Genès Champanelle F-63122 France

The meat industry cannot respond to increases in demand by ever increasing resource use. The industry must find solutions to issues regarding animal welfare, health and sustainability and will have to do so in the face of competition from emerging non-traditional meat and protein products in an increasingly complex regulatory environment. These novel meat and protein products, otherwise known as ‘artificial meat＇ are utilising ground breaking technologies designed to meet the issues facing the conventional meat industry. These artificial meats, in vitro or cultured meat and meat from genetically modified organisms have no real capacity to compete with conventional meat production in the present environment. However, meat replacements manufactured from plant proteins and mycoproteins are currently the biggest competitors and are gaining a small percentage of the market. Manufactured meats may push conventional meat into the premium end of the market, and supply the bulk, cheap end of the market if conventional meat products become more expensive and the palatability and versatility of manufactured meats improve. In time the technology for other artificial meats such as meat from genetic modified organisms or cultured meat may become sufficiently developed for these products to enter the market with no complexity of the competition between meat products. Conventional meat producers can assimilate agroecology ecology concepts in order to develop sustainable animal production systems. The conventional meat industry can also benefit from assimilating biotechnologies such as cloning and genetic modification technologies, using the technology to adapt to the changing environment and respond to the increasing competition from artificial meats. Although it will depend at least partly on the evolution of conventional meat production, the future of artificial meat produced from stem cells appears uncertain at this time.

关键词： artificial meat in vitro meat meat industry consumer satisfaction sustainable production

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Development and validation of SuperDEM for non-spherical particulate systems using a superquadric particle method

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Particuology 2022年第2期20卷 74-90页

作者： Xi Gao Jia Yu Ricardo J.f.Portal jean-françois Dietiker Mehrdad Shahnam William A.Rogers National Energy Technology Laboratory MorgantownWV 26506USA Leidos Research Support Team MorgantownWV 26506USA Centro de Investigação em Modelação e Otimização de Sistemas Multifuncionais Instituto Superior de Engenharia de LisboaPolytechnic Institute of Lisbon1959-007 LisboaPortugal Instituto de Engenharia Mecânica–Instituto Superior Técnico Universidade de Lisboa1049-001 LisboaPortugal

This article presents the development and validation of the Superquadric Discrete Element Method(SuperDEM)for non-spherical particle simulation using a superquadric particle method in open-source CfD suite MfiX.A superquadric particle-particle contact algorithm with accelerating and stabilizing strategy was developed.A superquadric particle-arbitrary wall contact algorithm was developed,which enables the simulation in complex *** solver was validated by comparing with experimental data generated in this study or available in the *** include cylinder contacting with a wall,static packing of M&M chocolate candies in a cylindrical container,static packing of cylinders in a cylindrical container,dynamic angle of repose of cylinders in a rotating drum,and discharging of chocolate candies from a ***,MPI parallelization of the solver was implemented and the parallel performance of the solver using MPI was assessed through large-scale simulations of 1 million,10 million,and 100 million particles on up to 6800 cores,which demonstrates that the SuperDEM solver has great potential for industrial-scale systems simulation.

关键词： DEM Particle Non-spherical Superquadric Parallelization MfiX

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Microbial starch-binding domains are superior to granule-bound starch synthase I for anchoring luciferase to potato starch granules

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Progress in Natural Science:Materials International 2006年第12期16卷 1295-1299页

作者： jean-Paul VINCKEN Luc C.J.M. SUURS Richard G.f. VISSER Laboratory of Plant Breeding Department of Plant Sciences Wageningen University Wageningen The Netherlands

Microbial starch-binding domains (SBD) and granule-bound starch synthase I (GBSSI) are proteins which are accumulated in potato starch granules. The efficiency of SBD and GBSSI for targeting active luciferase reporter proteins to granules during starch biosynthesis was compared. GBSSI or SBD sequences were fused to the N- or C-terminus of the luciferase (LUC) gene, via an artificial Pro-Thr encoding linker sequence. The genes were introduced into an amylose-free (amf) potato mutant. It appeared that SBD was superior to GBSSI as a targeting sequence, mainly because the luciferase retained higher activity in the SBD-containing fusion proteins than in the GBSSI-containing ones.

关键词： luciferase GBSS I SBD amf potato.

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