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Silicone matrices for controlled dexamethasone release:toward a better understanding of the underlying mass transport mechanisms

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Regenerative Biomaterials 2023年第1期10卷 498-509页

作者： Thitiphorn Rongthong Adam Qnouch Maria Maue Gehrke Laurent Paccou Paulo Oliveira Florence Danede Jeremy Verin Christophe Vincent jean-francois Willart Florence Siepmann Juergen Siepmann Univ.Lille INSERMCHU LilleU1008F-59000 LilleFrance Univ.Lille UMR CNRS 8207UMETF-59655 Villeneuve d’AscqFrance

Dexamethasone-loaded silicone matrices offer an interesting potential as innovative drug delivery systems,*** the treatment of inner ear diseases or for ***,very long drug release periods are targeted:several years/*** renders the development and optimization of novel drug products cumbersome:experimental feedback on the impact of the device design is obtained very slowly.A better understanding of the underlying mass transport mechanisms can help facilitating research in this field.A variety of silicone films were prepared in this study,loaded with amorphous or crystalline *** polymorphic drug forms were investigated,the film thickness was altered and the drug optionally partially/completely exchanged by much more water-soluble dexamethasone‘phosphate’.Drug release studies in artificial perilymph,scanning electron microscopy,optical microscopy,differential scanning calorimetry,X-ray diffraction and Raman imaging were used to elucidate the physical states of the drugs and polymer,and of the systems’structure as well as dynamic changes thereof upon exposure to the release *** particles were initially homogeneously distributed throughout the *** hydrophobicity of the matrix former very much limits the amounts of water penetrating into the system,resulting in only partial drug *** mobile drug molecules diffuse out into the surrounding environment,due to concentration ***,Raman imaging revealed that even very thin silicone layers(<20µm)can effectively trap the drug for prolonged periods of *** physical state of the drug(amorphous,crystalline)did not affect the resulting drug release kinetics to a noteworthy extent.

关键词： silicone matrix drug release mechanism dexamethasone dexamethasone phosphate Raman imaging

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主编特邀

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心理科学进展 2011年第5期19卷 617-623页

作者： jean-francois Bonnefon 杜雪蕾饶俪琳法国国家科学研究中心图卢兹大学

编者按：本期“主编特邀”的作者是法国心理学家jean—FrangoisBonnefon，现任法国国家科学研究中心,（CNRS）研究员，法国图卢兹大学CLLE（Cognition，Langues，Langage et Ergonomie）研究所所长。Bonnefon的研究领域涉及两个学科—... 详细信息

编者按：本期“主编特邀”的作者是法国心理学家jean—FrangoisBonnefon，现任法国国家科学研究中心,（CNRS）研究员，法国图卢兹大学CLLE（Cognition，Langues，Langage et Ergonomie）研究所所长。Bonnefon的研究领域涉及两个学科——心理学／语言学，以及计算机科学／人工智能。他主要针对理性心理活动的三剑客——推理、判断和决策——进行了大量的研究工作，并在Psychological Science、Psychological Review等学术期刊上发表过论文40余篇。本文中，Bonnefon将介绍一个在社会科学领域已引起广泛关注，但却缺乏行为心理学研究的判断与决策问题——教条悖论。该悖论普遍存在于群体决策和判断整合过程之中。他通过总结以往的研究结果、分析初步的实证数据，对这一问题的研究意义、研究现状和发展方向进行了深入探讨。相信本文将给关心判断与决策领域的心理学者带来新的研究思路。

关键词：主编心理学家科学研究中心社会科学领域决策问题计算机科学心理学研究人工智能

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Performances of local poultry breed fed black soldier fly larvae reared on horse manure

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Animal Nutrition 2018年第1期4卷 73-78页

作者： Nassim Moula Marie-Louise Scippo Caroline Douny Guy Degand Edwin Dawans jean-francois Cabaraux jean-Luc Hornick Rudy C.Medigo Pascal Leroy Frederic Francis Johann Detilleux Fundamental and Applied Research for Animal&Health Animal Production DepartmentFaculty of Veterinary MedicineUniversity of Liege Fundamental and Applied Research for Animal&Health Food Science DepartmentFaculty of Veterinary MedicineUniversity of Liege Functional and Evolutionary Entomology Gembloux Agro-Bio TechUniversity of Liege

In poultry,feed based on maggots,like larvae of black soldier fly(Hermetia illucens) is an attractive option to substitute current ingredients which are expensive and often in direct or indirect competition with human *** information is currently available on the utility of these larvae in poultry feed,so goals of this study were to determine whether larvae could be reared on horse manure under traditional farming conditions and to evaluate the growth performances of a local poultry fed these larvae and the fatty acids profiles of their *** freezing and thawing,larvae were introduced in the feed of Ardennaise chickens between 30 and 80 days of *** in the control group received a commercial standard feed,while those in the treatment group received the same commercial feed in which 8% was substituted with whole fresh larvae corresponding to 2% on a dry matter *** ± standard errors of larval length and weight were 20.67 ± 2.21 mm and 0.14 ± 0.02 g,*** larval percentages of dry matter and of substances extractable in diethyl ether were 24.6% and 23.1%,*** fatty acids profiles were predominantly composed of lauric acid(28.1%) and palmitic acid(22.0%).Least squares means of weekly weights of chicken,adjusted for the effects of sex,replication and initial weights,were significantly higher(P < 0.05) by 77.03 ± 53.37 g in larvae-fed than in control *** other measurements were not statistically different between larvae-fed and control chicken,including fatty acid profiles,protein content and w6/w3 ratio.

关键词： Insect farming Chicken Local breed Growth performance Meat quality Fatty acid profile

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Update of Meat Standards Australia and the cuts based grading scheme for beef and sheepmeat

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Journal of Integrative Agriculture 2018年第7期17卷 1641-1654页

作者： Sarah P.F.Bonny Rachel A.O'Reilly David W.Pethick Graham E.Gardner jean-francois Hocquette Liselotte Pannier School of Veterinary and Life Sciences Murdoch UniversityMurdochWA 6150Australia Clermont Université INRAVetAgro SupUMR1213Recherches sur les HerbivoresSaint-Genes Champanelle F-63122France

Changing markets and evolving consumer demand present new challenges for the beef and sheep industries. In response, the industry has been investing in innovations to deliver new products and management systems to consumers. One such innovation is the Meat Standards Australia（MSA） system. This system is a Total Quality Management System, aimed at delivering an eating quality guarantee to consumers, and through this adding value to the entire supply chain. At present, it is well developed for beef and still evolving for sheepmeat. MSA has identified Critical Control Points（CCPs） in the production, pre-slaughter, processing and value-adding aspects of the supply chain that impact on consumer palatability through the large-scale taste testing of meat by untrained consumers. These CCPs are used as either（1） mandatory criteria determining eligibility for grading, and（2） inputs in a model predicting the palatability of individual combinations of muscle and different cooking methods. Through the prediction of palatability, MSA increases consumer satisfaction and is used to provide assurance for branded products and new marketing innovations in Australia and internationally. This has added significant value to the Australian beef industry, with several retail examples demonstrating consumer willingness to pay more for premium quality beef and sheepmeat products based on the MSA grading scores. This price differential at retail allows the value of the carcass to be calculated based on the eating quality as well as the volume produced, thereby delivering a financial reward for farmers producing high quality carcasses. The continuous quality scale of MSA allows producers to realise the financial gain of incremental improvements in quality, as well as the precise economic weights associated with traits such as marbling, ossification score, or breed. The use of MSA in this fashion has underpinned a new and innovative supply chain where the pricing is transparent and allows produ

关键词： eating quality consumer beef sheep Meat Standards Australia international cut

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KGmax Curves Associated With Second Generation Intact Stability Criteria for Different Types of Ships

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Journal of Marine Science and Application 2016年第3期15卷 223-235页

作者： francois Grinnaert jean-Yves Billard jean-Marc Laurens French Naval Academy Research Institute Brest 29240 France ENSTA Bretagne Brest 29200 France

Currently, second generation intact stability criteria are being developed and evaluated by the International Maritime Organization(IMO). In this paper, we briefly present levels 1 and 2 assessment methods for the criteria of pure loss of stability and parametric roll failure modes. Subsequently, we show the KG_(max) curves associated with these criteria. We compute these curves for five different types of ships and compare them with the curves embodied in the current regulations. The results show that the safety margin ensured by the first level-1 method of calculation for both pure loss of stability and parametric roll seems to be excessive in many cases. They also show that the KG_(max) given by the second level-1 method and by the level-2 method may be very similar. In some cases, the level-2 method can be more conservative than the second level-1 method, which is unanticipated by the future regulation. The KG_(max) curves associated with parametric roll confirm that the C11 container ship is vulnerable to this failure mode. The computation of the second check coefficient of parametric roll level 2(C2) for all possible values of KG reveals the existence of both authorized and restricted areas on the surface formed by both the draft and KG, which may replace the classical KG_(max) curves. In consequence, it is not sufficient to check that C2 is lower than the maximum authorized value(R_(PR0)) for a fixed ship's loading condition.

关键词： pure loss of stability parametric roll KGmax curve second generation intact stability criteria

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New flavan and unusual chalcone glycosides from Drypetes parvifolia

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Chinese Chemical Letters 2008年第8期19卷 943-946页

作者： Viviane Nadège Nenkep Jovita Chi Shirri Hanh Trinh Van-Dufat Falindor Sipepnou Philippe Vérité Elisabeth Seguin francois Tillequin jean Wandji Department of Organic Chemistry University of Yaounde-1Faculty of ScienceP.O.Box 812YaoundeCameroon Laboratoire de Pharmacognosie de l'Université Paris Descartes UMR/CNRS N 8638Faculté des Sciences Biologiques et Pharmaceutiques4-Avenue de l'Observatoire75006 ParisFrance Laboratoire de Chimie Analytique UFR de Médecine Pharmacie Rouen22-Bid Gambetta76183 Rouen Cedex 1France Laboratoire de Pharmacognosie UFR de Médecine Pharmacie Rouen22-Bld Gambetta76183 Rouen Cedex 1France

Two new compounds 7-hydroxy-5-O-（β-D-glucopyranoside） flavan （1） and （Z）-4＇,6＇-dihydroxy-2＇-O-（β-D-glucopyranoside） chalcone （2）, along with eight known compounds, were isolated from the stem bark of Drypetes parvifolia （Euphorbiaceae）. Their structures were established on the basis of spectroscopic analysis and chemical evidence.

关键词： Drypetes parvifolia Flavonoid glycosides 7-Hydroxy-5-O-(β-D-glucopyranoside) flavan (Z)-4',6'-Dihydroxy-2'-O-(β-D-glucopyr-anoside) chalcone

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Antiplasmodial activity of traditional polyherbal remedy from Odisha, India:Their potential for prophylactic use

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Asian Pacific Journal of Tropical Biomedicine 2015年第12期5卷 982-986页

作者： Prakash Bangalore Nagendrappa jean-francois Franetich Frederick Gay Audrey Lorthiois Padma Venkatasubramanian Dominique Mazier Institute of Trans-Disciplinary Health Sciences and Technology Foundation for Revitalisation of Local Health Traditions Manipal University Cimi-Paris (UPMC UMRS CR7 Inserm U1135 CNRS ERL 8255) AP-HP Pitié-Salpêtrière Hospital Group

Objective:To evaluate the potential prophylactic activity of traditional polyherbal remedy against ***:A traditional polyherbal remedy against malaria from Odisha,India was evaluated for its potential prophylactic activity using in vitro hepatic cell lines assay and the murine malaria system Plasmodium yoelii yoelii/Anopheles ***:The polyherbal extract inhibited the Plasmodium yoelii hepatic stages in vitro(IC500.74 mg/m L),a therapeutic index of *** mice treated with the aqueous extract(2 000 mg/kg/day),peak parasitaemia values were 81%lower in the experimental2.35%±0.14%as compared to controls 12.62%±0.52%(P<0.001),suggesting significant prophylactic ***:The observations provide a proof of concept for a traditional malaria prophylactic remedy used by tribal populations in India.

关键词： Polyherbal remedy Plasmodium Malaria prophylaxis Antiplasmodial activity

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Molecular investigation of Tuscan sweet cherries sampled over three years: gene expression analysis coupled to metabolomics and proteomics

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Horticulture Research 2021年第1期8卷 1-24页

作者： Roberto Berni Sophie Charton Sebastien Planchon Sylvain Legay Marco Romi Claudio Cantini Giampiero Cai jean-francois Hausman Jenny Renaut Gea Guerriero Department of Life Sciences University of Sienavia P.A.Mattioli 4I-53100 SienaItaly TERRA Teaching and Research Center Gembloux Agro-Bio TechUniversity of Liège5030 GemblouxBelgium Environmental Research and Innovation Department Luxembourg Institute of Science and Technology41Rue du BrillL-4422 BelvauxLuxembourg Environmental Research and Innovation Department Luxembourg Institute of Science and Technology5rue BommelL-4940 HautcharageLuxembourg Istituto per la BioEconomia(IBE CNR) Dipartimento di Scienze BioAgroAlimentarivia Aurelia 4958022 FollonicaItaly

Sweet cherry(Prunus avium L.)is a stone fruit widely consumed and appreciated for its organoleptic properties,as well as its nutraceutical *** here investigated the characteristics of six non-commercial Tuscan varieties of sweet cherry maintained at the Regional Germplasm Bank of the CNR-IBE in Follonica(Italy)and sampled ca.60 days post-anthesis over three consecutive years(2016-2017-2018).We adopted an approach merging genotyping and targeted gene expression profiling with *** complement the data,a study of the soluble proteomes was also performed on two varieties showing the highest content of *** identified the presence of flavanols and proanthocyanidins in highest abundance in the varieties Morellona and Crognola,while gene expression revealed that some differences were present in genes involved in the phenylpropanoid pathway during the 3 years and among the ***,proteomics on Morellona and Crognola showed variations in proteins involved in stress response,primary metabolism and cell wall *** the best of our knowledge,this is the first multi-pronged study focused on Tuscan sweet cherry varieties providing insights into the differential abundance of genes,proteins and metabolites.

关键词： metabolism maintained sweet

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Predictors of long-term clinical outcome of patients with acute massive pulmonary embolism after thrombolytic therapy

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Chinese Medical Journal 2003年第4期116卷 503-509页

作者：刘品明 Nicolas Meneveau francois Schiele jean Pierre Bassand Department of Cardiology Second Affiliated HospitalZhongshan University Service de Cardiologie Centre Hospitalier Universitare

To assess the in-hospital clinical course and the long-term evolution of acute massive pulmonary embolism after thrombolytic therapy and to identify predictors of adverse clinical outcome Methods A total of 260 patients hospitalized from January 1989 to October 1998 were retrospectively reviewed and followed up for 3 9 to 8 4 years Baseline characteristics and variables pre- and post-thrombolysis were identified Particular attention was paid to the clinical events, including death, recurrent thromboembolism, chronic thromboembolic pulmonary hypertension, and major bleeding attributable to the use of anticoagulants Kaplan-Meier event-free survival curves were generated Univariate analysis by means of the log-rank test was used to test each candidate variable for association with clinical outcome Multivariate analysis with the Cox proportional hazard model was used to determine independent predictors of the long-term outcome Results The in-hospital mortality rate was 8 5%, with 68 2% due to pulmonary embolism itself, and the follow-up mortality rate was 31 7%, with 29 2% due to recurrent embolism Factors associated with an adverse outcome in univariate analysis were: (1) prior thromboembolic diseases; (2) duration of anticoagulant therapy 50 mmHg after thrombolysis; and (6) greater than 30% obstruction of pulmonary vasculature identified by pulmonary ventilation/perfusion scintigraphy before hospital discharge Multivariate analysis identified three independent predictors of poor long-term outcome for patients with acute massive pulmonary embolism after thrombolysis; which were: (1) Doppler recording of pulmonary artery systolic pressure >50 mm Hg, with relative risk of 3 78 and a 95% confidence interval of 2 70 to 4 86; (2)

关键词： pulmonary embolism · deep venous thrombosis · thrombolytic therapy

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ACTIF,A Design Assistance for Interoperable Transportation Systems in France

ACTIF,A Design Assistance for Interoperable Transportation S...

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第一届中国智能交通年会

作者： jean-francois JANIN

The ACTIF project was launched in 2001 by the French Ministry of Transport to build a national frame for the deployment of ITS around the coun- *** a first phase of modelisation inspired by the foreign architectures (USA,Japan,European) it appeared that a specific method was needed to as- sist the authorities in charge of the deployment of real systems to precise their needs and their organisation.A tool has been develop to create architectures ap- propriate to these *** is now a combination of a conceptual model describing the whole domain of ITS,at a high level but including all modes of transport,a method to use it and a set of tools available without charge from the web site ***-actif,*** method is illustrated by case studies in vari- ous domains.

关键词： Architecture Interoperability Intermodality multimodal transport functional modelling ACTIF road information advanced traveller information system enforcement dissemination

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