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Impact of switching from ranibizumab to aflibercept on the number of intravitreous injection and follow up visit in wet AMD:results of real life ELU study

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International Journal of Ophthalmology(English edition) 2020年第2期13卷 252-256页

作者： Frederic Queguiner Kristina Bezirganyan jean christophe Courjaret Laurence Curel Guillaume Penaranda Maud Righini Chossegros Ophthalmology and Clinical Research Departments Hopital Saint JosephMarseille F-13008France Biostatistics Department Alphabio LaboratoryMarseille F-13003France

●AIM:To study if one of the two molecules could lead to a lower number of follow up visits and intra-vitreous injection(IVI)with the same efficacy.●METHODS:ELU(or"elected"in French)study is a retrospective study conducted in real life in patients presenting suboptimal response after ranibizumab IVI(phase 1)and secondary switched to aflibercept(phase 2).The number of follow up visits and IVI were compared in both *** acuity(VA)evolution and"switching"reasons were secondary analyzed.●RESULTS:We retrospectively included data of 33 patients(38 eyes)with age-related macular degeneration(AMD;mean age:77±7.7 y).The number of monthly follow up visits[median(Q1;Q3)]:was significantly lower with aflibercept(phase 2),respectively 1.0(0.81;1.49)visits in phase 1,versus 0.79(0.67;0.86)visits in phase *** median number of monthly IVI also significantly decreased in phase 2,respectively 0.67(0.55;0.90)IVI in phase 1,versus 0.55(0.45;0.67)IVI in phase *** mean VA evolution(VA final-VA initial)was similar in both phases,(P>0.05).Whatever the reason for"switching"(loss of efficacy,tachyphylaxis,tolerance problems),there was no incidence on VA evolution over the time.●CONCLUSION:Our results show that switching from ranibizumab to aflibercept in"suboptimal"patients significantly reduce the number of follow up visits and IVI,with a comparable *** decrease in visit number could improve patients’quality of life and reduce surgical risk by reducing the number of injections.

关键词： wet age-related macular degeneration anti-VEGF aflibercept ranibizumab follow up visit intravitreal injection visual acuity

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3D bioprinted breast cancer model reveals stroma-mediated modulation of extracellular matrix and radiosensitivity

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Bioactive Materials 2024年第12期42卷 316-327页

作者： Theo Desigaux Leo Comperat Nathalie Dusserre Marie-Laure Stachowicz Malou Lea jean-William Dupuy Anthony Vial Michael Molinari jean-christophe Fricain Francois Paris Hugo Oliveira Univ.Bordeaux Tissue Bioengineering INSERM U1026F-33000BordeauxFrance INSERM U1026 ART BioPrintF-33000BordeauxFrance Univ.Bordeaux Bordeaux ProteomeF-33000BordeauxFrance Univ.Bordeaux CNRSINSERMTBM-CoreUS5UAR 3427OncoProtF-33000BordeauxFrance Univ.Bordeaux CNRSBordeaux INPCBMNUMR 5248F-33600PessacFrance Services d’Odontologie et de Sante Buccale CHU BordeauxF-33000BordeauxFrance CRCINA INSERMCNRSUniv.NantesF-44000NantesFrance Institut de Cancerologie de l’Ouest F-44800Saint HerblainFrance

Deciphering breast cancer treatment resistance remains hindered by the lack of models that can successfully capture the four-dimensional dynamics of the tumor ***,we show that microextrusion bioprinting can reproducibly generate distinct cancer and stromal compartments integrating cells relevant to human *** findings unveil the functional maturation of this millimeter-sized model,showcasing the development of a hypoxic cancer core and an increased surface *** was also driven by the presence of cancer-associated fibroblasts(CAF)that induced elevated microvascular-like structures *** modulation was concomitant to extracellular matrix remodeling,with high levels of collagen and matricellular proteins deposition by CAF,simultaneously increasing tumor stiffness and recapitulating breast cancer fibrotic ***,our bioprinted model faithfully reproduced response to treatment,further modulated by ***,CAF played a protective role for cancer cells against radiotherapy,facilitating increased paracrine *** model holds promise as a platform to decipher interactions within the microenvironment and evaluate stroma-targeted drugs in a context relevant to human pathology.

关键词： Bioprinting Cancer microenvironment Extracellular matrix

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Benefit of combination β-blocker and endoscopic treatment to prevent variceal rebleeding: A meta-analysis

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World Journal of Gastroenterology 2010年第47期16卷 5982-5992页

作者： Natalie Funakoshi Frédérique Ségalas-Largey Yohan Duny Frédéric Oberti jean-christophe Valats Michael Bismuth jean-Pierre Daurès Pierre Blanc Department of Hepato-gastroenterology B Saint Eloi Hospital University Hospital of Montpellier Department of Statistics University Hospital of Nimes Department of Hepato-gastroenterology University Hospital of Angers

AIM: To determine whether the association of β-blockers with endoscopic treatment is superior to endoscopic treatment alone for the secondary prophylaxis of oesophageal variceal bleeding. METHODS: Randomised controlled trials comparing sclerotherapy (SCL) with SCL plus β-blockers (BB) or banding ligation (BL) with BL plus BB were identif *** outcomes were overall and 6, 12 and 24 mo rebleeding rates, as well as overall and 6, 12 and 24 mo mortality. Two statistical methods were used: Yusuf-Peto, and Der Simonian and Laird. Inter-trial heterogeneity was systematically taken into account. RESULTS: Seventeen randomised controlled trials were included, 14 with SCL and 3 with BL. Combination β-blocker and endoscopic treatment signif icantly reduced rebleeding rates at 6, 12 and 24 mo and overall [odds ratio (OR): 2.20, 95% conf idence interval (CI): 1.69-2.85, P<0.0001] compared to endoscopic treatment alone. Mortality at 24 mo was signif icantly lower for the combined treatment group (OR: 1.83, 95% CI:1.16-2.90, P= 0.009), as well as overall mortality (OR: 1.43, 95% CI:1.03-1.98, P= 0.03). CONCLUSION: Combination therapy should thus be recommended as the fi rst line treatment for secondary prophylaxis of oesophageal variceal bleeding.

关键词： Oesophageal varices Portal hypertension Cirrhosis Secondary prevention β-blockers Banding ligation

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Heat inactivation of the severe acute respiratory syndrome coronavirus 2

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Journal of Biosafety and Biosecurity 2021年第1期3卷 1-3页

作者： christophe Batéjat Quentin Grassin jean-Claude Manuguerra India Leclercq Institut Pasteur UnitéEnvironnement et Risques InfectieuxCellule d’Intervention Biologique d’Urgence(CIBU)28 rue du Dr.RouxParisFrance Universitéde Paris Cellule Pasteur28 rue du Dr.Roux F-75015 ParisFrance

Cell culture medium,nasopharyngeal and sera samples spiked with SARS-CoV-2 were subjected to heat inactivation for various periods of time,ranging from 30 s to 60 *** results showed that SARS-CoV-2 could be inactivated in less than 30 min,15 min,and 3 min at 56℃,65℃,and 95℃,*** data could help laboratory workers to improve their protocols by handling the virus in biosafety conditions.

关键词： Heat Inactivation SARS-CoV-2 Covid-19

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Bridging Continents,Shaping Futures

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China Today 2024年第10期73卷 20-21页

作者： jean-christophe DESLARZES Board of the Adecco Group

The combined strengths of China and Europe can build a workforce that is well-prepared for the future and capable of driving economic *** highly anticipated China-Europe Talent Forum 2024 provides us with an invaluable platform to discuss and enhance the strong ties between China and Europe,focusing on the future of talent *** relationship between China and Europe has long been marked by mutual respect and a deep commitment to collaboration in various sectors,including trade,technology,education,and culture.

关键词： mutual driving education

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Internal carotid thrombus in patients with inflammatory bowel disease:Two cases

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World Journal of Gastroenterology 2013年第5期19卷 773-775页

作者： Sébastien Richard Gioia Mione Julien Perrin Marie Toussaint-Hacquard jean-christophe Lacour Xavier Ducrocq Department of Neurology CHU NancyHospital Central54035 Nancy CedexFrance Department of Biological Hematology CHU Nancyhpitaux de Braboisrue du Morvan54511 Vandoeuvre-les-Nancy CedexFrance

Increased ischemic stroke risk is observed in patients with inflammatory bowel disease(IBD).Causes and physiopathological aspects of cerebral infarct,in this specific population,are less often *** is little information to provide guidelines for the best curative and preventive *** report 2 cases of ischemic strokes due to internal carotid thrombus in patients during active phase of *** of early atherosclerotic plaques activated by a hypercoagulation state may cause a thrombus.A combined therapy with heparin and corticosteroids was used for both our *** of the thrombus was obtained after several days without surgical treatment and shown by *** cases highlight an aetiology of stroke in patients with IBD and use of a synergic treatment to respond to hypercoagulability in link with IBD. Benefits and safety of this therapy should be confirmed with clinical studies.

关键词： Inflammatory bowel disease Ischemic stroke Carotid thrombus Hypercoagulable state Atherosclerosis

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Consequences of coinfection with protective symbionts on the host phenotype and symbiont titres in the pea aphid system

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Insect Science 2017年第5期24卷 798-808页

作者： Melanie Leclair Sarah Polin Thibaut Jousseaume jean-christophe Simon Akiko Sugio Stephanie Morliere Takema Fukatsu Tsutomu Tsuchida Yannick Outreman IGEPP Agrocampus Ouest INRA Universite de Rennes 1 Universite Bretagne-Loire Rennes France IGEPP Agrocampus OuestINRA Universit6 de Rennes 1 Le Rheu France Bioproduction Research Institute AIST Tsukuba Japan Graduate School of Science and Engineering University of Toyama Toyama Japan

Symbiotic associations between microbes and insects are widespread, and it is frequent that several symbionts share the same host individual. Hence, interactions can occur between these symbionts, influencing their respective abundance within the host with consequences on its phenotype. Here, we investigate the effects of multiple infections in the pea aphid, Acyrthosiphon pisurn, which is the host of an obligatory and several facultative symbionts. In particular, we study the influence of a coinfection with 2 protective symbionts： Harniltonella defensa, which confers protection against parasitoids, and Rickettsiella viridis, which provides protection against fungal pathogens and predators. The effects of Hamiltonella-Rickettsiella coinfection on the respective abundance of the symbionts, host fitness and efficacy of enemy protection were studied. Asymmetrical interactions between the 2 protective symbionts have been found： when they coinfect the same aphid individuals, the Rickettsiella infection affected Hamiltonella abundance within hosts but not the Hamiltonella-mediated protective phenotype while the Hamiltonella infection negatively influences the Rickettsiella-mediated protective phenotype but not its abundance. Harboring the 2 protective symbionts also reduced the survival and fecundity of host individuals. Overall, this work highlights the effects of multiple infections on symbiont abundances and host traits that are likely to impact the maintenance of the symbiotic associations in natural habitats.

关键词： Acyrthosiphon pisum Hamiltonella defensa host fitness multiple infections protective symbionts symbiont abundance

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Low incidence of spontaneous bacterial peritonitis in asymptomatic cirrhotic outpatients

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World Journal of Hepatology 2013年第3期5卷 104-108页

作者： jean-Franois Cadranel jean-Baptiste Nousbaum christophe Bessaguet Pierre Nahon Eric Nguyen-Khac Richard Moreau Thierry Thévenot Christine Silvain christophe Bureau Olivier Nouel christophe Pilette Thierry Paupard Arnaud Pauwels Thierry Sapey jean-Didier Grangé Albert Tran Gastroenterology and Nutrition Department Centre Hospitalier Laennec Department of Hepato-Gastroenterology University Hospital La Cavale Blanche Department d'Information Médicale Centre Hospitalier Department of Hepato-Gastroenterology Hpital Jean Verdier Department of Hepato-Gastroenterology Amiens University Hospital Department of Hepatology Hpital Beaujon Department of Hepatology University Hospital Jean Minjoz Department of Hepato-Gastroenterology Poitiers University Hospital Department of Hepato-Gastroenterology Purpan Hospital Department of Hepato-Gastroenterology Centre Hospitalier de Saint Brieuc Department of Hepato-Gastroenterology Centre Hospitalier Department of Hepato-Gastroenterology Centre Hospitalier de Dunkerque Department of Hepato-Gastroenterology Centre Hospitalier de Gonesse Department of Hepato-Gastroenterology Centre Hospitalier de Chateauroux Department of Hepatology Hpital Tenon Digestive Center University Hospital of Nice

AIM: To compare the incidence of spontaneous bacterial peritonitis in cirrhotic outpatients and inpatients undergoing therapeutic paracentesis METHODS: From January 1 to May 31, 2004, 1041 patients from 70 different hospitals underwent 2123 therapeutic abdominal paracentesis (AP) performed as a outpatient procedure in 355 and as inpatient procedure in 686 cases respectively. The following parameters were compared prospectively between outpatients and inpatients: spontaneous bacterial peritonitis (SBP) prevalence, age, gender, cause of cirrhosis, symptoms, score and grade according to Child-Pugh classification, cirrhosis complications, antibiotics treatment, serum creatinine, platelet count and ascitic protein concentration. RESULTS: SBP was observed in 91 patients. In the whole population the SBP prevalence was 8.7% (95%CI: 7.2-10.6) it was 11.7% (95%CI: 9.5-14.3) in inpatients and 3.1% (95%CI: 1.7-5.5) in outpatients (P < 0.00001). SBP prevalence was 8.3% (95%CI: 4.3-15.6) in symptomatic outpatients vs 1.2% (95%CI: 0.4-3.4) in asymptomatic outpatients (P < 0.002). Patients undergoing outpatient AP were significantly different from those undergoing inpatient AP; they were older (61.1 ± 11.1 years vs 59.4 ± 11.7 years; P = 0.028), cause of cirrhosis was less often alcohol (83 .7 vs 88.2%; P < 0.001), Child-Pugh score was lower (8.9 vs 10.1; P < 0.001) and more often B than C (63.7% vs 38%; P < 0.001). In addition, in outpatients the platelet count was higher (161 ± 93 Giga/L vs 143 ± 89 Giga/L; P = 0.003), serum total bilirubin concentration was lower (38.2 ± 60.7 μmol/L vs 96.3 ± 143.3 μmol/L; P < 0.0001), and ascitic protein concentration higher (17.9 ± 10.7 g/L vs 14.5 ± 10.9 g/L; P < 0.001) than in inpatients. CONCLUSION: In asymptomatic cirrhotic outpatients, the incidence of spontaneous bacterial peritonitis is low thus exploratory paracentesis could be avoided in these patients without significant risk.

关键词： Liver cirrhosis Ascites Ascitic fluid Bacterial infections Paracentesis Peritonitis

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A note on the regularity of the holes for permeability property through a perforated domain for the 2D Euler equations:Dedicated to Professor jean-Yves Chemin on the Occasion of His 60th Birthday

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Science China Mathematics 2019年第6期62卷 1121-1142页

作者： christophe Lacave Chao Wang Institut Fourier Université Grenoble AlpesCNRS School of Mathematical Sciences Peking University

For equations of order two with the Dirichlet boundary condition, as the Laplace problem, the Stokes and the Navier-Stokes systems, perforated domains were only studied when the distance between the holes d_ε is equal to or much larger than the size of the holes ε. Such a diluted porous medium is interesting because it contains some cases where we have a non-negligible effect on the solution when(ε, d_ε) →(0, 0).Smaller distances were avoided for mathematical reasons and for these large distances, the geometry of the holes does not affect or rarely affect the asymptotic result. Very recently, it was shown for the 2D-Euler equations that a porous medium is non-negligible only for inter-holes distances much smaller than the sizes of the *** this result, the boundary regularity of holes plays a crucial role, and the permeability criterion depends on the geometry of the lateral boundary. In this paper, we relax slightly the regularity condition, allowing a corner, and we note that a line of irregular obstacles cannot slow down a perfect fluid in any regime such thatε ln d_ε→ 0.

关键词： ideal fluids homogenization in perforated domains shrinking obstacles and the porous medium domains with corners

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Epidural anaesthesia restores pancreatic microcirculation and decreases the severity of acute pancreatitis

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World Journal of Gastroenterology 2006年第6期12卷 915-920页

作者： AlpDemirag CatherineMPastor PhilippeMorel NilgunGüvener GangMai ThierryBerney LeoHBühler Copinjean-christophe jean-LouisFrossard Andreas W.Sielenk mper Gang Mai Surgical Research Unit Department of SurgeryUniversity Hospital Geneva24Rue Micheli-du-Crest1211Geneva 14 Switzerland Division of Gastroenterology Department of Internal MedicineUniversity Hospital Geneva24Rue Micheli-du-Crest1211Geneva 14 Switzerland Department of Anaesthesiology and Intensive Care Medicine MUnster Germany Department of General Surgery West China HospitalSichuan UniversityChengdu 610041Sichuan Province China

AIM： To investigate the effect of epidural anaesthesia （EA） on pancreatic microcirculation during acute pancreatitis （AP）. METHODS： AP was induced by injection of sodium taurocholate into the pancreatic duct of Sprague-Dawley rats. To realize EA, a catheter was introduced into the epidural space between T7 and T9 and bupivacaine was injected. Microcirculatory flow was measured by laser Doppler flowmetry. Arterial blood gas analyses were performed. At the end of the experiment （≤ 5 h）, pancreas was removed for histology. The animals were divided into three groups： Group 1 （n =9）, AP without EA, Group 2 （n = 4）, EA without AP; and Group 3 （n = 6）, AP treated by EA. RESULTS： In Group 1, pancreatic microcirculatory flow prior to AP was 1414, 39 perfusion units （PU）. After AP, microcirculatory flow obviously decreased to 9 4-6 PU （P〈0.05）. Metabolic acidosis developed with base excess （BE） of - 14 4, 3 mmol/L. Histology revealed extensive edema and tissue necrosis. In Group 2, EA did not significantly modify microcirculatory flow. BE remained unchanged and histological analysis showed normal pancreatic tissue. In Group 3, AP initially caused a significant decrease in microcirculatory flow from 155 ± 25 to 11± 7 PU （P〈0.05）. After initiation of EA, microcirculatory flow obviously increased again to 81±31 PU （P〈0.05）. BE was -6±4 retool/L, which was significantly different compared to Group 1 （P〈0.05）. Furthermore, histology revealed less extensive edema and necrosis in pancreatic tissue in Group 3 than that in Group 1. CONCLUSION： AP caused dramatic microcirculatory changes within the pancreas, with development of metabolic acidosis and tissue necrosis. EA allowed partial restoration of microcirculatory flow and prevented development of tissue necrosis and systemic complications. Therefore, EA should be considered as therapeutic option to prevent evolution from edematous to necrotic AP.

关键词： Acute pancreatitis Epidural anaesthesia Pancreatic blood flow Microcirculation Taurocholic acid

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