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Advances in Entomology 2018年第2期6卷 160-169页

作者： jean christophe koussoubé Zakaria Ilboudo Antoine Waongo Antoine Sanon Laboratory of Fundamental and Applied Entomology University Ouaga I Pr Joseph KI-ZERBO Ouagadougou Burkina Faso

In West Africa and particularly in Burkina Faso, Roselle, Hibiscus sabdariffa L. (Malvaceae) is receiving increasing attention as a crop with potential for making great socio-economic impacts. The biology of Spermophagus niger, recently identified as the main insect pest in the storage of roselle seeds, is poorly known. The present study aimed at comparing the reproductive potential of this insect on the seeds of two roselle varieties Altissima and Sabdariffa, mainly grown in Burkina Faso to identify susceptible/resistant variety to the pest. The results obtained are the first complete data on life history traits of S. niger in laboratory conditions. Overall, they indicated that both seed varieties have similar susceptibility to S. niger. The main life history traits measured did not differ significantly on both varieties (P >0.05). However, the first generation individuals from the Altissima seeds were significantly larger (P = 0.0007 and P <0.0001 for males and females respectively) and weighed more (P <0.0001) than those from the other roselle variety. This result suggests that individuals from the Altissima variety may have a higher seed-damaging potential than those developed in the Sabdariffa variety and this potential might increase over successive generations. The consequences of such findings are discussed with a view to improving the post-harvest storage of roselle seeds and reducing losses in West Africa.

关键词： Hibiscus sabdariffa Spermophagus niger Life History Post-Harvest Storage Varietal Susceptibility Seed Damage

Lateral ring compression test applied to a small caliber steel jacket:Identification of a constitutive model

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Defence Technology（防务技术） 2024年第6期36卷 133-148页

作者： Yann Coget Yael Demarty christophe Czarnota Anthony Bracq jean-Sebastien Brest Alexis Rusinek French-German Research Institute of Saint-Louis 5 Rue Du General Cassagnou68300 Saint-LouisFrance Laboratoire d'Etude des Microstructures et de Mecanique des Materiaux(LEM3) CNRSUniversite de LorraineArts&Metiers ParisTechF-57000 MetzFrance

The evolution of threats and scenarios requires continuous performance improvements of ballistic protections for armed *** a modeling point of view,it is necessary to use sufficiently precise material behavior models to accurately describe the phenomena observed during the impact of a projectile on a protective *** this context,the goal of this paper is to characterize the behavior of a small caliber steel jacket by combining experimental and numerical *** experimental method is based on the lateral compression of ring specimens directly machined from the thin and small *** speeds and temperatures are considered in a quasi-static regime in order to reveal the strain rate and temperature dependencies of the tested *** Finite Element Updating Method(FEMU)is *** results are coupled with an inverse optimization method and a finite element numerical model in order to determine the parameters of a constitutive model representative of the jacket *** of the present model are verified against experimental results and a parametric study as well as a discussion on the identified material parameters are *** results indicate that the strain hardening parameter can be neglected and the behavior of the thin steel jacket can be described by a modeling without strain hardening sensitivity.

关键词： Full metal jacket ammunition Lateral ring compression Inverse identification Numerical simulation

Bridging Continents,Shaping Futures

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China Today 2024年第10期73卷 20-21页

作者： jean-christophe DESLARZES Board of the Adecco Group

The combined strengths of China and Europe can build a workforce that is well-prepared for the future and capable of driving economic *** highly anticipated China-Europe Talent Forum 2024 provides us with an invaluable platform to discuss and enhance the strong ties between China and Europe,focusing on the future of talent *** relationship between China and Europe has long been marked by mutual respect and a deep commitment to collaboration in various sectors,including trade,technology,education,and culture.

关键词： mutual driving education

Lighting up aggregate emission of perylene diimide by leveraging polymerization-mediated through-space charge transfer and π-π stacking

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Science China Chemistry 2024年

作者： Suiying Ye Désirée Füglistaller Tian Tian Anjay Manian Sudhir Kumar Celine Nardo Andrew J.Christofferson Salvy P.Russo Chih-Jen Shih jean-christophe Leroux Yinyin Bao Institute of Pharmaceutical Sciences Department of Chemistry and Applied Biosciences ETH Zurich Vladimir-Prelog-Weg 3 Institute for Chemical and Bioengineering Department of Chemistry and Applied Biosciences ETH Zurich Vladimir-Prelog-Weg 1-5 ARC Centre of Excellence in Exciton Science School of Science RMIT University School of Science STEM College RMIT University

The molecular engineering of fluorescent organic/polymeric materials, specifically those emitting in the deep red to near-infrared spectrum, is vital for advancements in optoelectronics and biomedicine. Perylene diimide(PDI), a well-known fluorescent scaffold, offers high thermal and photophysical stability but suffers from fluorescence quenching in solid or aggregate states due to intense π-π interactions. To mitigate this, simple and versatile methods for strong PDI aggregate emission without extensive synthetic demands are highly desirable but still lacking. Here, we report a straightforward strategy to enhance the solid-state emission of PDI by introducing certain degree of through-space charge transfer(TSCT) via controlled radical polymerization,which can efficiently distort the typical face-to-face PDI stacking, enabling greatly enhanced deep red emission. This is achieved by growing electron-donating star-shape styrenic(co)polymers from a multidirectional electron-accepting PDI initiator. The incorporation of polycyclic aromatic monomers further shifted the emission into the near-infrared region, albeit with a reduced intensity. Overall, the emission of the PDI-based TSCT polymers can be systematically manipulated by leveraging the balance between PDI stacking and the TSCT degree, as confirmed by both experimental study and theoretical calculations. Our approach circumvents complex synthetic procedures, offering highly emissive materials with large Stokes shifts and showing broad potential for optoelectronic technology.

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Targeted therapy for capillary-venous malformations

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Signal Transduction and Targeted Therapy 2024年第7期9卷 3024-3039页

作者： Lola Zerbib Sophia Ladraa Antoine Fraissenon Charles Bayard Marina Firpion Quitterie Venot Sanela Protic Clément Hoguin Amandine Thomas Sylvie Fraitag jean-Paul Duong Sophie Kaltenbach Estelle Balducci Coline Lefevre Patrick Villarese Vahid Asnafi Christine Broissand Nicolas Goudin Ivan Nemazanyy Gwennhael Autret Bertrand Tavitian christophe Legendre Nadia Arzouk Veronique Minard-Colin Caroline Chopinet Michael Dussiot Denise MAdams Tristan Mirault Laurent Guibaud Paul Isenring Guillaume Canaud UniversitéParis Cité ParisFrance INSERM U1151 Institut Necker-Enfants MaladesParisFrance Service d’Imagerie Pédiatrique Hôpital Femme-Mère-EnfantHCLBronFrance CREATIS UMR 5220 Villeurbanne 69100France Service de Radiologie Mère-Enfant Hôpital NordSaint EtienneFrance Service d’Anatomie pathologique Hôpital Necker-Enfants MaladesAP-HPParisFrance Laboratoire d’Oncohématologie Hôpital Necker-Enfants MaladesAP-HPParisFrance Pharmacie Hôpital Necker-Enfants MaladesAP-HPParisFrance Necker Bio-Image Analysis INSERM US24/CNRS UMS 3633ParisFrance Platform for Metabolic Analyses Structure Fédérative de Recherche NeckerINSERM US24/CNRS UMS 3633ParisFrance Plateforme Imageries du Vivant Universitéde ParisPARCCINSERMParisFrance Service de Néphrologie Transplantation AdultesHôpital Necker-Enfants MaladesAP-HPParisFrance Service de Transplantation Hôpital La PitiéSalpétrièreAP-HPParisFrance Department of Pediatric and Adolescent Oncology INSERM 1015Gustave RoussyUniversitéParis-SaclayVillejuifFrance Service de Physiologie&Explorations Fonctionnelles Cardiovasculaires CHU de LilleLille 59000France INSERM U1163 Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutic ImplicationsLaboratoire d’Excellence GR-ExParisFrance Division of Oncology Comprehensive Vascular Anomalies ProgramChildren’s Hospital of PhiladelphiaPhiladelphiaPAUSA Service de Médecine Vasculaire hôpital Européen Georges-PompidouParisFrance Nephrology Research Group L’Hôtel-Dieu de Québec Research CenterDepartment of MedicineFaculty of MedicineLaval UniversityQuebecQC G1R2J6Canada Unitéde médecine translationnelle et thérapies ciblées Hôpital Necker-Enfants MaladesAP-HPParisFrance CNRS UMR8253 Institut Necker-Enfants MaladesParisFrance

Sporadic venous malformations are genetic conditions primarily caused by somatic gain-of-function mutation of PIK3CA or TEK,an endothelial transmembrane receptor signaling through *** malformations are associated with pain,bleedings,thrombosis,pulmonary embolism,esthetic deformities and,in severe cases,life-threatening *** authorized medical treatment exists for patients with venous ***,we created a genetic mouse model of PIK3CA-related capillary venous malformations that replicates patient *** showed that these malformations only partially signal through AKT *** compared the efficacy of different drugs,including rapamycin,a mTORC1 inhibitor,miransertib,an AKT inhibitor and alpelisib,a PI3Kαinhibitor at improving the lesions seen in the mouse *** demonstrated the effectiveness of alpelisib in preventing vascular malformations’occurrence,improving the already established ones,and prolonging *** these findings,we were authorized to treat 25 patients with alpelisib,including 7 children displaying PIK3CA(n=16)or TEK(n=9)-related capillary venous malformations resistant to usual therapies including sirolimus,debulking surgical procedures or percutaneous *** assessed the volume of vascular malformations using magnetic resonance imaging(MRI)for each *** demonstrated improvement in all 25 *** malformations previously considered intractable were reduced and clinical symptoms were *** showed a decrease of 33.4%and 27.8%in the median volume of PIK3CA and TEK malformations respectively,over 6 months on *** conclusion,this study supports PI3Kαinhibition as a promising therapeutic strategy in patients with PIK3CA or TEK-related capillary venous malformations.

关键词： PIK3CA malformations venous

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连接中欧,塑造未来

今日中国 2024年第10期73卷 22-23页

作者：邓敬熙瑞士德科集团

中欧双方强强联手,将培养面向未来、推动经济增长的人才队伍。备受期待的2024中欧人才论坛重点关注人才发展的未来,为进一步增进中欧关系、加强中欧交流提供了一个宝贵平台。长期以来,中欧交往一直注重相互尊重,并在贸易、科技、教育和... 详细信息

中欧双方强强联手,将培养面向未来、推动经济增长的人才队伍。备受期待的2024中欧人才论坛重点关注人才发展的未来,为进一步增进中欧关系、加强中欧交流提供了一个宝贵平台。长期以来,中欧交往一直注重相互尊重,并在贸易、科技、教育和文化等各领域开展深度合作。在中欧培养适应性强、创新水平高、有韧性的人才,对于推动中欧关系持续蓬勃发展至关重要。我们今天面临的全球性挑战—从科技的快速进步到环境问题的不断出现—都在告诉我们,人类需要一支技术娴熟、能够灵活适应环境变化的人才队伍。

关键词：人才队伍中欧关系深度合作全球性挑战相互尊重强强联手灵活适应面向未来

Redox and acetylation coordinate ABA-independent osmotic stress response

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Molecular Plant 2022年第4期15卷 583-585页

作者： christophe Belin jean-Philippe Reichheld Laboratoire Génome et Développement des Plantes UniversitéPerpignan Via Domitia66860 PerpignanFrance Laboratoire Génome et Développement des Plantes CNRS66860 PerpignanFrance

Osmotic stress caused by drought or high salt concentrations is a major threat that limits plant development and affect crop *** the context of climate change,understanding the mechanisms by which plants perceive their environment to adapt to their development is a major question.A common feature of plants being exposed to osmotic stress is the accumulation of excessive reactive oxygen species(ROS)(Martinière et al.,2019).ROS can oxidatively damage biological molecules,such as nucleic acids,proteins,and lipids,but also play important signaling *** protect from ROS-induced oxidation,living organisms have developed a large panel of enzymatic and non-enzymatic systems to remove ROS and oxidized molecules.

关键词： functions. enzymatic coordinate

Mechanical strength of soda-lime glass sandblasted by gravitation

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Friction 2015年第1期3卷 65-71页

作者： Fouad ROUMILI Saci BENBAHOUCHE jean-christophe SANGLEBOEUF Laboratoire de Mécanique de Précision Appliquée Institut d’Optique et Mécanique de PrécisionUniversitéFerhat AbbasSétif19000Algérie Institut de Physique de Rennes UMR CNRS 6251 Bât.10BCampus de Beaulieu35042 Rennes cedexFrance

Damage to a glass surface by sandblasting has a remarkable effect on its mechanical properties and *** this study,we analyze the superficial deterioration of soda-lime glass and its influence on the mechanical *** by gravitation from a fixed height causes damages by the free fall of different quantities of sand,which we performed for a selected grain size and at different angles of *** characterize the surface state,we used different roughness measures(the arithmetic mean value of the roughness Ra,the root mean square roughness Rq,and the maximum roughness Rmax)and measured the optical transmission(transmittance)at different points on the specimen surface using a *** determine the mechanical strength,we proceeded by two methods:first,by a shock ball(falling ball),and then by biaxial bending using circular *** effects of the surface damage on the optical transmission and the mechanical strength of the glass are graphically presented and discussed in this paper.

关键词： sandblasting mechanical strength roughness soda lime glass

Three decades of unveiling the complex chemistry of C-nitroso species with computational chemistry

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Organic Chemistry Frontiers 2022年第1期9卷 223-264页

作者： Pauline Bianchi jean-christophe M.Monbaliu Center for Integrated Technology and Organic Synthesis MolSys Research UnitUniversity of LiègeB-4000 Liège(Sart Tilman)Belgium

C-Nitroso species are characterized by a unique nitrogen–oxygen combination located next to a carbon backbone,which confers them a unique ambiphilic and high reactivity towards nucleophilic,electrophilic but also radical *** this ambivalence can be seen as a strong asset for developing versatile synthetic aminohydroxylation and/or hydroxylamination processes mainly through nitroso Diels–Alder,nitroso ene,and nitrosoaldol reactions,it also contributes to complex optimization and rationalization arising from the many competitive pathways,that is,the occurrence of regioisomers and stereoisomers,as well as dimerization and tautomerization *** reactivity profiles are usually seen by synthetic organic chemists as major hurdles to overcome,despite the armada of analytical and purification methods available to them,and hence to achieve selective and exploitable developments of such *** rise of computational chemistry and resources has certainly changed their perspectives,since it provides a very different angle to gather insights on intrinsic properties,reactivity,and *** silico chemistry also provides a robust alternative to time and resource-consuming synthetic work and can therefore contribute to alleviate wasteful preparations by guiding the chemist toward the best combination of reagents to achieve high selectivity and *** synergistic combination of synthetic organic chemistry and computational chemistry,within the specific context of the complex chemistry of C-nitroso species,is discussed in this *** review aims at giving an overview of the molecular and chemical properties obtained through computational chemistry as an enabling support for the rationalization and optimization of reactions relying on ambiphilic C-nitroso species over the 3 last *** provides clear,concise,and illustrated guidelines for the synthetic chemist in search of inspiration through computations.

关键词： chemistry reactivity isomers

The Séchilienne (France) Landslide:a Non-typical Progressive Failure Implying Major Risks

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Journal of Mountain Science 2011年第2期8卷 117-123页

作者： jean-Louis DURVILLE christophe BONNARD Pierre POTHERAT Conseil général de l'environnement et du développement durable Paris France Independent expert PBBG SA Lausanne Switzerland Centred'études techniques de l'équipement Lyon France

The National Road RN 91 has been threatened for about twenty-five years by a huge landslide, located 25 km south-east to the town of Grenoble (France). If several million cubic meters of rock fall down, the debris will dam the valley. Then the failure of the dam by overtopping and rapid erosion might result in a catastrophic flood and dramatic consequences for human life, environment and economy throughout the valley. The paper presents the hazard assessment based on geological and hydrological surveys, including small scale hydraulic tests, as well as the risk evaluation that has been performed. The risk management relies first upon a high level monitoring and an emergency plan; various mitigation strategies have been considered.

关键词： Landslide Progressive failure Séchilienne France