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Management of digestive bleeding related to portal hypertension in cirrhotic patients:A French multicenter cross-sectional practice survey

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World Journal of Gastroenterology 2006年第48期12卷 7810-7814页

作者： Pierre Ingrand Jérme Gournay Pierre Bernard Frédéric Oberti Brigitte Bernard-Chabert Arnault Pauwels Philippe Renard Eric Bartoli jean-Franois Cadranel jean-claude Barbare Isabelle Ingrand Michel Beauchant Clinical Research Center Poitiers University France Hepato-Gastroenterology Centre Hospitalier Universitaire Nantes France Hepato-Gastroenterology Centre Hospitalier Universitaire Saint-André Bordeaux France Hepato-Gastroenterology Centre Hospitalier Universitaire Angers France Hepato-Gastroenterology Centre Hospitalier Universitaire Reims France Hepato-Gastroenterology Centre Hospitalier Gonesse France Hepato-Gastroenterology Centre Hospitalier Argenteuil France Hepato-Gastroenterology Centre Hospitalier Universitaire Amiens France Hepato-Gastroenterology Centre Hospitalier Creil France Hepato-Gastroenterology Centre Hospitalier Compiègne France Hepato-Gastroenterology Centre Hospitalier Universitaire Poitiers France

AIM: To investigate the conformity of management practices of gastrointestinal hemorrhage in cirrhotic patients with relevant guidelines. METHODS: A questionnaire on the management of digestive bleeding was completed for all consecutive cirrhotic patients admitted to 31 French hospitals. RESULTS: One hundred and twenty-six bleeding events were recorded. It was the first bleeding episode in 79 patients (63%), of whom 40 (51%) had a prior diagnosis of cirrhosis and 25 (32%) had previously undergone an endoscopy. The bleeding episode was a recurrence in 46 patients (37%). The median time between onset and admission was 4 h, but exceeded 12 h in 42% of cases. There was an agreement between centers forearly vasoactive drug administration (87% of cases), association with ligation (42%) more often than sclerosis (21%) at initial endoscopy, and antibiotic prophylaxis (64%). By contrast, prescription of beta-blockade alone or in combination (0 to 100%, P = 0.003) for secondary prophylaxis and lactulose (26% to 86%, P = 0.04), differed among centers. CONCLUSION: In French hospitals, management of bleeding related to portal hypertension in cirrhotic patients is generally in keeping with the consensus. Broad variability still remains concerning beta-blockade use for secondary prophylaxis. Screening for esophageal varices, the use of antibiotic prophylaxis and patients information need to be improved.

关键词： Digestive bleeding Portal hypertension Cirrhosis Evaluation studies

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New Insights in the Biodegradability and the Ecotoxicological Effects of Solar Products Containing Mineral and Chemical UV-Filters on Marine Zoo- and Phytoplanktons: An in silico and in vitro Study

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Journal of Cosmetics, Dermatological Sciences and Applications 2024年第1期14卷 98-111页

作者： jean-claude Hubaud Karim Mekideche jean-Eric Branka Luc Lefeuvre HELIOSCIENCE Cité de la cosmétique 2 rue Odette Jasse Marseille France EPHYSCIENCE 498ter route de Saint Joseph de Porterie Nantes France Laboratoires Dermatologiques d’Uriage Neuilly-sur-Seine France

Background: Cosmetic formulations, and particularly solar products which contain mineral and chemical UV-filters, are often suspected of causing harmful effects on marine fauna and flora. After the publication of our work in 2019 concerning the ecotoxicological effects of such formulations on corals (Seriatopora hystrix), we here provide some new information about the biodegradability and the ecotoxicological effects of these products on marine zoo- and phytoplankton. Therefore, we choose to realize in silico and in vitro studies of the biodegradability of several solar products but also to evaluate the ecotoxicological effects of these products on one phytoplankton, i.e. Phaeodactylum tricornutum, and one zooplankton, i.e. Acartia tonsa, of a great importance for sea species survival (notably as sources of food). Materials and methods: Two different approaches were used to study the biodegradability of the tested products: One in silico method and an in vitro one. 2 solar products were involved in the in silico study which consisted in the determination of the degradation factor (DF) of each ingredient of the tested formulas in order to finally obtain their estimated biodegradability percentage. Already available data concerning each ingredient coupled to a computer model developed with one of our partners were used to achieve this study. The in vitro study involved 8 formulas containing UV-filters and was led by following the OECD 301 F guidelines. Ecotoxicological studies of 7 of the formulas containing UV-filters were for their part realized by following the ISO 10253 guidelines for the experiments led with Phaeodactylum tricornutum, and the ISO 14669 guidelines for the experiments led with Acartia tonsa. In these studies, the effect of each tested product on crustaceans’ mortality and algal growth inhibition was assessed. Results: The in silico study predicted that formulas containing chemical UV-filters display a high biodegradability (superior to the threshol

关键词： UV-Filters Chemical UV-Filter Biodegradability Ecotoxicology in silico in vitro Zooplankton Phytoplankton Phaeodactylum tricornutum Acartia tonsa

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化学溶液方法制备涂层导体CexLa1-xO2薄膜的研究

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无机材料学报 2009年第6期24卷 1201-1204页

作者：赵跃索红莉 GRIVEL jean-claude 叶帅刘敏马麟周美玲北京工业大学材料科学与工程学院北京100124 Riso National Laboratory DK-4000 Roskilde Denmark

获得多功能单一过渡层是简化涂层导体多层结构的主要课题之一.采用化学溶液方法制备La掺杂CeO2过渡层,研究La掺杂量对CeO2薄膜表面形貌和双轴取向生长的影响.结果表明La掺杂量为10mol%的薄膜表面平整致密,且能保持锐利的双轴织构.通过... 详细信息

获得多功能单一过渡层是简化涂层导体多层结构的主要课题之一.采用化学溶液方法制备La掺杂CeO2过渡层,研究La掺杂量对CeO2薄膜表面形貌和双轴取向生长的影响.结果表明La掺杂量为10mol%的薄膜表面平整致密,且能保持锐利的双轴织构.通过多次涂敷工艺,获得具有120nm厚的Ce0.9La0.1O2过渡层.采用脉冲激光沉积方法在Ce0.9La0.1O2/NiW结构模板层上沉积了YBCO超导薄膜,其起始临界转变温度达到90.5K.这表明采用化学溶液方法制备Ce0.9La0.1O2薄膜是一种有前景的简化涂层导体多层结构的方法.

关键词：涂层导体化学溶液方法掺杂CeO2薄膜织构

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Spatial and Temporal Structures of the Macrozoobenthos from the Intertidal Zone of the Kneiss Islands (Central Mediterranean Sea)

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Open Journal of Marine Science 2016年第2期6卷 223-237页

作者： Nawfel Mosbahi jean-Philippe Pezy jean-claude Dauvin Lassad Neifar Laboratoire de Biodiversité et Ecosystèmes Aquatiques Faculté des Sciences de Sfax Université de Sfax Sfax Tunisie CNRS UMR 6143 M2C Laboratoire Morphodynamique Continentale et C?tière Université de Caen Normandie UNICAEN Caen France

The present study analyses the spatio-temporal variability of the macrozoobenthos from the intertidal zone of the Kneiss Islands (Gulf of Gabès, Tunisia). Samples were collected once from 34 stations, while seasonal variations were studied by sampling four times at 12 stations over the period 2013-2014. A total of 159 macrobenthos taxa associated with intertidal Zostera noltei beds are identified from the 34 stations, with a taxonomic dominance of crustaceans (32%), molluscs (29%) and annelids (27%). Abundance varies from 9244 to 36,844 ind·m-2 with a mean value of 14,346 ind·m-2. Analysis of the trophic structure shows that the majority of stations are strongly represented by carnivores (41%), followed by the non-selective deposit feeders (16%). Cluster analysis and multidimensional scaling allow identification of three main benthic assemblages based on species abundance, corresponding to different sediment types and organic matter contents. The seasonal variability in abundance, diversity and community structure is mainly due to spring and summer recruitment. The biotic indices (i.e. AMBI, BO2A and BENTIX) show that the intertidal area of Kneiss Islands exhibits a good ecological status.

关键词： Kneiss Islands Zostera noltei Spatial Distribution Seasonal Variability Benthic Macrofauna

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NiWO4 powders prepared via polymeric precursor method for application as ceramic luminescent pigments

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Journal of Advanced Ceramics 2020年第1期9卷 55-63页

作者： Naiara A.LIMA Lorena D.S.ALENCAR Máximo SIU-LI Carlos A.C.FEITOSA Alexandre MESQUITA jean-claude M’PEKO Maria I.B.BERNARDI Instituto de Física de Sao Carlos Universidade de Sao Paulo13560-970 Sao CarlosSPBrazil Instituto Federal de Mato Grosso do Sul IFMS79200-000 AquidauanaMSBrazil Departamento de Física Centro de Ciências Exatas e TecnologiaUniversidade Federal do MaranhaoUFMA65080-805Sao LuisMABrazil Instituto de Geociências e Ciências Exatas Departamento de FísicaUniversidade Estadual Paulista13506-900Rio ClaroSPBrazil

Ni WO4 was prepared using the polymeric precursor method and studied in terms of physical and chemical properties to verify its stability for industrial applications as *** characterization was accomplished using thermal analyses,X-ray diffraction(XRD),scanning electron microscopy(SEM),photoluminescence(PL)and UV–Vis spectroscopies,colorimetric coordinates,and Raman *** the temperature,successive exothermic reactions were observed and they are related with thermal decomposition of the organic *** stability was reached at^700℃.The material is verified to become completely free of second phase at^800℃.The end Ni WO4 powders showed an intense charge transfer(CT)-related tail centered in the ultraviolet region,resulting in a yellow *** addition,the powders exhibited broad excitation band and broad deep blue–green emission band,which were enhanced with increasing powders’crystallinity.

关键词： nickel tungstate yellow pigment colorimetric coordinate optical property structural characterization

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盘磨机低浓磨浆过程强度表征的有效性及应用

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中国造纸 2023年第7期42卷 57-62,152页

作者：刘欢董继先 ROUX jean-claude 蒲永平陕西科技大学材料科学与工程学院陕西西安710021 陕西科技大学机电工程学院中国轻工业装备制造智能化重点实验室陕西西安710021 格勒诺布尔-阿尔卑斯大学 Grenoble-INP-Pagora法国格勒诺布尔F-38000

本课题采用理论分析方法研究了现有低浓磨浆强度对于不含挡坝等距直齿磨盘低浓磨浆过程的强度表征效果。结果表明,单个磨齿交错区域的净法向力(fnnet)及切向力(ftnet)是目前唯一具有实际意义的有效低浓磨浆强度,其不仅适用于不含挡坝等... 详细信息

本课题采用理论分析方法研究了现有低浓磨浆强度对于不含挡坝等距直齿磨盘低浓磨浆过程的强度表征效果。结果表明,单个磨齿交错区域的净法向力(fnnet)及切向力(ftnet)是目前唯一具有实际意义的有效低浓磨浆强度,其不仅适用于不含挡坝等距直齿磨盘低浓磨浆过程的表征,并可扩展至含挡坝磨盘及弧形齿磨盘。而具有实际意义的比边缘负荷(SELC及SELT)的应用具有一定的局限性,仅适用于恒定参数磨盘低浓磨浆过程的强度表征。实际上,低浓磨浆强度的合理建立、选择及应用不仅反映对磨浆机理的认知,且直接影响低浓磨浆过程的优化控制、齿型参数设计及选择。

关键词：制浆造纸盘磨机低浓磨浆磨浆强度表征参数

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Laparoscopic management of an ectopic pregnancy after in vitro fertilization and embryo transfer at CHRACERH:A case report

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Laparoscopic, Endoscopic and Robotic Surgery 2018年第3期1卷 70-73页

作者： Belinga Etienne Noa Ndoua claude Cyrille Ayissi Gregory Kasia Onana Yves Bertrand Kasia jean-Marie Department of Gynecology and Obstetrics Faculty of Medicine and Biomedical ScienceUniversity of Yaounde IYaoundeCameroon Hospital Center for Research and Application in Endoscopic Surgery and Human Reproduction YaoundeCameroon

*** Initially,in vitro fertilization and embryo transfer(IVF-ET)was designed to solve tubal factors infertility(TFI)by placing the embryo(s)within the uterine ***,in some cases,an ectopic implantation occurs as the embryo can enter the *** pregnancy(EP)is the location of the pregnancy outside the intrauterine *** prevalence of EP following assisted reproductive technology(ART)ranges between 2.1%and 8.6%of all pregnancies and it can reach up to 11%inwomen with tubal factors infertility history.

关键词： Ectopic pregnancy Laparoscopic management In vitro fertilization Embryo transfer

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喀麦隆啤酒废水厌氧生物处理的研究

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太阳能学报 2001年第2期22卷 230-235页

作者：郑平梅玲玲 Fogno jean claude 浙江大学环境工程系杭州310029 浙江省卫生防疫站杭州310009 雅温得第一大学

为了经济有效地控制喀麦隆啤酒厂的有机废水污染 ,选用上流式厌氧污泥床 (UASB)反应器 ,进行了常温厌氧生物处理的试验。结果表明 ,当地平均气温 2 2 6℃ ,足以维持反应器的正常工作 ;但应采取措施降低温度的昼夜波动。糖化废水、发醇... 详细信息

为了经济有效地控制喀麦隆啤酒厂的有机废水污染 ,选用上流式厌氧污泥床 (UASB)反应器 ,进行了常温厌氧生物处理的试验。结果表明 ,当地平均气温 2 2 6℃ ,足以维持反应器的正常工作 ;但应采取措施降低温度的昼夜波动。糖化废水、发醇废水和啤酒过滤废水混合处理的效果优于各自单独处理。处理混合废水时 ,适宜的进水COD浓度为 110 0 0mg/L左右 ,适宜的容积COD负荷为 12 5 0g/ (L·d) ,适宜的水力停留时间为 1天。在此条件下 ,COD去除率可达 89%以上 ,容积COD去除率 11 76g/ (L·d) ,容积沼气产率 4 0 6L/ (L·d)。试验证实。

关键词：啤酒厌氧生物处理废水处理

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Liver insulin-like growth factor 2 methylation in hepatitis C virus cirrhosis and further occurrence of hepatocellular carcinoma

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World Journal of Gastroenterology 2008年第35期14卷 5419-5427页

作者： Philippe Couvert Alain Carrié Jacques Pariès Jenny Vaysse Audrey Miroglio Antoine Kerjean Pierre Nahon Jamel Chelly jean-claude Trinchet Michel Beaugrand Nathalie Ganne-Carrié INSERM U551 Dyslipopro-teinemia and Atherosclerosis Research UnitParis F-75013France Université Paris6 UMR S551Paris F-75013France AP-HP Groupe hospitalier Pitié SalpétrièreService de Biochimie endocrinienne et OncologiqueParis F-75013France Department of Public health Jean Verdier HospitalAP-HPBondy 93140France Department of Biochemistry Jean Verdier HospitalAP-HPBondy 93140France Cochin Institut-INSERM-CNRS-University Paris 5-CHU Cochin Paris 75014France Department of Hepato-Gastroenterology Jean Verdier HospitalAP-HPBondy 93140France UPRES EA3409 University Paris 13Paris F-75651France

AIM: To assess the predictive value of the insulinlike growth factor 2 (Igf2) methylation profile for the occurrence of Hepatocellular Carcinoma (HCC) in hepatitis C (HCV) cirrhosis. METHODS: Patients with: (1) biopsy-proven compensated HCV cirrhosis; (2) available baseline frozen liver sample; (3) absence of detectable HCC; (4) regular screening for HCC; (5) informed consent for genetic analysis were studied. After DNA extraction from liver samples and bisulfite treatment, unbiased PCR and DHPLC analysis were performed for methylation analysis at the Igf2 locus. The predictive value of the Igf2 methylation profile for HCC wasassessed by Kaplan-Meier and Cox methods. RESULTS: Among 94 included patients, 20 developed an HCC during follow-up (6.9 ± 3.2 years). The methylation profile was hypomethylated, intermediate and hypermethylated in 13, 64 and 17 cases, respectively. In univariate analysis, two baseline parameters were associated with the occurrence of HCC: age (P = 0.01) and prothrombin (P = 0.04). The test of linear tendency between the three ordered levels of Igf2 methylation and probability of HCC occurrence was significant (Log Rank, P = 0.043; Breslow, P = 0.037; Tarone-Ware, P = 0.039). CONCLUSION: These results suggest that hypomethylation at the Igf2 locus in the liver could be predictive for HCC occurrence in HCV cirrhosis.

关键词： Liver cancer Cirrhosis Insulin-growth factor 2, DNA methylation

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ACCURATE RANGE GATING TECHNIQUE WITH MODE LOCKED DYE LASERS

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天津大学学报(自然科学与工程技术版) 1982年第2期 93-101页

作者： jean-claude Diels,Joel J.Fontaine North Texas State University University of Louis Pasteur

The use of subpicosecond passively mode locked dye lasers, combined with nonlinear detection is shown to open the field of "range gating" to microscopic dimensions. We present a one dimensional application of this tec... 详细信息

关键词： mode ACCURATE RANGE GATING TECHNIQUE WITH MODE LOCKED DYE LASERS

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