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Internal anal sphincter augmentation and substitution

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Gastroenterology Report 2014年第2期2卷 106-111页

作者： Fernando de la Portilla Unidad de Gestion Clinica de Cirugia General y del Aparato Digestivo Instituto de Biomedicina de Sevilla(IBIS)SevilleSpain

There is an increasing recognition of the importance of internal anal sphincter(IAS)dysfunction presenting as passive faecal *** problem may manifest after anal sphincterotomy or following the more minimally invasive operations for haemorrhoids,as well as with advancing *** of the poor results of IAS plication and the beneficial outcomes with peri-urethral bulking agents in urology,these materials have been developed for use in IAS *** review outlines the basic purported mechanisms of action,defining the materials in clinical use,their methods of deployment,complications and reported *** is still much that is unknown concerning the ideal agent or the volume and the technique of deployment,which will only be answered by powerful,prospective,randomized,controlled *** specific role of autologous stem cells designed to regenerate the sphincters in cases of functional impairment or muscle loss is yet to be seen.

关键词： faecal incontinence internal anal sphincter dysfunction internal anal sphincter augmentation bulking agents

Subjective experience and visual attention to a historic building:A real-world eyetracking study

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Frontiers of Architectural Research 2020年第4期9卷 774-804页

作者： Luis Alfonso de la Fuente Suarez Architecture School Universidad Autonoma de Nuevo LeonSon Nicolos de los Garza(Monterrey)66455Mexico

The objective of this exploratory study is to discover the relations between visual attention to an architectural work and the subjective experiences produced during its observation.A subjective experience with a building is the specific manner in which an architectural element or the building as a whole are presented to a *** qualities of the element as how they are perceived and the inner world of the observer are both considered in this subjective *** aims of this study are to describe the experience that a building generates in people,pinpoint what has attracted the participant's attention during each view of the building in an itinerary;and understand which aspects of this selected case study have made it an object of attend *** eye-tracking study was carried out using a portable eye *** tool allowed the participants to walk freely around the exterior of a historic train station in the city of Monterrey,*** groups of participants,with routes starting from opposite sides of the building,contemplated it while using the eye *** tracking allowed for the identification of the architectural elements that were objects of attention,the lengths of observation,and the points of view from which the elements were *** data collection techniques,such as the think-aloud protocol and a special type of survey,were used to deeply understand the experiences that accompanied the visual exploration of the historic *** suggest that the participants observed the different architectural elements for a time that was neither influenced by the route used to explore the building nor the point where that route was *** architectural elements identified as examples of high-quality architecture and perceived as aesthetically pleasing by the participants during the itinerary were observed for longer times.

关键词： Eye tracking Architecture Attention Subjective experience Data visualization

Edge robotics:are we ready?an experimental evaluation of current vision and future directions

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Digital Communications and Networks 2023年第1期9卷 166-174页

作者： Milan Groshev Gabriele Baldoni Luca Cominardi Antonio de la Oliva Robert Gazda University Carlos Ⅲ of Madrid Leganes28028MadridSpain ZettaScale Technology SARL Saint-Aubin91190France InterDigital Inc. WilmingtonDE19809USA

Cloud-based robotics systems leverage a wide range of Information Technologies(IT)to offer tangible benefits like cost reduction,powerful computational capabilities,data offloading,***,the centralized nature of cloud computing is not well-suited for a multitude of Operational Technologies(OT)nowadays used in robotics systems that require strict real-time guarantees and *** computing and fog computing are complementary approaches that aim at mitigating some of these challenges by providing computing capabilities closer to the *** goal of this work is hence threefold:i)to analyze the current edge computing and fog computing landscape in the context of robotics systems,ii)to experimentally evaluate an end-to-end robotics system based on solutions proposed in the literature,and iii)to experimentally identify current benefits and open challenges of edge computing and fog *** show that,in the case of an exemplary delivery application comprising two mobile robots,the robot coordination and range can be improved by consuming real-time radio information available at the ***,our evaluation highlights that the existing software,wireless and virtualization technologies still require substantial evolution to fully support edge-based robotics systems.

关键词： Edge robotics experimental fog MEC Virtualization ROS Fog05

In-Situ Annealed Ti_(3)C_(2)T_(x) MXene Based All-Solid-State Flexible Zn-Ion Hybrid Micro Supercapacitor Array with Enhanced Stability

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Nano-Micro Letters 2021年第6期13卷 332-342页

作者： la Li Weijia Liu Kai Jiang Di Chen Fengyu Qu Guozhen Shen State Key laboratory for Superlattices and Microstructures Institute of SemiconductorsChinese Academy of Sciences and Center of Materials Science and Optoelectronic EngineeringUniversity of Chinese Academy of SciencesBeijing 100083People’s Republic of China School of Mathematics and Physics University of Science and TechnologyBeijingBeijing 100083People’s Republic of China Falculty of Hepato-Pancreato-Biliary Surgery Chinese PLA General HospitalInstitute of Hepatobiliary Surgery of Chinese PLA and Key Laboratory of Digital Hepetobiliary SurgeryChinese PLABeijing 100853People’s Republic of China College of Chemical and Chemistry Harbin Normal UniversityHarbinPeople’s Republic of China

Zn-ion hybrid supercapacitors(SCs)are considered as promising energy storage owing to their high energy density compared to traditional *** to realize the miniaturization,patterning,and flexibility of the Zn-ion SCs without affecting the electrochemical performances has special meanings for expanding their applications in wearable integrated ***_(3)C_(2)T_(x) cathode with outstanding conductivity,unique lamellar structure and good mechanical flexibility has been demonstrated tremen-dous potential in the design of Zn-ion SCs,but achieving long cycling stability and high rate stability is still big ***,we proposed a facile laser writing approach to fabricate patterned Ti_(3)C_(2)T_(x)-based Zn-ion micro-supercapacitors(MSCs),followed by the in-situ anneal treatment of the assembled MSCs to improve the long-term stability,which exhibits 80%of the capacitance retention even after 50,000 charge/discharge cycles and superior rate *** influence of the cathode thickness on the electrochemical performance of the MSCs is also *** the thickness reaches 0.851μm the maximum areal capacitance of 72.02 mF cm^(−2)at scan rate of 10 mV s^(−1),which is 1.77 times higher than that with a thickness of 0.329μm(35.6 mF cm^(−2)).Moreover,the fab-ricated Ti_(3)C_(2)T_(x) based Zn-ion MSCs have excellent flexibility,a digital timer can be driven by the single device even under bending state,a flexible LED displayer of“TiC”logo also can be easily lighted by the MSC arrays under twisting,crimping,and winding conditions,demonstrating the scalable fabrication and application of the fabricated MSCs in portable electronics.

关键词： Ti_(3)C_(2)T_(x) MXene laser writing Zn-ion hybrid supercapacitor Flexible energy storage

The Jacobian Dual of Certain Mixed Product Ideals

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Algebra Colloquium 2020年第2期27卷 263-280页

作者： M.la Barbiera M.lahyane G.Restuccia Dipartimento di Scienze Matematiche e Informatiche Scienze Fisiche e Scienze Della TerraUniversity of Messina98166 MessinaItaly Instituto de Fisica y Matematicas(IFM)Universidad Michoacana de San Nicolas de Hidalgo(UMSNH)Edificio C-3 Ciudad UniversitariaC.P.58040 MoreliaMichoacanMexico

We consider the symmetric algebra of a class of monomial ideals generated by *** these ideals with linear syzygies,we determine their Jacobian dual modules and study their duality properties.

关键词： graded algebra symmetric algebra monomial ideal Jacobian dual

Determination of Parameters of Time-delayed Embedding Algorithm Using Koopman Operator-based Model Predictive Frequency Control

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CSEE Journal of Power and Energy Systems 2021年第6期7卷 1140-1151页

作者： Xiawen Li Chetan Mishra Shichao Chen Yajun Wang Jaime De la Ree Dominion Energy RichmondVAUSA Thorlabs Quantum Electronics. JessupMDUSA Department of Electrical and Computer Engineering Virginia Polytechnic Institute and State UniversityBlacksburgVAUSA

Power systems around the world have been registering a degenerating inertial response in view of the growth of inverter-based resources along with the withdrawal of conventional coal ***,there is a need for swift frequency support and its control,preferably by means of power electronic-interfaced storage devices,owing to their beneficial *** being particularly efficient,pragmatically,the traditional model-based non-linear control techniques are not highly popular in power system control design,primarily due to the complications faced in obtaining accurately suitable models for certain power system ***,the modelfree Koopman operator-based model predictive control(KMPC)has proven to be highly conducive for data-driven non-linear control *** principle behind KMPC is to change the coordinates in a manner to get an approximately linear model,which can then be controlled using a linear model predictive *** this study,we employed time-delayed embedding of measurements to reconstruct a new set of preferable coordinates,thereby suggesting an approach for finding the optimal number of time lags and the embedding dimensions which are the key parameters of this *** efficacy of this KMPC framework is established by adopting a decentralized frequency control problem through a decoupled synchronous machine system,which we proposed for both the Kundur two-area system as well as the IEEE 39-bus test system.

关键词： False nearest neighbors koopman operator model predictive control non-linear control time-delayed embedding

Analysis of protein features and machine learning algorithms for prediction of druggable proteins

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Frontiers of Electrical and Electronic Engineering in China 2018年第4期6卷 334-343页

作者： Tanlin Sun Luhua la Jianfeng Pei Center for Quantitative Biology Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100871China Beijing National laboratory for Molecular Science State Key Laboratory for Structural Chemistry of Unstable and Stable SpeciesCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China Peking-Tsinghua Center for Life Sciences Peking UniversityBeijing 100871China

Background Computational tools have been widely used in drug discovery process since they reduce the time and cost. Prediction of whether a protein is druggable is fundamental and crucial for drug research pipeline. Sequence based protein function prediction plays vital roles in many research areas. Training data, protein features selection and machine learning algorithms are three indispensable elements that drive the successfulness of the *** In this study, we tested the performance of different combinations of protein features and machine learning algorithms, based on FDA-approved small molecules’ targets, in druggable proteins *** also enlarged the dataset to include the targets of small molecules that were in experiment or clinical *** We found that although the 146-d vector used by Li et al. with neuron network achieved the best training accuracy of 91.10%, overlapped 3-gram word2vec with logistic regression achieved best prediction accuracy on independent test set (89.55%) and on newly approved-targets. Enlarged dataset with targets of small molecules in experiment and clinical investigation were trained. Unfortunately, the best training accuracy was only 75.48%. In addition, we applied our models to predict potential targets for references in future *** Our study indicates the potential ability of word2vec in the prediction of druggable protein. And the training dataset of druggable protein should not be extended to targets that are lack of verification. The target prediction package could be found on https://***/***/pkumdl/target_prediction.

关键词： druggable protein drug target word2vec deep learning

THE FORMATION, EVOLUTION AND OPTIMAZATION OF TERRITORIAL STRUCTURE IN THE SOUTHERN CHINA

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Chinese Geographical Science 2000年第1期10卷 45-52页

作者： la-chang Lu Xue-qiang Xu Department of Geography Guangzhou Normal University Guangzhou P. R. China Center of Urban & Regional Studies Zhongshan University Guangzhou P. R. China

With the change of geopolitical pattern of the world, pacific rim area increases economic cooperation, instead of military antagonism. After reform and open to outside world, the southern China takes in an amount of investment from Hongkong, Macao and Taiwan, taking advantage of superior geo environment and thus forms a topical model of core periphery in the southern China. The core periphery model in the southern China is territorially made of three parts: core area — Hong Kong, Macao and Taiwan; peripherial area — Zhujiang delta; second core area — parts of Hunan Province, Jiangxi Province, Fujian Province and Hainan Province and Guangxi Zhuang Autonomous Region. Its evolutional stage of this model can be divided into four stages: (1) the stage of polarization of core area; (2) the stage of the second core area strongly controlled by core area; (3) the transitional stage of the second area; (4) the stage of the southern China space integrity. Taking the core periphrial model in the southern China as an integrity of interrelational and rational division, its whole functional organized system is “input product assemble output”, core area is mainly then as the managed and transported center, the second area plays a product and productive control function and becomes center of manufacturing, study and development, periphrial area constructs as the center of material and raw material and the base of agricultural and side line products. Based on the analysis of the formative structure, evolutional law and the design of territorial function, we suggust the way of territerial optimazation as follows: (1) establishing the large hinterland which takes Xijiang basin as its core; (2) construct the high and renewed technological corridor; (3) constructing stable and varied material and raw material base; (4) reinforcing the organization and adjustment and managment between core area, periphrial area and second periphrial area. (5) constucting the varied corridor among core are

关键词： the southern China territorial structure formation and evolution territorial optimization

Antidepressant foods:An evidence-based nutrient profiling system for depression

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World Journal of Psychiatry 2018年第3期8卷 97-104页

作者： laura R la Chance Drew Ramsey Centre for Addiction and Mental Health Department of Psychiatry University of Toronto Department of Psychiatry Columbia University College of Physicians and Surgeons

AIM To investigate which foods are the most nutrient dense sources of nutrients demonstrated by the scientific literature to play a role in the prevention and promotion of recovery from depressive disorders. METHODS A systematic literature review was conducted to derive a list of Antidepressant Nutrients from the 34 nutrients known to be essential for humans using level of evidence criteria. Nutritional data was extracted for a subset of foods with a high content of at least 1 Antidepressant Nutrient using a USDA database. These foods were analyzed for Antidepressant Nutrient density resulting in an Antidepressant Food Score(AFS). Plant and animal foods were analyzed separately. RESULTS Twelve Antidepressant Nutrients relate to the prevention and treatment of depressive disorders: Folate, iron, longchain omega-3 fatty acids(EPA and DHA), magnesium, potassium, selenium, thiamine, vitamin A, vitamin B6, vitamin B12, vitamin C, and zinc. The highest scoring foods were bivalves such as oysters and mussels, various seafoods, and organ meats for animal foods. The highest scoring plant foods were leafy greens, lettuces, peppers, and cruciferous vegetables. CONCLUSION The AFS is based on a nutrient profiling system devised to identify foods with the highest nutrient density of nutrients with clinical evidence to support theirrole in depressive disorders. This list of foods and food categories with the highest density of the 12 Antidepressant Nutrients, the Antidepressant Foods, should be considered by researchers in the design of future intervention studies and clinicians as dietary options to support prevention and recovery from depression disorders.

关键词： Depressive disorder Mental disorders Diet Diet therapy Food