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Correlation between Central and Lateral Neck Dissection in Differentiated Thyroid Carcinoma

International Journal of Otolaryngology and Head & Neck Surgery 2012年第3期1卷 109-115页

作者： Olivia Mazzaschi Marine Lefevre Bruno Angelard Nathalie Chabbert-Buffet jean lacau st.guily Sophie Perie Department of Otolaryngology-Head and Neck Surgery Faculty of MedicineUniversity Pierre et Marie Curie Paris VITenon HospitalAssistance Publique-Hopitaux de ParisParisFrance Department of Pathology Faculty of MedicineUniversity Pierre et Marie Curie Paris VITenon HospitalAssistance Publique-Hopitaux de ParisParisFrance Department of Obstetrics Gynaecology and Reproductive Medicine-Endocrinology SectionFaculty of MedicineUniversity Pierre et Marie Curie Paris VITenon HospitalAssistance Publique-Hopitaux de ParisParisFrance

Objective: To determine the histopathological correlation between central and lateral neck metastasis in differentiated thyroid carcinoma, and its potential therapeutic impact. Although the central neck dissection (CND) is recommended in differentiated thyroid carcinoma, the indication for lateral neck dissection (LND) remains controversial. Design: Retrospective study. Methods and Main Outcome Measures: Pathological analysis of systematic ipsilateral central neck dissection (CND) and LND performed with total thyroidectomy in differentiated thyroid carcinoma was retrospectively reviewed according to “side” and to “patient”. Results: A total of 56 sides (46 patients) were suitable for analysis. Analysis by “side” revealed that CND and LND dissection samples were both negative in 15 cases, both positive in 32, CND was positive and LND was negative for 8 cases and CND was negative and LND was positive in 1 case. The combined presence of positive LND and positive CND was therefore observed in 32/40 “sides” and 26/46 “patients”. Analysis by “side” of the impact of the treatment decision to perform ipsilateral LND only in patients with positive CND and vice versa demonstrated a sensitivity, specificity, and accuracy of 97%, 65%, and 84%, respectively. Conclusions: In most cases, the presence of positive LND was associated with positive ipsilateral CND. The very low prevalence of positive LND in patients with negative CND may justify LND as a second step procedure only in patients with positive CND, except in the case of documented lateral neck metastasis.

关键词： Central Neck Dissection Lateral Neck Dissection Differentiated Thyroid Carcinoma Pathological Analysis Thyroid Carcinoma Neck Metastasis

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吞咽视频内镜检查对Zenker′s憩室手术效果的评估作用

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上海交通大学学报（医学版） 2011年第6期31卷 821-823页

作者：陈佳瑞 jean lacau Saint guily 王家东上海交通大学医学院附属仁济医院耳鼻咽喉头颈外科上海交通大学耳鼻咽喉研究所上海200001 法国巴黎皮埃尔与玛丽.居里-巴黎第六大学附属Tenon医院耳鼻咽喉头颈颌面外科巴黎75020

目的探讨吞咽视频内镜检查(VESS)中观察到的潮汐症(RTS)现象对Zenker′s憩室的诊断及手术疗效评估作用。方法收集1998年5月—2010年4月法国巴黎Tenon医院耳鼻咽喉头颈颌面外科确诊并接受手术治疗的148例连续性Zenker′s憩室病例的临床... 详细信息

目的探讨吞咽视频内镜检查(VESS)中观察到的潮汐症(RTS)现象对Zenker′s憩室的诊断及手术疗效评估作用。方法收集1998年5月—2010年4月法国巴黎Tenon医院耳鼻咽喉头颈颌面外科确诊并接受手术治疗的148例连续性Zenker′s憩室病例的临床资料。对手术前和手术后VESS中RTS出现的情况进行回顾性分析;随机选择病例38例,记录术前VESS中RTS出现前的吞咽次数,并分析其与术前食道吞钡检查中记录的Zenker′s憩室大小的关系;在VESS视频记录中回顾性寻找25例非Zenker′s憩室的食道上段括约肌功能障碍患者吞咽过程中的RTS表现。结果 148例患者术前VESS中均有RTS表现。症状出现前吞咽次数与食道憩室大小无明显关联(P>0.05)。术后对121例患者的随访发现,111例患者术后症状明显改善且VESS中RTS完全消失;10例患者症状复发,其中7例患者在平均随访37个月时VESS中再次出现RTS表现。25例非Zenker′s憩室的食道上段括约肌功能障碍患者的VESS记录中未发现RTS表现。结论 VESS中观察到的RTS是Zenker′s憩室的特征性表现。VESS可作为诊断Zenker′s憩室的一项辅助检查及在随访过程中评估手术疗效的有效手段。

关键词： Zenker′s食管憩室潮汐症吞咽视频内镜

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Hepatitis C virus: Virology, diagnosis and management ofantiviral therapy

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World Journal of Gastroenterology 2007年第17期13卷 2461-2466页

作者： stéphane Chevaliez jean-Michel Pawlotsky French National Reference Center for Viral Hepatitis B C and deltaDepartment of Virology & INSERM U841 Henri Mondor Hospital University of Paris XII Créteil France

Hepatitis C virus (HCV) infects approximately 170 million individuals worldwide. Prevention of HCV infection complications is based on antiviral therapy with the combination of pegylated interferon alfa and ribavirin. The use of serological and virological tests has become essential in the management of HCV infection in order to diagnose infection, guide treatment decisions and assess the virological response to antiviral therapy. Anti- HCV antibody testing and HCV RNA testing are used to diagnose acute and chronic hepatitis C. The HCV genotype should be systematically determined before treatment, as it determines the indication, the duration of treatment, the dose of ribavirin and the virological monitoring procedure. HCV RNA monitoring during therapy is used to tailor treatment duration in HCV genotype 1 infection, and molecular assays are used to assess the end-of-treatment and, most importantly the sustained virological response, i.e. the endpoint of therapy.

关键词： Hepatitis C virus serological tests HepatitisC virus genotype HCV RNA quantification Interferon alpha Ri-bavirin-

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Anatomical and electrophysiological plasticity of locomotor networks following spinal transection in the salamander

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Neuroscience Bulletin 2013年第4期29卷 467-476页

作者： jean-Marie Cabelguen stéphanie Chevallier Ianina Amontieva-Potapova Céline Philippe Neurocentre Magendie INSERM U 862 - Bordeaux University

Recovery of locomotor behavior following spinal cord injury can occur spontaneously in some vertebrates, such as fish, urodele amphibians, and certain reptiles. This review provides an overview of the current status of our knowledge on the anatomical and electrophysiological changes occurring within the spinal cord that lead to, or are associated with the [e-expression of locomotion in spinally-transected salamanders. A better understanding of these processes will help to devise strategies for restoring locomotor function in mammals, including humans.

关键词： salamander spinal cord locomotor recovery regeneration

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High-Density Nanowells Formation in Ultrafast Laser-Irradiated Thin Film Metallic Glass

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Nano-Micro Letters 2022年第6期14卷 308-322页

作者： Mathilde Prudent Djafar Iabbaden Florent Bourquard stéphanie Reynaud Yaya Lefkir Alejandro Borroto jean-François Pierson Florence Garrelie jean-Philippe Colombier Univ Lyon UJM-Saint-EtienneCNRSInstitute of Optics Graduate SchoolLaboratoire Hubert CurienUMR CNRS 551642023 St-EtienneFrance Universitéde Lorraine CNRSIJL54000 NancyFrance

We present an effective approach for fabricating nanowell arrays in a one-step laser process with promising applications for the storage and detection of chemical or biological *** thin films of metallic glasses are manufactured with a selected composition of Zr_(65)Cu_(35),known to exhibit remarkable mechanical properties and glass forming *** nanowell arrays spontaneously form in the ultrafast laser irradiation spot with dimensions down to 20 *** flared shape observed by transmission electron microscopy is ideal to ensure chemical or biological material immobilization into the *** also indicates that the localization of the cavitation-induced nanopores can be tuned by the density and size of the initial nanometric interstice from the columnar structure of films deposited by magnetron *** addition to the topographic functionalization,the laser-irradiated amorphous material exhibits structural changes analyzed by spectroscopic techniques at the nanoscale such as energy-dispersive X-ray spectroscopy and electron energy loss *** reveal structural changes consisting of nanocrystals of monoclinic zirconia that grow within the amorphous *** mechanism is driven by local oxidation process catalyzed by extreme temperature and pressure conditions estimated by an atomistic simulation of the laser-induced nanowell formation.

关键词： Nanowell Nanoripple Metallic glass Surface functionalization Femtosecond laser

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Interendoscopist variability in proximal colon polyp detection is twice higher for serrated polyps than adenomas

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World Journal of Gastroenterology 2016年第38期22卷 8549-8557页

作者： jean-François Bretagne stéphanie Hamonic Christine Piette jean-François Viel Guillaume Bouguen Service des maladies de l'appareil digestif hopital PontchaillouCentre hospitalo-universitaire de Rennes35033 RennesFrance Service d'épidémiologie et de santé publique Centre hospitalo-universitaire de Rennes35033 Rennes France Association pour le dépistage des cancers en Ille et Vilaine 35033 RennesFrance

AIM To assess the interendoscopist variability in the detection of colorectal polyps according to their location and histological *** This study was a retrospective analysis of prospectively collected data from a regional colorectal cancer(CRC) screening program; 2979 complete colonoscopies from 18 endoscopists were included. Variability in performance between endoscopists for detection of at least one adenoma(A), one proximal adenoma(PA), one distal adenoma(DA), and one proximal serrated polyp(PSP) was assessed by using multilevel logistic regression *** The observed detection rates among the 18 endoscopists ranged from 24.6% to 47.6%(mean = 35.7%) for A, from 19.1% to 39.0%(mean = 29.4%) for DA, from 6.0% to 22.9%(mean = 12.4%) for PA, and from 1.3% to 19.3%(mean = 6.9%) for *** adjusting for patient-level variables(sex, age), the interendoscopist detection rates variability achieved a significant level for A, PA, and PSP but not for DA(P = 0.03, P = 0.02, P = 0.02 and P = 0.08, respectively). This heterogeneity, as measured by the variance partition coefficient, was approximately threefold higher for PA(6.6%) compared with A(2.1%), and twofold higher for PSP(12.3%) compared with *** These results demonstrate significant interendoscopist variability for proximal polyp particularly for serrated p o l y p s, b u t n o t f o r d i s t a l a d e n o m a d e t e c t i o n. These findings contribute to explain the decreased effectiveness of complete colonoscopies at preventing proximal CRCs and the need to carefully assess the proximal colon during scope procedure.

关键词： Colonoscopy Colorectal cancer Adenoma Serrated polyp Proximal polyp Detection rate Quality performance

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Glucose regulates LXRα subcellular localization and function in rat pancreatic β-cells

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Cell Research 2006年第7期16卷 661-670页

作者： AudreyHelleboid-Chapman stéphaneHelleboidHeidelindeJakel CatherineTimmerman Christian Sergheraert Francois Pattou JamilaFruchart-Najib jean-CharlesFruchart Atherosclerosis Department UR 545 INSERMthe Faculty of PharmacyLille 2 University1 rue du Professeur Calmette BP245Lille cedex 59019France Synthesis Structure and Biomolecule FunctionUMR 8525 CNRSPasteur Institute of LilleLille 2 UniversityLilleFrance Cell Therapy for Diabetes ERIT-M 0106Facultyof Medecine University of Lille 2/INSERMLille 59045France

Liver X receptors(LXRs)are members of the nuclear receptor superfamily,which have been implicated in lipid ho-meostasis and more recently in glucose ***,we show that glucose does not change LXRα protein level,but affects its localization in pancreatic β-***α is found in the nucleus at 8 mM glucose and in the cytoplasm at4.2 *** of glucose translocates LXRα from the cytoplasm into the ***,after the activation ofLXR by its synthetic non-steroidal agonist(T0901317),insulin secretion and glucose uptake are increased at 8 mM anddecreased at 4.2 mM glucose in a dose-dependent ***,at low glucose condition,okadaic acid reversedLXRα effect on insulin secretion,suggesting the involvement of glucose signaling through a phosphorylation-dependentmechanism.

关键词： LXR β-cells insulin secretion glucose uptake subcellular localization

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Clinical guidelines: Involvement of peers increases physician adherence

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World Journal of Gastroenterology 2008年第2期14卷 322-323页

作者： Pascal Vignally Roland Sambuc stéphanie Gentile jean Charles Grimaud Department of Public Health Faculty of Medicine Marseille France Department of Gastroenterology University hospital Marseille France

The literature illustrates the important issue of physician adherence to guidelines in their daily practice. In a quantitative study, we asked a random sample of 100 hospital gastroenterologists to evaluate their knowledge of guidelines and awareness of promoters. The degree to which guidelines were considered reliable was not related to the scientific evidence but was significantly associated with the promoter. The French Society of Gastroenterology was considered to be a more reliable promoter than national health agencies and pharmaceutical industries. Gastroenterologists become aware of guidelines mainly through their specialty society (62%). Specialty societies appear to be a more important source of information on guidelines for physicians. National health agencies should involve the specialty societies in the guideline development process to achieve changes in clinical practice.

关键词： Guidelines Adherence Quality Quantitative study

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Petrography of alluvial sands as a past and present environmental indicator:Case of the Loire River(France)

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International Journal of Sediment Research 2013年第3期28卷 285-303页

作者： jean-Jacques MACAIRE Isabelle GAY-OVEJERO Michel BACCHI Constantin COCIRTA Luc PATRYL stéphane RODRIGUES University Franqois-Rabelais of Tours University Francois-Rabelais of Tours SARL RIVE 4. Commissariat a l'Energie Atomique-CEA DAMDIF

Four sample sets of the Upper and Middle Loire river sands were analyzed in order to study the impact of natural and anthropogenic factors on their petrographic composition in space(on an 800 km stretch) and *** was determined by modal analysis of three sand-size fractions using a polarizing optical microscope and calculated for each sample("standard sand" = Sst).The watershed is composed mainly of endogenic(Massif Central) and sedimentary(southern Parisian Basin) rocks.B-set sands collected in channels for different water flows in 1996 show that Sst compositions vary by only 5%.Present-day sands in the Upper Loire and Middle Loire have very high petrographic immaturity comparing to others worldwide fluvial sands,although bio-climatic conditions favor sand maturation by source-rock weathering in the *** shows the strong impact of the Massif Central on sediment yield due to relief rejuvenation as a consequence of the formation of the Alps during the *** sands stored during the Weichselian and the Holocene in the Middle Loire floodplain,although partly weathered since their deposition,show higher inputs from the endogenic rocks of the Massif Central than present-day *** can be explained by Weichselian periglacial conditions and the development of crop farming since the Neolithic,which favored mechanical erosion,particularly in the Massif Central which is characterized by a cold,humid climate and steep *** upstream-downstream change in the composition of presently deposited sand is low in the diked *** shows however that basalt and some heavy mineral grains are vulnerable to abrasion during transport and indicates a marked sediment yield from ancient sediment stored in the *** is in line with the high incision of the river bed over the last 150 years partly due to dam construction and aggregate mining.

关键词： Fluvial sand Sand petrography Sediment source Tectonics impact Human impact Loire river

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Production of liquid bio-fuel from catalytic de-oxygenation:Pyrolysis of beech wood and flax shives

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燃料化学学报 2019年第2期47卷 153-166页

作者： Chetna Mohabeer Luis Reyes Lokmane Abdelouahed stéphane Marcotte jean-Christophe Buvat Lucette Tidahy Edmond Abi-Aad Bechara Taouk Normandie Univ INSA Rouen NormandieUNIROUENLaboratoire de Sécurité des Procédés Chimiques Normandie Univ INSA Rouen NormandieUNIROUEN Université du Littoral Cte d'Opale Unité de Chimie Environnementale et Interactions sur le Vivant

This study presents a detailed analysis of the catalytic de-oxygenation of the liquid and gaseous pyrolytic products of two biomasses (beech wood and flax shives) using different catalysts (commercial HZSM-5 and H-Y,and lab-synthesised Fe-HZSM-5,Fe-H-Y,Pt/Al2O3 and CoMo/Al2O3). The experiments were all conducted in a semi-batch reactor under the same operating conditions for all feed materials. BET specific surface area,BJH pore size distribution and FT-IR technologies have been used to characterise the catalysts,while gas chromatography-mass spectrometry (GC-MS),flame ionisation detection (GC-FID) and thermal conductivity detection (GC-TCD) were used to examine the liquid and gaseous pyrolytic products. It was firstly seen that at higher catalyst-to-biomass ratios of 4∶1,de-oxygenation efficiency did not experience any further significant improvement. FeHZSM-5 was deemed to be the most efficient of the catalysts utilised as it helped reach the lowest oxygen contents in the bio-oils samples and the second best was HZSM-5. It was also found that HZSM-5 and H-Y tended to privilege the decarbonylation route(production of CO),whilst their iron-modified counterparts favoured the decarboxylation one (production of CO2) for both biomasses studied. It was then seen that the major bio-oil components (carboxylic acids) underwent almost complete conversion under catalytic treatment to produce mostly unoxygenated aromatic compounds,phenols and gases like CO and CO2. Finally,phenols were seen to be the family most significantly formed from the actions of all catalysts.

关键词： pyrolysis biomass catalytic treatment de-oxygenation bio-oil upgrading

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