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Using Optical Tweezers to Study the Friction of the Red Blood Cells

Advances in Bioscience and Biotechnology 2024年第2期15卷 100-111页

作者： edoukoua jea. michel konin Pavel Yale Abadê Ange-Boris N’guessan Kouassi Benoit Kouakou Abaka michel Kouacou Eugene Megnassan Département des Sciences et Techniques Université Alassane Ouattara Bouaké C&#244te d’Ivoire Laboratoire d’Instrumentation Image et Spectroscopie (L2IS) Institut National Polytechnique Félix Houphou&#235t-Boigny (INPHB) Yamoussoukro C&#244te d’Ivoire Classes préparatoires aux grandes Ecoles Université de San Pedro San Pedro C&#244te d’Ivoire Laboratoire de Physique Fondamentale et Appliquée Université Nangui Abrogoua (UNA) Abidjan C&#244te d’Ivoire

In the last two decades the study of red blood cell elasticity using optical tweezers has known a rise appearing in the scientific research with regard to the various works carried out. Despite the various work done, no study has been done so far to study the influence of friction on the red blood cell indentation response using optical tweezers. In this study, we have developed a new approach to determine the coefficient of friction as well as the frictional forces of the red blood cell. This approach therefore allowed us to simultaneously carry out the indentation and traction test, which allowed us to extract the interfacial properties of the microbead red blood cell couple, among other things, the friction coefficient. This property would be extremely important to investigate the survival and mechanical features of cells, which will be of great physiological and pathological significance. But taking into account the hypothesis of friction as defined by the isotropic Coulomb law. The experiment performed for this purpose is the Brinell Hardness Test (DB).

关键词： Friction Indentation Optical Tweezers Tribology Red Blood Cells

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Human Eosinophil Cell Manipulation by Optical Tweezers

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Open Journal of Biophysics 2024年第3期14卷 330-338页

作者： Pavel Yale jea. michel edoukoua.konin Abadê Ange-Boris N’guessan michel Abaka Kouacou Jérémie T. Zoueu Laboratoire dInstrumentation Image et Spectroscopie (L2IS) Institut National Polytechnique Houphout-Boigny (INPHB) Yamoussoukro Cte dIvoire Laboratoire de Chimie et de Physique Appliques Sciences et Techniques Universit Alassane Ouattara Bouak Cte dIvoire

In this work, lateral deformation of human eosinophil cell during the lateral indentation by an optically trapped microbead of diameter 4.5 µm is studied. The images were captured using a CCD camera and the Boltzmann statistics method was used for force calibration. Using the Hertz model, we calculated and compared the elastic moduli resulting from the lateral force, showing that the differences are important and the force should be considered. Besides the lateral component, the setup also allows us to examine the lateral cell-bead interaction. The mean values of the properties obtained, in particular the elastic stiffness and the shear stiffness, were Eh = (37.76 ± 2.85) µN/m and Gh = (12.57 ± 0.32) µN/m. These results show that the lateral indentation can therefore be used as a routine method for cell study, because it enabled us to manipulate the cell without contact with the laser.

关键词： Optical Tweezers Human Eosinophil Cell Indentation Shear Stiffness

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Dynamics Study of the Deformation of Red Blood Cell by Optical Tweezers

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Open Journal of Biophysics 2017年第2期7卷 59-69页

作者： konin E. jea. michel Yale Pavel Megnassan Eugene michel A. Kouacou Jeremie T. Zoueu Laboratoire d’Instrumentation Image et Spectroscopie UMRI EEA INP-HB Yamoussoukro Cote d’Ivoire Laboratoire de Physique Fondamentale et Appliquée UNA Abidjan Cote d’Ivoire

In recent years, extensive research has been carried out on red blood cells in order to investigate their mechanical properties. The interest in these studies has been possible thanks to the technological innovations made in the field of micro or nano manipulation of biological and non-biological particles without physical contact. In the present project, we have developed a new approach to study the deformation of red blood cells moving against a trapped microbead by applying a sinusoidal voltage (DC offset 3.5 Vpp) to the stage at 0.4 Hz frequencies. The oscillating movement imposed on the stage highlights the indentation test and the tensile test known for the study of mechanical behavior of materials. The mechanical properties found are: the modulus of elasticity (Young Modulus), the shear modulus, the coefficient of hardening and erythrocyte resistance coefficient. The axial shear modulus 25.00 ± 1.5 μN/m and the transversal shear modulus 15.7 ± 4.63 μN/m were compared to those in the literature. These values were respectively determined by Hooke’s law and the Hertz model.

关键词： Optical Tweezers Elasticity Mechanical Properties Tensile Indentation

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Prognostic Role of Pulse Pressure in the Acute Phase of Myocardial Infarction

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World Journal of Cardiovascular Diseases 2015年第8期5卷 254-260页

作者： Justin Koffi Christoph konin Yves N’goran Arnaud Ekou Ambroise Gnaba Esaie Soya Marie Paul N’Cho Mottoh Bénédict Boka michel Adoh Adoh Institute of Cardiology of Abidjan University of Cocody Abidjan Ivory Coast Hospital of the National Police Abidjan Ivory Coast

Objective: Pulse pressure is a cardiovascular risk factor. The aim of our study was to assess the short and medium term prognosis of myocardial infarction in the African black having a high pulse pressure. Methods: We performed a comparative retrospective study of 200 patients hospitalized in the Cardiology Institute of Abidjan. The first group (100 patients) had a high pulse pressure (≥60 mmHg). The second (100 patients) had normal pulse pressure (≤60 mmHg). The primary outcome was mortality. Secondary endpoints were represented by hemodynamic complications, rhythmic and conduction disturbances. Both groups of patients were matched. The matching is performed by socio-demographic criteria, the seat of necrosis and cardiovascular risk factors. The authors explained the choice of 60 mmHg as references because in all their studies they have realized that it is from 60 mmHg pulse pressure morbid events that occur in prospective studies and retrospective studies in stiffness of the great arteries is responsible for all these events. Pulse pressure is in itself, an independent cardiovascular risk factor in systolic blood pressure, diastolic blood pressure when associated with myocardial infarction, it becomes from 60 mmHg poor prognostic factor especially in the acute phase. Results: The mean age was 54.46 ± 10.10 years for patients with normal pulse pressure and 52.32 ± 10.89 years in patients with high pulse pressure. Patients with elevated pulse pressure were twice as left ventricular failure (Chi2 = 3.71;P = 0.048 = 2 OR 95% CI = 0.93 to 4.29). These patients had an ejection fraction and fractional shortening double bass (Chi2 = 31.23 P = 0.00001, OR = 2.2 95% CI 0.8 to 17.4) 10 mmHg for increased pulse pressure we observed an average growth of 18% mortality rate. Mortality was three times higher in patients with elevated pulse pressure (Khi2 = 15, 06 ddl = 1 P = 0.0001 OR = 3.34 95% CI 1.72 to 6.52). Conclusion: The high pulse pressure represented an independent poor

关键词： Myocardial Infarction Pulsed Pressure African

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