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光影交错——蒙特利尔娱乐城

设计家 2014年第5期 92-97页

作者： Yves Dagenais jean-Pierre Letourneux Luc Doucet Vincent Lauzon Dominic Genest Marco Goyette claude Provencher Eugenio Carelli Brent Swanson jean-Luc Rémy Hani Diab Daniel Legault Menkès Shooner Dagenais LeTourneux Provencher_Roy Architectes MSDL PROVENCHER_ROY

地点:加拿大,蒙特利尔面积:45,000平方米完工:2013年照片来源:Marc Cramer,Stéphane Groleau,v2com设计理念项目的定位是关键,MSDL的创始人Yves Dagenais与娱乐城最有发言权的营销团队讨论,认为不能仅仅考虑项目在城市中的地理位置,还... 详细信息

地点:加拿大,蒙特利尔面积:45,000平方米完工:2013年照片来源:Marc Cramer,Stéphane Groleau,v2com设计理念项目的定位是关键,MSDL的创始人Yves Dagenais与娱乐城最有发言权的营销团队讨论,认为不能仅仅考虑项目在城市中的地理位置,还要考虑它的客户群。改造后的娱乐城提供了个性化的室内空间,通过游戏、灯光和蒙特利尔特色来定位其主题。光无处不在,来自灯光和背光墙过滤后的光像从一个巨大的、开放式的镀铬管里发射出来一样,使空间具有渗透性,并将博彩区从娱乐区中分离开来。设计特色建筑师通过一个横跨四层的环绕圆形中庭的设计简化了空间。

关键词：营销团队娱乐区自助餐厅 Cramer 休息区人体模型 Marco claude Vincent Brent

The “Two Camels” of Koussa: A Massive Ferrous Meteorite in Mayo Binka (North-West Region in Cameroon)

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Open Journal of Geology 2015年第9期5卷 649-654页

作者： Bernard Njom Aurélien Temenou Tiolo Jacques Bertrand Onana Yanick Nyobe Bayi Augustin Patrice Moussango Ibohn Simon Pierre Mbog Bassong Michel Guy Awana Ateba Madi Boukar Thierry Abou’ou Ango jean claude Ngoute Belle Koumedjalla Georges Emmanuel Ekodeck Faculté des Sciences Université de Yaoundé I Yaoundé Cameroun Institut de Recherches Géologiques et Minières (I.R.G.M) Yaoundé Cameroun Musée National Cameroun Yaoundé Cameroun

At Koussa in Mayo Binka, a hundred kilometers northeasterly from the town of Bamenda, the Capital of the North-West Region in Cameroon, an enormous block of native iron of several tons in mass is found. The observation of the Southern view of this block let anyone see a configuration which surprisingly recalls two camels in an attitude that these animals generally adopt when they are at rest. This strong resemblance with the attitude of these animals in rest has led the local populations in identifying this enormous metallic block with the name of “the two camels’ couple” or simply stills “the two camels”. The test conducted with the acid let the Neumann figures be revealed the Neumann figures which confirm this metallic block as being a ferrous meteorite or a siderite of the?Hexaedrites?class.

关键词： Koussa Mayo Binka Bamenda Cameroon Neumann Figures PDF’s Hoba Hexaedrites BIF

Radiotherapy for gynecologic cancerin nonagenarian patients：a framework for new paradigms

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Chinese Journal of Cancer 2016年第7期35卷 382-384页

作者： Benoite Mery Sylvie Mengue Ndong jean-Baptiste Guy Avi Assouline Alexander T.Falk Anais Valeille Jane-Chloc Trone Romain Rivoirard Pierre Auberdiac Alexis Vallard Sophie Espenel Guillaume Moriceau Olivier Collard Claire Bosacki jean-Philippe Jacquin Guy de Laroche Pierre Fournel Cyrus Chargari Nicolas Magne Department of Medical Oncology Lucien Neuwirth Cancer Institute42271 Saint Priest En Jarez France Department of Radiotherapy Lucien Neuwirth Cancer Institute42271 Saint Priest En Jarez France Department of Radiotherapy Porte De Saint Cloud Clinical Center92100 Boulogne-Billancourt France Department of Radiotherapy Claude Bernard Private Hospital81000 Albi France Department of Radiotherapy Val-De-Grace Military Hospital75230 Paris France Department of Radiation Oncology Antoine Lacassagne Center06100 Nice France

No consensus exists regarding the role of radiotherapy in the management of gynecologic cancer in nonagenarian *** retrospectively reviewed the outcomes of 19 consecutive nonagenarian patients with gynecologic cancer(6 endometrial cancers,6 cervical cancers,4 vulvar cancers,and 3 vaginal cancers) who were treated with *** was performed mainly in a palliative setting(n = 12;63.2%),with a median dose of 45 Gy(range,6-76 Gy).Infrequent major acute or late toxicities were *** 19 patients,9(47.4%) experienced tumor progression,5(26.3%) experienced complete response,2(10.5%) experienced stable disease and/or partial *** last follow-up,12 patients(63.2%) had died;most deaths(n = 9) occurred because of the *** results suggest that radiotherapy is feasible in the treatment of nonagenarian patients with gynecologic cancer.

关键词：癌症患者妇科放疗放射治疗框架肿瘤患者子宫内膜癌肿瘤治疗

Helicobacter pylori Virulence Genes cagA, babA2, and vacA Detection in Dyspeptic Patients from Burkina Faso

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American Journal of Molecular Biology 2023年第3期13卷 141-155页

作者： Tegwinde Rebeca Compaore Kalifou Traore Nômawendé Ines Compaore Lassina Traore Sylvie Zida Serge Theophile Soubeiga Dinanibe Kambire jean claude R. P. Ouedraogo Aminata Dickel Sidibe Yasmine Astrid Sana Tani Sagna Wendkuuni Florencia Djigma Henri Gautier Ouedraogo Jacques Simpore Département Biomédical et Santee Publique Institut de Recherche en Sciences de la Santé (IRSS) Ouagadougou Burkina Faso Centre de Recherche Biomoléculaire Pietro Annigoni (CERBA) Ouagadougou Burkina Faso Laboratoire de Biologie et de Génétique Moléculaire (LABIOGENE) Université Joseph KI-ZERBO Ouagadougou Burkina Faso Clinique El Fateh-Suka Service de médecine et de spécialités médicales Ouagadougou Burkina Faso Département de Médecine et de Pharmacopée Traditionnelle Institut de Recherche en Sciences de la Santé (IRSS) Ouagadougou Burkina Faso

The diverse clinical presentation of Helicobacter pylori (H. pylori) infection results from the interaction between bacterial virulence, host genetics, socio-demographic and environmental factors. This study aimed to characterize Helicobacter pylori virulence genes and the associated behavioral factors among dyspeptic patients in Burkina Faso. Two hundred and fifty (250) stool samples were collected from patients with dyspepsia seen at health centers in Ouagadougou, Burkina Faso. Bacterial deoxyribonucleic acid (DNA) was extracted using a commercial kit. Virulence genes were detected using conventional multiplex Polymerase Chain Reaction with specific primers. The overall prevalence of Helicobacter pylori of the 250 participants was 91.20%. CagA virulence gene was present among 20.19% of individuals, while babA2 and vacA were detected respectively among 9.65% and 67.54% of the population positive for Helicobacter pylori. Among vacA subtypes, vacAs1 was the most frequent, with 39.04%, followed by vacAi1 (19.74%), vacAi2 (17.54%), and vacAs2 with 10.96%. Regarding vacAm1 and vacAm2, they were less frequent at 6.14% each. “Handwashing three times or less per day” significantly increased the risk of having vacAi2 allele and H. pylori rRNA16s, with p-values of 0.013 and 0.020, respectively. The consumption of non-tap water increases the risk of carrying the cagA virulence gene. Additionally, H. pylori-positive patients living with more than four (4) people in their household had about two times the risk of having the vacAs1 allele. The present study shows the detection of Helicobacter pylori cagA, vacA subtypes, and babA2 by stool a PCR method in Burkina Faso. The strong association between sanitary habits and virulence factors depicts the composite interaction between ecological factors, gastric mucosa, and bacteria. Therefore, the synergic action of these factors should be considered when aiming for bacterial eradication and gastric pathology cure.

关键词： Helicobacter pylori Stool cagA babA2 vacA

Optimization of a Method for the Simultaneous Determination of Phloroglucinol and Trimethylphloroglucinol by High Performance Liquid Chromatography in Routine Use in a Pharmaceutical Industry in Abidjan

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Open Journal of Optimization 2023年第2期12卷 11-24页

作者： jean-Kisito Kouamé Mariette Désirée Yéhé claude Bérenger Ngalemo Ngantchouko Amani Germain Brou Carine Nina Ablé Aya Mélissa Diane Kouadio Bi Gogoua Désiré Vagny Vincent De Paul Ovi Christophe N’cho Amin Gildas Komenan Gbassi National Public Health Laboratory (NPHL) Food Control Service Abidjan Ivory Coast Department of Analytical Sciences and Public Health Training and Research Unit (UFR) of Pharmaceutical and Biological Sciences Félix Houphou&#235t Boigny University Abidjan Ivory Coast Higher Institute of Health Sciences of the University of the Mountains (UdM) Bangangté Cameroon

In order to provide the population with safe, effective and good quality medicines, the pharmaceutical industries, before releasing batches of their products into the pharmaceutical circuit, put in place internal dosage methods to control the quality of these products. The present study consisted in optimizing a method for the simultaneous determination of Phloroglucinol (PHG) and Trimethylphloroglucinol (TPH) by high performance liquid chromatography (HPLC) routinely used in a pharmaceutical industry located in a township in Abidjan (Ivory Coast). The basic chromatographic conditions were those routinely used for the determination of these two molecules: mobile phase: acetonitrile/water (60/40), stationary phase (C18 BDS Hypersil 250 mm * 4.6 mm - 5 μm), detection wavelength (265 nm), flow rate, injection volume and run time configured at the equipment level were respectively 1 mL/min, 10 μL and 8 min. The method of preparation of the analytes (PHG and TPHG) was also applied by the pharmaceutical industry. The application of these different parameters at the equipment level made it possible to determine a chromatogram which highlights three chromatographic peaks with respective retention times (RT) of 0.773 min (unidentified compound), 2.275 min (PHG) and 7.269 min for an analysis time of 8 min with a better resolution of the peaks and baseline. The progressive optimization of different parameters such as the stationary phase (C18 YMC 150 mm * 4.6 mm - 3 μm), the proportion of the mobile phase: acetonitrile/water (80/20), the flow rate impelled by the pump (0.8 mL/min) and the modification of the analyte preparation mode (same amount of PHG and TPHG in a 50 mL volumetric flask) resulted in a final chromatogram that highlighted two chromatographic peaks at the respective RT of 2.391 min (PHG) and 3.735 min (TPHG) at a run time of 6 min. The chromatographic conditions that led to the final chromatogram can be used routinely by the pharmaceutical industry for the dete

关键词： PHG TPHG Pharmaceutical Industry Chromatographic Profile Chromatographic Peak

Epstein-Barr病毒相关疾病的IgG/Z抗体检测

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病毒学报 1992年第3期8卷 218-222页

作者：曾毅 jean-claude Nicolas Guy Schwaab Guy de The Bernard Clausse Thomas Tursz Irene Joab 中国预防医学科学院病毒学研究所法国Rothschild医院法国Gustave Roussy肿瘤研究所法国巴斯德研究所

血清中Epstein-Barr病毒(EBV)的IgG/Z抗体对鼻咽癌和传染性单核细胞增多症是较特异的,其阳性率分别为85.7％和84％。50％的伯基特淋巴瘤病人亦有IgG/Z抗体。正常人则没有,但有IgG/VCA等抗体,表明IgG/Z抗体在初次感染后是容易消失的。Z... 详细信息

血清中Epstein-Barr病毒(EBV)的IgG/Z抗体对鼻咽癌和传染性单核细胞增多症是较特异的,其阳性率分别为85.7％和84％。50％的伯基特淋巴瘤病人亦有IgG/Z抗体。正常人则没有,但有IgG/VCA等抗体,表明IgG/Z抗体在初次感染后是容易消失的。Z抗原与EBV复制相关,故IgG/Z抗体对鼻咽癌不仅有诊断意义,还可能有预后的意义。

关键词：鼻咽肿瘤 EB病毒抗体 IgG/Z

Radiotherapy among nonagenarians with anal or rectal carcinoma: should we avoid or adapt treatment?

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Chinese Journal of Cancer 2017年第10期36卷 524-525页

作者： Alexis Vallard Chloé Rancoule jean-Baptiste Guy Avi Assouline Alexander T. Falk Pierre Auberdiac Julien Langrand-Escure Cyrus Chargari Nicolas Magné Department of Radiotherapy Lucien Neuwirth Cancer Institute 108 BisAvenue Albert.Raimond BP 60008 42271 Saint.Priest En Jarez France Department of Radiotherapy Porte De Saint Cloud Clinical Centre 92100 Boulogne-Billancourt France Department of Radiation Oncology Antoine Lacassagne Centre 06100 Nice France Department of Radiotherapy Claude Bernard Private Hospital 81000 Albi France Department of Radiotherapy Val-De-Grace Military Hospital 75230 Paris France

Dear editor,Radiotherapy is a cornerstone in the management of anal or rectal cancer. Because elderly patients are often excluded from clinical trials, little is known about radiotherapy’s therapeutic index (efficacy/toxicity ratio) in the geriatric population [1]. Still, the ageing of population imposes the challenge to treat older cancer patients and probably to adjust their treatment [2]. A few studies reported data on radiation-induced toxicities in nonagenarian patients, but data on efficacy are still scarce. For rectal cancer, preoperative radiotherapy programs were suggested to be feasible in elderly patients [3–5], with a preference for short protocols without chemotherapy [4]. For anal cancer, the safety of radiochemotherapy was only reported in limited sets of elderly patients [6]. The objective of the present study was to report efficacy and toxicity data on the radiotherapy treatment of nonagenarian patients with anal or rectal *** analyzed the data of 34 nonagenarian patients with anal or rectal cancers: 27 (79.4%) with a rectal adenocarcinoma and 7 (20.6%) with an anal canal squamous cell carcinoma.

关键词： Radiotherapy feasible in elderly patients

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西南冲绳海槽的微震活动性与断层作用

世界地震译丛 2008年第4期39卷 29-41页

作者： jean-claude Sibuet Chao-Shing Lee Shu-Kun Hsu Frauke Klingelhoefer Yves Auffret Pascal Pelleau Jacques Crozon Cheng-Horng Lin 李细兵国家海洋局第二海洋研究所

2003年12月,在冲绳海槽西南部布设了15台海底地震仪。在10天的被动地震实验中,记录定位到了超过3000次的微震。地震活动的特点表现为在所有仪器的附近始终不断地有小地震发生。除了一群地震位于西南冲绳海槽的南部外(群2),所有的地震活... 详细信息

2003年12月,在冲绳海槽西南部布设了15台海底地震仪。在10天的被动地震实验中,记录定位到了超过3000次的微震。地震活动的特点表现为在所有仪器的附近始终不断地有小地震发生。除了一群地震位于西南冲绳海槽的南部外(群2),所有的地震活动基本上限制在西南冲绳海槽的中部。地震活动带在梨山断层北东-南西向的延伸带上突然中断。大多数地震沿东-西向正断层排列,显示了冲绳海槽当今活动正断层发生的位置以及它是如何解释冲绳海槽南北向扩张的。根据位于弧后火山痕迹区下方的深地震估计出的纵波速度谱,3～10Hz带宽内低频地震的出现证实了下地壳/上地幔岩浆房的存在。

关键词：西南冲绳海槽微震活动性正断层扩张弧后盆地横向火山痕迹

Happy Hypoxia in COVID-19 Patients at Kinshasa University Hospital (Democratic Republic of the Congo): Frequency and Vital Outcome

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Journal of Biosciences and Medicines 2021年第2期9卷 12-20页

作者： Ben Bepouka Hippolyte Situakibanza Ossam Odio jean Robert Makulo Madone Mandina Murielle Longokolo Nadine Mayasi Kazadi Mutombo Tresor Pata Godelive Nsangana Felly Tshikangu Donatien Mangala Dupont Maheshe Christine Namasale Serge Nkarnkwin Jonathan Muamba Gorby Ndaie Rodrigue Ngwizani Hervé Mole Gabriel Makeya Tharcisse Mabiala Patrick Mukuna Roger Kabango Patricia Kabuni Yves Yanga Aliocha Nkodila Hervé Keke Nice Musangu Papy Tshimanga Yamin Kokusa Bertin Nsitwayizatadi Eric Mukenge Guyguy Kamwiziku Gabriel Mbunsu jean claude Makangara Marcel Mbula jean Marie Kayembe Unit of Infectious Diseases Kinshasa University Hospital Kinshasa Democratic Republic of the Congo Unit of Nephrology Kinshasa University Hospital Kinshasa Democratic Republic of the Congo Unit of Reanimation Kinshasa University Hospital Kinshasa Democratic Republic of the Congo Unit of Vaccinology World Health Organization Kinshasa Democratic Republic of the Congo Department of Epidemiology Ministry of Health Kinshasa Democratic Republic of the Congo Unit of Physiotherapy Kinshasa Hospital University Kinshasa Democratic Republic of the Congo Unit of Microbiology Kinshasa Hospital University Kinshasa Democratic Republic of the Congo Unit of Pneumology Kinshasa University Hospital Kinshasa Democratic Republic of the Congo

Background: Happy hypoxia is a new feature found in COVID-19 patients. It consists of the presence of severe hypoxemia but normal breathing rate. Failure to identify this hypoxia may have negative consequences on the survival of the patient. The objective of the present study was to measure the frequency of patients with happy hypoxia and to evaluate their survival at the Kinshasa University Hospital (KUH). Methods: This was a historical cohort of 141 hospitalized patients with COVID-19 at KUH from March 23 to June 15, 2020. Happy hypoxia was defined as oxygen saturation below 90% without dyspnea. Socio-demographic data, co-morbidities, follow up time of hospitalization and outcomes were studied. Survival was assessed using the Kaplan Meier curve. Results: Out of 141 hospitalized patients with COVID-19, 79 (56%) patients were at the severe or critical stage and 9 (6.4%) had a happy hypoxia on admission. Patients who had happy hypoxia on admission were generally older than 60 years of age (55.6%) (p = 0.023). Comparison of survival curves, based on the presence or absence of happy hypoxia, shows a statistically significant difference (p = 0.001). The presence of happy hypoxia reduces survival. Conclusion: The frequency of happy hypoxia among COVID-19 patients was low. Survival was reduced in patients with happy hypoxia. Prehospital pulse oximetry could serve as an early warning signal for the detection of happy hypoxemia in COVID-19 patients.

关键词： COVID-19 Happy Hypoxia Frequency Outcome DR Congo