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Management of renal replacement therapy among adults in French intensive care units: A bedside practice evaluation

Journal of Intensive Medicine 2023年第2期3卷 147-154页

作者： Florian Jolly Marine Jacquier Delphine Pecqueur marie Labruyère Christophe Vinsonneau Isabelle Fournel jean-Pierre Quenot The READIAL Study group Service de Médecine Intensive-Réanimation CHU Dijon-BourgogneDijon 21000France Equipe Lipness Centre de recherche INSERM UMR1231 et LabEx LipSTICUniversitéde Bourgogne-Franche ComtéDijon 21000France INSERM CIC 1432Module Epidémiologie CliniqueDijon 21000France CHU Dijon-Bourgogne Centre d’Investigation CliniqueModule Epidémiologie Clinique/Essais CliniquesDijon 21000France Service de Médecine Intensive Réanimation-Unitéde Sevrage Ventilatoire et Réhabilitation CH de BethuneBethune 62408France 不详

Background:This study aimed to investigate renal replacement therapy (RRT) practices in a representative nationwide sample of French intensive care units (ICUs).Methods:From July 1 to October 5 2021, 67 French ICUs provided data regarding their ICU and RRT implementation. We used an online questionnaire to record general data about each participating ICU, including the type of hospital, number of beds, staff ratios, and RRT implementation. Each center then prospectively recorded RRT parameters from 5 consecutive acute kidney injury (AKI) patients, namely the indication, type of dialysis catheter used, type of catheter lock used, type of RRT (continuous or intermittent), the RRT parameters initially prescribed (dose, blood flow, and duration), and the anticoagulant agent used for the ***:A total of 303 patients from 67 ICUs were analyzed. Main indications for RRT were oligo-anuria (57.4%), metabolic acidosis (52.1%), and increased plasma urea levels (47.9%). The commonest insertion site was the right internal jugular (45.2%). In 71.0% of cases, the dialysis catheter was inserted by a resident. Ultrasound guidance was used in 97.0% and isovolumic connection in 90.1%. Citrate, unfractionated heparin, and saline were used as catheter locks in 46.9%, 24.1%, and 21.1% of cases, ***:Practices in French ICUs are largely compliant with current national guidelines and international literature. The findings should be interpreted in light of the limitations inherent to this type of study.

关键词： Renal replacement therapy Acute kidney injury Intensive care unit Practice evaluation Bedside

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Pit-and trench-forming osteoclasts:a distinction that matters

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Bone Research 2015年第4期3卷 199-209页

作者： Ditte MH Merrild Dinisha C Pirapaharan Christina M Andreasen Per Kjxrsgaard-Andersen Anas MJ Mùller Ming Ding jean-marie Delaissé Kent Sùe Department of Clinical Cell Biology Vejle Hospital/Lillebaelt HospitalInstitute of Regional Health ResearchUniversity of Southern Denmark Orthopaedic Research Laboratory Department of Orthopedic Surgery and TraumatologyOdense University HospitalUniversity of Southern Denmark Department of Orthopedic Surgery Vejle Hospital/Lillebaelt Hospital

Osteoclasts（OCs）seeded on bone slices either drill round pits or dig long *** pits correspond to intermittent resorption,trenches correspond to continuous and faster resorption and require a distinct assembly of the resorption *** is unknown whether the distinction between pits and trenches has any biological *** OCs prepared from different blood donors,we found that female OCs achieved increased resorption mainly through pit formation,whereas male OCs did so through trench *** formation went along with high collagenolytic activity and high cathepsin K（CatK）expression,thereby allowing deeper demineralization.A specific CatK inhibitor abrogated the generation of trenches,while still allowing the generation of *** obtained from bone marrow were more prone to generate trenches than those obtained from *** electron microscopy of bone surfaces eroded in vivo showed trenches and pits of similar size as those made by OCs in *** conclude that the distinction between trench-and pit-forming OCs is relevant to the differences among OCs from different skeletal sites,different individuals,including gender,and results from differences in colIagenolytic *** indicates a biological relevance and highlights the importance of discriminating between pits and trenches when assessing resorption.

关键词： trench cathepsin collagen faster prone assembly highlights thereby correspond apparatus

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Epidemiological and Computed Tomography Aspects of Facial Trauma at Kira Hospital in Bujumbura

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Open Journal of Radiology（放射学期刊） 2024年第2期 83页

作者： Sébastien Manirakiza jean marie Banziriyubusa Stany Harakandi Patrice Barasukana Chantal Murekatete Daniel Nduwayo jean Bosco Bizimana Léopold Nzisabira

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Evaluation of Rhizobium tropici-Derived Extracellular Polymeric Substances on Selected Soil Properties, Seed Germination, and Growth of Black-Eyed Peas (Vigna unguiculata )

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Agricultural Sciences（农业科学） 2024年第5期 548页

作者： Jonathan Alunge Metuge Erneste Havugimana jean Rugandirababisha Zachary N. Senwo marie Chantal Mutimawurugo

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Using Tangent Boost along a Worldline and Its Associated Matrix in the Lie Algebra of the Lorentz Group

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Journal of Modern Physics 2017年第8期8卷 1190-1212页

作者： Michel Langlois Martin Meyer jean-marie Vigoureux IRRG Besan&Ccedil on France Laboratoire de Mathématiques Université de Franche-Comté Besan&Ccedil on Cedex France Institut UTINAM UMR CNRS 6213 Université de Franche-Comté Besan&Ccedil on Cedex France

In order to generalize the relativistic notion of boost to the case of non inertial particles and to general relativity, we look closer into the definition of the Lie group of Lorentz matrices and its Lie algebra and we study how this group acts on the Minskowski space. We thus define the notion of tangent boost along a worldline. This very general notion gives a useful tool both in special relativity (for non inertial particles or/and for non rectilinear coordinates) and in general relativity. We also introduce a matrix of the Lie algebra which, together with the tangent boost, gives the whole dynamical description of the considered system (acceleration and Thomas rotation). After studying the properties of Lie algebra matrices and their reduced forms, we show that the Lie group of special Lorentz matrices has four one-parameter subgroups. These tools lead us to introduce the Thomas rotation in a quite general way. At the end of the paper, we present some examples using these tools and we consider the case of an electron rotating on a circular orbit around an atom nucleus. We then discuss the twin paradox and we show that when the one who made a journey into space in a high-speed rocket returns home, he is not only younger than the twin who stayed on Earth but he is also disorientated because his gyroscope has turned with respect to earth referential frame.

关键词： Lie Group of Lorentz Matrices Lie Algebra Tangent Boost along a Worldline Acceleration Special Relativity General Relativity Thomas Rotation Twin Paradox Inertial Particles Non Inertial Particles

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Knowledge,attitudes and practices concerning epilepsy among nurses and midwives working in primary health care settings in Ouagadougou of Burkina Faso

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Acta Epileptologica 2023年第2期6卷 90-99页

作者： Alfred Anselme Dabilgou Alassane Dravé Julie marie Adeline Wendlamita Kyelem Fatimata Kinda Christian Napon Athanase Millogo jean Kaboré Department of Neurology University Hospital Yalgado OuedraogoBox 7022Ouagadougou 03Burkina Faso Department of Neurology Regional University Hospital of Ouahigouya03 BP 7009 Ouagadougou 03Burkina Faso Department of Neurology University Hospital of Bogodogo14 Box 371Ouagadougou 14Burkina Faso Department of Neurology Souro Sanou University Teaching Hospital01Box 676Bobo DioulassoBurkina Faso

Background In developing countries,there is a lack of epilepsy knowledge among health *** objective of this study was to assess the knowledge,attitude and practice concerning epilepsy among nurses and midwives working in primary health care settings in *** We carried out a cross-sectional study in the health districts of Ouagadougou from August 1st to September 15th,*** nurses and midwives working in three health districts were included in this *** A total of 213 participants with a mean age of 39.5 years were included in the survey;79.81%of them had a general certification in secondary education and 62%had a professional experience of more than 10 *** 99%of the participants had not received training on epilepsy-related care during the last six *** addition,74.5%of the participants had a good knowledge on epilepsy and 65%had a good practice toward *** level of knowledge was associated with the workplace,years of training,and the professional *** level of knowledge about epilepsy was also associated with the level of education,while there was a significant link between professional status and nurses’level of practice in the management of *** Efforts must be made to provide continuing education for nurses in order to improve their knowledge on epilepsy.

关键词： Epilepsy Knowledge Attitude Practice Paramedics Ouagadougou Burkina

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Construction and Update of an Online Ensemble Score Involving Linear Discriminant Analysis and Logistic Regression

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Applied Mathematics 2022年第2期13卷 228-242页

作者： Benoî t Lalloué jean-marie Monnez Eliane Albuisson IECL (Institut Elie Cartan de Lorraine) Inria (Project-Team BIGS) Centre National de la Recherche Scientifique (CNRS) Université de Lorraine Nancy France Inserm U1116 Centre d’Investigation Clinique Plurithématique 1433 Université de Lorraine Nancy France IECL (Institut Elie Cartan de Lorraine) Centre National de la Recherche Scientifique (CNRS) Université de Lorraine Nancy France Délégation à la Recherche Clinique et à l’Innovation(DRCI) CHRU de Nancy Vand&#339 uvre-lès-Nancy France Département Grand-Est de Recherche en Soins Primaires Faculté de Médecine Vand&#339 uvre-lès-Nancy France

The present aim is to update, upon arrival of new learning data, the parameters of a score constructed with an ensemble method involving linear discriminant analysis and logistic regression in an online setting, without the need to store all of the previously obtained data. Poisson bootstrap and stochastic approximation processes were used with online standardized data to avoid numerical explosions, the convergence of which has been established theoretically. This empirical convergence of online ensemble scores to a reference “batch” score was studied on five different datasets from which data streams were simulated, comparing six different processes to construct the online scores. For each score, 50 replications using a total of 10N observations (N being the size of the dataset) were performed to assess the convergence and the stability of the method, computing the mean and standard deviation of a convergence criterion. A complementary study using 100N observations was also performed. All tested processes on all datasets converged after N iterations, except for one process on one dataset. The best processes were averaged processes using online standardized data and a piecewise constant step-size.

关键词： Learning for Big Data Stochastic Approximation Medicine Ensemble Method Online Score

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SNOMED CT: A Clinical Terminology but Also a Formal Ontology

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Journal of Biosciences and Medicines 2023年第11期11卷 326-333页

作者： Constant Joseph Koné Michel Babri jean marie Rodrigues Félix Houphouë t-Boigny National Polytechnic Institute Yamoussoukro Cote d’Ivoire University jean Monnet Saint Etienne France

Context and Objective: Over the past few decades, terminologies developed for clinical descriptions have been increasingly used as key resources for knowledge management, data integration, and decision support to the extent that today they have become essential in the biomedical and health field. Among these clinical terminologies, some may possess the characteristics of one or several types of representation. This is the case for the Systematized Nomenclature of Human and Veterinary Medicine—Clinical Terms (SNOMED CT), which is both a clinical medical terminology and a formal ontology based on the principles of semantic web. Methods: We present and discuss, on one hand, the compliance of SNOMED CT with the requirements of a reference clinical terminology and, on the other hand, the specifications of the features and constructions of descriptive of SNOMED CT. Results: We demonstrate the consistency of the reference clinical terminology SNOMED CT with the principles stated in James J. Cimino’s desiderata and we also show that SNOMED CT contains an ontology based on the EL profile of OWL2 with some simplifications. Conclusions: The duality of SNOMED CT shown is crucial for understanding the versatility, depth, and scope in the health field.

关键词： SNOMED CT Clinical Terminology Ontology OWL2

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Bladder-colon chronic cross-sensitization involves neuro-glial pathways in male mice

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World Journal of Gastroenterology 2022年第48期28卷 6935-6949页

作者： Karim Atmani Fabien Wuestenberghs Maximilien Baron Illona Bouleté Charlène Guérin Wafa Bahlouli David Vaudry jean Claude do Rego jean-Nicolas Cornu Anne-marie Leroi Moïse Coëffier Mathieu Meleine Guillaume Gourcerol Nutrition Gut and Brain Unit(Inserm U1073)Institute for Research and Innovation in BiomedicineUniversitéde Rouen NormandieRouen 76000France Department of Gastroenterology and Hepatology UniversitéCatholique de LouvainCHU UCL NamurYvoir 5530Belgium Department of Physiology CHU RouenUniversitéde Rouen NormandieRouen 76031France Department of Urology CHU RouenUniversitéde Rouen NormandieRouen 76000France Inserm UMR 1245Team Epigenetics and Pathophysiology of Neurodevelopmental DisordersUniversitéde Rouen NormandieRouen 76000France Behavioural Analysis Platform(SCAC) HeRacLeS Inserm US51-CNRS UAR2026Institute for Research and Innovation in BiomedicineUniversitéde Rouen NormandieRouen 76000France Department of Nutrition CHU RouenUniversitéde Rouen NormandieRouen 76000France Inserm U1107 NeuroDolClermont Auvergne UniversityClermont-Ferrand 63000France

BACKGROUND Irritable bowel syndrome and bladder pain syndrome often overlap and are both characterized by visceral *** pelvic organs share common sensory pathways,it is likely that those syndromes involve a cross-sensitization of the bladder and the *** precise pathophysiology remains poorly *** To develop a model of chronic bladder-colon cross-sensitization and to investigate the mechanisms *** Chronic cross-organ visceral sensitization was obtained in C57BL/6 mice using ultrasound-guided intravesical injections of acetic acid under brief isoflurane *** sensitivity was assessed in conscious mice by measuring intracolonic pressure during isobaric colorectal ***,used as a marker of colorectal inflammation,was measured in the colon,and colorectal permeability was measured using chambers.c-Fos protein expression,used as a marker of neuronal activation,was assessed in the spinal cord(L6-S1 level)using *** fluorescent protein on the fractalkine receptor-positive mice were used to identify and count microglia cells in the L6-S1 dorsal horn of the spinal *** expression of NK1 receptors and MAPK-p38 were quantified in the spinal cord using western *** Visceral hypersensitivity to colorectal distension was observed after the intravesical injection of acetic acid vs saline(P<0.0001).This effect started 1 h post-injection and lasted up to 7 d *** increased permeability or inflammation was shown in the bladder or colon 7 d *** hypersensitivity was associated with the increased expression of c-Fos protein in the spinal cord(P<0.0001).In green fluorescent protein on the fractalkine receptor-positive mice,intravesical acetic acid injection resulted in an increased number of microglia cells in the L6-S1 dorsal horn of the spinal cord(P<0.0001).NK1 receptor and MAPK-p38 levels were increased in the spinal cord up to 7 d after

关键词： Cross-organ sensitization MAPK-p38 Microglia NK1 receptor Pain Visceral hypersensitivity

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From Matter to Life:Chemistry?Chemistry!

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复旦学报（自然科学版） 2007年第5期46卷 562-页

作者： jean-marie LEHN ISIS Université Louis PasteurStrasbourg and Collège de France

1 Results Animate as well as inanimate matter,living organisms as well as materials,are formed of molecules and of the organized entities resulting from the interaction of molecules with each *** provides the bridge between the molecules of inanimate matter and the highly complex molecular architectures and systems which make up living organisms. Synthetic chemistry has developed a very powerful set of methods for constructing ever more complex *** chemistry seeks to con...

关键词： inanimate matter living organism supramolecular chemistry

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