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Profile of retinal diseases in adult patients attending two major eye clinics in Kinshasa,the Democratic Republic of Congo

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International Journal of Ophthalmology(English edition) 2020年第10期13卷 1652-1659页

作者： Nelly N.Kabedi David L.Kayembe jean-claude Mwanza Departmemt of Ophthalmology School of MedicineUniversity of KinshasaKinshasa XIDemocratic Republic of Congo Department of Ophthalmology School of MedicineUniversity of North Carolina at Chapel HillNC 27599USA

AIM:To determine the frequency and types of retinal diseases and the extend of the related visual loss in adult patients attending two public eye clinics of Kinshasa,Democratic Republic of ***:Review of medical records of patients with retinal diseases seen in the major eye clinics in Kinshasa,the University Hospital of Kinshasa(UHK)and Saint Joseph Hospital(SJH),from January 2012 to December *** and diagnoses were retrieved and *** measures were frequency and prevalence of retinal diseases,blindness and low ***:A total of 40965 patients aged 40 y or older were examined during this period in both *** these,1208 had retinal disease,giving a 3-year and an annual prevalence of 3%and 1%,*** age was 61.7±10.7 y,and 55.8%of the patients were *** hypertension(68.1%)and diabetes(43.3%)were the most common systemic *** retinopathy(41.8%),diabetic retinopathy(37.9%),age-related macular degeneration(AMD;14.6%),and chorioretinitis and retinal vein occlusion(7.3%each)were the most common retinal diseases,with 3-year prevalence rates of 1.3%,1.0%,0.43%,and 0.21%*** low vision and blindness were present in 26.8%and 8.4%of the patients at *** causes of low vision and blindness were diabetic retinopathy(14.8%),AMD(4.9%),retinal detachment(2.8%),and retinal vein occlusion(2.5%).The prevalence was significantly higher among males than females,and at the UHK than ***:Retinal diseases are common among Congolese adult patients attending eye clinics in *** cause a significant proportion of low vision and blindness.

关键词： retinal disorders Kinshasa,Democratic Republic of Congo sub-Saharan Africa pattern

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Utility of combining spectral domain optical coherence tomography structural parameters for the diagnosis of early Glaucoma: a mini-review

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Eye and Vision 2018年第1期5卷 91-101页

作者： jean-claude Mwanza Joshua L.Warren Donald L.Budenz Department of Ophthalmology School of MedicineUniversity of North Carolina at Chapel HillChapel HillNCUSA Department of Biostatistics Yale UniversityNew HavenCTUSA

Optical coherence tomography(OCT)has moved to the forefront of imaging modalities in the management of glaucoma and retinal *** is modifying how glaucoma and glaucoma progression are diagnosed clinically and augmenting our understanding of the *** provides multiple parameters from various anatomic areas for glaucoma diagnosis,evaluation of treatment efficacy,and progression *** the use of multiple parameters has increased the likelihood of detecting early structural changes,diagnosing glaucoma in early stages is often challenging when the damages are subtle and not apparent on OCT scans,in addition to the fact that assessment of OCT parameters often yields conflicting *** promising approach is to combine multiple individual parameters into a composite parameter from the same test to improve diagnostic accuracy,sensitivity,and *** review presents current evidence regarding the value of spectral domain OCT composite parameters in diagnosing early glaucoma.

关键词： Optical coherence tomography Combination of parameters Early glaucoma

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Integrating Functional Status Information into Knowledge Graphs to Support Self-Health Management

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Data Intelligence 2023年第3期5卷 636-662页

作者： Mauro Dragoni Tania Bailoni Ivan Donadello jean-claude Martin Helena Lindgren Fondazione Bruno Kessler TrentoItaly Free University of Bolzano BolzanoItaly LISN-CNRS Universite Paris SaclayParisFrance Umea University UmeaSweden

Functional Status Information(FSI)describes physical and mental wellness at the whole-person *** includes information on activity performance,social role participation,and environmental and personal factors that affect the well-being and quality of *** and analyzing this information is critical to address the needs for caring for an aging global population,and to provide effective care for individuals with chronic conditions,multi-morbidity,and *** knowledge graphs(PKGs)represent a suitable way for meaning in a complete and structured way all information related to people's FSI and reasoning over them to build tailored coaching solutions supporting them in daily life for conducting a healthy *** this paper,we present the development process related to the creation of a PKG by starting from the HeLis ontology in order to enable the design of an Al-enabled system with the aim of increasing,within people,the self-awareness of their own functional *** particular,we focus on the three modules extending the HeLis ontology aiming to represent(i)enablers and(ii)barriers playing potential roles in improving(or deteriorating)own functional status and(iii)arguments driving the FSI collection ***,we show how these modules have been instantiated into real-world scenarios.

关键词： Knowledge Graph Personal Healthcare Functional Status Enablers Barriers Arguments

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Effects of water-borne copper on the gills and hepatopancreas of Macrobrachium rosenbergii

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Integrative Zoology 2008年第4期3卷 299-310页

作者： Na LI Qiang MA Jian YANG Yunlong ZHAO jean-claude BROCHON School of Life Science East China Normal UniversityShanghaiChina Key Laboratory of Ecological Environment and Resources of Inland Fisheries Freshwater Fisheries Research CenterChinese Academy of Fishery SciencesWuxiChina National Research Center Laboratory of Biotechnology and Application Genetic PharmacologyEcole Normale Supérieure CachanCachan cedexFrance

We focused on elucidating the toxic effects of water-borne copper on the giant freshwater prawn Macrobrachium *** seven days of exposure to copper(Cu2+)at concentrations ranging from 0.01 mg L–1 to 0.5 mg L–1,three isozymes,malate dehydrogenase,alkaline phosphatase and esterase,were analyzed and compared using polyacrylamide electrophoresis(PAGE)and biochemical *** results indicated that the electrophoretic patterns of the isozymes showed a copper-concentration-related *** doses of copper stimulated strong expression of the three *** patterns of malate dehydrogenase and alkaline phosphatase gradually became weaker or even lost as the level of copper *** contrast,esterase patterns exhibited an increased molecular heterogeneity at higher copper concentrations.A transmission electron microscope was used to study ultrastructure differences in the gills and hepatopancreas of ***,and the results showed significant structural damage at increased levels of copper compared with the control *** basement mem-branes and mitochondira in the gills were seriously damaged,the cuticle electron density distribution was not homogeneous,and an infolded basement membrane,circularized nucleus,disintegrated nuclear membrane,and decreased mitochondria number and size were observed in the ***,flowing out of karyoplasms,partly falling microvilli,decreased mitochondrion,partly disappeared mitochondrial cristae,and a thinned matrix were observed in the *** findings indicate that exposure to elevated copper levels might damage the ultrastructure of the gills and hepatopancreas of *** and might further weaken their normal physical *** were quite sensitive to environmental stress and changes in isozyme elctrophoretic patterns might be effective biomarkers of environmental contamination.

关键词： copper gills hepatopancreas isozymes Macrobrachium rosenbergii polyacrylamide electrophoresis.

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Analysis of the Progressive Collapse Behavior of the RC Frame Structures Reinforced by High-Performance Composite Material

Analysis of the Progressive Collapse Behavior of the RC Fram...

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作者： Evina Mvondo jean claude（艾维）东南大学

学位级别：硕士

本文旨在对钢-连续纤维复合筋(Steel Fiber Composite Bar,简称SFCB)加固钢筋混凝土框架抗连续倒塌性能进行分析研究,利用软件SAP2000.V15.0.1,建立了 22mx18m,层高16m的典型钢筋混凝土框架结构模型,进行传统钢筋加固和SFCB筋加固下结... 详细信息

本文旨在对钢-连续纤维复合筋(Steel Fiber Composite Bar,简称SFCB)加固钢筋混凝土框架抗连续倒塌性能进行分析研究,利用软件SAP2000.V15.0.1,建立了 22mx18m,层高16m的典型钢筋混凝土框架结构模型,进行传统钢筋加固和SFCB筋加固下结构性能的对比;根据相关SFCB筋材性能研究,确定软件中力学性能的调整系数,以更接近筋材的实际情况;利用备用路径法对模型分别进行角柱,中柱,内柱拆除的三种情况,对剩余结构抗连续倒塌性能进行分析研究,得到不同同情况的下的结论;研究SFCB筋二次刚度和塑性铰旋转能力对结构抗连续倒塌的影响,在软件中,通过调整系数的方法,不断提高二次刚度和塑性铰旋转能力,对比分析两种材料性能对结构的作用,得出相应结;根据所有的研究结果,对SFCB筋加固混凝土框架结构抗连续倒塌性能进行评估,并提出相关建议

关键词：连续倒塌混凝土框架结构 SFCB 二次刚度塑性铰

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Investigation of dynamics of discrete framed structures by a numerical wave-based method and an analytical homogenization approach

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Chinese Journal of Aeronautics 2017年第1期30卷 66-74页

作者： Zhou Changwei Sun Xiangkun Mohamed Ichchou Abdel-Malek Zine jean-Pierre Lainé Stephane Hans claude Boutin Laboratory of Tribology and Systems Dynamics Ecole Centrale de Lyon Ecully 69134 France Institut Camille Jordan Ecole Centrale de Lyon Ecully 69134 France Laboratory of Tribology and Systems Dynamics Ecole Nationale des Travaux Publics de l'Etat Vaulx-en-Velinx 69518 France

In this article, the analytical homogenization method of periodic discrete media（HPDM）and the numerical condensed wave finite element method（CWFEM） are employed to study the longitudinal and transverse vibrations of framed structures. The valid frequency range of the HPDM is re-evaluated using the wave propagation feature identified by the CWFEM. The relative error of the wavenumber by the HPDM compared to that by the CWFEM is illustrated in functions of frequency and scale ratio. A parametric study on the thickness of the structure is carried out where the dispersion relation and the relative error are given for three different thicknesses. The dynamics of a finite structure such as natural frequency and forced response are also investigated using the HPDM and the CWFEM.

关键词： Framed structures Homogenization method Periodic structures Wave finite element method Wave propagation

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Effect of the synthesis route on the structural and dielectric properties of SrBi1.8Y0.2Nb2O9 ceramics

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International Journal of Minerals,Metallurgy and Materials 2018年第11期25卷 1304-1312页

作者： Mohamed Afqir Amina Tachafine Didier Fasquelle Mohamed Elaatmani jean-claude Carru Abdelouahad Zegzouti Mustapha El Hammioui Laboratoire des Sciences des Matériaux Inorganiques et leurs Applications Facultédes Sciences SemlaliaUniversitéCadi AyyadMarrakech 40000Maroc Unite de Dynamique et Structure des Materiaux Moleculaires Universite du Littoral-Cote d’OpaleCalais 62100France Laboratoire de recherche sur la réactivitédes matériaux et l’optimisation des procédés Facultédes Sciences SemlaliaUniversitéCadi Ayyad 40000MarrakechMaroc

This work is devoted to the synthesis and characterization of yttrium-doped SrBi_2Nb_2O_9 ceramics prepared by three methods: solid state reaction, co-precipitation, and hydrothermal. Multiple characterizations, specifically scanning electron microscopy(SEM), X-ray powder diffraction(XRD), and Fourier transform infrared spectroscopy(FTIR), were used to validate the structural feature. The crystallite size was estimated by Scherrer's formula and the Williamson–Hall plot. The effect of the process on the band intensities of the FTIR spectra was investigated. The crystallite size and microstructure of ceramics prepared from different synthesis processes were strongly influenced by the sinterability. SEM images revealed nanograin ceramics for materials prepared by co-precipitation and hydrothermal methods and micrograin ceramics prepared by the solid state method. The synthesized compounds underwent phase transitions at 480–465°C. The dielectric and electrical properties of these Y-doped SrBi_2Nb_2O_9 ceramics appear to be dependent on the grain size.

关键词： Aurivillius,synthesis routes crystallite size microstructure dielectric

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Investigation of the hydro-mechanical behaviour of fouled ballast

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第4期14卷 244-255页

作者： Yu-jun CUI Trong Vinh DUONG Anh Minh TANG jean-claude DUPLA Nicolas CALON Alain ROBINET Laboratoire Navier/CERMES Ecole des Ponts ParisTechBlaise PascalCité DescartesChamps-sur-Marne 77455 Marne-la-Vallée Cedex-France French National Railway Company 93574La Plaine St DenisFrance

In this study,a fouled ballast taken from the site of Sénissiat,France,was *** the hydraulic behaviour,a large-scale cell was developed allowing drainage and evaporation tests to be carried out with monitoring of both suction and volumetric water content at various positions of the *** was observed that the hydraulic conductivity of fouled ballast is decreasing with suction increase,as for common unsaturated *** effect of fines content was found to be *** the mechanical behaviour,both monotonic and cyclic triaxial tests were carried out using a large-scale triaxial *** water contents were *** results were interpreted in terms of shear strength and permanent axial *** appeared that the water content is an important factor to be accounted for since any increase of water content or degree of saturation significantly decreases the shear strength and increases the permanent *** modelling has been attempted based on the experimental *** model in its current state is capable of describing the effects of stress level,cycle number and water content.

关键词： Fouled ballast Degree of saturation Hydraulic behaviour Mechanical behaviour Fines content Constitutive modelling

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Hepatocellular carcinoma in patients with hepatitis C virus-related chronic liver disease

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World Journal of Gastroenterology 2007年第17期13卷 2455-2460页

作者： jean-claude Trinchet Nathalie Ganne-Carrié Pierre Nahon Gisèle N’kontchou Michel Beaugrand Service d'Hépato-Gastroentérologie Hpital Jean Verdier Assistance Publique-Hpitaux de Paris UPRES EA 3409 and UPRES EA 3410 UFR SMBH Université Paris 13 Bondy France

Hepatitis C virus (HCV) is a major cause of hepatocellular carcinoma (HCC) worldwide due to the high prevalence of HCV infection and the high rate of HCC occurrence in patients with HCV cirrhosis. A striking increase in HCC incidence has been observed during the past decades in most industrialized countries, partly related to the growing number of patients infected by HCV. HCC is currently the main cause of death in patients with HCV-related cirrhosis, a fact that justifies screening as far as curative treatments apply only in patients with small tumors. As a whole, treatment options are similar in patients with cirrhosis whatever the cause. Chemoprevention could be also helpful in the near future. It is strongly suggested that antiviral treatment of HCV infection could prevent HCC occurrence, even in cirrhotic patients, mainly when a sustained virological response is obtained.

关键词： Hepatocellular carcinoma Cirrhosis Hepatitis C virus Epidemiology Screening Treatment Prevention

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Origami-Based Design for 4D Printing of 3D Support-Free Hollow Structures

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Engineering 2022年第5期8卷 70-82页

作者： Bingcong Jian Frederic Demoly Yicha Zhang H.Jerry Qi jean-claude Andre Samuel Gomes Laboratoire Interdisciplinaire Carnot de Bourgogne UMR 6303 Centre National de la Recherche Scientifique&Universitede Technologie de Belfort-MontbeliardUniversite Bourgogne Franche-ComteBelfort 90400France George W.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA Laboratoire Reactions et Genie des Procedes UMR 7274 Centre National de la Recherche Scientifique-Universitede LorraineNancy 54001France

The integration of additive manufacturing(AM)in design and engineering has prompted a wide spectrum of research efforts,involving topologically optimized solid/lattice structures,multimaterial structures,bioinspired organic structures,and multiscale structures,to name a ***,except for obvious cases,very little attention has been given to the design and printing of more complex three-dimensional(3D)hollow structures or folded/creased *** of the main reasons is that such complex open or closed 3D cavities and regular/freeform folds generally lead to printing difficulties from support-structure-related *** address this barrier,this paper aims to investigate four-dimensional(4D)printing as well as origami-based design as an original research direction to design and build 3D support-free hollow *** work consists of describing the rough 3D hollow structures in terms of two-dimensional(2D)printed origami precursor layouts without any support *** origami-based definitions are then embodied with folding functions that can be actuated and fulfilled by 3D printed smart *** desired 3D shape is then built once an external stimulus is applied to the active materials,therefore ensuring the transformation of the 2D origami layout to 3D *** demonstrate the relevance of the proposal,some illustrative cases are introduced.

关键词： Origami-based design 4D printing Smart material Hollow 3D structures Additive manufacturing

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