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Indian Anti-Malaria OMARIA Is Effective Against African Drug Resistant <i>P. falciparum</i>Field Isolates and Laboratory Strains;without Toxicity

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International Journal of Clinical Medicine 2012年第1期3卷 1-8页

作者： jean bernard lekana-douki Deepak Bhattacharya Rafika Zatra Fousseyni S. Toure-Ndouo 不详

OMARIA which is used to treat malaria in Odisa province, India, was investigated in Africa. The in-vitro anti-malarial activity of OMARIA was tested on P. falciparum strains FCB (chloroquine-resistant) and 3D7 (chloroquine-sensitive) and on fresh clinical isolates from Gabon, using the DELI method. Host cell toxicity was analysed with the MTT test. Interesting activity was observed. Inhibition concentrations (IC50) were 20.6 ± 5.2 μg/ml and 14.1 ± 4.3μg/ml respectively on FCB and 3D7 strains. On clinical isolates, the mean of IC50 was 10.65 ± 4.8μg/ml. OMARIA is highly potent against all field isolates tested by us (Gabon includes Pfmdr1 N86). Lethal dose on Vero cells being 165 ± 10.7μg/ml indicate a selective index of 13 for FCB, i.e., non-toxic. Data substantiates scientific rationale for use of OMARIA. This information and such understanding can be used in searching African phyto parables (for use in Africa with similar results as in India) and in new drug design. With Indian assistance, Punica granatum can also be cultivated in Central Africa, and OMARIA can be made, with an aim to Fight Malaria at Home.

关键词： Fruit Extracts OMARIA Antiplasmodial Activity Asia-Africa Efficacy Cytotoxicity Drug Resistant-Field Isolates Plasmodium Falciparum

Antigenicity of Synthetic Peptides Derived from Plasmodium Apoptosis-Linked Pathogenicity Factors

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Journal of Life Sciences 2012年第6期6卷 587-594页

作者： Ulrick Bisvigou Estelle Sonya Zang-Edou Florian Noulin Rafika Zatra Ludovic Mevono jean-bernard lekana-douki Dominique Mazier Frederick Gay Fousseyni S. Toure Ndouo Unit of Medical Parasitology International Centre for Medical Research of Franceville (CIRMF) Franceville B.P. 769 Gabon Departement de Sante Publique de Medecine Legale et du Travail Universite des Sciences de la Sante Libreville B.P. 4009 Gabon Medical Research Unit Albert Sehweitzer Hospital Lambarene Gabon Departement de Parasitologie-Mycologie Medecine Tropicale Universitd des Sciences de la Sante Libreville B.P. 4009 Gabon Inserm/UPMC UMR S 945 Universite Pierre et Marie Curie Paris France AP-HP Groupe Hospitalier Pitid-Salpetriere Service Parasitologie-Mycologie Paris France

Background： Plasmodium falciparum malaria remains a major life-threatening disease. Recently, the Plasmodium apoptosis-linked pathogenicity factors （PALPF） have been identified. These antigens PALPF are expressed only by P falciparum-infected erythrocytes triggering endothelial cell apoptosis （apoptogenic）. Methods： We designed ten synthetic peptides （PI to P10） from PALPF： PF07 0032, PF10_0226, PFI0130c, PFD0875c and MAL13P1.206, and analyzed their antigenicity with an ELISA method using plasma samples from subjects living in Dienga, Gabon. Results： Four peptides showed good reactivity with human antibodies. The prevalence rate of specific IgG was 61%, 51%, 44% and 34% for P5, P6, P4 and P2, respectively. The median optical density of total IgG anti-P2 was higher than that directed against P4 and P6 （P = 0.009; P = 0.012 respectively）. The prevalence rate oflgG subclasses determined with plasma samples recognizing peptide 5 for IgGl, 2, 3 and 4 isotypes was 69%, 45%, 76% and 62%, respectively. All the subjects had at least one immunoglobulin subclass, while 13 （44%） had both IgG1 and IgG3 antibodies. There was no significant difference in the prevalence rate of anti-P5 IgG1, IgG3 and IgG4. Conclusion： These results warrant further immunogenicity studies of peptides 2, 4, 5 and 6 with a view of a tentative to antimalarial vaccine development.

关键词： Malaria vaccine candidate antigenicity immunoglobulin IgG PALPE

Density Results in Sobolev Spaces Whose Elements Vanish on a Part of the Boundary

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Chinese Annals of Mathematics,Series B 2011年第6期32卷 823-846页

作者： jean-Marie Emmanuel bernard Laboratoire Analyse et Probabitilités Université d'Evry val d'Essonne23 Boulevard de France91037 EVRYFrance

This paper is devoted to the study of the subspace of Wm＇＂ of functions that vanish on a part γ0 of the boundary. The author gives a crucial estimate of the Poincare constant in balls centered on the boundary of γ0. Then, the convolution-translation method, a variant of the standard mollifier technique, can be used to prove the density of smooth functions that vanish in a neighborhood of γ0, in this subspace. The result is first proved for m = 1, then generalized to the case where m 〉 1, in any dimension, in the framework of Lipschitz-continuous domain. However, as may be expected, it is needed to make additional assumptions on the boundary of γ0, namely that it is locally the graph of some Lipschitz-continuous function.

关键词： Density results Boundary value problems Sobolev spaces

Combination of Tsoft and ET34-ANA-V80 software for the preprocessing and analysis of tide gauge data in French Polynesia

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Geodesy and Geodynamics 2023年第1期14卷 26-34页

作者： bernard Ducarme jean-Pierre Barriot Fangzhao Zhang Catholic University of Louvain Georges Lemaître Centre for Earth and Climate Research(ELI)1348 Louvain-la-NeuveBelgium Geodesy Observatory of Tahiti University of French Polynesia(UPF)PunaauiaFrench Polynesia College of Geodesy and Geomatics Shandong University of Science and TechnologyQingdao 266590China

Since 2008 a network of five sea-level monitoring stations was progressively installed in French *** stations are autonomous and data,collected at a sampling rate of 1 or 2 min,are not only recorded locally,but also transferred in real time by a radio-link to the NOAA through the GOES *** new ET34-ANA-V80 version of ETERNA,initially developed for Earth Tides analysis,is now able to analyze ocean tides *** a two-step validation scheme,we took advantage of the flexibility of this new version,operated in conjunction with the preprocessing facilities of the Tsoft software,to recover co rrected data series able to model sea-level variations after elimination of the ocean tides *** performed the tidal analysis of the tide gauge data with the highest possible selectivity(optimal wave grouping)and a maximum of additional terms(shallow water constituents).Our goal was to provide corrected data series and modelled ocean tides signal to compute tide-free sea-level variations as well as tidal prediction models with centimeter *** also present in this study the characteristics of the ocean tides in French Polynesia and preliminary results concerning the non-tidal variations of the sea level concerning the tide gauge setting.

关键词： Tide gauges Tidal data processing Mean sea level

Conductance hysteresis and inelastic excitations at hydrogen decorated cerium atoms and clusters in a tunnel junction

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Nano Research 2016年第10期9卷 3171-3178页

作者： Rouzhaji Tuerhong Shawulienu Kezilebieke bernard Barbara jean-Pierre Bucher Institut Universitaire de France Universite de Strasbourg 23 rue du Loess F-67034 Strasbourg France Institut Neel CNRS Universite Grenoble-Alpes F-38042 Grenoble France

Voltage-controlled conductance and switching induced by single molecules or atoms are ideally studied in scanning tunneling microscope （STM） tunnel junctions. While the objects under consideration are mostly used in their original form, little is known of the possibilities of in situ adjustments of their properties. Here, we evidence properties of a tunnel junction made of a Ce atom/cluster built by atomic manipulation on Au（111） at a temperature of 4.6 K in the presence of H2. The conductance through the object is characterized by a switching voltage corresponding to an opening or closing of an inelastic electron tunneling conductance channel at 50 mV for a Ce atom and 140 mV for a Ce cluster and by charging. We demonstrate that the electronic properties of an STM junction can be engineered in a simple way by in situ guiding of the H2 pinning at an atomic cluster.

关键词： conductance hysteresis inelastic electron tunelingspectroscopy (IETS) switching Ce clusters scanning tunneling microscope (STM)/scanning tunneling spectroscopy (STS)

Monitoring absolute vertical land motions and absolute sea-level changes from GPS and tide gauges data over French Polynesia

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Geodesy and Geodynamics 2024年第1期15卷 13-26页

作者： Xianjie Li jean-Pierre Barriot bernard Ducarme Marania Hopuare Yidong Lou Geodesy Observatory of Tahiti University of French PolynesiaFaa'a 98702French Polynesia Catholic University of Louvain Georges Lemaître Centre for Earth and Climate Research(ELI)1348 Louvain-la-NeuveBelgium GNSS Research Center Wuhan UniversityWuhan 430079China State Key Laboratory of Information Engineering in Surveying Mapping and Remote SensingWuhan UniversityWuhan 430079China

In this study,we estimate the absolute vertical land motions at three tidal stations with collocated Global Navigation Satellite System(GNSS)receivers over French Polynesia during the period 2007-2020,and obtain,as ancillary results,estimates of the absolute changes in sea level at the same *** verify our processing approach to determining vertical motion,we first modeled vertical motion at the International GNSS Service(IGS)THTI station located in the capital island of Tahiti and compared our estimate with previous independent determinations,with a good *** obtained the following estimates for the vertical land motions at the tide gauges:Tubuai island,Austral Archipelago-0.92±0.17 mm/yr,Vairao village,Tahiti Iti:-0.49±0.39 mm/yr,Rikitea,Gambier Archipelago-0.43±0.17 mm/*** absolute variations of the sea level are:Tubuai island,Austral Archipelago 5.25±0.60 mm/yr,Vairao village,Tahiti Iti:3.62±0.52 mm/yr,Rikitea,Gambier Archipelago 1.52±0.23 mm/*** discuss these absolute values in light of the values obtained from altimetric measurements and other means in French Polynesia.

关键词： GPS Tide gauges Sea level changes Vertical land motion

Enhancing laccase stability and activity for dyes decolorization using ZIF-8@MWCNT nanocomposite

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Chinese Journal of Chemical Engineering 2022年第8期35卷 66-75页

作者： Pascal Habimana Yanjun Jiang Jing Gao jean bernard Ndayambaje Osama M.Darwesh jean Pierre Mwizerwa Xiaobing Zheng Li Ma School of Chemical Engineering and Technology Hebei University of TechnologyTianjin 300130China University of Rwanda College of Science and Technology3900 KigaliRwanda Department of Agricultural Microbiology National Research CentreCairo 12622Egypt College of Mechatronics and Control Engineering Shenzhen UniversityShenzhen 518060China

The continuous use of chemical dyes in various industries,and their discharge into industrial effluents,results in severe problems to human life and water *** have the ability to decolorize dyes and toxic chemicals in industrial effluents as green *** possible industrial applications have been limited by poor reusability,low stability,and loss of free laccase *** this research,lac-case was immobilized on zeolitic imidazolate framework coated multi-walled carbon nanotubes(Laccase@ZIF-8@MWCNTs)via metal affinity adsorption to develop an easy separable and stable *** optimum reaction conditions for immobilized laccase are at a pH of 3.0 and a temperature of 60℃.The immobilized laccase was enhanced in storage and thermal *** results indicated that Laccase@ZIF-8@MWCNTs still maintained 68%of its original activity after 10 times of repeated *** importantly,the biocatalytic system was applied for decolorization of different dyes(20 mg·L^(-1))without a mediator,and up to 97.4%for Eriochrome black T and 95.6%Acid red 88 was achieved in 25 *** with these properties may be used in a variety of environmental and industrial applications.

关键词： Metal-organic framework Zeolitic imidazolate framework Reusability and stability Immobilized laccase Dye decolorization

Cambrian explosion fossils from the North China craton

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National Science Review 2022年第7期9卷 13-13页

作者： jean-bernard Caron Department of Natural History Royal Ontario Museum

Our understanding of the Cambrian explosion has relied heavily on a few exceptional fossil deposits preserving soft-bodied animals,the so-called Burgess-Shale-type deposits,or BSTs for *** are named after the famous Canadian fossil deposit discovered by Charles Walcott in *** ofwhere they come from or their age,all BSTs preserve soft-bodied fossils as carbonaceous remains.

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Characteristics of patients with Wilson disease in the United States: An insurance claims database study

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World Journal of Hepatology 2024年第5期16卷 791-799页

作者： Thomas Daniel-Robin Pradeep Kumar bernard Benichou jean-Philippe Combal Vivet Therapeutics Paris 75008France Clarivate Noida 201301Uttar PradeshIndia

BACKGROUND Wilson disease(WD)is a progressive,potentially fatal degenerative disease affecting the liver and central nervous *** its low prevalence,collecting data on large cohorts of patients with WD is *** insur-ance claims databases provide powerful tools to collect retrospective data on large numbers of patients with rare *** To describe patients with WD in the United States,their treatment and clinical outcome,using a large insurance claims *** This retrospective,longitudinal study was performed in the Clarivate Real-World Data Product *** patients with≥2 claims associated with an Interna-tional Classification of Diseases 10(ICD-10)diagnostic code for WD(E83.01)between 2016 and 2021 were included and followed until death or study *** were divided into two groups by whether or not they were documented to have received a specific treatment for *** manifestations,hospital-isations,liver transplantation and death were *** Overall,5376 patients with an ICD-10 diagnostic code for WD were *** mean age at inclusion was 41.2 years and 52.0%were men.A specific WD treatment was documented for 885 patients(15.1%),although the number of patients taking zinc salts may be underestimated due to over the counter *** inclusion,the mean age of patients with a documented treatment was 36.6±17.8 years vs 42.2±19.6 years in those without a documented *** follow-up,273 patients(5.1%)*** with the American general population,the standardised mortality ratio was *** proportion of patients with a documented WD-specific treatment who died during follow-up was 4.0%and the mean age at death 52.7 *** Patients treated for WD in the United States had an excess early mortality compared with the American *** findings indicate that there is a significant unmet need for effective treatment for WD in the United States.

关键词： Wilson disease Mortality Treatment Copper chelators Zinc acetate United States