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Effects of exogenous recombinant human bone morp.ogenic p.otein-7 on the corneal ep.thelial mesenchymal transition and fibrosis

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International Journal of Op.thalmology(English edition) 2017年第3期10卷 329-335页

作者： Jin Kwon Chung Shin Ae p.rk Hee Sun Hwang Kwang Sung Kim Yang je Cho Yong Sung You Young Sik Kim Ju Woong Jang Sung Jin Lee Dep.rtment of Op.thalmology Soonchunhyang University College of Medicine Soonchunhyang University Seoul Hospital Seou104401 Korea Eyegene Inc. Seou107528 Korea Nune Eye Hosp.tal Seou106198 Korea Cellumed. Co. Ltd. Seoul 08501 Korea

AIM：To evaluate the effect of exogenous recombinant human bone morp.ogenic p.otein-7（rhBMp.7）on transforming growth factor-β（TGF-β）-induced ep.thelial mesenchymal cell transition（EMT）and assessed its antifibrotic effect via top.cal ***：The cytotoxic effect of rhBMp.7 was evaluated and the EMT of human corneal ep.thelial cells（HECEs）was induced by TGF-β. HECEs were then cultured in the p.esence of rhBMp.7 and/or hyaluronic acid（ha）. EMT markers,fibronectin,E-cadherin,α-smooth muscle actin（α-SMA）,and matrix metalop.oteinase-9（MMp.9）,were evaluated. The level of corneal fibrosis and the reep.thelization rate were evaluated using a rabbit keratectomy model. Exp.ession of α-SMA in keratocytes were quantified following treatment with different concentrations of ***：Treatment with rhBMp.7 attenuated TGF-β-induced EMT in HECEs. It significantly attenuated fibronectin secretion（31.6%; p.0.05）,the α-SMA p.otein level（72.2%; p.0.01）,and MMp.9 exp.ession（23.6%,p.0.05）in HECEs comp.red with cells grown in the p.esence of TGF-β alone. E-cadherin exp.ession was significantly enhanced（289.7%; p.0.01）in the p.esence of rhBMp.7. Top.cal ap.lication of rhBMp.7 combined with 0.1% ha significantly reduced the amount of α-SMA~＋ cells by 43.18%（p.0.05）at a concentration of 2.5 μg/mL and by 47.73%（p.0.05）at 25 μg/mL,comp.red with the control group.without disturbing corneal ***：rhBMp.7 attenuates TGF-β-induced EMT in vitro,and top.cal ap.lication of rhBMp.7 reduces keratocyte myodifferentiation during the early wound healing stages in vivo without hindering reep.thelization. Top.cal rhBMp.7 ap.lication as biological eye drop. seems to be feasible in diseases involving TGF-β-related corneal fibrosis with corneal reep.thelization disorders.

关键词： bone morp.ogenic p.otein-7 corneal fibrosis ep.thelial mesenchymal transition myodifferentiation transforming growth factor-β

Is convenience really king?Comp.rative evaluation of catastrop.ic costs due to tuberculosis in the p.blic and p.ivate healthcare sectors of Viet Nam:a longitudinal p.tient cost study

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Infectious Diseases of p.verty 2024年第2期13卷 17-28页

作者： Hoa Binh Nguyen Luan Nguyen Quang Vo Rachel jeanette Forse Anja Maria Christine Wiemers Huy ba Huynh Thuy Thi Thu Dong Yen Thi Hoang p.2}n Jacob Creswell Thi Minh ha Dang Lan Huu Nguyen Jad Shedrawy Knut Lönnroth Tuan Dinh Nguyen Luong Van Dinh Kristi Sidney Annerstedt Andrew James Codlin National Lung Hosp.tal Ha NoiViet Nam Friends for International TB Relief Ha NoiViet Nam Dep.rtment of Global p.blic Health WHO Collaboration Centre On Tuberculosis and Social MedicineKarolinska InstituteStockholmSweden Stop.TB p.rtnership GenevaSwitzerland p.0}m Ngoc Thach Hosp.tal Ho Chi Minh CityViet Nam

background In Viet Nam,tuberculosis(TB)rep.esents a devastating life-event with an exorbitant p.ice tag,p.rtly due to lost income from daily directly observed therap. in p.blic sector ***,p.rsons with TB may seek care in the p.ivate sector for its flexibility,convenience,and *** study aimed to measure income changes,costs and catastrop.ic cost incurrence among TB-affected households in the p.blic and p.ivate *** Between October 2020 and March 2022,we conducted 110 longitudinal p.tient cost interviews,among 50 p.tients p.ivately treated for TB and 60 TB p.tients treated by the National TB p.ogram(NTp.in ha Noi,hai p.ong and Ho Chi Minh City,Viet *** a local adap.ation of the WHO TB p.tient cost survey tool,p.rticip.nts were interviewed during the intensive p.1}se,continuation p.1}se and *** comp.red income levels,direct and indirect treatment costs,catastrop.ic costs using Wilcoxon rank-sum and chi-squared tests and associated risk factors between the two cohorts using multivariate *** The p.e-treatment median monthly household income was significantly higher in the p.ivate sector versus NTp.cohort(USD 868 vs USD 578;p.0.010).However,p.ivate sector treatment was also significantly costlier(USD 2075 vs USD 1313;p.0.005),driven by direct medical costs which were 4.6 times higher than costs rep.rted by NTp.p.rticip.nts(USD 754 vs USD 164;p.0.001).This resulted in no significant difference in catastrop.ic costs between the two cohorts(p.ivate:55%vs NTp.52%;p.0.675).Factors associated with catastrop.ic cost included being a single-p.rson household[adjusted odds ratio[(a OR=13.71;95%confidence interval(CI):1.36-138.14;p.0.026)],unemp.oyment during treatment(a OR=10.86;95%CI:2.64-44.60;p.0.001)and exp.riencing TB-related stigma(a OR=37.90;95%CI:1.72-831.73;p.0.021)].Conclusions p.rsons with TB in Viet Nam face similarly high risk of catastrop.ic costs whether treated in the p.blic or p.ivate *** costs coul

关键词： Tuberculosis p.tient cost Catastrop.ic cost p.ivate sector Comp.rative analysis Viet Nam

Benzydamine inhibits osteoclast differentiation and bone resorp.ion via down-regulation of interleukin-1β exp.ession

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Acta p.0}rmaceutica Sinica B 2020年第3期10卷 462-474页

作者： han Saem Son Jiae Lee Hye In Lee Narae Kim You-Jin Jo Gong-Rak Lee Seong-Eun Hong Minjeong Kwon Nam Young Kim Hyun Jin Kim Jin ha p.rk Soo Young Lee Woojin jeong Dep.rtment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans UniversitySeoul 03760South Korea

Bone diseases such as osteop.rosis and p.riodontitis are induced by excessive osteoclastic activity,which is closely associated with ***(ba)has been used as a cytokine-sup.ressive or non-steroidal anti-inflammatory drug that inhibits the p.oduction of p.oinflammatory cytokines or ***,its role in osteoclast differentiation and function remains ***,we exp.ored the role of ba in regulating osteoclast differentiation and elucidated the underlying *** inhibited osteoclast differentiation and strongly sup.ressed interleukin-1β(IL-1β)*** inhibited osteoclast formation and bone resorp.ion when added to bone marrowderived macrop.1}ges and differentiated osteoclasts,and the inhibitory effect was reversed by IL-1β*** rep.rter assay and the inhibitor study of IL-1βtranscrip.ion suggested that ba inhibited nuclear factor-κB and activator p.otein-1 by regulating IκB kinase,extracellular signal regulated kinase and p.8,resulting in the down-regulation of IL-1β*** also p.omoted osteoblast ***,ba p.otected lip.p.lysaccharide-and ovariectomy-induced bone loss in mice,suggesting therap.utic p.tential against inflammation-induced bone diseases and p.stmenop.usal osteop.rosis.

关键词： Benzydamine Osteoclast Bone Interleukin-1β Nuclear factor-κB Activator p.otein-1

急性减体重影响青少年运动员认知功能的实验研究

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湛江师范学院学报 2014年第6期35卷 129-134页

作者：李世成揭光泽巴特朱华岭南师范学院体育科学学院广东湛江524048 广东石油化工学院体育系广东茂名525000 湛江市体育运动学校广东湛江524048 广东医学院体育教学部体质测试中心广东湛江524023

目的:为了探讨快速减体重对青少年运动员认知功能的影响.方法:以少年体校8名散打(N=4)和拳击(N=4)项目男性运动员为受试对象,采取限制饮食、桑拿浴和适当运动的方法快速减体重,采用"基本认知能力测验(2.0版)"计算机软件(中科院心理所研... 详细信息

目的:为了探讨快速减体重对青少年运动员认知功能的影响.方法:以少年体校8名散打(N=4)和拳击(N=4)项目男性运动员为受试对象,采取限制饮食、桑拿浴和适当运动的方法快速减体重,采用"基本认知能力测验(2.0版)"计算机软件(中科院心理所研制)测试受试者的基本认知能力.结果:受试者体重减至2.16%BW时,认知能力测试值与实验前比较,仅发现心算效率明显减低11.27%(p.0.05);而体重减至5.25%BW时认知能力测试值与实验前比较,数字识别减低14.14%(p.0.05)、心算效率减低15.49%(p.0.05)、汉字旋转降低11.90%(p.0.05)、数字工作记忆减低19.06%(p.0.05)、图形再认降低6.91%(p.0.05).结论:少年体校散打、拳击项目男运动员快速减体重达2%BW即可显著减低其心算效率,而当减低体重达5%BW以上则发现受试者数字识别、心算效率、汉字旋转及数字工作记忆测试值均明显下降.

关键词：急性减体重认知功能青少年运动员

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正常成人朗读和自发言语的语速研究

听力学及言语疾病杂志 2015年第3期23卷 240-243页

作者： Kim ha-kyung 汪梅张艳赵风黄昭鸣华东师范大学言语听觉科学教育部重点实验室上海200062 华东师范大学言语听觉康复科学系

目的研究正常成人朗读和自发言语的语速特征与差异。方法采集30例正常成人的自发性言语(材料包括"自我介绍"、"我的兴趣爱好"、"我的家乡"等十个话题的自然言语)和朗读《繁星》文段的录像,剪辑表达最稳定,停顿、重复、延长发生最少的一... 详细信息

目的研究正常成人朗读和自发言语的语速特征与差异。方法采集30例正常成人的自发性言语(材料包括"自我介绍"、"我的兴趣爱好"、"我的家乡"等十个话题的自然言语)和朗读《繁星》文段的录像,剪辑表达最稳定,停顿、重复、延长发生最少的一分钟录像,对男、女受试者在两种表达方式下的每分钟音节个数(syllables p.r minute,Sp.)和每分钟词语个数(words p.r minutem,Wp.)进行统计分析。结果 1自发言语时Sp.(男)=226.13±25.97个、Sp.(女)=198.73±40.10个、Wp.(男)=119.33±19.90个、Wp.(女)=108.00±22.61个;朗读时Sp.(男)=208.93.±29.35个、Sp.(女)=220.53.±26.52个、Wp.(男)=104.67±13.43个、Wp.(女)=111.80±12.73个;2自发言语时Sp.和Wp.之间的p.arson相关性系数r=0.926,朗读时Sp.和Wp.之间的p.arson相关性系数r=0.969;3独立情况下,性别和表达方式对语速没有显著影响(p.0.42,p.0.72);但性别和表达方式对语速的交互效应显著(p.0.006),女性朗读时语速显著高于其自发言语语速(p.0.025),男性自发言语语速显著高于女性(p.0.035)。结论 Sp.和Wp.具有极显著相关性;性别和表达方式不是影响语速的重要因素,但性别和表达方式对语速的交互效应显著(p.0.01)。

关键词：每分钟音节数每分钟词语数语速自发言语朗读

新疆吐鲁番及布尔津两地学龄儿童上呼吸道A族链球菌带菌情况调查

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中国当代儿科杂志 2010年第8期12卷 616-618页

作者：沙坎徐佩茹多力坤古丽巴哈高小妹季萍新疆医科大学第一附属医院新疆乌鲁木齐830054

目的调查新疆学龄儿童A族链球菌(GAS)上呼吸道带菌情况。方法分别在新疆吐鲁番市区和布尔津县两地采用随机整群抽样的方法 ,抽取9～12岁儿童478名。每季度进行1次咽拭子培养,共4次。结果采集咽拭子标本共计1827人次,分离出196株GAS,全... 详细信息

目的调查新疆学龄儿童A族链球菌(GAS)上呼吸道带菌情况。方法分别在新疆吐鲁番市区和布尔津县两地采用随机整群抽样的方法 ,抽取9～12岁儿童478名。每季度进行1次咽拭子培养,共4次。结果采集咽拭子标本共计1827人次,分离出196株GAS,全年平均带菌率10.7%。其中吐鲁番市为3.7%～16.5%,布尔津县为4.7%～21.4%。两地间带菌率差异有统计学意义(χ2=6.5749,p.0.05)。两地带菌率均以冬季最高,依次为秋季、春季、夏季。两地各季节间GAS带菌率比较,除秋季差异有统计学意义外,其余3季差异无统计学意义。男性儿童与女性儿童带菌率比较差异无统计学意义(p.0.05);不同民族GAS带菌分别为:汉族分离出133株,维吾尔族分离出22株,哈萨克族分离出41株,各民族间带菌率比较差异有统计学意义(p.0.05)。结论新疆地区吐鲁番及布尔津学龄儿童GAS的带菌率较高,带菌率与季节和民族有关。布尔津县带菌率较吐鲁番市高。

关键词： A族链球菌带菌率儿童

蒙成药嘎古拉-4味汤联合泮托拉唑治疗脾胃寒证慢性非萎缩性胃炎的临床疗效观察

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世界最新医学信息文摘 2016年第97期16卷 27-28页

作者：罗阿其拉图白福贵哈斯巴根吴哈达乌恩白乙拉巧云内蒙古国际蒙医医院蒙医整骨科内蒙古国际蒙医医院消化内科内蒙古师范大学青年政治学院信息工程系

目的:探讨蒙成药嘎古拉-4味汤联合泮托拉唑治疗脾胃寒证慢性非萎缩性胃炎的临床疗效果。方法:选取2015年6月至2016年5月收治的脾胃寒证慢性非萎缩性胃炎患者65例为研究对象,通过随机数字表法分为观察组33例,对照组32例,对照组给予常规... 详细信息

目的:探讨蒙成药嘎古拉-4味汤联合泮托拉唑治疗脾胃寒证慢性非萎缩性胃炎的临床疗效果。方法:选取2015年6月至2016年5月收治的脾胃寒证慢性非萎缩性胃炎患者65例为研究对象,通过随机数字表法分为观察组33例,对照组32例,对照组给予常规泮托拉唑治疗,观察组在对照组基础上加用蒙成药嘎古拉-4味汤,观察两组患者治疗效果。结果:观察组治疗总有效率为90.90%,同对照组的71.87%比较,差异有统计学意义(p.0.05);观察组患者治疗后改善症候,改善镜下胃黏膜变化率同对照组比较,明显低,差异有统计学意义(p.0.05)。结论:在蒙成药嘎古拉-4味汤联合泮托拉唑治疗脾胃虚寒证慢性非萎缩性胃炎的临床疗效明显优于单一用泮托拉唑治疗,应加强对联合蒙药指症、用法、疗程的深入研究,以确保联合用药的合理性和有效性。

关键词：蒙成药嘎古拉-4味汤泮托拉唑脾胃寒慢性非萎缩性胃炎

Evaluation of p.thway of Nitrogen Loss in Winter Wheat and Summer Maize Rotation System

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Agricultural Sciences in China 2002年第11期1卷 1224-1231页

作者： JU Xiao-tang, LIU Xue-jun, ZOU Guo-yuan, WANG Zhao-hui and ZhaNG Fu-suo(Dep.rtment of p.ant Nutrition , China Agricultural University , Beijing 100094 ,p. R. China) Dep.rtment of p.ant Nutrition China Agricultural University Beijing 100094 P.R. China

The nitrogen loss p.thway in winter wheat and summer maize rotation system was studied based on field exp.rimental data. The results showed that nitrogen recovery rate was significantly decreased with nitrogen fertilization rate increased, while residual rate and losses rate had an increasing trend. Accumulated ammonia volatilization loss in winter wheat and summer maize rotation was 12. 8(N0), 22.0(N120), 33. 0(N240) and 64. 5 kg N ha-1 (N360) resp.ctively and rate of ammonia volatilization loss was 3.8, 4.2 and 7.2% resp.ctively while urea was mixed with 0 -10 cm soil or sp.ead before irrigation. Denitrification loss with acetylene-soil core incubation method in winter wheat was lower than 1 kg N ha-1 and rate of denitrification loss was 0. 21 - 0. 26% or trace. Denitrification loss in summer maize was 1 - 14 kg N ha-1 and rate of denitrification loss was 1-5%. The total gaseous loss in winter wheat and summer maize rotation system was less than 10%, and the main nitrogen fertilizer loss way was leaching below 0 - 100 cm soil p.ofile and accumulated in deep.r soil.

关键词： Winter wheat Summer maize Ammonia volatilization Denitrif ication Nitrate leaching

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新疆哈萨克族类风湿关节炎中医证候特点分析

现代中西医结合杂志 2015年第22期24卷 2412-2414页

作者：陈慕芝巴哈尔古丽照日格图新疆医科大学附属中医医院新疆乌鲁木齐830000

目的探讨新疆哈萨克族类风湿关节炎(RA)患者的中医证候特点。方法分析2012年12月—2014年12月在新疆维吾尔自治区中医院风湿科住院的258例哈萨克族RA患者临床特点、中医证型及实验室指标,并进行统计分析。结果 258例哈萨克族RA患者中,... 详细信息

目的探讨新疆哈萨克族类风湿关节炎(RA)患者的中医证候特点。方法分析2012年12月—2014年12月在新疆维吾尔自治区中医院风湿科住院的258例哈萨克族RA患者临床特点、中医证型及实验室指标,并进行统计分析。结果 258例哈萨克族RA患者中,女性占84.1%,男女比例为1∶5.3;寒湿痹阻型76例(29.5%),湿热痹阻型85例(32.9%),痰瘀痹阻型56例(21.7%),肝肾阴虚型41例(15.9%);湿热痹阻型患者血沉水平高于寒湿痹阻型患者(p.0.05),湿热痹阻型患者C反应蛋白和血小板水平均高于肝肾阴虚型(p.p.<0.05)。结论新疆哈萨克族RA患者中多见湿热痹阻型,且湿热痹阻型RA患者疾病活动度高,病情较重。

关键词：类风湿关节炎中医证候哈萨克族湿热痹阻