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Liver insulin-like growth factor 2 methylation in hepatitis C virus cirrhosis and further occurrence of hepatocellular carcinoma

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World Journal of Gastroenterology 2008年第35期14卷 5419-5427页

作者： Philippe Couvert Alain Carrié jacques Pariès Jenny Vaysse Audrey Miroglio Antoine Kerjean Pierre Nahon Jamel Chelly jean-Claude Trinchet Michel Beaugrand Nathalie Ganne-Carrié INSERM U551 Dyslipopro-teinemia and Atherosclerosis Research UnitParis F-75013France Université Paris6 UMR S551Paris F-75013France AP-HP Groupe hospitalier Pitié SalpétrièreService de Biochimie endocrinienne et OncologiqueParis F-75013France Department of Public health Jean Verdier HospitalAP-HPBondy 93140France Department of Biochemistry Jean Verdier HospitalAP-HPBondy 93140France Cochin Institut-INSERM-CNRS-University Paris 5-CHU Cochin Paris 75014France Department of Hepato-Gastroenterology Jean Verdier HospitalAP-HPBondy 93140France UPRES EA3409 University Paris 13Paris F-75651France

AIM: To assess the predictive value of the insulinlike growth factor 2 (Igf2) methylation profile for the occurrence of Hepatocellular Carcinoma (HCC) in hepatitis C (HCV) cirrhosis. METHODS: Patients with: (1) biopsy-proven compensated HCV cirrhosis; (2) available baseline frozen liver sample; (3) absence of detectable HCC; (4) regular screening for HCC; (5) informed consent for genetic analysis were studied. After DNA extraction from liver samples and bisulfite treatment, unbiased PCR and DHPLC analysis were performed for methylation analysis at the Igf2 locus. The predictive value of the Igf2 methylation profile for HCC wasassessed by Kaplan-Meier and Cox methods. RESULTS: Among 94 included patients, 20 developed an HCC during follow-up (6.9 ± 3.2 years). The methylation profile was hypomethylated, intermediate and hypermethylated in 13, 64 and 17 cases, respectively. In univariate analysis, two baseline parameters were associated with the occurrence of HCC: age (P = 0.01) and prothrombin (P = 0.04). The test of linear tendency between the three ordered levels of Igf2 methylation and probability of HCC occurrence was significant (Log Rank, P = 0.043; Breslow, P = 0.037; Tarone-Ware, P = 0.039). CONCLUSION: These results suggest that hypomethylation at the Igf2 locus in the liver could be predictive for HCC occurrence in HCV cirrhosis.

关键词： Liver cancer Cirrhosis Insulin-growth factor 2, DNA methylation

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On the MOSFET-Based Temperature Sensitive Element for Bolometer Application

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Journal of Earth Science and Engineering 2014年第8期4卷 464-469页

作者： Etienne Fuxa jean-jacques Yon Jalal Jomaah Bolometer Research Group (LIB) DOPT (Department of Optics & Photonics) CEA (Alternative Energies and Atomic EnergyCommission) LETI Grenoble 38000 France LAHC (Laboratory of Hyperfrequencies and Characterization) IMEP (Mieroelectronics Electromagnetism and PhotonicsInstitute) Grenoble 38000 France

This paper focuses on the study of thermal performances of MOS （metal-oxide-semiconductor） transistors for uncooled infrared bolometer applications. Such devices can be used in various applications both military and civil, such as defence and security, medical applications, industrial surveillance, etc. Series of measurements were conducted to obtain TCC （temperature coefficient of current） versus gate voltage and temperature curves. The TCC is a figure of merit for a device used as the sensitive element in a bolometer that represents its sensitivity to temperature and as such is a good indicator of the detector attainable performance. The measurements were confronted to Atlas simulations, and showed that in the subthreshold region the TCC ranges from 4%/K all the way to 9%/K which represents a great improvement compared to state of the art thermistor bolometers. Analytic expressions of the TCC are also derived from current equations of the MOSFET （MOS field effect transistor） drain current to help understanding the effect of drain to source voltage, mobility, temperature and threshold voltage sensibility to temperature, in all three operation modes of the transistor （subthreshold, ohmic and saturation）. It was also determined that gate length does not have an influence on the TCC until short channel effects are factored in.

关键词： Bolometer uncooled infrared detection MOSFET.

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Assessment of Sediment and Pollutants in Buyo Lake, Ivory Coast, Using SWAT （Soil and Water Assessment Tool） Model

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Journal of Chemistry and Chemical Engineering 2013年第11期7卷 1054-1059页

作者： Tanoh jean-jacques Koua jean Patrice Jourda Kan jean Kouame Kouao Armand Anoh Laboratory for Remote Sensing and Spatial Analysis Applied to Hydrogeology Fdlix Houphouet-Boigny University ofCocody-Abidjan Abidjan 22522 Ivory Coast Environment and Mechanical Engineering Department "'Vasile Alecsandri'" University of Bacau Bacau 600015 Romania

The changes in land use in the last 30 years in the territory of agro-forest watershed of Lake Buyo resulted in significant sediment into the lake. Sediments are a preferred means of transportation for certain pollutants, like phosphorus in excess. By mapping the source areas of erosion, the authors can determine the risk areas and help to prioritize interventions in the territory. This mapping is done using the SWAT （soil and water assessment tool） model. Several types of data, including topography, land use, soil and climate data are needed to run the model. In this paper, all different steps are presented, from the designing of HRU （hydrological response units）, basic units to run the SWAT model until the simulations. The establishment of HRU has three main stages： space discretization, land use and soil data integration and HRU distribution：（1） space discretization which consist in extracting the limits and the water network of the watershed from the DEM （digital elevation model） and in subdividing them into sub-basins; （2） land use and soil data integration： it consists in digitizing the physical maps of land use and of soils under Mapinfo 7.5 and in keeping them in ＂shape＂ format; （3） HRU distribution： it leads to subdivide the sub-watersheds in small units that combine a single soil type and one type of land use. It appears from this study to obtain 23 sub-watersheds and 71 HRU. Once the HRU designed, it is necessary to integrate climate data, data on physico-chemical characteristics of soils and agricultural practices, before starting the simulations. This will allow the model to assess the risk of sedimentation and eutrophication of the lake using the MUSLE （modified universal soil loss equation） and phosphorus cycle.

关键词： Erosion land use SWAT model phosphorus sediment.

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十二烷基(6)聚氧乙烯醚分子泡沫双层的X射线反射

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科学通报 2003年第12期48卷 1295-1297页

作者：沈强 Benattar jean-jacques 李欣刘少杰山东大学胶体与界面化学教育部重点实验室 Service de Physique del’Etat Condense CEA/SaclayF-91191 Gif-sur-Yvette CedexFrance 'Servicede Physique de'Etat Condense CEA/SaclayF-91191 Gif-sur-Yvette CedexFrance

采用X射线反射法(X-ray reflectometry)测定了十二烷基(6)聚氧乙烯醚(C_(12)E_6)分子所形成的自由站立式(free-standing)泡沫双层的结构参数。结果表明:此双层膜中的疏水碳氢链区、极性头区和表面活性剂分子单层之间3个区域的厚度分别为... 详细信息

采用X射线反射法(X-ray reflectometry)测定了十二烷基(6)聚氧乙烯醚(C_(12)E_6)分子所形成的自由站立式(free-standing)泡沫双层的结构参数。结果表明:此双层膜中的疏水碳氢链区、极性头区和表面活性剂分子单层之间3个区域的厚度分别为0.90,1.35和1.31nm;电子密度分别为2.4×10^(-3),2.6×10^(-3)和2.3×10^(-3)电子数/nm^3;区域之间的界面粗糙度为0.34nm。泡沫双层中两极性头区之间不含自由水,而且其厚度在红外光线的照射下可变薄0.40nm;这可能是由于结构水被破坏所致。

关键词：十二烷基(6)聚氧乙烯醚牛顿黑膜 X射线反射泡沫膜离子性表面活性剂

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利用手性N-氰乙基-2-羟基蒎烷-3-酮亚胺合成光学活性2-乙基环丙烷氨基酸

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高等学校化学学报 1998年第8期19卷 1256-1261页

作者：苏桂发广西师范大学化学化工系

以２－羟基蒎烷－３－酮（１）与氨基乙腈缩合得到的手性酮亚胺（２）为中间体，经去质子化，在Ｐｄ（０）催化下与１，４－二氯－２－丁烯（３）发生串联反应，得到光学活性环丙烷衍生物（４），产率约为７０％，反应的非对映立体选择... 详细信息

以２－羟基蒎烷－３－酮（１）与氨基乙腈缩合得到的手性酮亚胺（２）为中间体，经去质子化，在Ｐｄ（０）催化下与１，４－二氯－２－丁烯（３）发生串联反应，得到光学活性环丙烷衍生物（４），产率约为７０％，反应的非对映立体选择性（ｄ．ｅ．）为１００％．化合物４经选择性还原后水解，即可制得光学活性２－乙基环丙烷氨基酸，产物的对映体过量（ｅ．ｅ．）为３３％．

关键词：手性乙基环丙烷氨基酸羟基蒎烷酮合成

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华南早更新世巨猿动物群的ESR／U-系年代

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第四纪研究 2016年第5期36卷 1224-1235页

作者：邵庆丰韩非 jean—jacques Bahain 南京师范大学地理科学学院南京210023 中国地震局地质研究所地震动力学国家重点实验室北京100029 Departement de Prehistoire du Museum National d'Histoire Naturelle Paris 75013 France

华南的第四纪喀斯特洞穴堆积含有丰富的哺乳动物群化石，其中以步氏巨猿（Gigantopithecus blacki）为代表的巨猿动物群化石一直备受学术界关注。为建立巨猿动物群演化的绝对年代框架，本文采用牙化石ESR/U-系结合测年法测定重庆龙骨坡... 详细信息

华南的第四纪喀斯特洞穴堆积含有丰富的哺乳动物群化石，其中以步氏巨猿（Gigantopithecus blacki）为代表的巨猿动物群化石一直备受学术界关注。为建立巨猿动物群演化的绝对年代框架，本文采用牙化石ESR/U-系结合测年法测定重庆龙骨坡、广西田东吹风洞和么会洞以及广西崇左三合大洞动物群的地质年代。牙化石ESR/U-系结合测年法是将牙化石样品的ESR分析（古剂量和年剂量）与U-系分析（U-Th同位素）相结合用来模拟牙齿各个组织在地质时期的U-吸附过程，以计算牙组织中的U对古剂量的贡献，因此ESR/U-系年代比常规ESR年代更准确。本文测定了28个大型哺乳动物牙化石的ESR/U-系年代，结果表明龙骨坡动物群的地质年代为上新世晚期至早更新世早期，可限定为2.86~1.95Ma；吹风洞和么会洞动物群的地质年代在误差范围内一致，为1.97~1.38Ma；三合大洞动物群的地质年代为早更新世晚期至中更新世之初，约910~600ka。

关键词：早更新世巨猿动物群绝对年代牙化石 ESR/U-系结合测年法

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Reliability of the MPPT Control on the Energy Parameters of a Photovoltaic Generator

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World Journal of Engineering and Technology 2020年第3期8卷 537-550页

作者： Batassou Guilzia jeannot Mandeng jean jacques Mane Mane jeannot Laboratory of Computer and Automatic Engineering UFD of Engineering Sciences ENSET University of Douala Douala Cameroon University Institute of Technology UIT University of Douala Douala Cameroon

This article describes a technique that allows a photovoltaic (PV) production unit to obtain the maximum power at all times. Here, we use the MPPT control via fuzzy logic on a DC/DC boost-type converter. In order to achieve our goals, we first proceeded to model a PV panel. The resulting model offers the possibility to better account for the influence of different physical quantities such as temperature, irradiation, series resistance, shunt resistance and diode saturation current. Thus, the maximum power to be provided by the PV system is acquired by fuzzification and defuzzification of the input and output variables of the converter. Subsequently, a virtual model of an 800 Watt PV prototype is implemented in the Matlab environment. The simulation results obtained and presented, show the feasibility and efficiency of the proposed technology. Indeed, for a disturbance caused by a variation in brightness, our system guarantees the maximum stable power after 1.4 s. While for a load variation, the maximum power is continuous.

关键词： Low Voltage Photovoltaic System Fuzzy Logic Maximum Power Point

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Prevalence of the Functional Dyspepsia and Associated Factors in the Chronic Hemodialysis Patients of the National Teaching Hospital “HKM” of Cotonou

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Open Journal of Nephrology 2015年第1期5卷 14-24页

作者： jean jacques Sehonou jacques Vigan Bruno Léopold Agboton Gbètondji Michel Massi University Clinic of Internal Medicine of the National Teaching Hospital “Hubert K Maga” (CNHU-HKM) Cotonou Benin University Clinic of Nephrology and Hemodialysis of the National Teaching Hospital “HKM” of Cotonou Cotonou Benin

Aim: To study the functional dyspepsia in chronic hemodialysis patients of CNHU-HKM of Cotonou. Methods: This descriptive, analytical and cross-sectional study ran from 1 September 2013 to 28 February 2014 in the University Clinic of Nephrology Dialysis of CNHU-HKM of Cotonou. It included all chronic renal failure patients on hemodialysis for at least 9 months prior to the survey. After identifying the patients with upper gastrointestinal disorders, we had submitted to clinical Rome III criteria for functional dyspepsia. Upper endoscopy was performed in patients with clinical criteria of functional dyspepsia. Clinical factors associated, paraclinical and therapeutic were sought by logistic regression in univariate analysis. Data were analyzed using EPI DATA version 3.1. Results: 1) One hundred and thirty-one haemodialysis patients had participated in the study (sex ratio: 1.5, average age 49.6 ± 12.4 years). 2) The prevalence was 71.8% for upper gastrointestinal disorders, 64.9% for dyspeptic syndrome and 1.5% for functional dyspepsia. 3) They were associated to clinical criteria of functional dyspepsia of Roma III, the presence of high blood pressure, hypocalcaemia, treatment with calcic inhibitors and iron supplementation. Conclusion: Functional dyspepsia is uncommon in hemodialysis. The search of an organic cause is imperative for every dyspepsia.

关键词： Benin Chronic Haemodialysis Functional Dyspepsia Dyspepsia Upper Gastrointestinal Disorders

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Clinical Comparison of Pencil Beam Convolution and Clarkson Algorithms for Dose Calculation

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Journal of Cancer Therapy 2013年第10期4卷 1485-1489页

作者： Abdulhamid Chaikh jean-Yves Giraud jacques Balosso Joseph Fourier University Grenoble France

Purpose: The purpose of this work is to study and quantify the differences in calculated dose computed with two algorithms available in treatment planning systems: Pencil Beam Convolution and Clarkson. Material and Methods: Four different types of treatment cases were analyzed: lung, head and neck, brain and prostate. For each case, the volume definition was based on a clinical CT-scan acquisition. The patients were treated with 3-dimensional radiation therapy. For each patient, 2 treatment plans were generated using exactly the same configuration of beams. In plan 1 and plan 2, the dose was calculated using the Clarkson and Pencil Beam Convolution algorithms, respectively, without heterogeneity correction. To evaluate the treatment plans, the monitor units, isodose curves, dose volume histograms and quality index were compared. A statistical analysis was carried out using Wilcoxon signed rank test. Results: The difference observed for monitor unites was 1.2% for lung and less than 1% for head and neck, brain and prostate. Wilcoxon test showed that there was “no statically significant difference, (p > 0.05)”. The dosimetric parameters derived from dose volume histograms were higher for organs at risks using Clarkson compared to Pencil Beam Convolution algorithm inviting clinician to make “safer” prescriptions. For quality index there was no statistically significant difference between both algorithms for all quality indexes, (p > 0.05). Conclusion: The clinical evaluation of a treatment plan should be made regarding the calculation algorithm which, in turn, is linked to the experience of the clinician.

关键词： Treatment Planning Dose Distribution Isodose Monitor Unit PBC Clarkson

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加纳国家健康保险方案效率评价研究

加纳国家健康保险方案效率评价研究

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作者： jean-jacques DOMINIQUE BERAUD 江苏大学

学位级别：硕士

在多年直接支付医疗保健费用以后,包括加纳、肯尼亚和卢旺达在内的一些非洲国家,通过高质量的医疗保险和医疗保健,建立了公共卫生保护计划,特别是针对穷人的医疗保健。然而在过去的十年中,加受国家健康保险局(NHIA)控制的加纳国家健康... 详细信息

在多年直接支付医疗保健费用以后,包括加纳、肯尼亚和卢旺达在内的一些非洲国家,通过高质量的医疗保险和医疗保健,建立了公共卫生保护计划,特别是针对穷人的医疗保健。然而在过去的十年中,加受国家健康保险局(NHIA)控制的加纳国家健康保险计划(NHIS)在可持续性,准确、及时的年度统计报告方面正面临着许多问题,导致其无法实现全民医保(UHC)的共同目标。本研究旨在评估国家健康保险方案的效率,首先介绍国家健康保险方案相关概念,然后分析国家健康保险局(NHIA)自创建以来的各种职能及其资金来源,并明确了健康保险方案面临的一些主要挑战及其现状。通过对健康保险相关文献的分析确定了用于解决各种健康保险问题的方法,数据来自于国家健康保险局(NHIA)和加纳卫生部(MoH)数据库。本研究有助于促使NHIA能够开发一个可持续发展的系统,可以有效地提高NHIS的质量并监管其监督下的各个机构。本文运用复杂网络系统将国家健康保险局(NHIA)分成四个主要区域(北部、南部、东部和西部地区),并根据国家健康保险局(NHIA)的设施数量分组(医院、诊所、药房、政府拨款),通过使用UCINET、Netdraw软件,对转诊病人数、专业人员数和资金数量进行加权。在具体网络分析中,我们采用接近平均值、信息中心度和特征值来确定哪个地区比其他地区更有效。利用R软件进行回归分析,对各区域内的专业人员数、资金和转诊病人数进行研究,并对整个国家健康保险局(NHIA)网络模型进行评估。研究结果显示,专业人员数量和资金的影响在一些地区不显著。然而,在整个NHIA网络中资金来源影响不显著,总体分析却表明专业人员数量对NHIA网络有正向影响;国家健康保险局(NHIA)网络内存在积极的信息流动,促进了该网络内转诊病人数量。资金数量的影响不显著是因为国家健康保险局(NHIA)的首要目标是满足用户的满意度并降低治疗费用。事实仍然是,要实现一个国家的国民健康保险计划的效率,主要通过对相关资源的大量投资以及大量医疗保健专业人员的可获得性来实现。根据研究结果提出了一些建议,包括建立更强大的支出控制系统以实现长期可持续性,扩大健康保险计划配套并建立可以计算机化系统以有效控制并防止服务提供商提出的索赔要求膨胀。

关键词：国家健康保险局效率评价复杂网络制定决策

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