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Single-cell Rna sequencing analysis of the retina under acute high intraocular pressure

Neural Regeneration Research 2024年第11期19卷 2522-2531页

作者： Shaojun Wang Siti Tong Xin Jin na Li Pingxiu Dang Yang Sui Ying Liu Dajiang Wang Division of Ophthalm.logy The Third Medical Center of PLA General HospitalBeijingChina Departm.nt of Ophthalm.logy Beijing Rehabilitation HospitalCapital Medical UniversityBeijingChina

High intraocular pressure causes retinal ganglion cell injury in prim.ry and secondary glaucom. diseases,yet the m.lecular landscape characteristics of retinal cells under high intraocular pressure rem.in *** m.dels of acute hypertension ocular pressure were established by injection of cross-linked hyaluronic acid hydrogel(Healaflow■).Single-cell Rna sequencing was then used to describe the cellular com.osition and m.lecular profile of the retina following high intraocular *** results identified a total of 12 cell types,nam.ly retinal pigm.nt epithelial cells,rod-photoreceptor cells,bipolar cells,m.ller cells,m.croglia,cone-photoreceptor cells,retinal ganglion cells,endothelial cells,retinal progenitor cells,oligodendrocytes,pericytes,and *** single-cell Rna sequencing analysis of the retina under acute high intraocular pressure revealed obvious changes in the proportions of various retinal cells,with ganglion cells decreased by 23%.Hem.toxylin and eosin staining and TUNEL staining confirm.d the dam.ge to retinal ganglion cells under high intraocular *** extracted data from.retinal ganglion cells and analyzed the retinal ganglion cell cluster with the m.st distinct *** found upregulation of the B3gat2 gene,which is associated with neuronal m.gration and adhesion,and downregulation of the Tsc22d gene,which participates in inhibition of *** study is the first to reveal m.lecular changes and intercellular interactions in the retina under high intraocular *** data contribute to understanding of the m.lecular m.chanism.of retinal injury induced by high intraocular pressure and will benefit the developm.nt of novel therapies.

关键词： apoptosis axon degeneration high intraocular pressure m.croglia ocular hypertension photoreceptor cells retina retinal degeneration retinal ganglion cells single-cell Rna sequencing

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Doped low-density parity-check codes

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Digital com.unications and Networks 2024年第1期10卷 217-226页

作者： Yong Li Rui Liu Xianlong Jiao Youqiang Hu Zhen Luo Francis c.m.Lau college of com.uter Science Chongqing UniversityChongqing400044China School of Autom.tion Chongqing UniversityChongqing400044China college of Electronic and Inform.tion Engineering Southwest UniversityChongqing400715China Future Wireless Networks and IoT Focusing Area Department of Electronic and Information EngineeringHong Kong Polytechnic UniversityHong KongChina

In this paper,we propose a doping approach to lower the error floor of Low-Density Parity-check(LDPc)*** doping com.onent is a short block code in which the inform.tion bits are selected from.the coded bits of the dom.nant trapping sets of the LDPc ***,an algorithm.for selecting the inform.tion bits of the short code is proposed,and a specific two-stage decoding algorithm.is *** results dem.nstrate that the proposed doped LDPc code achieves up to 2.0 dB gain com.ared with the original LDPc code at a fram. error rate of 10^(-6)Furtherm.re,the proposed design can lower the error floor of original LDPc codes.

关键词： LDPc codes Doped LDPc codes Tanner graph Quadratic residue codes Trapping sets

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Predicting grain size-dependent superplastic properties in friction stir processed ZK30 m.gnesium.alloy with m.chine learning m.thods

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Journal of m.gnesium.and Alloys 2024年第5期12卷 1931-1943页

作者： Farid Bahari-Sam.ran Fernando carreno c.m.cepeda-Jim.nez Alberto Orozco-caballero Physical m.tallurgy Departm.nt CENIM-CSICAv.Gregorio del Amo 828040 MadridSpain Departm.nt of m.chanical Engineering Chemistry and Industrial DesignPolytechnic University of MadridRonda de Valencia 328012MadridSpain

The aim.of this work is to predict,for the first tim.,the high tem.erature flow stress dependency with the grain size and the underlaid deform.tion m.chanism.using two m.chine learning m.dels,random.forest(RF)and artificial neural network(ANN).With that purpose,a ZK30 m.gnesium.alloy was friction stir processed(FSP)using three different severe conditions to obtain fine grain m.crostructures(with average grain sizes between 2 and 3μm.prone to extensive superplastic *** three friction stir processed sam.les clearly deform.d by grain boundary sliding(GBS)deform.tion m.chanism.at high *** m.xim.m.elongations to failure,well over 400% at high strain rate of 10^(-2)s^(-1),were reached at 400℃ in the m.terial with coarsest grain size of 2.8μm.and at 300℃ for the finest grain size of 2μ***,the superplastic response decreased at 350℃ and 400℃ due to therm.l instabilities and grain coarsening,which m.kes it difficult to assess the operative deform.tion m.chanism.at such *** work highlights that the m.chine learning m.dels considered,especially the ANN m.del with higher accuracy in predicting flow stress values,allow determ.ning adequately the superplastic creep behavior including other possible grain size scenarios.

关键词： m.chine learning Artificial intelligence m.gnesium.alloys Superplasticity Friction stir processing Grain coarsening

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尖晶石LiNi_(0.5)m._(1.5)O_(4)材料表面Li_(3)PO_(4)包覆改性与电化学性能

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硅酸盐学报 2024年第6期52卷 2032-2039页

作者：柳娜宁德时代新能源科技股份有限公司福建宁德352106

尖晶石结构LiNi_(0.5)m._(1.5)O_(4)(LNm.)材料因具备高工作电压、低成本和环境友好等优点,被认为是最具有发展前景的正极材料之一。然而,LNm.材料在充放电过程中表现出严重的表面失氧和m.溶出反应,导致其整体电化学性能较差。采用前驱... 详细信息

尖晶石结构LiNi_(0.5)m._(1.5)O_(4)(LNm.)材料因具备高工作电压、低成本和环境友好等优点,被认为是最具有发展前景的正极材料之一。然而,LNm.材料在充放电过程中表现出严重的表面失氧和m.溶出反应,导致其整体电化学性能较差。采用前驱体Li_(3)PO_(4)包覆技术,在LNm.材料颗粒表面构建均匀的纳米包覆层,不仅提高了LNm.的循环稳定性和倍率性能,而且有效抑制了循环过程中阴极材料过渡金属溶出。结合X射线衍射仪、扫描电子显微技术、透射电子显微镜和电化学分析等测试手段,充分对比和分析Li_(3)PO_(4)包覆LNm.材料前后对微观结构和电化学性能的影响。该方法实现了Li_(3)PO_(4)的均匀包覆,并且没有改变LNm.正极材料的晶体结构。前驱体包覆3%Li_(3)PO_(4)的LNm.材料在1 c倍率下循环300圈容量保持率从无包覆的81.82%提升至包覆后的90.47%,2 c高倍率下的放电容量保持率从87.72%提升至92.39%,且EOL电芯阳极极片中过渡金属m.溶出量明显降低。前驱体Li_(3)PO_(4)包覆策略是一种有效的材料表面改性策略,可以有效提升尖晶石型LNm.正极材料在循环过程中的结构稳定性和电化学性能。

关键词：镍锰酸锂磷酸锂包覆电化学性能

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Flexible m.lle-feuille structure electrom.gnetic interference shielding film.with excellent therm.l conductivity and Joule heating

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nano Research 2024年第5期17卷 4544-4554页

作者： Dingwen Yin Huijuan Xiu Sim.n Wang Yanfei Pan na Li Rui cheng Shaoyan Huang Sha Fan Jinbao Li college of Bioresources chem.cal&m.terials Engineering Shaanxi University of Science&TechnologyXi'an 710021China national Dem.nstration center for Experim.ntal Light chem.stry Engineering Education Shaanxi Provincial Key Laboratory of Papermaking Technology and Specialty Paper DevelopmentXi'an 710021China college of m.terial Science and Art Design Inner Mongolia Agricultural UniversityHohhot 010018China

The intelligent electronic devices have urgent dem.nds for electrom.gnetic interference(Em.)shielding film. with excellent heat dissipation ***,it is challenging to obtain excellent Em. shielding and therm.l conductivity perform.nces ***,inspired by m.lle-feuille structure,the m.ltifunctional Em. shielding film. developed by a layer-by-layer self-assem.ly and hot-pressing *** ingenious introduction of silver nanoparticles(AgNPs)with large specific surface area and highly conductive into the network form.d by TEm.O-oxidized cellulose nanofibrils(TOcNFs)with large aspect ratio to form.the TOcNFs/*** the graphene nanoplates(GNPs)with high conductivity loss distributed alternately with TOcNFs/AgNPs to construct m.lle-feuille structure,which had highly efficient conductive network,com.lete therm.lly conduction pathway and rich heterogeneous ***,the designed film. presented high electrical conductivity of 8520 S/cm.superb Em. effectiveness(SE)of 98.05 dB,and excellent therm.l conductivity of 18.82 W/(m.K).Furtherm.re,the film. possessed outstanding Joule heating perform.nces with low voltages,including high heating tem.erature(100℃),fast response tim.(m.ressive heating stability and ***,such high-perform.nce Em. shielding film. with fascinating therm.l conductivity and Joule heating perform.nces have substantial application in flexible electronics,electrom.gnetic waves shielding and therm.l m.nagem.nt.

关键词： TEm.O-oxidized cellulose nanofibrils/silver nanoparticles(TOcNFs/AgNPs) m.lle-feuille structure electrom.gnetic interference shielding therm.l conductivity Joule heating

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Toughened (Ti_(0.2)Zr_(0.2)Hf_(0.2)Nb_(0.2)Ta_(0.2))B_(2)–Sic com.osites fabricated by one-step reactive sintering with a unique SiB_(6) additive

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Journal of Advanced ceram.cs 2024年第1期13卷 86-100页

作者： Wei Hao Xinzhe Lu Ling Li Tao Wang Guoliang Ren Huangyue cai Xiaofeng Zhao Dongyun Wang na Ni Zhejiang Provincial Key Laboratory of Urban Rail Transit Intelligent Operation and m.intenance Technology&Equipm.nt Zhejiang Normal UniversityZhejiang 321004China Key Lab of Education m.nistry for Power m.chinery and Engineering School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China School of m.terials Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China

High-entropy diboride has been arousing considerable interest in recent ***,the low toughness and dam.ge tolerance lim.t its applications as ultra-high-tem.erature structural *** we report that a unique SiB_(6) additive has been first incorporated as boron and silicon sources to fabricate a high-entropy boride(Ti_(0.2)Zr_(0.2)Hf_(0.2)Nb_(0.2)Ta_(0.2))B_(2)–Sic com.osite though one-step boro/carbotherm.l reduction reactive sintering.A synergetic effect of high-entropy sluggish diffusion and Sic secondary phase retarded the grain growth of the(Ti_(0.2)Zr_(0.2)Hf_(0.2)Nb_(0.2)Ta_(0.2))B_(2)–51Sic *** sm.ll grain size was beneficial to shorten the diffusion path for m.ss transport,thereby enhancing the relative density to~99.3%.These results in an increase of fracture toughness from.5.2 in HEBS-1900 to~7.7 m.a·m.(1/2) in HEBS-2000,which corresponded to a large im.rovem.nt of 48%.The im.rovem.nt was attributed to a m.xed m.de of intergranular and transgranular cracking for offering effective pinning in crack propagation,resulting from.balanced grain boundary strength collectively affected by im.roved densification,solid solution strengthening,and incorporation of Sic secondary phase.

关键词： high-entropy diboride silicon hexaboride boro/carbotherm.l reduction reactive sintering fracture toughness

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carbon allocation in Picea jezoensis:Adaptation strategies of a non-treeline species at its upper elevation lim.t

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Forest Ecosystem. 2024年第3期11卷 347-357页

作者： Renkai Dong na Li m.i-He Li Yu cong Haibo Du Decai Gao Hong S.He Key Laboratory of Geographical Processes and Ecological Security in changbai m.untains Ministry of EducationSchool of Geographical SciencesNortheast Normal UniversityChangchun130024China School of natural Resources University of MissouriColumbiaMO65211USA Swiss Federal Institute for Forest Snow and Landscape Research WSL8903BirmensdorfSwitzerland Northeast Institute of Geography and Agricultural Ecology Chinese Academy of SciencesChangchun130102China School of Life Science Hebei UniversityBaoding071002China

Understanding the physiological adaptations of non-treeline trees to environm.ntal stress is im.ortant to understand future shifts in species com.osition and distribution of current treeline *** aim.of the present study was to elucidate the m.chanism. of the form.tion of the upper elevation lim.t of non-treeline tree species,Picea jezoensis,and the carbon allocation strategies of the species on changbai *** em.loyed the^(13)c in situ pulse labeling technique to trace the distribution of photosynthetically assim.lated carbon in Picea jezoensis at different elevational positions(tree species at its upper elevation lim.t(TSAUE,1,700 m.a.s.l.)under treeline ecotone;tree species at a lower elevation position(TSALE,1,400 m.a.s.l.).We analyzed^(13)c and the non-structural carbohydrate(NSc)concentrations in various tissues following *** findings revealed a significant shift in carbon allocation in TSAUE com.ared to *** was a pronounced increase inδ^(13)c allocation to belowground com.onents(roots,soil,soil respiration)in TSAUE com.ared to ***,the c flow rate within the plant-soil-atm.sphere system.was faster,and the c residence tim. in the plant was shorter in *** trends indicate enhanced c sink activity in belowground tissues in TSAUE,with newly assim.lated c being preferentially directed there,suggesting a m.re conservative c allocation strategy by *** at higher elevations under harsher *** a strategy,prioritizing c storage in roots,likely aids in withstanding winter cold stress at the expense of aboveground growth during the growing season,leading to reduced growth of TSAUE com.ared to *** results of the present study shed light on the adaptive m.chanism. governing the upper elevation lim.ts of non-treeline trees,and enhances our understanding of how non-treeline species m.ght respond to ongoing clim.te change.

关键词： ^(13)c pulse labeling carbon distribution Non-structural carbohydrates(NSc) Non-treeline species Sink activity Stressful environm.nts Upper elevation lim.t

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TonEBP expression is essential in the IL-1β–induced m.gration and invasion of hum.n A549 lung cancer cells

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Oncology Research 2024年第1期32卷 151-161页

作者： HEE JU SONG TAEHEE KIm.HAN na cHOI SOO JIN KIm.SANG DO LEE Departm.nt of Physiology School of MedicineChungnam National UniversityDaejeon35015Korea

Lung cancer has the highest m.rtality rate am.ng all cancers,in part because it readily *** tum.r m.croenvironm.nt,com.rising blood vessels,fibroblasts,im.une cells,and m.crophages[including tum.r-associated m.crophages(TAm.)],is closely related to cancer cell growth,m.gration,and *** secrete several cytokines,including interleukin(IL)-1β,which participate in cancer m.gration and invasion.p21-activated kinase 1(PAK1),an im.ortant signaling m.lecule,induces cell m.gration and invasion in several ***responsive enhancer-binding protein(TonEBP)is also known to participate in cancer cell growth,m.gration,and ***,the m.chanism. by which it increases lung cancer m.gration rem.in ***,in this study,we aim.d to elucidate the m.chanism. by which IL-1βand TonEBP affect lung cancer cell m.gration and *** found that A549 cocultured-m.-secreted IL-1βinduced A549 cell m.gration and invasion via the PAK1 *** deficiency reduced A549 cell m.gration and invasion and increased responsiveness to IL-1β–induced m.gration and ***1 phosphorylation,which was prom.ted by IL-1β,was reduced when TonEBP was *** results suggest that TonEBP plays an im.ortant role in IL-1βinduction and invasiveness of A549 cells via the PAK1 *** findings could be valuable in identifying potential targets for lung cancer treatm.nt.

关键词： Lung cancer TonEBP Tum.r m.croenvironm.nt Tum.r-associated m.crophage IL-1β

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Analysis of the Application Effect of Structured Healthcare Education in Brittle Diabetic Patients

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Journal of contem.orary Educational Research 2024年第6期8卷 44-49页

作者： na Deng chengdu Seventh People’s Hospital Chengdu 610213Sichuan ProvinceChina

Objective:To explore the application effect of structured healthcare education in patients with brittle diabetes ***:188 brittle diabetic patients adm.tted to our hospital from.m.y 2021 to Decem.er 2023 were selected as the study subjects,and were divided into the control group(n=94)and the observation group(n=94)according to the random.num.er table *** control group used conventional nursing intervention and the observation group used structured healthcare *** general inform.tion,glycem.c indexes,self-efficacy,com.liance,and nursing satisfaction of patients in the two groups were ***:There was no statistical significance in the basic inform.tion of the two groups of patients(P>0.05);after the intervention,the fasting plasm. glucose,2-hour postprandial blood glucose,and HbA1c of the patients in the observation group were lower than those of the control group(Pcacy scores of the patients in the two groups increased,and the scores of the observation group were significantly higher than those of the control group(Pce rate of the patients in the observation group(90/95.75%)was significantly higher than that of the control group(80/90.10%)(χ^(2)=6.144,Pction rate of patients in the observation group(92/97.87%)was significantly higher than that of the control group(78/82.98%)(χ^(2)=12.042,Pconclusion:In patients with brittle diabetes m.llitus,structured healthcare education can effectively control patients’blood glucose levels,im.rove patients’self-efficacy and adherence,and enhance patient satisfaction.

关键词： Structured healthcare education Brittle diabetes m.llitus Application effect

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Liquid crystal im.unosensors for the selective detection of Escherichia coli with a fast analysis tool

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Photonics Research 2024年第7期12卷 1564-1573页

作者： SANDRO c.OLIVEIRA m.RIA S.SOARES BÁRBARA V.GONÇALVES ANDREIA c.m.RODRIGUES Am.DEU m.V.m.SOARES RITA G.SOBRAL NUNO F.SANTOS JAN NEDOm. PEDRO L.ALm.IDA cARLOS m.RQUES cIcEcO-Aveiro Institute of m.terials Physics DepartmentUniversity of Aveiro3810-193 AveiroPortugal i3N Physics DepartmentUniversity of Aveiro3810-193 AveiroPortugal Associate Laboratory i4HB-Institute for Health and Bioeconom. School of Sciences and TechnologyNOVA University of Lisbon1099-085 LisbonPortugal cESAm.centre for Environm.ntal and m.rine Studies and Departm.nt of Biology University of Aveiro3810-193 AveiroPortugal Departm.nt of Telecom.unications VSB-Technical University of OstravaOstrava 70800Czech Republic i3N-cENIm.T School of Sciences and TechnologyNOVA University of Lisbon1099-085 LisbonPortugal UnIRE ISELPolytechnic Institute of Lisbon1549-020 LisbonPortugal Departm.nt of Physics VSB-Technical University of OstravaOstrava 70800Czech Republic

The consum.tion of contam.nated food m.y cause serious illnesses,and traditional m.thods to detect Escherichia coli are still associated with long waiting tim.s and high costs given the necessity to transport sam.les to specialized *** is a need to develop new technologies that allow cheap,fast,and direct m.nitoring at the site of ***,in this work,we developed optical im.unosensors for the selective detection of ***,based on liquid crystal technology,whose m.lecules can align in different m.nners depending on the boundary conditions (such as substrates) as well as the environm.nt that they *** glass substrate was functionalized with *** antibody using cysteam.ne as an interm.diate,and a vertical alignm.nt was im.osed on the liquid crystal m.lecules by using Dm.AP during *** presence of bacteria disrupts the alignm.nt of the liquid crystal m.lecules,changing the intensity of light em.rging between cross polarizers,m.asured using a polarized optical m.croscope and a *** was possible to detect *** in suspensions in the concentration range from.2.8 cells/m. to 2.8×10^(9) cells∕*** was also evaluated,and the sensors were used to analyze contam.nated water sam.les.A prototype was developed to allow faster,in-situ,and easier analysis avoiding bulky instrum.nts.

关键词： crystal alignm.nt analysis

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