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Comment on review article:Chronic hepatitis C virus infection cascade of care in pediatric patients

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World Journal of Gastroenterology 2022年第14期28卷 1494-1498页

作者： Nouhoum Bouare Mamadou Keita jean delwaide Biomedical Sciences National Institute of Public HealthBamako 1771Mali Department of Prevention Medical and Psychosocial ManagementCSLSHIV-TB-HBamako E 595Mali Department of Gastroenterology and Hepatology CHULiegeLiege 4000Belgium

An enhanced cascade of care should include a younger population,helping to achieve the goal of the World Health Organization with a focus on elimination in the pediatric ***,enhanced screening and awareness efforts and continued education of health care providers will improve the outcomes of chronic hepatitis C virus(HCV)infection in the pediatric *** present work discusses and comments on the topic"cascade of care in HCV chronic pediatric patients".

关键词： Cascade of care Hepatitis C virus Chronic patients Pediatric population Disease management Commentary

Guillain-Barrésyndrome following hepatitis E

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World Journal of Gastroenterology 2009年第13期15卷 1645-1647页

作者： jean Philippe Loly Estelle Rikir Maxime Seivert Emile Legros Pierre Defrance Jacques Belaiche Gustave Moonen jean delwaide Department of Hepato-Gastroenterology CHU Sart TilmanUniversitéde Liège Department of Neurology CHU Sart TilmanUniversitéde Liège General Practitioner Department of Hepato-Gastroenterology CHPLT La Tourelle

Guillain-Barrésyndrome(GBS)is often triggered by a preceding bacterial or viral ***,it has been observed in association with acute hepatitis A,B and C,and three cases have been previously described in India in which GBS was associated with acute hepatitis E.A molecular mimicry mechanism is supposed to be involved in the pathogenesis of GBS triggered by infectious agents,although the nature of the shared epitopes has not been characterized in most instances,including that in the case of hepatotropic *** report a case of GBS following acute hepatitis E in a European *** presence of antiganglioside GM2 antibodies in this patient suggested molecular mimicry involving ganglioside GM2 in the pathogenesis of GBS associated with hepatitis E.

关键词： Gangliosides Guillain-Barré syndrome Hepatitis E Molecular mimicry Viral hepatitis

Overlap syndrome consisting of PSC-AIH with concomitant presence of a membranous glomerulonephritis and ulcerative colitis

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World Journal of Gastroenterology 2014年第16期20卷 4811-4816页

作者： Odile Warling Christophe Bovy Carla Combra Timothée Noterdaeme jean delwaide Edouard Louis Department of Internal Medicine CHU de LiègeUniversity of Liège4000 LiegeBelgium Department of Internal Medicine NephrologyCHU de LiègeUniversity of Liège4000 LiegeBelgium Department of Abdominal Surgery and Transplantation CHU de LiègeUniversity of Liège4000 LiegeBelgium Department of Cardiovascular Surgery German Heart Center80636 MunichGermany Department of Internal Medicine GastroenterologyCHU de LiègeUniversity of Liège4000 LiegeBelgium

The association of primary sclerosing cholangitis(PSC)and autoimmune hepatitis(AIH)is known as an overlap syndrome(OS).OS can also be described in the setting of concomitant presence of AIH and *** diseases can in some cases be associated with ulcerative *** this case report we describe,to our knowledge,the first case in the literature of a young Caucasian male suffering from ulcerative colitis and an overlap syndrome consisting of an association betweenPSC-AIH,with the concomitant presence of a membranous glomerulonephritis.

关键词： Primary sclerosing cholangitis Autoimmune hepatitis Overlap syndrome Ulcerative colitis Membranous glomerulonephritis

18-Fluoro-deoxyglucose uptake in inflammatory hepatic adenoma:A case report

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World Journal of Hepatology 2017年第11期9卷 562-566页

作者： Willy Liu jean delwaide Noella Bletard Philippe Delvenne Paul Meunier Roland Hustinx Olivier Detry Department of Abdominal Surgery and Transplantation CHU Liege (CHU-ULg) Department of Hepato-gastroenterology CHU Liege (CHU-ULg) Department of Pathology CHU Liege(CHU-ULg) Department of Pathology CHU Liege (CHU-ULg) Department of Radiology CHU Liege (CHUULg) Department of Nuclear Imaging CHU Liege (CHU-ULg)

Positron emission tomography computed tomography (PET-CT) using 18-Fluoro-deoxyglucose (18FDG) is an imaging modality that reflects cellular glucose metabolism. Most cancers show an uptake of 18FDG and benign tumors do not usually behave in such a way. The authors report herein the case of a 38-year-old female patient with a past medical history of cervical intraepithelial neoplasia and pheochromocytoma, in whom a liver lesion had been detected with PET-CT. The tumor was laparoscopically resected and the diagnosis of inflammatory hepatic adenoma was confirmed. This is the first description of an inflammatory hepatic adenoma with an 18FDG up-take.

关键词： Liver surgery Liver tumor Liver cancer Benign tumor Laparoscopy Prognosis

Epidemiological profiles of human immunodeficiency virus and hepatitis C virus infections in Malian women:Risk factors and relevance of disparities

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World Journal of Hepatology 2013年第4期5卷 196-205页

作者： Nouhoum Bouare Andre Gothot jean delwaide Sebastien Bontems Dolores Vaira Laurence Seidel Paul Gerard Christiane Gerard Department of Clinical Biology Laboratory HematologyImmuno-Hematology and AIDS Reference Laboratory B35Centre Hospitalier UniversitaireUniversité de Liège4000 LiègeBelgium Department of Hepatology and Gastroenterology Centre Hospitalier UniversitaireUniversité de Liège4000 LiègeBelgium Department of Public Health(Biostatistics) Centre Hospitalier UniversitaireUniversité de Liège4000 LiègeBelgium Institute of Mathematics Université de Liège4000 LiègeBelgium

AIM:To document the epidemiologic patterns and risk factors of human immunodeficiency virus(HIV)and hepatitis C virus(HCV)infections in Mali in order to develop prevention means for both ***:Two prospective studies were conducted in Bamako in 2009 among 1000 pregnant women(i.e.,young women)who consulted six reference health centers,and in 2010,among 231 older women who attended general practice in two *** tests and molecular analysis(performed only for HCV)were used to quantify the frequencies of both *** data were collected from patients recruited through a *** risk factors of both diseases were identified by univariate and multivariate ***:HCV seroprevalence was 0.2% for young and 6.5% for older *** prevalence was similar in both populations(4.1% vs 6.1%).In older women,the analysis of risk factors highlighted an association between HCV infection and episodes of hospitalization(P < 0.01).The study did not show an association between HIV infection and the variables such as hospitalization,transfusion,tattoo,dental care,and endoscopy.A significant decrease of HIV seroprevalence was detected in young women who used condoms for contraception more than for other purposes(P < 0.01).By contrast,HIV seroprevalence was significantly increased in young women using condoms mainly to prevent sexual infections rather than for contraception(P < 0.01).No HCV/HIV coinfection was detected in our ***:Risk factors and epidemiologic data of HIV and HCV as well as the absence of co-infection strongly suggest epidemiological disparities between these diseases.

关键词： Hepatitis C virus Human immunodeficiency virus Epidemiology Risk factors Women Mali Bamako

Prevalence of HIV and HCV infections in two populations of Malian women and serological assays performances

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World Journal of Hepatology 2012年第12期4卷 365-373页

作者： Nouhoum Bouare Dolores Vaira Andre Gothot jean delwaide Sebastien Bontems Laurence Seidel Paul Gerard Christiane Gerard Department of Hematobiology Immuno-Hematology and AIDS Reference Laboratory B35CHU-ULg4000 LiegeBelgium Department of Hepatology and Gastroenterology CHU-ULg4000 LiegeBelgium Department of Public Health(Biostatistics) CHU-ULg4000 LiegeBelgium Institute of Mathematics ULg4000 LiegeBelgium

AIM: To estimate the prevalence of human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infections in women in Mali and to evaluate the performance of serological assays.

关键词： Human immunodeficiency virus Hepatitis C virus Serology Molecular diagnostics Women West Africa Bamako

Donation after cardio-circulatory death liver transplantation

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World Journal of Gastroenterology 2012年第33期18卷 4491-4506页

作者： Hieu Le Dinh Arnaud de Roover Abdour Kaba Séverine Lauwick jean Joris jean delwaide Pierre Honoré Michel Meurisse Olivier Detry Department of Abdominal Surgery and Transplantation University Hospital of Liège University of Liège 4000 Liège Belgium Department of Anesthesia and Intensive Care Medicine University Hospital of Liège University of Liège 4000 Liège Belgium Department of Hepatology and Gastroenterol-ogy University Hospital of Liège University of Liège 4000 Liège Belgium

The renewed interest in donation after cardio-circulatory death (DCD) started in the 1990s following the limited success of the transplant community to expand the donation after brain-death (DBD) organ supply and following the request of potential DCD families. Since then, DCD organ procurement and transplantation activities have rapidly expanded, particularly for nonvital organs, like kidneys. In liver transplantation (LT), DCD donors are a valuable organ source that helps to decrease the mortality rate on the waiting lists and to increase the availability of organs for transplantation despite a higher risk of early graft dysfunction, more frequent vascular and ischemia-type biliary lesions, higher rates of re-listing and re-transplantation and lower graft survival, which are obviously due to theinevitable warm ischemia occurring during the declaration of death and organ retrieval process. Experimental strategies intervening in both donors and recipients at different phases of the transplantation process have focused on the attenuation of ischemia-reperfusion injury and already gained encouraging results, and some of them have found their way from pre-clinical success into clinical reality. The future of DCD-LT is promising. Concerted efforts should concentrate on the identification of suitable donors (probably Maastricht category Ⅲ DCD donors), better donor and recipient matching (high risk donors to low risk recipients), use of advanced organ preservation techniques (oxygenated hypothermic machine perfusion, normothermic machine perfusion, venous systemic oxygen persufflation), and pharmacological modulation (probably a multi-factorial biologic modulation strategy) so that DCD liver allografts could be safely utilized and attain equivalent results as DBD-LT.

关键词： Non-heart-beating donation Complication Bile duct Allocation Ischemia Ischemia-reperfusion injury Liver disease

Liver transplantation for acute hepatic failure due to chemotherapy-induced HBV reactivation in lymphoma patients

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World Journal of Gastroenterology 2011年第25期17卷 3069-3072页

作者： Timothée Noterdaeme Luc Longrée Christian Bataille Arnaud Deroover Anne Lamproye jean delwaide Yves Beguin Pierre Honoré Olivier Detry Department of Abdominal Surgery and Transplantation CHU de LiègeUniversity of Liège Department of Medicine Division of Hematology and OncologyCHC LiègeUniversity of Liège Department of Internal Medicine CHR HuyUniversity of Liège Department of Hepatogastroenterology CHU de LiègeUniversity of Liège Department of Medicine Division of HematologyCHU LiègeUniversity of Liège

Hepatitis B （HBV） reactivation induced by chemotherapy is problem encountered recently in the management of malignant diseases. Chemotherapy-induced HBV reacti- vation may ultimately lead to terminal acute liver failure. Liver transplantation （LT） currently remains the only definitive treatment option for such cases, but is generally denied to patients suffering from malignancy. Here, the authors describe 2 cases of cancer-free and HBV graft renfection-free survival after LT performed for terminal liver failure arising from HBV reactivation induced by chemotherapy for advanced stage lymphoma. These 2 cases, and some other reports in the literature, may suggest that patients suffering from hematologic malignan- cies and terminal liver disease can be considered for LT if the prognosis of their hematologic malignancy is good.

关键词： Liver transplantation Contraindication Cancer Liver failure Chemotherapy Hepatitis 13 virus

Cadaveric liver transplantation for non-acetaminophen fulminant hepatic failure:A 20-year experience

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World Journal of Gastroenterology 2007年第9期13卷 1427-1430页

作者： Olivier Detry Arnaud De Roover Carla Coimbra jean delwaide Marie-France Hans Marie Hélène Delbouille Joseé Monard jean Joris Pierre Damas Jacques Belache Michel Meurisse Pierre Honoré Department of Liver Surgery and Transplantation University of Liège CHU Sart Tilman B35Liège B4000 Belgium Department of Hepato- gastroenterology University of Liège CHU Sart Tilman B35 Liège B4000 Belgium Department of Anaesthesia and Intensive Care University of Liège CHU Sart Tilman B35Liège B4000Belgium

AIM: To investigate the long-term results of liver transplantation (LT) for non-acetaminophen fulminant hepatic failure (FHF). METHODS: Over a 20-year period, 29 FHF patients underwent cadaveric whole LT. Most frequent causes of FHF were hepatitis B virus and drug-related (not acetaminophen) liver failure. All surviving patients were regularly controlled at the out-patient clinic and none was lost to follow-up. Mean follow-up was 101 mo. RESULTS: One month, one-, five- and ten-year patient survival was 79%, 72%, 68% and 68%, respectively. One month, one-, five- and ten-year graft survival was 69%, 65%, 51% and 38%, respectively. Six patients needed early (< 2 mo) retransplantation, four for primary non-function, one for early acute refractory rejection because of ABO blood group incompatibility, and one for a malignant tumor found in the donor. Two patients with hepatitis B FHF developed cerebral lesions peri-transplantion: One developed irreversible and extensive brain damage leading to death, and one suffered from deep deficits leading to continuous medical care in a specialized institution. CONCLUSION: Long-term outcome of patients transplanted for non-acetaminophen FHF may be excellent. As the quality of life of these patients is also particularly good, LT for FHF is clearly justified, despite lower graft survival compared with LT for other liver diseases.

关键词： Liver transplantation Liver failure Surgery Hepatitis B Liver support