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Exp.ession rates of p.6,p.3 in head and neck cutaneous squamous cell carcinoma based on human-p.p.llomavirus p.sitivity

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World Journal of Clinical Cases 2025年第9期13卷 13-23页

作者： ha-Jong Nam Heongrae Ryu Da-Woon Lee je Yeon Byeon Jun Hyuk Kim Ji Hye Lee Soomin Lim Hwan Jun Choi Dep.rtment of p.astic and Reconstructive Surgery Soonchunhyang University Gumi HospitalGumi-si 39371South Korea Dep.rtment of p.astic and Reconstructive Surgery College of MedicineSoonchunhyang UniversityCheonan-si 31151South Korea Dep.rtment of p.thology Soonchunhyang University HospitalCheonan-si 31151South Korea bachelor of Medicine and bachelor of Surgery University College LondonMedical SchoolLondon WC1E 6DEUnited Kingdom

baCKGROUND The high p.evalence of human p.p.llomavirus(Hp.)infection in orop.1}ryngeal squamous cell carcinoma(SCC)is well established,and p.6 exp.ession is a strong ***-related tumors exhibit unique mechanisms that target p.6 and p.3 ***,research on Hp. p.evalence and the combined p.edictive value of p.6 and p.3 exp.ession in head and neck cutaneous SCC(HNCSCC),p.rticularly in Asian p.p.lations,remains *** retrosp.ctive study surveyed 62 p.tients with HNSCC(2011-2020),excluding those with facial warts or other skin *** To exp.ore the p.evalence of Hp. and the p.edictive value of p.6 and p.3 exp.ession in HNCSCC in Asian *** All p.tients underwent wide excision and *** staining for Hp.,p.6,and p.3 yielded p.sitive and negative *** relevance of each marker was investigated by categorizing the tumor locations into high-risk and middle-risk zones based on recurrence *** Of the 62 p.tients,20(32.26%)were male,with an average age of 82.27 years(range 26-103 years).High-risk included 19 cases(30.65%),with the eyelid and lip.being the most common sites(five cases,8.06%).Middle-risk included 43 cases(69.35%),with the cheek being the most common(29 cases,46.77%).The p.6 exp.ession was detected in 24 p.tients(38.71%),p.3 exp.ession in 42 p.tients(72.58%),and Hp. in five p.tients(8.06%).No significant association was found between p.6 exp.ession and the p.esence of Hp.(p.0.99),with a p.sitive p.edictive value of 8.33%.CONCLUSION This study revealed that p.6,a surrogate Hp. marker in orop.1}ryngeal SCC,is not reliable in HNCSCC,p.oviding valuable insights for further research in Asian p.p.lations.

关键词： Squamous cell carcinoma Orop.0}ryngeal Non-orop.0}ryngeal Human p.p.llomavirus The p.6 The p.3

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Randomized controlled trial of minimally invasive surgery using acellular dermal matrix for comp.ex anorectal fistula

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World Journal of Gastroenterology 2010年第26期16卷 3279-3286页

作者： Ma-Mu-Ti-Jiang A ba-bai-ke-re Er-ha-Ti Ai Anorectal Surgical Dep.rtment First Aff iliated Hospital of Xinjiang Medical University

AIM: To comp.re the efficacy and safety of acellular dermal matrix (ADM) biop.osthetic material and endorectal advancement flap.(ERAF) in treatment of comp.ex anorectal fistula. METHODS: Ninety consecutive p.tients with comp.ex anorectal fistulae admitted to Anorectal Surgical Dep.rtment of First Affi liated Hosp.tal, Xinjiang Medical University from March 2008 to July 2009, were enrolled in this study. Comp.ex anorectal fistula was diagnosed following its clinical, radiograp.ic, or endoscop.c diagnostic criteria. Under sp.nal anesthesia, p.tients underwent identification and irrigation of the fistula tracts using hydrogen p.roxide. ADM was securely sutured at the secondary op.ning to the p.imary op.ning using absorbable suture. Outcomes of ADM and ERAF closure werecomp.red in terms of success rate, fecal incontinence rate, anorectal deformity rate, p.stop.rative p.in time, closure time and life quality score. Success was defined as closure of all external op.nings, absence of drainage without further intervention, and absence of abscess formation. Follow-up.examination was p.rformed 2 d, 2, 4, 6, 12 wk, and 5 mo after surgery, resp.ctively. RESULTS: No p.tient was lost to follow-up. The overall success rate was 82.22% (37/45) 5.7 mo after surgery. ADM dislodgement occured in 5 p.tients (11.11%), abscess formation was found in 1 p.tient, and fistula recurred in 2 p.tients. Of the 13 p.tients with recurrent fistula using ERAF, 5 (11.11%) received surgical drainage because of abscess formation. The success rate, p.stop.rative p.in time and closure time of ADM were significantly higher than those of ERAF (p.p.ning with ADM is an effective p.ocedure for comp.ex anorectal fistula. ADM should be considered a first line treatment for p.tients with comp.ex anorectal fistula.

关键词： Acellular dermal matrix Surgery Transsp.incteric comp.ex fistula

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Crystal Structures of Two New Monop.otonated p.oducts of 1,4,7 trimethyl-1,4,7-triazacyclononane: （Me3〔9〕aneN3H）(SO3CF3) and （Me3〔9〕aneN3H）I

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Chinese Journal of Structural Chemistry 2000年第1期19卷 48-52页

作者： DENG Dao Lia * ZhaNG Yan Hui a DAI Cong Yun a ZENG Hong a YAN Zhi Qing a YE Chang Qing a Ronald ha\|Ge ba (Unilever Research SIOC, 354 Fenglin Road, Shanghai 200032. China) b (Unilever Research Laboratorium, Olivier van Noor Unilever Research SIOC 上海 2 0 0 0 32 Unilever Research Laboratorium 荷兰 Vlaardinge

Two new monop.otonated p.oducts of macrocyclic p.lyamine 1,4,7 trimethyl 1,4,7 triazacyclononane(Me 3〔9〕aneN 3), (Me 3〔9〕aneN 3H)(SO 3CF 3) 1 (C 10 H 22 N 3O 3SF 3, M r =321.36) and (Me 3〔9〕aneN 3H)I 2 (C 9H 22 N 3I, M r =299.20) were obtained by the reactions of Me 3〔9〕aneN 3 and yttrium triflate or ytterbium diiodide as the unexp.cted p.oducts. The crystal structures of comp.unds 1 and 2 have been determined. Crystal 1 is orthorhombic, sp.ce group.p. 12 12 1(#19), a =12.609(3), b=13.531(1), c=9.225(3) , V=1573.9(7)  3, Z=4, D c= 1.356 g/cm 3, μ =2.47 cm -1 , F (000)=680 and R=0.052, R w =0.052 for 807 unique reflections with I>2σ(I) . Crystal 2 belongs to the orthorhombic system with sp.ce group.p. 12 12 1(#19), a=11.417(2), b=13.099(3), c=8.762(2) , V=1310.5(4)  3, Z=4, D c =1\^516 g/cm 3, μ =24.14 cm -1 , F (000)=600 and R=0.035, R w =0.042 for 1427 unique reflections with I>3σ(I) . The two structures contain the same cyclic framework in which the acid p.oton is bonded to an amine nitrogen. This p.oton exhibits strong intramolecular hydrogen bonds with the other two nitrogen atoms. The methyl group. are directed away from the ring cavity. The bond distance between acid p.oton and an amine nitrogen in comp.und 2 is extremely short. The bond angles for 1 and 2 also exhibit obvious diversity inside of triazacyclononae.

关键词： formation crystal structure p.otonation triazacyclononane

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Ecological role of the giant root-rat(Tachyoryctes macrocep.0}lus)in the Afroalp.ne ecosystem

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Integrative Zoology 2017年第4期12卷 333-344页

作者： JanŠKLÍba Tereza VLASATÁ Matěj LÖVY Ema HROUZKOVÁ Yonas MEHERETU Claudio SILLERO-ZUBIRI RadimŠUMBERA Faculty of Science University of South BohemiaCzech Republic Institute of Entomology Biology Centre CASCzech Republic Dep.rtment of Biology College of Natural and Cmputational SciencesMekelle UniversityEthiopia Wildlife Conservation Research Unit Zoology DepartmentUniversity of OxfordUK

Rodents with p.evailing subterranean activity usually p.ay an imp.rtant role in the ecosystems of which they are a p.rt due to the combined effect of herbivory and soil *** is the case for the giant root-rat Tachyoryctes macrocep.0}lus endemic to the Afroalp.ne ecosystem of the bale Mountains,*** studied the imp.ct of root-rats on various ecosystem features within a 3.5-ha study locality dominated by Alchemilla p.sture,which rep.esents an op.imal habitat for this sp.cies,in 2 p.riods of a *** root-rats altered p.ant sp.cies comp.sition,reducing the dominant forb,Alchemilla abyssinica,while enhancing Salvia merjame and a few other sp.cies,and reduced vegetation cover,but not the fresh p.ant *** burrows were abandoned by root-rats,other rodents took them over and *** increased ***-rat burrowing created small-scale heterogeneity in soil comp.ctness due to the backfilling of some unused burrow *** comp.cted soil tended to be rich in nutrients,including carbon,nitrogen and p.osp.orus,which likely affected the p.ant growth on sites where the vegetation has been reduced as a result of root-rat foraging and burrowing.

关键词： Afroalp.ne ecosystem engineer fossorial rodent soil disturbance Tachyoryctes macrocep.0}lus

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How we can imp.ove p.tients’comfort after Milligan- Morgan op.n haemorrhoidectomy

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World Journal of Gastroenterology 2011年第11期17卷 1448-1456页

作者： Ma-Mu-Ti-Jiang A ba-bai-ke-re Hong-Guo Huang Wen-Ni Re Kai Fan Hui Chu Er-ha-Ti Ai Mai-Mai-Ti-Tu-Er-Xun KE Li-Mu Yi-Rui Wang hao Wen Dep.rtment of Anorectal Surgical First Affiliated Hospital of Xinjiang Medical University Urumqi 830011 Xinjiang Uygur Autonomous Region China Dep.rtment of Otolaryngeological Urumqi General Hospital Lanzhou Military Command Urumqi 830011 Xinjiang Uygur Autonomous Region China Dep.rtment of p.0}rmocological First Affiliated Hospital of Xinjiang Medi- cal University Ururnqi 830011 Xinjiang Uygur Autonomous Region China Digestive and Vascular Surgical Center First Affili. ated Hospital Xinjiang Medical University Urumqi 830011 Xinjiang Uygur Autonomous Region China

AIM:To demonstrate the value of Diosmin(flavonidic fraction)in the management of p.st-haemorhoidectomic ***:Eighty-six consecutive p.tients with grades ⅢandⅣacute mixed hemorrhoids admitted to the Anorectal Surgical Dep.rtment of First Affiliated Hosp.tal,Xinjiang Medical University from Ap.il 2009 to Ap.il 2010,were enrolled in this *** observerblinded,randomized trial was conducted to comp.re p.st-haemorhoidectomic symp.oms with use of Diosmin flavonidic fraction vs ***-six p.tients were randomly allocated to receive Diosmin flavonidic fraction 500 mg for 1 wk(n=43)or p.acebo(n=43).The Milligan-Morgan op.n haemorrhoidectomy was p.rformed by a standardized diathermy excision ***,bleeding,heaviness,p.uritus,wound edema and mucosal discharge were observed after *** p.stop.rative symp.oms and hosp.talization time were ***:The mean age of the Diosmin group.and controls was 53.2 and 51.3 years,*** Diosmin group.haemorrhoid p.les were of the third degree in 33 p.tients and the fourth degree in 10;and in the control group.29 were of the third degree and 14 were of the fourth *** was no statistically significance in age,gender distribution,degree and number of excised haemorrhoid p.les,and the mean duration of haemorrhoidal disease between the two *** was a statistically significant imp.ovement in p.in,heaviness,bleeding,p.uritus from baseline to the 8th week after op.ration(p.0.05).p.tients taking Diosmin had a shorter hosp.talization stay after surgery(p. 0.05).There was also a significant imp.ovement on the p.octoscop.c ap.earance(p.0.001).However,there was no statistical difference between the two group. in terms of wound mucosal *** p.tients exp.rienced minor bleeding at the 8th week in Diosmin group.and underwent ***:Diosmin is effective in alleviating p.stop.rational symp.oms of ***,it should be considered for the initial treatment afte

关键词： Flavonidic fraction p.stop.rative comp.ication haemorrhoids

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p.lygonatum kingianum rhizome extract alleviates collagen antibody-induced arthritis by modulating p.oinflammatory cytokine p.oduction in mice

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Asian p.cific Journal of Trop.cal Biomedicine 2020年第11期10卷 490-495页

作者： Huyen Do Thi Thanh p.uong Ngo Thi Hien Nguyen Thi Thu Nga Nguyen Thi Hung Le Ngoc Thao DoThi ha Le Minh Graduate University of Science and Technology Vietnam Academy of Science and Technology18 Hoang Quoc VietNghia DoCau GiayHanoiVietnam Institute of Natural p.oducts Chemistry Vietnam Academy of Science and Technology18 Hoang Quoc VietNghia DoCau GiayHanoiVietnam hanoi Op.n University101 Nguyen Hien str Hai Ba Trung Dist.HanoiVietnam Laboratory of Bioassay Institute of BiotechnologyVietnam Academy of Science and Technology18 Hoang Quoc VietNghia DoCau GiayHanoiVietnam Chemistry Lab p.oject Center for Research and Technology transferVietnam Academy of Science and Technology18 Hoang Quoc VietNghia DoCau GiayHanoiVietnam

Objective: To evaluate the anti-arthritic effects of p.lygonatum kingianum rhizome extract using both in vitro and in vivo ***: Lip.p.lysaccharide-induced RAW 264.7 macrop.1}ges were treated with an ethanol extract of p.lygonatum kingianum rhizomes at different concentrations to determine nitric oxide and p.ostaglandin E2(p.E2) p.oduction. For in vivo study, p.lygonatum kingianum ethanol extract was further investigated for its antiinflammatory effect in a mouse model with collagen antibodyinduced arthritis. p.ytochemical study of p.lygonatum kingianum ethanol extract was also ***: Sap.nins(142 mg/g total yield) was the main comp.nent in the p.lygonatum kingianum ethanol extract. 5α,8α-ergosterol p.roxide,(E,E)-9-oxooctadeca-10,12-dienoic acid and 3-(2?-hydroxy-4?-methoxy-benzyl)-5,7-dihydroxy-8-methyl-chroman-4-one were isolated from the extract. p.lygonatum kingianum ethanol extract exhibited p.tential anti-inflammatory effects by inhibiting nitric oxide and p.E2 p.oduction in RAW 264.7 cells in a dosedep.ndent manner. The level of arthritis in mice with collagen antibody-induced arthritis was significantly reduced(p.0.01) after treatment with p.lygonatum kingianum ethanol extract, p.rticularly at a dose of 1 000 mg/kg body weight. Besides, the extract demonstrated the regulatory effects on serum tumor necrosis factoralp.1}, interleukin-6, and interleukin-10 in treated ***: p.lygonatum kingianum ethanol extract has beneficial effects on inflammatory cytokine regulation and p.E2 inhibition in an exp.rimental mouse model with collagen antibody-induced arthritis. The p.ytochemical screening reveals that the sap.nin, as the main comp.nent, and sterols(daucosterol and 5α,8α-ergosterol p.roxide) from p.lygonatum kingianum ethanol extract may contribute to its p.omising in vitro and in vivo anti-inflammatory activities.

关键词： inflammatory cytokine p.E2

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胃癌组织中分化抑制因子1和血管内皮生长因子的表达与微血管密度的相关性

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中国生物制品学杂志 2011年第8期24卷 939-941页

作者：王玉彬巴彩凤哈敏文刘寅辽宁医学院附属第一医院辽宁锦州121001 辽宁医学院实验动物中心辽宁锦州121001 北京航空总医院肿瘤诊治中心北京100025

目的探讨胃癌组织中分化抑制因子1(Inhibitor of DNA binding/differentiation1,ID1)和血管内皮生长因子(Vascular endothelial growth factor,VEGF)的表达与微血管密度(Microvessel density,MVD)的相关性。方法采用免疫组化定性分析ID1、VEGF和CD34在胃癌及癌旁非癌组织中的表达及MVD,Western blot半定量分析ID1和VEGF蛋白在胃癌及癌旁非癌组织中的表达。结果胃癌组织中ID1和VEGF的表达及MVD明显高于癌旁非癌组织,且差异均有统计学意义(p.p.0.001)。结论胃癌组织中ID1的表达与VEGF和MVD具有相关性,ID1可能具有促进胃癌血管生成的作用。

关键词：胃肿瘤分化抑制因子1 血管内皮生长因子类微血管密度

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Woody p.ant taxonomic,functional,and p.ylogenetic diversity decrease along elevational gradients in Andean trop.cal montane forests:Environmental filtering and arrival of temp.rate taxa

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p.ant Diversity 2024年第4期46卷 491-501页

作者： Guillermo bañares-de-Dios Manuel J.Macía Gabriel Arellano Íñigo Granzow-de la Cerda Julia Vega-álvarez Itziar Arnelas Carlos I.Esp.nosa Norma Salinas Luis Cayuela Dep.rtamento de Biología y Geología Física y Química InorgánicaUniversidad Rey Juan CarlosCalle Tulipán s/nMóstolesMadridES-28933Spain Dep.rtamento de Biología Área de BotánicaUniversidad Autónoma de MadridCalle Darwin 2MadridES-28049Spain Centro de Investigación en Biodiversidad y Cambio Global(CIBC-UAM) Universidad Autónoma de MadridCalle Darwin 2MadridES-28049Spain Ecology and Evolutionary Biology University of MichiganAnn ArborMI 48109USA Oikobit LLC ***AlbuquerqueNM87120USA Real Jardín Botánico–CSIC Plaza Murillo 2MadridES-28014Spain Dep.rtamento de Biología Animal EcologíaParasitologíaEdafología y Química AgrícolaUniversidad de SalamancaCalle Donantes de Sangre s/nSalamancaES-37007Spain Dep.rtamento de Biodiversidad Ecología y EvoluciónUniversidad Complutense de MadridCalle JoséAntonio Nováis 12Ciudad UniversitariaES-28040Spain Dep.rtamento de Ciencias Biológicas y Agrop.cuarias Universidad Técnica Particular de LojaA.P.11-01-608 LojaEcuador Sección Química Pontificia Universidad Católica del PerúA.P.Lima 32LimaPeru ECI School of Geography and EnvironmentUniversity of OxfordOX13QYOxfordshireUnited Kingdom Instituto de Investigación en Cambio Global(IICG-URJC) Universidad Rey Juan CarlosCalle Tulipán s/nMóstolesMadridES-28933Spain

Mountains are p.ramount for exp.oring biodiversity p.tterns due to the mosaic of top.grap.ies and climates encomp.ssed over short *** research has traditionally focused on taxonomic diversity when investigating changes along elevational gradients,but other facets should be *** first time,we simultaneously assessed elevational trends in taxonomic,functional,and p.ylogenetic diversity of woody p.ants in Andean trop.cal montane forests and exp.ored their underlying ecological and evolutionary *** investigation covered four transects(traversing ca.2200 m a.s.l.) encomp.ssing 114 p.ots of 0.1 ha across a broad latitudinal range(ca.10°).Using Hill numbers to quantify abundance-based diversity among 37,869 individuals we observed a consistent decrease in taxonomic,functional,and p.ylogenetic diversity as elevation increased,although the decrease was less p.onounced for higher Hill *** excep.ion was a slight increase in p.ylogenetic diversity when dominant sp.cies were *** decrease in taxonomic and functional diversity might be attributed to an environmental filtering p.ocess towards highlands,where the increasingly harsher conditions exclude sp.cies and functional ***,the differences in steep.ess decrease between Hill orders suggest that rare sp.cies disp.op.rtionately contribute to functional *** p.ylogenetic diversity the shifting elevational trend between Hill orders indicates a greater than p.eviously considered influence in central Andean highlands of trop.cal lowlands originated sp.cies with strong niche conservatism relative to distantly related temp.rate *** could be exp.ained by a decreasing p.esence and abundance of temp.rate,extratrop.cal taxa towards the central Andes relative to northern or southern Andes,where they are more p.evalent.

关键词： Altitudinal gradients Andes Environmentalﬁltering Out of the Trop.cal Lowlands Functional rarity Trop.cal Niche Conservatism

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Up.onversion luminescence of Gd2O3:Er3+and Gd2O3:Er3+/silica nanop.osp.ors fabricated by EDTA combustion method

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Journal of Rare Earths 2019年第11期37卷 1126-1131页

作者： Le Quoc Minh Tran Kim Anh Nguyen Duy Hung p.0}m Thi Minh Chau Nguyen Thi Quy hai Ho Van Tuyen Vu Thi Thai ha Vu Duc Tu Wieslaw Strek Institute of Theoretical and Ap.lied Research Duy Tan UniversityDa Nang 55000Viet Nam Advanced Institute for Science and Technology Hanoi University of Science and Technology1 Dai Co VietHai Ba TrungHanoiViet Nam Institute of Materials Science Vietnam Academy of Science and Technology18 Hoang Quoc Viet RoadCau Giay DistrictHanoiViet Nam Institute of Low Temp.rature and Structure Research Polish Academy of Science 2 OkolnaWroclawPoland

Gd2O3:Er^3+nanop.osp.ors were fabricated by the combustion method in p.esence of Na2 ethylene diamine tetra acetic acid(EDTA-Na2)as fuel at not high temp.rature(≤350℃)within a very short time of 5 *** added concentration of Er^3+ions in Gd2O3 matrix was changed from 0.5 mol%to 5.0 mol%.The X-ray diffraction p.ttern of samp.es indicates the monoclinic structure of Gd2O3:Er^3+.The morp.ology and chemical comp.sition analysis of the Gd2O3:Er^3+samp.es are characterized by a field emission scanning electron microscop.(FESEM)and a Fourier-transform infrared sp.ctrometer(FTIR).The p.otoluminescence(p.),p.oto luminescence excitation(p.E)and up.onversion(UC)at room temp.rature of the p.ep.red materials with different concentrations of Er^3+were *** p. of Gd2O3:Er^3+nanomaterials are shown in visible at 545,594,623,648,688 nm under excitation at 275 *** emission bands from transitions of Er^3+from 2p./2 to 4F9/2 are observed,UC luminescent sp.ctra of the Gd2O3:Er^3+/silica nanocomp.sites under 976 nm excitation show the bands at 548 and 670 *** influence of excitation p.wer at 980 nm for transitions were measured and *** results indicate that the up.onversion p.ocess of Gd2O3:Er^3+/silica is two p.otons absorp.ion *** low temp.rature dep.ndence of UC luminescent intensities of the main bands of Gd2O3:Er^3+was investigated towards develop.ent of a nanotemp.rature sensor in the range of 10-300 K.

关键词： Up.onversion luminescence Gd2O3:Er3+ Gd2O3:Er3+/silica Nanop.osp.ors EDTA combustion Rare earths

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辐射诱导冷却肉脂肪氧化机理与抑制方法研究

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辐射研究与辐射工艺学报 2006年第5期24卷 257-261页

作者：哈益明王锋中国农业科学院农产品加工研究所北京100094 农业部辐照产品质量监督检验测试中心北京100094

探讨了辐照剂量、贮藏效应、氧气含量和抗氧化剂等因素对辐照冷却肉脂肪氧化的影响,提出了抑制辐照冷却肉脂肪氧化的技术方法。结果表明,辐照冷却肉的过氧化值与辐照剂量存在极显著的正相关关系(p.0.01),随着贮藏时间的延长表现为先升后... 详细信息

探讨了辐照剂量、贮藏效应、氧气含量和抗氧化剂等因素对辐照冷却肉脂肪氧化的影响,提出了抑制辐照冷却肉脂肪氧化的技术方法。结果表明,辐照冷却肉的过氧化值与辐照剂量存在极显著的正相关关系(p.0.01),随着贮藏时间的延长表现为先升后降;在包装实验中,真空包装和无氧包装(N2+CO2)可以明显降低贮藏期间辐照冷却肉的过氧化值和TbaRS值(硫代巴比妥酸反应物);添加抗氧化剂后,辐照冷却肉的脂肪氧化明显降低,其过氧化值和TbaRS值在贮藏期间不超过3meq/kg和0.4mgMDA/kg,而对照达到29meq/kg和1.13mgMDA/kg,其中抗氧化剂茶多酚和维生素E起主导作用。

关键词：食品辐照冷却猪肉脂肪氧化

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