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蜱中贝氏考克次体流行状况调查

中国卫生检验杂志 2011年第8期21卷 2048-2049,2052页

作者：郭桐生陈素明鲍春梅 jean luc llabers jean Marc Rolain 曲芬毛远丽解放军第302医院临床检验医学中心 URMITE CNRS-IRD UMR 6236Facultéde Médecineet de PharmacieUniversite de la Mediterranee

目的:了解法国新喀里多尼亚地区蜱中贝氏考克次体的流行状况。方法:以贝氏考克次体的16SrRNA为靶基因,病原体的RNA自蜱中提取,使用荧光定量PCR技术,检测法国新喀里多尼亚地区三种蜱共456株中贝氏考克次体的流行率。结果:以30为CT值,共... 详细信息

目的:了解法国新喀里多尼亚地区蜱中贝氏考克次体的流行状况。方法:以贝氏考克次体的16SrRNA为靶基因,病原体的RNA自蜱中提取,使用荧光定量PCR技术,检测法国新喀里多尼亚地区三种蜱共456株中贝氏考克次体的流行率。结果:以30为CT值,共检测出阳性334株,阳性率73.2%。按蜱种分类:硬蜱虫2株皆为阴性;血红扇头蜱阳性163株,阳性率69.9%;边缘革蜱阳性171株,阳性率77.4%。结论:法国蜱中贝氏考克次体的流行率很高,不同种蜱阳性率不同。

关键词：蜱贝氏考克次体

Developing molecular-level models for organic field-effect transistors

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National Science Review 2021年第4期8卷 167-180页

作者： Haoyuan Li jean-luc Brédas School of Chemistry and Biochemistry and Center for Organic Photonics and Electronics Georgia Institute of Technology Department of Chemistry and Biochemistry University of Arizona

Organic field-effect transistors(OFETs) are not only functional devices but also represent an important tool for measuring the charge-transport properties of organic semiconductors(OSs). Thus, efforts to understand the performance and characteristics of OFET devices are not only useful in helping achieve higher device efficiencies but also critical to ensuring accuracy in the evaluations of OS charge *** studies rely on OFET device models, which connect the measured current characteristics to the properties of the OSs. Developing such OFET models requires good knowledge of the charge-transport processes in OSs. In device active layers, the OS thin films are either amorphous(e.g. in organic light-emitting diodes and organic solar cells) or crystalline(e.g. those optimized for charge transport in OFETs). When the electronic couplings between adjacent OS molecules or polymer chain segments are weak, the charge-transport mechanism is dominated by hopping processes, which is the context in which we frame the discussion in this Review. Factors such as disorder, mobility anisotropy, traps, grain boundaries or film morphology all impact charge transport. To take these features fully into account in an OFET device model requires considering a nano-scale, molecular-level resolution. Here, we discuss the recent development of such molecular-resolution OFET models based on a kinetic Monte Carlo approach relevant to the hopping regime. We also briefly describe the applicability of these models to high-mobility OFETs,where we underline the need to extend them to incorporate aspects related to charge delocalization.

关键词： organic semiconductors charge transport kinetic Monte Carlo simulations mobility measurements gradual channel approximation

Effect of conspecific and heterospecific urine odors on the foraging behavior of the golden spiny mouse

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Integrative Zoology 2013年第1期8卷 1-8页

作者： Claude BAUDOIN Abraham HAIM jean-luc DURAND Experimental and Comparative Ethology University of Paris 13VilletaneuseFrance Israeli Center for Interdisciplinary Research in Chronobiology University of HaifaHaifaIsrael

The common spiny mouse(Acomys cahirinus)inhibits the foraging activity of the golden spiny mouse(***).These two sympatric species of spiny mice,which are considered habitat competitors,occur in extreme arid *** test this theory of competition,the influence of urinary odors of both conspecific and heterospecific mice on the foraging behavior of *** was studied under controlled laboratory *** adult males,born in captivity and unfamiliar to the odors of the donor mice,were tested in 3 experimental conditions choosing between 2 seed patches that were scented with urine of either heterospecifics(***),conspecifics(***)or controls(odors of the tested individual).Of the 20 males,12 were also tested with urine of unfamiliar gerbils,bushy-tailed jird,considered as competitors in the *** conspecific and heterospecific urine samples from Acomys significantly reduced foraging behavior of *** when compared to the control *** inhibitory effect of the Acomys urine does not result from the novelty of chemical stimuli of the urine because no effect was shown with unfamiliar gerbil *** findings are in accordance with the general theory that *** dominates the foraging activity of *** hypothesize that chemical cues in the urine of Acomys *** induce a negative effect on the foraging behavior of ***.

关键词： Acomys spp. foraging behavior golden spiny mouse Sekeetamys calurus urine odors

Loco-regional treatments of unresectable hepatocellular carcinoma:safety first

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Hepatobiliary Surgery and Nutrition 2022年第2期11卷 324-326页

作者： jean-luc Raoul Institut de Cancérologie de l’Ouest NantesFrance

Hepatocellular carcinoma(HCC)is a severe liver cancer that complicates underlying severe liver *** a long time,palliative treatment of unresectable HCC was loco-regional and based on tumor arterial hypervascularization and intra-tumor retention of Lipiodol when injected *** 1995,it was demonstrated that transarterial chemoembolization(TACE)reduced tumor growth and size,but did not significantly improve survival,because any benefit was offset by worsened liver function(1).Despite the failure to demonstrate improved survival,TACE remained the most commonly used palliative treatment worldwide for many *** 2002,two RCTs demonstrated the efficacy of TACE,but only in highly selected patients(2).The good indications for TACE were limited to certain intermediate stage HCC,PS 0(or possibly 1),with preserved liver function(Child-Pugh A without ascites),without vascular invasion,and had to be carried out in a selective manner to minimize the ischemic insult to non-tumoral tissue(3,4).In scores evaluating survival after a first TACE,the parameters linked to liver toxicity were more important than tumor response!In a recent comparison of TACE with lenvatinib,TACE but not lenvatinib was responsible for a severe decrease in the liver function(evaluating by the ALBI score)from baseline,and this acute deterioration persisted in the chronic period(5).The price to pay for the efficacy of TACE is thus liver function.

关键词： treatment spite invasion

A new path to highly conducting n-dopedπ-conjugated polymers

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Science China Chemistry 2023年第1期66卷 4-6页

作者： jean-luc Bredas John R.Reynolds Department of Chemistry and Biochemistry The University of ArizonaTucsonArizona 85721-0088United States School of Chemistry and Biochemistry School of Materials Science and EngineeringGeorgia Tech Polymer NetworkCenter for Organic Photonics and ElectronicsGeorgia Institute of TechnologyAtlantaGeorgia 30332-0400United States

In an article recently published in Nature[1],Fei Huang,Yong Cao,and their co-workers report on aπ-conjugated polymer,poly(benzodifurandione),PBFDO,prepared by an oxidative polymerization and whose continuous backbon... 详细信息

关键词： conjugated conducting backbone

Diagnosis of prostate cancer

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Asian Journal of Urology 2019年第2期6卷 129-136页

作者： jean-luc Descotes University Hospital of Grenoble CHU de GrenobleCS 1021738043 Grenoble cedex 9France

Diagnosis of prostate cancer(PCa)and adequate staging play a fundamental role for clinical and patient *** major advances in biology and imaging,rectal examination and prostate-specific antigen(PSA)blood test remain the cornerstone for screening,and multiparametricmagnetic resonance imaging(mpMRI)for local *** advances in mpMRI lead to standardised interpretation and increased prescription by clinicians in order to improve detection of clinically significant PCa and select patients requiring targeted *** its indication remains controversial in biopsy-naǐve *** medicine is also in a continuous evolution and utilisation of new radiopharmaceutical agent like choline or 68gallium with computed tomography or magnetic resonance imaging has led to the improvement in the detection of lymph nodes,distant metastases and prostate *** this very heterogneneous disease,combined utilisation of these tools will help clinicians and patients in choosing the most appropriate and personalised treatment.

关键词： Prostate cancer Staging Prostate-specific antigen Multiparametric magnetic resonance imaging Markers

Second-Order Invariant Domain Preserving ALE Approximation of Euler Equations

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Communications on Applied Mathematics and Computation 2023年第2期5卷 923-945页

作者： jean-luc Guermond Bojan Popov Laura Saavedra Department of Mathematics Texas A&M UniversityCollege StationUSA Departamento de Matemática Aplicada a la Ingeniería Aeroespacial Universidad Politécnica de MadridMadridSpain

An invariant domain preserving arbitrary Lagrangian-Eulerian method for solving non-linear hyperbolic systems is *** numerical scheme is explicit in time and the approximation in space is done with continuous finite *** method is made invar-iant domain preserving for the Euler equations using convex limiting and is tested on vari-ous benchmarks.

关键词： Conservation equations Hyperbolic systems Arbitrary Lagrangian-Eulerian Moving meshes Invariant domains High-order method Convex limiting Finite element method

Monitoring and factors affecting levels of airborne and water bromoform in chlorinated seawater swimming pools

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Journal of Environmental Sciences 2017年第8期29卷 262-270页

作者： jean-luc Boudenne Julien Parinet Carine Demelas Tarek Manasfi Bruno Coulomb Aix Marseille Univ CNRS LCE13331 Marseille France Arises 94700 Maisons-Alfort France

Water and air quality of eight seawater swimming pools using chlorine disinfection was measured during four sampling campaigns, spread on one full-year, and in four thalassotherapy centers located in Southeast of France. Concentrations of trihalomethanes（THMs） in air and in water as well as concentrations of parameters, including nonpurgeable organic carbon（NPOC）, free residual chlorine（Cl_f）, pH, Kjeldhal Nitrogen（KN）, salinity,conductivity, bromide ions and, water and air temperature, were measured. Water and air samples were collected in triplicates morning — at the opening of the pools —, noon and night — at the closing of the pools —, in summer and winter. Data analysis was performed by Principal Component Analysis（PCA） and rotated component matrix, from both data quality and other parameters such as TOC, aromaticity（UV_（254））, pH, hygrometry, and free residual chlorine（Cl_f）. This statistical analysis demonstrates a high correlation between TOC, Cl_fand UV_（254） and THM levels found in air and water, particularly for the major ones（CHBr_3in water：300.0 μg/L mean, 1029.0 μg/L maximum; CHBr_3 in air： 266.1 μg/m^3 mean,1600.0 μg/m^3 maximum, and CHClBr_2 in water： 18.9 μg/L mean, 81.0 μg/L maximum;CHClBr_2 in air： 13.6 μg/m^3 mean, 150.0 μg/m^3maximum）. These high levels of bromoform（CHBr_3） are particularly worrisome in such health institutions, even these levels do not exceed the Permissible Exposure Limit（PEL） of 5 mg/m^3 as an 8 hour time-weighted average currently fixed by various administrations, such as Occupational Safety and Health Administration（OSHA）.

关键词： Trihalomethanes Bromoform Air Seawater Swimming pool Brominated compounds

Side channel attacks for architecture extraction of neural networks

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CAAI Transactions on Intelligence Technology 2021年第1期6卷 3-16页

作者： HervéChabanne jean-luc Danger Linda Guiga Ulrich Kühne Idemia ParisFrance Télécom Paris Institut Polytechnique de ParisParisFrance

Side channel attacks(SCAs)on neural networks(NNs)are particularly efficient for retrieving secret information from *** differentiate multiple types of threat scenarios regarding what kind of information is available before the attack and its purpose:recovering hyperparameters(the architecture)of the targeted NN,its weights(parameters),or its *** this survey article,we consider the most relevant attacks to extract the architecture of *** also categorize SCAs,depending on access with respect to the victim:physical,local,or *** targeting the architecture via local SCAs are most *** of today,physical access seems necessary to retrieve the weights of an *** notably describe cache attacks,which are local SCAs aiming to extract the NN's underlying *** countermeasures have emerged;these are presented at the end of the survey.

关键词： architecture networks neural