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Renin-angiotensin system in the pathogenesis of liver fibrosis

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World Journal of Gastroenterology 2009年第21期15卷 2579-2586页

作者： Regina Maria Pereira Robson Augusto Souza dos Santos Filipi Leles da Costa Dias Mauro martins Teixeira Ana Cristina Simoes e silva Department of Pediatrics Faculty of MedicineFederal University of Minas Gerais Laboratory of Hypertension Department of Physiology and BiophysicsInstitute of Biological SciencesFederal University of Minas Gerais Laboratory of Immunopharmacology Department of Biochemistry and ImmunologyInstitute of Biological SciencesFederal University of Minas Gerais

Hepatic fibrosis is considered a common response to many chronic hepatic *** is a multifunctional process that involves several cell types,cytokines,chemokines and growth factors leading to a disruption of homeostatic mechanisms that maintain the liver *** spite of many studies regarding the development of fibrosis,the understanding of the pathogenesis remains *** hepatic tissue remodeling process is highly complex,resulting from the balance between collagen degradation and *** the many mediators that take part in this process,the components of the Renin angiotensin system(RAS) have progressively assumed an important ***(Ang)□acts as a profibrotic mediator and Ang-(1-7),the newly recognized RAS component,appears to exert a counter-regulatory role in liver *** briefly review the liver fibrosis process and current aspects of the *** review also aims to discuss some experimental evidence regarding the participation of RAS mediators in the pathogenesis of liver fibrosis,focusing on the putative role of the ACE2-Ang-(1-7)-Mas receptor axis.

关键词：血管紧张素肝纤维化发病机制生态系统肾素细胞因子 RAS 生长因子

Natural sources, biosynthesis, biological functions, and molecular mechanisms of shikimic acid and its derivatives

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Asian Pacific Journal of Tropical Biomedicine 2023年第4期13卷 139-147页

作者： Gopalsamy Rajiv Gandhi Alan Bruno silva Vasconcelos Poovathumkal James Antony Monalisa martins Montalvão Mariana Nobre Farias de Franca Varghese Edwin Hillary Stanislaus Antony Ceasar dan Liu Division of Phytochemistry and Drug Design Department of BiosciencesRajagiri College of Social SciencesKalamaserryKochi 683104India Laboratory of Biology and Immunology of Cancer and Leishmania Department of MorphologyFederal University of SergipeSão Cristóvão 49100.000SergipeBrazil Nepal jesuit Society Human Resource Development and Research CentreKathmandu 44600Nepal Postgraduate Program of Health Sciences Federal University of SergipeCampus Prof.João Cardoso NascimentoAracaju 49060.108SergipeBrazil Division of Plant Molecular Biology and Biotechnology Department of BiosciencesRajagiri College of Social SciencesKalamaserryKochi 683104India School of Food and Biological Engineering Chengdu UniversityChengdu 610106China

Shikimic acid is a hydroaromatic compound possessing critical biological properties,such as antibacterial and antiviral *** review mainly focused on shikimic acid and its *** first briefly introduced the sources of shikimic acid and its derivatives and discussed their *** in vitro and in vivo studies indicate that shikimic acid and its derivatives exhibit diverse bioactivities,such as antioxidant,antiviral,anti-inflammatory,antibacterial,hypolipidemic,bone protective,skin protective,neuroprotective,and antidiabetic *** mainly focused on the related molecular ***,the wide range of bioactivities of shikimic acid and its derivatives indicate that a more detailed exploration of their potential for the prevention and treatment of certain diseases is warranted.

关键词： Natural products Shikimate Ginkgo biloba Neuroprotection Inflammation

Elderly Feeding and Nutrition during Hospitalization: An Integrative Review

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Open Journal of Nursing 2023年第11期13卷 735-753页

作者： José Baudilio Belzarez Guedez Maria Helena Lenardt Clovis Cechinel João Alberto martins Rodrigues daiane Maria da silva Marques Maria Angelica Binotto Graduate Program in Nursing Federal University of Paraná Curitiba Brazil Physical Education Department Midwest State University Irati Brazil

Objective: to search in the current literature the elements that exert an influence on feeding and nutrition in hospitalized aged people. Method: the following strategies were used for the integrative review stages: research question (Population or Patients;Exposure;Outcomes);analysis flowchart (Preferred Reporting Items for Systematic Reviews and Meta-analyses);and levels of evidence corresponding to the studies (Oxford Centre for Evidence-Based Medicine). The searches were conducted in the MEDLINE/PubMed, Biblioteca Virtual em Saúde, Embase, CINAHL and Scopus databases. Results: the initial search yielded 1808 studies, of which 34 comprised the analysis corpus after applying the inclusion/exclusion criteria. The assessments corresponding to nutritional status and to the risk factors for hospitalized aged people are fundamental in defining the diet. An association was found between inadequate energy intake, lack of appetite, infections, malignity, delirium and need for assistance in feeding. Dysphagia affected nutritional status and was associated with multimorbidities, cognitive impairment, malnutrition, higher dependence for the activities of daily living, and greater care need. Nutritional support improved the perioperative nutritional status, in addition to reducing the hospitalization times and the number of infectious complications. Conclusion: the main disorder that hinders meeting the nutritional needs is dysphagia, and is associated with aged people’s multimorbidity and dependence. The results provide geriatric and gerontological knowledge about elderly nutrition, in addition to targeting preventive and intervention treatments and care during hospitalization. .

关键词： Aged Inpatient Elderly Nutrition Hospitalization

Engineering Improved Photosynthesis in the Era of Synthetic Biology

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Plant Communications 2020年第2期1卷 1-17页

作者： Willian Batista-silva Paula da Fonseca-Pereira Auxiliadora Oliveira martins Agustin Zsogon Adriano Nunes-Nesi Wagner L.Araujo Departamento de Biologia Vegetal Universidade Federal de Vic¸osaVic¸osaMinas Gerais 36570-900Brazil

Much attention has been given to the enhancement of photosynthesis as a strategy for the optimization of crop *** traditional plant breeding is most likely reaching a plateau,there is a timely need to accelerate improvements in photosynthetic efficiency by means of novel tools and biotechnological *** emerging field of synthetic biology offers the potential for building completely novel pathways in predictable directions and,thus,addresses the global requirements for higher yields expected to occur in the 21st ***,we discuss recent advances and current challenges of engineering improved photosynthesis in the era of synthetic biology toward optimized utilization of solar energy and carbon sources to optimize the production of food,fiber,and fuel.

关键词： photosynthesis synthetic biology genetic engineering yield improvement targeted manipulation

Catalytic combustion of soot over ceria-zinc mixed oxides catalysts supported onto cordierite

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Journal of Environmental Sciences 2014年第3期26卷 694-701页

作者： Leandro Fontanetti Nascimento Renata Figueredo martins Rodrigo Ferreira silva Osvaldo Antonio Serra Department of Chemistry FFCLRP University of Sao Paulo

Modified substrates as outer heterogeneous catalysts was employed to reduce the soot generated from incomplete combustion of diesel or diesel/biodiesel blends, a process that harms the environment and public health. The unique storage properties of ceria （CeO2） makes it one of the most efficient catalysts available to date. Here, we proposed that ceria-based catalysts can lower the temperature at which soot combustion occurs; more specifically, from 610℃ to values included in the diesel exhausts operation range （300-450℃）. The sol-gel method was used to synthesize mixed oxide-based catalysts （CeO2：ZnO）; the resulting catalysts were deposited onto cordierite substrates. In addition, the morphological and structural properties of the material were evaluated by XRD, BET, TPR-H2, and SEM. Thermogravimetric （TG/DTA） analysis revealed that the presence of the catalyst decreased the soot combustion temperature by 200℃ on average, indicating that the oxygen species arise at low temperatures in this situation, promoting highly reactive oxidation reactions. Comparative analysis of soot emission by diffuse reflectance spectroscopy （DRS） showed that catalyst-impregnated cordierite samples efficiently oxidized soot in a diesel/biodiesel stationary motor： soot emission decreased by more than 70%.

关键词： soot oxidation mixed oxides ceria

COVID-19 Downgraded Already Impaired Mental Health of Medical Undergraduates during the Pandemic Years

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Journal of Biosciences and Medicines 2023年第5期11卷 166-180页

作者： Rodrigo Corrêa Falcão Rodrigues Alves Rodolffo da silva Fossa Vinicius de Calasans Timaco José Mariano Soares de Moraes Emilio Magalhães martins Will Rinaldo Henrique Aguilar da silva Luiz Antonio Vane Joaquim Edson Vieira Matheus Fachini Vane Faculdade de Ciências Médicas de Sã o José dos Campos S&atildeo José dos Campos Brazil Department of Anesthesiology Juiz de Fora Federal University Juiz de Fora Brazil Department of Anesthesiology Clinics Hospital University of S&atildeo Paulo Medical School S&atildeo Paulo Brazil Discipline of Anesthesiology Department of Surgery University of S&atildeo Paulo Medical School S&atildeo José dos Campos Brazil

Background: Measures to contain the COVID-19 transmission reached teaching routines of universities worldwide with possible mental health consequences for anxiety. This study assessed prevalence and risk factors for stress, depression, and anxiety (Sda) in medical students during quarantine by COVID-19. Methods: A cross-sectional observational study of medical students by means of the daSS-21 questionnaire. Risk factors for Sda were assessed based on epidemiologic questions related to COVID-19. Receiver Operating Characteristics (ROC) curves were calculated for each predictor, as well as sensitivity and specificity. Results: This survey reached 1009 responses. A prevalence of 77.5% for some Sda disorder was found, 63% being severe. Previous diagnosis of psychiatric disorder was a factor of risk for anxiety (OR 2.78 CI95% 1.44 - 14.25, p = 0.044), as well as for depression (OR 3.37 CI95% 1.98 - 6.02, p Conclusion: Psychiatric conditions as well as chronic illnesses were risk factors for high prevalence of anxiety, depression and stress during the COVID-19 pandemic among medical students.

关键词： Mental Health COVID-19 Students Medical Surveys and Questionnaires

Fracture Loci in Sheet Metal Forming: A Review

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Acta Metallurgica Sinica(English Letters) 2015年第12期28卷 1415-1425页

作者： M.Beatriz silva Kerim Isik A.Erman Tekkaya Paulo A.F.martins IDMEC Instituto Superior Técnico Universidade de Lisboa Institute of Forming Technology and Lightweight Construction Technical University of Dortmund

Fracture in sheet metal forming usually occurs as ductile fracture, rarely as brittle fracture, at the operating temperatures and rates of loading that are typical of real processes in two different modes：（1） tensile and（2） in-plane shear（respectively, the same as modes I and II of fracture mechanics）. The circumstances under which each mode will occur are identified in terms of plastic flow and ductile damage by means of an analytical approach to characterize fracture loci under plane stress conditions that takes anisotropy into consideration. Fracture loci was characterized by means of the fracture forming limit line and by the shear fracture forming limit line in the fracture forming limit diagram. Experiments were performed with single point incremental forming and double-notched test specimens loaded in tension, torsion and in-plane shear give support to the presentation and allow determining the fracture loci of AA1050-H111 aluminium sheets with1 mm thickness. The relation between fracture toughness and the fracture forming limits was also investigated by comparing experimental values of the strains at fracture obtained from a truncated conical part produced by single point incremental forming and from double-notched test specimens loaded in tension.

关键词： Sheet forming Fracture Fracture forming limit diagram

Current knowledge on esophageal atresia

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World Journal of Gastroenterology 2012年第28期18卷 3662-3672页

作者： Paulo Fernando martins Pinheiro Ana Cristina Simoes e silva Regina Maria Pereira Department of Pediatric Surgery Odilon Behrens HospitalAvenida JoséBonifácioSão CristovãoBelo Horizonte31210-690 Minas GeraisBrazil Department of Pediatrics Faculty of MedicineFederal University of Minas GeraisBelo Horizonte30130-100 Minas GeraisBrazil

Esophageal atresia (EA) with or without tracheoesophageal fistula (TEF) is the most common congenital anomaly of the esophagus. The improvement of survival observed over the previous two decades is multifactorial and largely attributable to advances in neonatal intensive care, neonatal anesthesia, ventilatory and nutritional support, antibiotics, early surgical intervention, surgical materials and techniques. Indeed, mortality is currently limited to those cases with coexisting severe life-threatening anomalies. The diagnosis of EA is most commonly made during the first 24 h of life but may occur either antenatally or may be delayed. The primary surgical correction for EA and TEF is the best option in the absence of severe malformations. There is no ideal replacement for the esophagus and the optimal surgical treatment for patients with long-gap EA is still contro-versial. The primary complications during the postoperative period are leak and stenosis of the anastomosis, gastro-esophageal reflux, esophageal dysmotility, fistula recurrence, respiratory disorders and deformities of the thoracic wall. data regarding long-term outcomes and follow-ups are limited for patients following EA/TEF repair. The determination of the risk factors for the complicated evolution following EA/TEF repair may positively impact long-term prognoses. Much remains to be studied regarding this condition. This manuscript provides a literature review of the current knowledge regarding EA.

关键词：食管知识闭锁手术治疗呼吸系统疾病重症监护营养支持功能障碍

Indian medicinal plants are effective in the treatment and management of COVID-19

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BIOCELL 2023年第4期47卷 677-695页

作者： SUBHASH CHANDRA SANTWANA PALAI EDINARDO FAGNER FERREIRA-MATIAS IVO CAVALCANTE PITA-NETO CÍCERO LUCAS GOMES-RAMALHO EDLANE martins DE ANDRADE RAY silva DE ALMEIda MARCELLO IRITI HENRIQUE DOUGLAS MELO-COUTINHO Department of Pharmaceutical Chemistry SGRR UniversityUttarakhand248001India Department of Pharmaceutical Chemistry HNB Garhwal UniversitySrinagar246174India Department of Veterinary Pharmacology&Toxicology College of Veterinary Science and Animal HusbandryBhubaneswar751003India CECAPE—College of Dentistry Juazeiro do Norte63050-203Brazil Department of Biological Chemistry Regional University of CaririCrato63105-000Brazil Department of Biomedical Surgical and Dental SciencesUniversitàdegli Studi di MilanoMilan20133Italy National Interuniversity Consortium of Materials Science and Technology Florence50121Italy

Indian medicinal plants are referred to as the“nectar of life”owing to their phytochemicals and bioactive complexes that are beneficial in treating *** disease 2019(COVID-19)is a global health issue without any proper *** indigenous plants of India can be exploited to control the precise signs of *** Ministry of AYUSH(Ayurveda,Yoga and Naturopathy,Unani,Siddha,and Homeopathy)has advised routine usage of medicinal plants for *** plants like Zingiber officinalis,Azadirachta indica,Ocimum sanctum,Nigella sativa,Withania somnifera,Curcuma longa,Piper nigrum,Allium sativum,Tinospora cordifolia,*** immunity-boosting,antiviral,antibacterial,antioxidant and anti-inflammatory actions that can suppress and treat symptoms of *** vitro,in vivo as well as in silico validation,these phytochemicals can help us to manage and treat COVID-19 *** integration of traditional knowledge in the prophylaxis of corona infection and current skills validating it for the development of precise and powerful therapeutic approaches will more efficiently resolve different clinical aspects of *** review focuses on both traditional and emergent methods to prevent and treat COVID-19 with various Indian medicinal plants along with their phytochemicals.

关键词： Antiviral Corona virus Diagnosis Immunity Herbs