检索结果-南通市图书馆

Brief electrical nerve stimulation enhances intrinsic repair capacity of the focally demyelinated central nervous system

引用

Neural Regeneration Research 2022年第5期17卷 1042-1050页

作者： Lydia Ayanwuyi Nataliya Tokarska Nikki A.mcLean jayne m.johnston Valerie m.K.Verge Department of Anatomy Physiology and PharmacologyUniversity of SaskatchewanSaskatoonSKCanada Cameco mS Neuroscience Research Center University of SaskatchewanSaskatoonSKCanada

Our lab has shown that brief electrical nerve stimulation(ES)has a dramatic impact on remyelination of lysophosphatidyl choline(LPC)-induced focally demyelinated rat peripheral nerves,while also inducing an axon-protective phenotype and shifting macrophages from a predominantly pro-inflammatory toward a pro-repair *** this same potential exists in the central nervous system is not ***,for proof of principle studies,the peripheral nerve demyelination and ES model was adapted to the central nervous system,whereby a unilateral focal LPC-induced demyelination of the dorsal column at the lumbar enlargement where the sciatic nerve afferents enter was created,so that subsequent ipsilateral sciatic nerve ES results in increased neural activity in the demyelinated *** reveal a robust focal demyelination at 7 days post-LPC *** of 1-hour ES at 7 days post-LPC polarizes macrophages/microglia toward a pro-repair phenotype when examined at 14 days post-LPC;results in smaller LPC-associated regions of inflammation compared to non-stimulated controls;results in significantly more cells of the oligodendroglial lineage in the demyelinated region;elevates myelin basic protein levels;and shifts the paranodal protein Caspr along demyelinated axons to a more restricted distribution,consistent with reformation of the paranodes of the nodes of *** also significantly enhanced levels of phosphorylated neurofilaments detected in the zones of demyelination,which has been shown to confer axon *** these findings support that strategies that increase neural activity,such as brief electrical stimulation,can be beneficial for promoting intrinsic repair following focal demyelinating insults in demyelinating diseases such as multiple *** animal procedures performed were approved by the University of Saskatchewan's Animal Research Ethics Board(protocol#20090087;last approval date:November 5,2020).

关键词： axon protection demyelination immune response lysophosphatidyl choline macrophage microglia multiple sclerosis myelin nervous system repair neural activity polarization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Personalized medicine:Clinical oncology on molecular view of treatment

引用

World Journal of Clinical Oncology 2024年第8期15卷 992-1001页

作者： Rafick Costa Dos Santos Da Silva Nathalia de Andrade Simon AndréAlves Dos Santos Gabriel De melo Olegário jayne Ferreira Da Silva Naide Oliveira Sousa manuel Alvarez Troncoso Corbacho Fabrício Freire de melo Instituto multidisciplinar em Saúde Universidade Federal da BahiaVitória Da Conquista 45029-094BahiaBrazil

Cancer,the second leading global cause of death,impacts both physically and *** treatments such as surgeries,chemotherapy,and radiotherapy have adverse effects,driving the need for more precise *** medicine enables more targeted *** mapping,alongside other molecular biology approaches,identifies specific genes,contributing to accurate *** review addresses,in clinical use,a molecular perspective on *** like alpha-fetoprotein,beta-human chorionic gonadotropin,5-hydroxyindoleacetic acid,programmed death-1,and cytotoxic T lymphocyte-associated protein 4 are explored,providing valuable ***,with an emphasis on artificial intelligence,revolutionizes the analysis of biological data,offering more accurate *** like liquid biopsy are emphasized for early *** medicine guides therapeutic strategies based on the molecular characteristics of the tumor,as evidenced in the molecular subtypes of breast *** allow personalized treatments,highlighting the role of trastuzumab and endocrine *** the benefits,challenges persist,including high costs,tumor heterogeneity,and ethical *** obstacles requires collaboration,ensuring that advances in molecular biology translate into accessible benefits for all.

关键词： Oncology Neoplasia molecular biology Personalized medicine molecular markers Cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biological soil crusts as an integral component of desert environments

引用

Ecological Processes 2013年第1期2卷 116-129页

作者： jayne Belnap Bettina Weber Department of Archaeology Simon Fraser UniversityBurnabyBC V5A 1S6Canada Department of Biology Plant Ecology and SystematicsUniversity of KaiserslauternP.O.Box 3049Kaiserslautern 67653Germany multiphase Chemistry Department Max Planck Institute for ChemistryHahn-Meitner-Weg 1Mainz 55128Germany

The biology and ecology of biological soil crusts,a soil surface community of mosses,lichens,cyanobacteria,green algae,fungi,and bacteria,have only recently been a topic of *** efforts began in the western U.S.(Cameron,Harper,Rushforth,and ***),Australia(Rogers),and Israel(Friedmann,Evenari,and Lange)in the late 1960s and 1970s(e.g.,Friedmann et al.1967;Evenari 1985,reviewed in Harper and marble 1988).However,these groups worked independently of each other and,in fact,were often not aware of each other’s *** addition,biological soil crust communities were seen as more a novelty than a critical component of dryland eco*** then,researchers have investigated many different aspects of these communities and have shown that although small to microscopic,biological soil crusts are critical in many ecological processes of *** often cover most of desert soil surfaces and substantially mediate inputs and outputs from desert soils(Belnap et al.2003).They can be a large source of biodiversity for deserts,as they can contain more species than the surrounding vascular plant community(Rosentreter 1986).These communities are important in reducing soil erosion and increasing soil fertility through the capture of dust and the fixation of atmospheric nitrogen and carbon into forms available to other life forms(Elbert et al.2012).

关键词： soil fertility component

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cost-effectiveness of lutetium(^177Lu)oxodotreotide vs everolimus in gastroenteropancreatic neuroendocrine tumors in Norway and Sweden

引用

World Journal of Clinical Cases 2020年第20期8卷 4793-4806页

作者： jayne Palmer Oscar R Leeuwenkamp Ossian Health Economics and Communications Basel 4051Switzerland Advanced Accelerator Applications Geneva 1204Switzerland

BACKGROUND Gastroenteropancreatic neuroendocrine tumors(GEP-NETs)represent a relatively rare and heterogenous group of *** available treatment options for patients with progressive GEP-NETs include lutetium(177 Lu)oxodotreotide(177 LuDotatate)and everolimus[as well as sunitinib for patients with pancreatic NETs(P-NETs)].AIm To perform a health economic analysis to determine the cost-effectiveness of 177 LuDotatate compared with everolimus in patients with unresectable or metastatic midgut-NETs or P-NETs in both Sweden and *** Simulations were performed using a three-state partitioned survival model and analyses were performed separately for patients with midgut-NETs and *** input data were sourced from an indirect comparison that utilized survival data from clinical trials of 177 Lu-Dotatate and *** analyses were performed from the healthcare payer perspective over a time horizon of 20 *** Sweden,future costs and clinical outcomes were discounted at 3%per *** Norway,a discount rate of 4%per annum was *** For Sweden,improved survival outcomes and higher lifetime costs with 177 LuDotatate resulted in an incremental cost-effectiveness ratio(ICER)of SEK 391194 per quality-adjusted life year(QALY)gained for midgut NETs and SEK 16764 per QALY gained for P-NETs for 177 Lu-Dotatate compared with *** Norway,the corresponding ICERs were NOK 244444 per QALY gained and NOK 106451 per QALY gained,***-way sensitivity analyses revealed that the results were most sensitive to changes in drug acquisition costs and health state utility *** In both Sweden and Norway,from a healthcare provider perspective,177 LuDotatate is likely to be considered cost-effective relative to everolimus for the treatment of patients with unresectable or metastatic,progressive midgut-NETs or P-NETs.

关键词： Cost Cost-effectiveness Neuroendocrine tumors 177Lu-Dotatate Sweden Norway

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hypertension and Heart Failure as Predictors of mortality in an Adult Congenital Heart Defect Population

引用

Congenital Heart Disease 2021年第4期16卷 333-355页

作者： Cheryl Raskind-Hood Kashaine A.Gray jayne morgan Wendy m.Book Department of Epidemiology Emory School of Public HealthAtlantaGeorgiaUSA Department of Public Health Mercer University College of Health ProfessionsAtlantaGeorgiaUSA Division of Cardiovascular Research Piedmont HospitalAtlantaGeorgiaUSA Division of Cardiology Emory University School of MedicineAtlantaGeorgiaUSA

Early intervention to prevent premature mortality is vital for adults with congenital heart defects(CHD).Anatomic complexity and comorbid conditions are thought to contribute to CHD *** hypertension(HTN)and heart failure(HF)are the comorbid conditions among the most prevalent causes of death in the United States,and commonly accompany CHD,it is crucial to evaluate whether they are reliable predictors of mortality for adults with CHD(ACHD)independent of anatomic CHD complexity.A retrospective cross-sectional analysis of ACHD,aged 18–64,with concomitant HTN and/or HF and at least one health care encounter during 2008–2010 were *** 5,397 ACHD patients(18.3%HTN without HF,4.4%HF without HTN,8.3%with both),3.0%died(n=163)during the study ***,the sample was 45.1%white,61.4%female,and 29.0%had a complex *** those who died,23.3%had HTN without HF,17.2%had HF without HTN,and 42.3%had *** analyses revealed that older age,male gender,black race,and having public health insurance were associated with increased mortality during the three-year study period compared to ACHD patients who were younger,female gender,white race,and covered by private health *** patients diagnosed with non-complex CHD lesions(i.e.,shunts,valves,or shunts+valves)were at greater risk of dying compared to those with severe complex *** CHD type was assessed separately,those with valve lesions were more likely to die compared to those with complex CHD *** adjustment for age,gender,race,insurance and CHD complexity,ACHD patients with HF,with or without HTN,were equally likely to die during the study ***,ACHD patients with HF,without or without HTN,who had valve defects were more likely to die during the three-year study period compared to patients with complex CHDs.

关键词： Congenital heart defect risk factors hypertension heart failure mortality

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Grasshoppers （Orthoptera： Acrididae） select vegetation patches in local-scale responses to foliar nitrogen but not phosphorus in native grassland

引用

Insect Science 2011年第5期18卷 533-540页

作者： Viviana Loaiza jayne L. Jonas Anthony Joern Division of Biology Kansas State University Manhattan Kansas USA

Key elements such as nitrogen （N） and phosphorus （P） are often limiting relative to the nutritional needs of herbivores that feed on them. While N often limits insect herbivores in natural terrestrial ecosystems, the effect of P is poorly studied in the field, even though compelling hypotheses from the ecological stoichiometry literature predict its importance. We evaluated small-scale spatial distributions of, and herbivory by, grasshoppers among neighboring plots that vary in foliar-N and -P in tallgrass prairie. Grasshopper densities were 67% greater in N-fertilized plots but detected no effect to grasshopper densities from P-fertilizer. Leaf damage to the dominant grass Andropogon gerardii was 32% greater in N-fertilized plots, but no response to foliar-P was detected. Herbivore damage to a common forb, goldenrod （Solidago missouriensis）, was not strongly linked by fertilizer treatments, although there was increased leaf damage in N-fertilizer treatments when no P was applied （a significant N ~ P interaction）. Under field conditions at local scales, we conclude that spatially heterogeneous distributions of grasshoppers are primarily affected by foliar-N in host plants with little evidence that P-levels contribute to the spatial patterns.

关键词： Andropogon gerardii ecological stoichiometry insect herbivory Konza Prairie N-P fertilization experiment Solidago rnissouriensis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sequence-Independent Identification of Active LTR Retrotransposons in Arabidopsis

引用

molecular Plant 2018年第3期11卷 508-511页

作者： jayne,Griffiths marco,Catoni mayumi,Iwasaki Jerzy,Paszkowski The Sainsbury Laboratory University of Cambridge Cambridge UK [∗]Corresponding author Present Address: University of Geneva Geneva Switzerland

Dear Editor,LTR retrotransposons （LTR-TEs） are mobile genetic elements that often comprise a large portion of the host genome and are particularly abundant in genomes of plants （Lisch, 2013）. They transpose through an RNA transcript that is reverse transcribed to an extrachromosomal DNA （ecDNA） of the original element that can insert at a new genomic location （Wicker et al., 2007）.

关键词： Arabidopsis LTR 鉴定人染色体 DNA RNA 元素植物

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Operational effects of the UNOT gate on classical and quantum correlations

引用

Science Bulletin 2018年第12期63卷 765-770页

作者： Kuan Zhang Jiajun ma Xiang Zhang jayne Thompson Vlatko Vedral Kihwan Kim mile Gu Center for Quantum Information Institute for Interdisciplinary Informotion SciencesTsinghua UniversityBeijing 100084China Department of Atomic and Laser Physics.Clarendon Laboratory University of OxfordOxford OX1 3PUUK Department of Physics Renmin University of ChinaBeijing 100872China Centre for Quantum Technologies National University of SingaporeSingapore 117543Singapore Department of Physics Notional University of SingaporeSingapore 117551Singapore School of mathematical and Physical Sciences Nanyang Technological UniversitySingapore 637371Singapore Complexity Institute Nanyang Technological UniversitySingapore 637335Singapore

The NOT gate that flips a classical bit is ubiquitous in classical information *** its quantum analogue,the universal NOT(UNOT) gate that flips a quantum spin in any alignment into its antipodal counterpart is strictly *** we explore the connection between this discrepancy and how UNOT gates affect classical and quantum *** show that while a UNOT gate always preserves classical correlations between two spins,it can non-locally increase or decrease their shared discord in ways that allow violation of the data processing *** experimentally illustrate this using a multi-level trapped ^(171)Yb^+ ion that allows simulation of anti-unitary operations.

关键词： Quantum information Universal NOT gate Quantum correlations Quantum discord Data processing inequality Embedding quantum simulation Ion trap

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Self-management of coronary heart disease in older patients after elective percutaneous transluminal coronary angioplasty

引用

Journal of Geriatric Cardiology 2016年第5期13卷 393-400页

作者： Susan Dawkes Graeme D Smith Lawrie Elliott Robert Raeside jayne H Donaldson School of Nursing Midwifery and Social Care Edinburgh Napier University Scotland United Kingdom Department of Nursing and Community Health Glasgow Caledonian University Scotland United Kingdom Employment Research Institute Edinburgh Napier University Scotland United Kingdom School of Health Sciences University of Stirling Scotland United Kingdom

Objective To explore how older patients self-manage their coronary heart disease （CHD） aider undergoing elective percutaneous transluminal coronary angioplasty （PTCA）. methods This mixed methods study used a sequential, explanatory design and recruited a convenience sample of patients （n = 93） approximately three months after elective PTCA. The study was conducted in two phases. Quantitative data collected in Phase 1 by means of a self-administered survey were subject to univariate and bivariate analysis. Phase 1 findings in- formed the purposive samplhag for Phase 2 where ten participants were selected from the original sample for an in-depth interview. Qualita- tive data were analysed using thematic analysis. This paper will primarily report the findings from a sub-group of older participants （n = 47） classified as 65 years of age or older. Results 78.7% （n = 37） of participants indicated that they would manage recurring angina symptoms by taking glyceryl trinitrate and 34% （n = 16） thought that resting would help. Regardless of the duration or severity of the symptoms 40.5% （n = 19） would call their general practitioner or an emergency ambulance for assistance during any recurrence of angina symptoms. Older participants weighed less （P = 0.02） and smoked less （P = 0.01） than their younger counterparts in the study. Age did not seem to affect PTCA patients＇ likelihood of altering dietary factors such as fruit, vegetable and saturated fat consumption （P = 0.237）. Conclusions The findings suggest that older people in the study were less likely to know how to correctly manage any recurring angina symptoms than their younger counterparts but they had fewer risk factors for CHD. Age was not a factor that influenced participants＇ likelihood to alter lifestyle factors.

关键词： Angina pectoris Coronary disease Percutaneous transluminal coronary angioplasty Self-management

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

FOXO3a as a sensor of unilateral nerve injury in sensory neurons ipsilateral, contralateral and remote to injury

引用

Neural Regeneration Research 2020年第12期15卷 2353-2361页

作者： Jovan CDHasmatali Jolly De Guzman jayne mjohnston Hossein Noyan Bernhard HJuurlink Vikram misra Valerie mKVerge Department of Anatomy Physiologyand PharmacologyUniversity of SaskatchewanSaskatoonSKCanada Cameco mS Neuroscience Research Center University of SaskatchewanSaskatoonSKCanada Department of Veterinary microbiology University of SaskatchewanSaskatoonSKCanada

Emerging evidence supports that the stress response to peripheral nerve injury extends beyond the injured neuron,with alterations in associated transcription factors detected both locally and remote to the ***-induced nuclear translocation of the transcription factor forkhead class box O3a(FOXO3a)was initially linked to activation of apoptotic genes in many neuronal ***,a more complex role of FOXO3a has been suggested in the injury response of sensory neurons,with the injured neuron expressing less *** elucidate this response and test whether non-injured sensory neurons also alter FOXO3a expression,the temporal impact of chronic unilateral L4–6 spinal nerve transection on FOXO3a expression and nuclear localization in adult rat dorsal root ganglion neurons ipsilateral,contralateral or remote to injury relative to na?ve controls was *** na?ve neurons,high cytoplasmic and nuclear levels of FOXO3a colocalized with calcitonin gene related peptide,a marker of the nociceptive *** hour post-injury,an acute increase in nuclear FOXO3a in small size injured neurons occurred followed by a significant decrease after 1,2 and 4 days,with levels increasing toward pre-injury levels by 1 week post-injury.A more robust biphasic response to the injury was observed in uninjured neurons contralateral to and those remote to *** levels of FOXO3a peaked at 1 day,decreased by 4 days,then increased by 1 week post-injury,a response mirrored in C4 dorsal root ganglion neurons remote to *** altered expression contralateral and remote to injury supports that spinal nerve damage has broader systemic impacts,a response we recently reported for another stress transcription factor,Luman/*** early decreased expression and nuclear localization of FOXO3a in the injured neuron implicate these changes in the cell body response to injury that may be ***,the broader systemic changes support the existence of stress/inj

关键词： cell body response contralateral response dorsal root ganglion peripheral nerve injury plasticity sciatic nerve sensory neuron stress systemic transcription factor unilateral peripheral nerve injury

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：