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Numerical Study of Laminar-turbulent Transition on a Platein a Low-Speed Tunnel with Contoured Wall

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Journal of Thermal Science 1999年第2期8卷 89-96页

作者： Zhenping Feng Weiliang lou jean Hourmouziadis Institute of Turbomachinery Xi’an Jiaotong University Xi’an P.R.China Jet Propulsion Laboratory Berlin University of Technology Berlin Germany

Laminar-turbulent transition flow phenomena on a flat plate in a low-speed wind tunnel at different Reynolds numberswere studied numerically. The now calculation is based on an inviscid/boundary layer interaction method with modifiedAbu-Ghannam/Shaw (AGS ) transihon criterion. The test sechon has non- symmetric al contoured walls, and the plate islocated biased the bottom side with a height ratio of 26: 14. In test case of steady flow, a laminar-turbulent transihontakes place and a small separation bubble occurs on the upper side of the plate, when the inlet Reynolds number is assmall as 0.63lx10-6. The predicted transihon location agrees well with that of the test results, but the separation bubbleis hardly to see from the calculatod velocity profiles though the printed data of velocity in this region do show thenegahve values. The further numerical Predictions with different Reynolds numbers corresponding to the incoming flowvelocities show that when the Reynolds number is greater than 1.379xl0-6, the separahon bubble does not occur, whichis coincident with the experimental results. The influence of the side wall geomeny on the transihon on the plate is alsostudied.

关键词： Iaminar-turbulent transition flat plate low speed tunnel numerical study

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Monitoring absolute vertical land motions and absolute sea-level changes from GPS and tide gauges data over French Polynesia

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Geodesy and Geodynamics 2024年第1期15卷 13-26页

作者： Xianjie Li jean-Pierre Barriot Bernard Ducarme Marania Hopuare Yidong lou Geodesy Observatory of Tahiti University of French PolynesiaFaa'a 98702French Polynesia Catholic University of louvain Georges Lemaître Centre for Earth and Climate Research(ELI)1348 Louvain-la-NeuveBelgium GNSS Research Center Wuhan UniversityWuhan 430079China State Key Laboratory of Information Engineering in Surveying Mapping and Remote SensingWuhan UniversityWuhan 430079China

In this study,we estimate the absolute vertical land motions at three tidal stations with collocated Global Navigation Satellite System(GNSS)receivers over French Polynesia during the period 2007-2020,and obtain,as ancillary results,estimates of the absolute changes in sea level at the same *** verify our processing approach to determining vertical motion,we first modeled vertical motion at the International GNSS Service(IGS)THTI station located in the capital island of Tahiti and compared our estimate with previous independent determinations,with a good *** obtained the following estimates for the vertical land motions at the tide gauges:Tubuai island,Austral Archipelago-0.92±0.17 mm/yr,Vairao village,Tahiti Iti:-0.49±0.39 mm/yr,Rikitea,Gambier Archipelago-0.43±0.17 mm/*** absolute variations of the sea level are:Tubuai island,Austral Archipelago 5.25±0.60 mm/yr,Vairao village,Tahiti Iti:3.62±0.52 mm/yr,Rikitea,Gambier Archipelago 1.52±0.23 mm/*** discuss these absolute values in light of the values obtained from altimetric measurements and other means in French Polynesia.

关键词： GPS Tide gauges Sea level changes Vertical land motion

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Evaluation of left atrial remodelling following percutaneous left atrial appendage closure

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Journal of Geriatric Cardiology 2017年第8期14卷 496-500页

作者： Zakaria Jalal Xavier Iriart Marie-lou Dinet Olivier Comeloup Xavier Pillois Hubert Cochet jean-Benoit Thambo Department of Paediatric and Adult Congenital Cardiology Bordeaux University Hospital Pessac France Electrophysiology and Heart Modeling Institute IHU Lirye Fondation Bordeaux UniversitO Pessac-Bordeaux France Centre de recherche Cardio-Thoracique de Bordeaux INSERM Bordeaux France Department of Radiology Bordeaux University Hospital Pessac France

Atrial fibrillation prevalence is increasing with age, reaching up to 5% of patients older than 65 years, and is associated with 20%-30% of stroke episodes in that population.

关键词： Atrial fibrillation Left atrial appendage Left atrial remodeling Percutaneous closure

Increased expression of CSP and CYP genes in adult silkworm females exposed to avermectins

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Insect Science 2015年第2期22卷 203-219页

作者： Ning Xuan Xia Guo Hong-Yan Xie Qi-Nian lou Xing-Bo Lu Guo-Xia Liu jean-Francois Picimbon Biotechnology Research Center Shandong Provincial Key Laboratory for Genetic Improvement Cultivation Ecology and Physiology of Crops Shandong Academy of Agricultural Sciences Jinan Shandong Silkworm Institute Shandong Academy of Agricultural SciencesYantai plant Protection Institute Shandong Academy of Agricultural Sciences Jinan China

We analyzed 20 chemosensory protein （CSP） genes of the silkworm Bombyx mori. We found a high number of retrotransposons inserted in introns. We then analyzed expression of the 20 BrnorCSP genes across tissues using quantitative real-time polymerase chain reaction （PCR）. Relatively low expression levels of BmorCSPs were found in the gut and fat body tissues. We thus tested the effects of endectocyte insecticide abamectin （B 1 a and Blb avermectins） on BmorCSP gene expression. Quantitative real-time PCR experi- ments showed that a single brief exposure to insecticide abamectin increased dramatically CSP expression not only in the antennae but in most tissues, including gut and fat body. Furthermore, our study showed coordinate expression of CSPs and metabolic cytochrome P450 enzymes in a tissue-dependent manner in response to the insecticide. The function of CSPs remains unknown. Based on our results, we suggest a role in detecting xenobiotics that are then detoxified by cytochrome P450 anti-xenobiotic enzymes.

关键词： abamectin Bombyx mori chemosensory protein cytochrome P450 oxidase insecticide moth

Abemaciclib, a Recent Novel FDA-Approved Small Molecule Inhibiting Cyclin-Dependant Kinase 4/6 for the Treatment of Metastatic Breast Cancer: A Mini-Review

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Open Journal of Medicinal Chemistry 2020年第3期10卷 128-138页

作者： lou Anna Voli Janat A. Mamyrbékova jean-Pierre Bazureau Institut des Sciences Chimiques de Rennes ISCR UMR CNRS 6226 Université de Rennes 1 Campus de Beaulieu Campus de Beaulieu Bat. 10A CS 74205 263 Avenue du Général Leclerc 35042 Rennes Cedex France Laboratoire de Chimie Bio-Organique et de Subtances Naturelles (LCBOSN) Université Nangui Abrogoua Voie Express d’Abobo Adjamé Abidjan C&#244 te d’Ivoire

Abemaciclib (Verzerio®) is a cell cycle inhibitor of both CDK4 and CDK6. In 2017, abemaciclib was approved by the Food and Drug Administration (FDA) and, in 2018 by the European Medicines Agency (EMA) for the treatment of postmenopausal women with hormone receptor positive (HR+), human epidermal growth factor receptor 2 negative (HER2−) advanced breast cancer. In this mini-review, we provide a series of information for respectively their targets and its selectivity, results on preclinical trial, clinical phase I, II and III trials, and some perspectives. We also describe the batch and flow steps used for the synthesis of this cancer drug.

关键词： Approved Drug Abemaciclib FDA EMA CDK4/6 Protein Kinase Inhibitor Metastatic Breast Cancer

Does the Animal Origin Influence the Calcification of Xenograft Tissue Heart Valve Substitutes? Comparison between Bovine and Camel Pericardium in a Subcutaneous Rat Model

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International Journal of Clinical Medicine 2015年第9期6卷 700-709页

作者： Fatima Al Harmoodi Salah Al Shafy Michel Guichardant jean-Jacques lebrun Francoise Thivolet Olivier Jegaden Department of biomedical engineering Khalifa University Abu Dhabi UAE Department of cardiac surgery Zayed Military Hospital Abu Dhabi UAE Chemistry-Biology Health Area Institut Multidisciplinaire de Biochimie des lipides Institut National des Sciences Appliquées Lyon France Institute of Analytic Sciences Centre National de la Recherche Scientifique Villeurbanne France Department of Biology Hospices Civils de Lyon Claude Bernard University Lyon1 Lyon France Department of Cardiac Surgery Cleveland Clinic Abu Dhabi Abu Dhabi UAE Claude Bernard University Lyon1 Lyon France Cleveland Clinic Lerner College of Medicine—Case Western Reserve University Cleveland Ohio USA

Objective: To validate the hypothesis that camel pericardium could be more protected than bovine pericardium against calcification process according to the huge difference in their respective lifestyle and lifetime. Methods: Glutaraldehyde (GA) fixed bovine and camel pericardium samples (BP and CP respectively) were both implanted in 30 New Zealand white rats (2 BP and 2 CP matched specimens in each animal) and explanted after 60 days. Unimplanted GA-fixed samples of both species served as control. Matched implanted samples and unimplanted samples were randomly submitted to elemental analysis by spectroscopy, phospholipid extraction, macroscopic and X-ray examination and histology. Results: At 60 days, calcium and phosphorus content were respectively 9.54% ± 3.1% and 4.79% ± 1.4% of tissue dry weight in BP, and 12.52% ± 2.7% and 6.14% ± 1.3% of tissue dry weight in CP (ns). In X-ray analysis, the calcification score was 1.28 ± 0.45 and 2.14 ± 0.98 in BP and CP samples respectively without significant difference (p < 0.08). In histology, calcifications were lower in BP than in CP: 1.37 ± 0.85 vs 2.28 ± 0.83 (ns);collagen fibers were better conserved in BP than in CP: 2.4 ± 0.48 vs 1.87 ± 0.78 (ns), and less disoriented: 25% vs 62% (ns). In unimplanted samples, there was a higher but not significant rate of extracted lipids in CP: 5.7 ± 1.8 vs 9.5 ± 3.8 nanomoles in PS fraction and 11.3 ± 3.7 vs 19 ± 7.7 nanomoles in total fatty acids, in BP and CP samples respectively. All results were in conjunction and demonstrated a higher but not significant rate of mineralization in camel pericardium after implantation, which could be related to a higher but not significant basic rate of phospholipid and fatty acids. Conclusion: This experiment study in a subcutaneous rat model has failed to valid our hypothesis. Because the differences observed between bovine and camel pericardium did not reach the significance, at the best, there is no difference between both species and at th

关键词： Pericardium Calcification Bovine Camel Xenograft Tissue Heart Valve Substitutes

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离子渗氮技术的发展与工业应用

热处理技术与装备 1988年第4期 9-15页

作者： lebrun jean—Paul 曹敏达北京机电研究所

近年来,离子渗氮经历了相当大的发展,特别在法国,有近百台设备在运行,这个数字为五年前的4～5倍。最近的研究表明,这种趋势在今后十年还将继续下去。在本届年会上,就此专题从科学及技术观点提交了许多论文。我们提交的论文,目的是提出... 详细信息

近年来,离子渗氮经历了相当大的发展,特别在法国,有近百台设备在运行,这个数字为五年前的4～5倍。最近的研究表明,这种趋势在今后十年还将继续下去。在本届年会上,就此专题从科学及技术观点提交了许多论文。我们提交的论文,目的是提出更具体的探讨,以及那些日常运用此项工艺的操作者的观点。

关键词：离子渗氮气体渗氮工业应用

Post-Translational Regulation of AtFER2 Ferritin in Response to Intracellular Iron Trafficking during Fruit Development in Arabidopsis

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Molecular Plant 2009年第5期2卷 1095-1106页

作者： Karl Ravet Brigitte Touraine Sun A. Kim Francoise Cellier Sebastien Thomine Mary lou Guerinot jean-Francois Briat Frederic Gaymard Biochimie et Physiologie Moleculaire des Plantes (B&PMP) Unite Mixte de Recherche CNRS INRA Universite Montpellier 2 SupAgro Place Viala Bat. 7 F-34060 Montpellier France Department of Biological Sciences Dartmouth College 6044 Gilman Hall Hanover NH 03755 USA Institut des Sciences du Vegetal CNRS Bat 23 Avenue de la Terrasse 91198 Gif-sur-Yvette France

Ferritins are major players in plant iron homeostasis. Surprisingly, their overexpression in transgenic plants led only to a moderate increase in seed iron content, suggesting the existence of control checkpoints for iron loading and storage in seeds. This work reports the identification of two of these checkpoints. First, measurement of seed metal content during fruit development in Arabidopsis thaliana reveals a similar dynamic of loading for Fe, Mn, Cu, and Zn. The step controlling metal loading into the seed occurs by the regulation of transport from the hull to the seed. Second, metal loading and ferritin abundance were monitored in different genetic backgrounds affected in vacuolar iron transport （AtVIT1, AtNRAMP3, AtNRAMP4） or plastid iron storage （AtFER1 to 4）. This approach revealed （1） a post-translational reg- ulation of ferritin accumulation in seeds, and （2） that ferritin stability depends on the balance of iron allocation between vacuoles and plastids. Thus, the success of ferritin overexpression strategies for iron biofortification, a promising approach to reduce iron-deficiency anemia in developing countries, would strongly benefit from the identification and engineering of mechanisms enabling the translocation of high amounts of iron into seed plastids.

关键词： Nutrient and metal transport iron transport ferritin post-transcriptional control biofortification Arabidopsis.

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