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Profile of People Livin. with HIV after 24 Weeks of Treatmen. with Dolutegravir in.Kin.hasa

Advan.es in.In.ectious Diseases 2023年第4期13卷 660-674页

作者： Berry I. Bon.en.a Ben.it O. Kaben.ele marie-Thérèse A. S. Sombo Guy M. M. Bumoko Hippolyte n. T. Situakiban.a Fridolin.K. K. Kodon.i Gauthier K. Mesia Marian. M. Lusakiban.a jean marie n. kayembe Baudouin.B. Buassa Richard L. Kalala Erick n. Kaman.u Faculty of Medicin. Bel Campus Technological University Kinshasa Democratic Republic of Congo Focus HIV/AIDS Research Group Kinshasa Democratic Republic of Congo Departmen. of In.ern.l Medicin. Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of Congo Departmen. of n.urology Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of Congo Biochemistry Laboratory Faculty of Pharmaceutical Sciences University of Kinshasa Kinshasa Democratic Republic of Congo Clin.cal Pharmacology Un.t Department of Pharmacology Faculty of Medicine and Pharmaceutical Sciences University of Kinshasa Kinshasa Democratic Republic of Congo Service of Molecular Biochemistry Department of Basic Sciences Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of Congo

In.roduction. The sixth mon.h appoin.men. (M6) is crucial because at the start of the ART course, it is an.in.icator of the progn.sis of the evolution.of care an. decision.makin. on.the con.in.ity of treatmen.. Objective: The objective of this study is therefore to presen. the profile of People Livin. with HIV un.er treatmen. with Dolutegravir 6 mon.hs after startin. ART in.Kin.hasa. Methods: The presen. study is a cross-section.l view at M6 of a prospective cohort to determin. the profile of People Livin. with HIV (PLHIV) after 6 mon.hs of ARV Treatmen. (ART) in.Kin.hasa, DRC. Durin. the M6 appoin.men., from April to August 2022, a sample of 5 ml of blood was taken.for the various an.lyzes from all HIV patien.s in.luded. The collection.of sociodemographic data as well as biological an. clin.cal data was carried out un.er the same con.ition. as at in.lusion. The parameters recorded durin. M6 were: age, sex, an. religion. level of study, marital status, profession. socio-econ.mic level, height, weight, Body Mass In.ex (BMI), clin.cal profile, opportun.stic in.ection. as well as biochemical an. molecular assessmen.. Results: In.M6, 62 patien.s were registered in.ludin. 38 women.(61.3%), thus givin. a sex ratio of 1.58 in.favor of women. Fifty-seven.(57) patien.s did n.t respon. to the appoin.men., represen.in. a loss rate of 47.89%. The most common.age group is between.36 an. 45 years old with 16 patien.s (26.7%). The mean.age was 42.4 ± 13.3 years. The mean.weight was 60.5 ± 15.4 kg with a mean.BMI of 22.6 ± 5.8 kg/m2. Thirty-four (34) patien.s (61.82%) were in.Clin.cal Stage 3. Thirty-six (36) patien.s (67.92%) had a n.rmal clin.cal con.ition. The most common.opportun.stic in.ection. amon. patien.s in.M6 were: skin.pruritus (25.8%), dermatitis (22.6%) an. rash (21%). The mean.values of biochemical parameters of patien.s in.M6 were within.n.rmal ran.es. The median.VL value was 2.92 log10 Rn. copies/ml with 17.75% of patien.s experien.in. major failure of f

关键词： Profile PLHIV 6 Mon.hs of ART Dolutegravir Kin.hasa

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Profile of People Livin. with Human.Immun.deficien.y Virus In.tiatin. Treatmen. in.the Dolutegravir Era in.Kin.hasa, Democratic Republic of Con.o

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World Journ.l of AIDS 2023年第3期13卷 95-115页

作者： Berry I. Bon.en.a Ben.it O. Kaben.ele marie-Thérèse A. S. Sombo Guy M. M. Bumoko Hippolyte n. T. Situakiban.a Fridolin.K. K. Kodon.i Gauthier K. Mesia Marian. M. Lusakiban.a jean marie n. kayembe Georges L. Mvumbi Baudouin.B. Buassa Richard L. Kalala Erick n. Kaman.u Faculty of Medicin. Bel Campus Technological University Kinshasa Democratic Republic of Congo “HIV/AIDS Focus” Research Group Kinshasa Democratic Republic of Congo Departmen. of In.ern.l Medicin. Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of Congo Departmen. of n.urology Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of Congo Laboratory of Biochemistry Faculty of Pharmaceutical Sciences University of Kinshasa Kinshasa Democratic Republic of Congo Clin.cal Pharmacology Un.t Department of Pharmacology Faculty of Medicine and Pharmaceutical Sciences University of Kinshasa Kinshasa Democratic Republic of Congo Service of Molecular Biochemistry Department of Basic Sciences Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of Congo

Backgroun.: For several decades, the in.roduction.of An.iRetrovirals (ARVs) has improved the symptomatology of People Livin. with HIV (PLHIV), a spectacular reduction.in.morbidity an. mortality, an.improvemen. in.life expectan.y an. quality of life of PLHIV. Objective: The objective of this study was to determin. the profile of PLHIV in.tiatin. An.iRetroViral Treatmen. (ART) in.the era of Dolutegravir in.Kin.hasa. Methods: Cross-section.of a prospective cohort to determin. the profile of PLHIV in.tiatin. ART in.Kin.hasa. The in.lusion. were from October 04, 2021 to February 15, 2022. Con.irmation.of the diagn.sis was carried out by n.sted PCR. The in.lusion.criteria were: bein. at least 18 years old, con.irmed HIV positive, n.ïve to ART, con.en.in. an. havin. sign.d an.in.ormed con.en.. The parameters of in.erest followed for the presen. study were: age, sex, religion. level of study, marital status, occupation. height, weight, body mass in.ex (BMI), the clin.cal profile, the opportun.stic in.ection. as well as the para-clin.cal assessmen. (biochemistry an. molecular biology). Results: 67 (56.3%) women.an. 52 (43.7%) men.were in.luded, thus 119 patien.s, all con.irmed positive for HIV by n.sted PCR on.the gag, pol an. en. region.. The average age of the patien.s in.luded is 39.87 ± 12.36 years an. the most represen.ed age group is that of 36 to 45 years with 37 patien.s (31.9%). The average height was 1.66 ± 0.08 meters, with an.average weight of 56.41 ± 13.30 kg, givin. an.average Body Mass In.ex (BMI) of 21.54 ± 5.17 kg/m2. The majority of patien.s were married (46.1%), of Protestan. religion.(70.7%), with secon.ary education.(66.7%), an. workin. in.the in.ormal sector (29.4%). 49 patien.s (41.5%) were in.clin.cal stage 3 an. 55 patien.s (47.0%) had a n.rmal clin.cal status. Malaria (45.4%) an. tuberculosis (29.4%) were the most common.Opportun.stic In.ection.. The mean.values of the patien.s’ assessed biochemical parameters were within.the ran.es. The

关键词： Profile PLHIV Startin. of ART Dolutegravir Kin.hasa

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Profile of retin.l diseases in.adult patien.s atten.in. two major eye clin.cs in.Kin.hasa,the Democratic Republic of Con.o

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In.ern.tion.l Journ.l of Ophthalmology(En.lish edition. 2020年第10期13卷 1652-1659页

作者： n.lly n.Kabedi David L.kayembe jean-Claude Mwan.a Departmemt of Ophthalmology School of MedicineUniversity of KinshasaKinshasa XIDemocratic Republic of Congo Departmen. of Ophthalmology School of MedicineUniversity of North Carolina at Chapel HillNC 27599USA

AIM:To determin. the frequen.y an. types of retin.l diseases an. the exten. of the related visual loss in.adult patien.s atten.in. two public eye clin.cs of Kin.hasa,Democratic Republic of ***:Review of medical records of patien.s with retin.l diseases seen.in.the major eye clin.cs in.Kin.hasa,the Un.versity Hospital of Kin.hasa(UHK)an. Sain. Joseph Hospital(SJH),from Jan.ary 2012 to December *** an. diagn.ses were retrieved an. *** measures were frequen.y an. prevalen.e of retin.l diseases,blin.n.ss an. low ***:A total of 40965 patien.s aged 40 y or older were examin.d durin. this period in.both *** these,1208 had retin.l disease,givin. a 3-year an. an.an.ual prevalen.e of 3%an. 1%,*** age was 61.7±10.7 y,an. 55.8%of the patien.s were *** hyperten.ion.68.1%)an. diabetes(43.3%)were the most common.systemic *** retin.pathy(41.8%),diabetic retin.pathy(37.9%),age-related macular degen.ration.AMD;14.6%),an. chorioretin.tis an. retin.l vein.occlusion.7.3%each)were the most common.retin.l diseases,with 3-year prevalen.e rates of 1.3%,1.0%,0.43%,an. 0.21%*** low vision.an. blin.n.ss were presen. in.26.8%an. 8.4%of the patien.s at *** causes of low vision.an. blin.n.ss were diabetic retin.pathy(14.8%),AMD(4.9%),retin.l detachmen.(2.8%),an. retin.l vein.occlusion.2.5%).The prevalen.e was sign.fican.ly higher amon. males than.females,an. at the UHK than.***:Retin.l diseases are common.amon. Con.olese adult patien.s atten.in. eye clin.cs in.*** cause a sign.fican. proportion.of low vision.an. blin.n.ss.

关键词： retin.l disorders Kin.hasa,Democratic Republic of Con.o sub-Saharan.Africa pattern

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Den.ity Results in.Sobolev Spaces Whose Elemen.s Van.sh on.a Part of the Boun.ary

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Chin.se An.als of Mathematics,Series B 2011年第6期32卷 823-846页

作者： jean-marie Emman.el BERn.RD Laboratoire An.lyse et Probabitilités Université d'Evry val d'Essonne23 Boulevard de France91037 EVRYFrance

This paper is devoted to the study of the subspace of Wm＇＂ of fun.tion. that van.sh on.a part γ0 of the boun.ary. The author gives a crucial estimate of the Poin.are con.tan. in.balls cen.ered on.the boun.ary of γ0. Then. the con.olution.tran.lation.method, a varian. of the stan.ard mollifier techn.que, can.be used to prove the den.ity of smooth fun.tion. that van.sh in.a n.ighborhood of γ0, in.this subspace. The result is first proved for m = 1, then.gen.ralized to the case where m 〉 1, in.an. dimen.ion. in.the framework of Lipschitz-con.in.ous domain. However, as may be expected, it is n.eded to make addition.l assumption. on.the boun.ary of γ0, n.mely that it is locally the graph of some Lipschitz-con.in.ous fun.tion.

关键词： Den.ity results Boun.ary value problems Sobolev spaces

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Multiplexin. techn.logy for in.vitro diagn.sis of pathogen.： the key con.ribution.of phosphorus den.rimers

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Scien.e Chin. Materials 2018年第11期61卷 1454-1461页

作者： jean Pierre Majoral jean marie Fran.ois Richard Fabre Alice Sen.scau Serge Mign.n. An.e-marie Camin.de Laboratoire de Chimie de Coordin.tion.du Cn.S 31077 Toulouse Cedex 4France LCC-Cn.S Un.versit6 de Toulouse CNRSToulouseFrance Den.ris 31670 LabegeFrance LISBP UMR CNRS 5504 INRA 79231077 Toulouse Cedex 04France Un.versite Paris Descartes PRES Sorbon.e Paris Cite CNRS-UMR 860Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicolgique75006 ParisFrance

After the microbiology based on.Pasteur's method an. polymerase chain.reaction.PCR), the diagn.sis compan. n.med Den.ris has proposed a third-gen.ration.of diagn.sis en.blin. the search of a broad ran.e of pathogen. with stron. sen.itivity an. specificity. This extraordin.ry profile was possible than.s to the use of phosphorus den.rimers for which various techn.ques of deposition.on.a given.support were in.estigated an. described an. an.lyzed in.this report.

关键词： phosphorus den.rimers diagn.sis Dn. arrays multiplexin. techn.logy

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Effects of in.ole-3-butyric acid an. age of stem cuttin.s on.root morphology,growth,an. survival of Corn.s sericea

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Journ.l of Forestry Research 2023年第2期34卷 433-440页

作者： Sahari In.ue Chibuzo Ilogu jean-marie Sobze n.rthern.Alberta In.titute of Techn.logy Centre for Boreal ResearchPeace RiverAB T8S 1R2Canada Fin. Phen.typin. Lab Crop Health and ProtectionHarpenden AL52JQUK

Red osier dogwood(Corn.s sericea L.),widely distributed throughout n.rth America,is essen.ial for wildlife,thus *** is recommen.ed for reclamation.or revegetation.of sites disturbed by oil an. gas extraction.because it tolerates a wide ran.e of soil types an. high pH *** germin.tion.of this species is extremely difficult with lon. stratification.requiremen.s an. poor germin.tion.cuttin.s facilitate *** this study,to develop techn.ques to propagate the species from stem cuttin.s,four con.en.ration. of in.ole-3-butyric acid(IBA)an. two cuttin. ages previous year’s growth(PYG)an. curren. year’s growth(CYG)were in.estigated for survival an. *** 4 mon.hs,survival rate,height growth,an. shoot biomass from PYG cuttin.s were en.an.ed with IB *** con.rast,IB A did n.t affect these parameters in.CYG *** morphology was sign.fican.ly affected by IB A con.en.ration.an. cuttin. ***,at higher con.en.ration.,in.reased root surface an. *** root surface area an. len.th of PYG cuttin.s were in.reased,which may facilitate the absorption.of essen.ial resources an. con.equen.ly in.rease *** results in.icate that in.reasin. the con.en.ration.of IB A may be an.effective way to have better plan. survival an. growth of previous year’s cuttin.s in.red osier dogwood.

关键词： Vegetative propagation IBA Chron.logical age Corn.s sericea L. Survival rate

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En.iron.en.al photocatalysis:Perspectives for Chin.

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Scien.e Chin. Chemistry 2010年第9期53卷 1831-1843页

作者： HERRMAn. jean marie In.titut de Recherches sur la Catalyse et l'En.iron.emen. de Lyon UMR 5256 Cn.S/Un.versité Lyon. 2 Av.Albert Einstein 69626 Villeurbanne Cedex

Photocatalysis is based on.the double aptitude of the photocatalyst(essen.ially titan.a) to simultan.ously adsorb reactan.s an. absorb efficien. *** photocatalysis is able to be efficien. in.Fin.,"Green. an. En.iron.en.al *** in.uces mild oxidation. in.the absen.e of water by gen.ratin. active n.utral atomic O* *** in.tan.e,the oxidation.of 4-tert-butyl-toluen. is 100% selective in.*** water treatmen.,man. toxic in.rgan.c ion. are oxidized in.their harmless upper oxidized *** elimin.tion.of organ.c pollutan.s is the main.field of water photocatalytic *** of aliphatic an. aromatic pollutan.s are totally min.ralized in.o CO2 an. in.ocuous in.rgan.c *** complex molecules,such as pesticides(herbicides,in.ecticides,fun.icides,etc.) or dyes,are totally *** example of green.chemistry is the total degradation.of dyes in.water,in.particular for the azo-dyes,with 100% selective degradation.of -n.n.azo-groups in.o *** is also active in.the "bio-world" by killin. bacteria(***,streptococcus,etc.) in.water without *** pollutan.s can.also be destroyed,especially all the VOC's(volatile organ.c compoun.s),providin. certain.air humidity en.blin. titan.a to produce crackin. OH* *** chemical en.in.erin. reason.,the photocatalyst has to be fixed on.a photo-in.rt *** these con.ition.,UV-irradiated titan.a-based photocatalysis could be applied to the elimin.tion.of air pollutan.s,VOC's,solven.s,odors,chemicals,*** treatmen. has to be associated with water an. solid waste treatmen. because of *** is con.ucted by coverin. water treatmen. pon.s or lagun.s by rafts on.which large sheets of Ahlstrom paper are deposited,supportin. titan.a associated with activated ***,virus AH5n.,a model virus close to H5n.,respon.ible for the avian.flu could be totally *** is directly con.ected wi

关键词： photocatalysis green chemistry en.iron.en.al chemistry air pollutan.s water pollutan.s solar en.rgy Chin.

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Matern.l Kn.wledge of Tuberculosis an. Bacillus Calmette Guerin.Vaccin.tion.in.Pediatric Health Services in.Kin.hasa

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Journ.l of Tuberculosis Research 2017年第1期5卷 30-43页

作者： Loukia Aketi Joseph Shiku Diayisu Zacharie Kashon.we Grace n.abikuen. Patrick kayembe Kalambay jean-marie kayembe Cardio-Pulmon.ry an. In.ectious Diseases Un.t Department of Pediatrics University Hospital of Kinshasa University of Kinshasa Kinshasa Democratic Republic of Congo Pn.umology Service Department of Internal Medicine University Hospital of Kinshasa University of Kinshasa Kinshasa Democratic Republic of Congo Epidemiology an. Biostatistics Public Health School University of Kinshasa Kinshasa Democratic Republic of Congo

In.roduction. To participate effectively in.the fight again.t tuberculosis (TB), mothers n.ed to have a good kn.wledge of TB an. its preven.ion. The objective of this study was to evaluate the kn.wledge of mothers about TB an. Bacillus Calmette Guérin.(BCG). Methods: This was a cross-section.l survey performed from September to December 2015 in.4 health care facilities of Kin.hasa. It con.ern.d mothers of children.who received BCG vaccin.. The frequen.ies an. chi-square of Pearson.were used to report results. Results: A total of 380 couples of the children.an. their mothers were recruited. The median.age of children.was 16 mon.hs (ran.es: 6 days to 59 mon.hs);224 (58.9%) of them received BCG durin. the period recommen.ed;62 (16.3%) experien.ed a side effect. There was a sign.fican. association.(p = 0.00) between.sides effects an. the delayed vaccin.tion. The average age of the mothers was 29.3 ± 6.4 years;352 (92.6%) had heard about TB;28 (7.4%) n.ver heard about it;168 (44.2%) kn.w that TB is a con.agious disease;on.y 111 (29.2%) kn.w the mode of tran.mission.87 (22.9%) did n.t kn.w an. sign. of TB, an. 54 (14.2%) kn.w about preven.ion.with the BCG vaccin.. Factors sign.fican.ly associated with the mothers’ lack of kn.wledge were a low level of education.(p = 0.01), youn. age (p = 0.02), an. place of residen.e (p = 0.04). Con.lusion. There is an.urgen. n.ed to improve the education.of the population. particularly those who lives in.poor con.ition. an. who are un.ducated.

关键词： Matern.l Kn.wledge Tuberculosis BCG Children

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Syn.hesis of a n.vel macrocyclic ligan. con.ain.n. bipyridin. un.ts

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Chin.se Journ.l of Chemistry 2000年第3期18卷 384-387页

作者：何永炳 LEHn.jean-marie Departmen. of Chemistry Wuhan University Wuhan Hubei 430072 China

The 6-hydroxymethyl-6'-tetrahydropyran.loxymethyl-2, 2'-bipyridin. (2) was syn.hesized by the reaction.of 6,6'-dihydroxymethyl-2, 2'-bipyridin. (1) with 3, 4-dihydroxypyran.(DHP). ***-6'-iodomethyl-2, 2'-bipyridin. (5) was obtain.d from mesylate an. iodizatin. reaction.of compoun. 2. The couplin. of 2 an. 5 followed by hydrolysis gave bis(6'-hydroxymethyl-2, 2'-bipyridin.-6-methyl) ether (7). The macrocyclic ligan. 8 was obtain.d by treatin. 7 an. 6, 6'-dibromethyl-2, 2'-bipyridin.. The syn.hetic con.ition. of the in.ermediate 2 an. macocyclic ligan. 8 were discussed.

关键词： azacrown.ether bipyridin. derivative macrocyclic ligan.

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A formal approach usin. SysML for capturin. fun.tion.l requiremen.s in.avion.cs domain

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Chin.se Journ.l of Aeron.utics 2019年第12期32卷 2717-2726页

作者： Shaofan.ZHU Jian.TAn. jean-marie GAUTHIER Raphael FAUDOU Beijin. Aeron.utical Scien.e an. Techn.logy Research In.titute COMACBeijing 102211China Samares-En.in.erin. Blagnac 31700France

In.this work,a Model-Based Systems En.in.erin. approach based on.Sys ML is *** approach is used for the capture an. the defin.tion.of fun.tion.l requiremen.s in.avion.cs *** motivation.of this work is triple:guide the capture of fun.tion.l requiremen.s,validate these fun.tion.l requiremen.s through fun.tion.l simulation.an. verify efficien.ly the con.isten.y of these fun.tion.l *** proposed approach is decomposed in.o several steps that are detailed to go from con.eptual model of avion.cs domain.to a formal fun.tion.l model that can.be simulated in.its operatin. *** achieve this work,a subset of Sys ML has been.used as an.in.ermediate modellin. lan.uage to en.ure progressive tran.formation.that can.be un.erstood an. agreed by system *** con.epts are in.roduced to en.ure theoretical con.isten.y of the *** addition.tran.formation.rules are defin.d an. the mappin.s between.con.epts of ARP4754 A civil aircraft guidelin.s an. Sys ML are formalized through *** resultin. formalization.en.bles en.in.ers to perform fun.tion.l simulation.of the top-level fun.tion.l architecture extracted from operation.l ***,the approach has been.tested on.an.in.ustrial avion.cs system called the On.oard Main.en.n.e System.

关键词： Avion.cs systems Con.eptual model Fun.tion.l simulation Model-Based Systems En.in.erin.

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