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DNA methylation profile of a hepatosplenic gamma/delta T-cell lymphoma patient associated with response to interferon-α therapy

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Cellular & Molecular Immunology 2021年第5期18卷 1332-1335页

作者： jaydeep bhat Anke KBergmann Silvio Waschina Christoph Nerl Christoph Kaleta Reiner Siebert Ole Ammerpohl Dieter Kabelitz Institute of Immunology Christian-Albrechts-University Kiel&University Hospital Schleswig-HolsteinCampus KielKielGermany Metabolic Programming School of Life Sciences WeihenstephanTechnical University Munich(TUM)85354FreisingGermany Institute of Human Genetics Christian-Albrechts-University Kiel&University Hospital Schleswig-HolsteinCampus KielKielGermany Institute of Human Genetics Medical School HannoverHannoverGermany Institute of Experimental Medicine Christian-Albrechts-University Kiel&University Hospital Schleswig-HolsteinCampus KielKielGermany Institute of Human Nutrition and Food Science Christian-Albrechts-University KielKielGermany Städtisches Krankenhaus München-Schwabing MunichGermany Institute of Human Genetics Ulm University&Ulm University Medical Center89081UlmGermany

The 2–5%γδT cells in healthy human peripheral blood recognize nonpeptide antigens,in contrast toαβT cells.1 DistinctγδT-cell malignancies have been identified,with hepatosplenic T-cell lymphoma(γδ-HSTL)being a rare but aggressive(median survival 13 months)subset.2γδ-HSTL usually presents with hepatosplenomegaly without lymphadenopathy,anemia,and *** is histologically characterized by the involvement of the hepatic sinusoids,splenic red pulp and bone marrow interstitium,with or without leukemic presentation in peripheral blood.3 A standard treatment regimen is not well established,but therapy mostly includes various chemotherapeutic ***,interferon-α(IFN-α)has been proven to be effective in some patients withγδ-HSTL,but other patients require allogeneic or autologous stem cell transplantation.

关键词： hepato splenic interferon

Comprehensive analysis of glacier recession(2000-2020)in the Nun-Kun Group of Glaciers,Northwestern Himalaya

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Journal of Mountain Science 2024年第3期21卷 768-785页

作者： Shakil Ahmad ROMSHOO Ummer AMEEN Mustafa Hameed bhat Tariq ABDULLAH Department of Geoinformatics University of KashmirSrinagarKashmir 190006India Islamic University of Science and Technology AwantiporaKashmir 192122India Centre of Excellence for Glacier Studies in the Western Himalaya University of KashmirSrinagarKashmir 190006India

Himalayan glaciers are shrinking rapidly,especially after *** shrinkage,however,shows a differential pattern in space and time,emphasizing the need to monitor and assess glacier changes at a larger *** this study,changes of 48 glaciers situated around the twin peaks of the Nun and Kun mountains in the northwestern Himalaya,hereafter referred to as Nun-Kun Group of Glaciers(NKGG),were investigated using Landsat satellite data during *** in glacier area,snout position,Equilibrium Line Altitude(ELA),surface thickness and glacier velocity were assessed using remote sensing data supplemented by field *** study revealed that the NKGG glaciers have experienced a recession of 4.5%±3.4%and their snouts have retreated at the rate of 6.4±1.6 m·a^(-1).Additionally,there was a 41%increase observed in the debris cover area during the observation *** the geodetic approach,an average glacier elevation change of-1.4±0.4 m·a^(-1)was observed between 2000 and *** observed mass loss of the NKGG has resulted in the deceleration of glacier velocity from 27.0±3.7 m·a^(-1)in 2000 to 21.2±2.2 m·a^(-1)in *** ELA has shifted upwards by 83.0±22 m during the *** morphological and topographic factors showed a strong influence on glacier ***,a higher recession of 12.9%±3.2%was observed in small glaciers,compared to 2.7%±3.1%in larger *** debris-covered glaciers showed lower shrinkage(2.8%±1.1%)compared to the clean glaciers(9.3%±5%).The glacier depletion recorded in the NKGG during the last two decades,if continued,would severely diminish glacial volume and capacity to store water,thus jeopardizing the sustainability of water resources in the basin.

关键词： Nun-Kun range Glacier recession Glacier snout Remote Sensing Himalaya Glacier velocity

Prospective randomized study to evaluate and compare the post-procedural sexual function in patients undergoing semi-rigid ureterorenoscopy for distal ureteric stones in three different operating room settings

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Asian Journal of Urology 2024年第2期11卷 331-338页

作者： Gajanan S.bhat Anuradha Shastry Sexual Medicine TSS Shripad Hegde Kadave Institute of Medical SciencesSirsiKarnatakaIndia Department of Urology Andrology and Sexual MedicineTSS Shripad Hegde Kadave Institute of Medical SciencesSirsiKarnatakaIndia

Objective:To evaluate and compare the effect of semi-rigid ureterorenoscopy on post-procedural sexual function with three different operating room ***:In this prospective randomized study,consecutive sexually active patients with normal pre-operative sexual function undergoing uncomplicated semi-rigid ureterorenoscopy for distal ureteric stones were randomized into three groups,with three different operating room ***-related anxiety and sexual function were assessed pre-operatively using Amsterdam Preoperative Anxiety and Information Scale and Brief Sexual Function Inventory(in males)and Female Sexual Function Index-6(in females),*** the participants were stented following the procedure,and the stent was removed after 3 ***-procedural sexual function and general discomfort were assessed and compared between three groups at 1 week,3 weeks,and 12 *** effect of surgery-related anxiety,preoperative sexual function,age,and general discomfort(including stent-related discomfort)on post-procedural sexual function were analyzed using multiple regression analysis.A p-value of less than 0.05 was considered statistically ***:Totally,327 eligible patients were randomized into three *** group of patients who underwent the procedural with a screen separating the operating area from the patient vision,while the patient could watch the endoscopy through a separate monitor,had better post-procedural sexual function compared to those who had total vision of the operating area as well as to those whose eyes were *** difference was statistically *** post-procedural reduction in sexual function could not be attributed to in situ stent ***:Our study showed that semi-rigid ureterorenoscopy can have significant negative effect on sexual function,which can be reduced with proper preoperative counseling and an ideal operating room settings.

关键词： Semi-rigid ureterorenoscopy Post-procedural sexual dysfunction Preoperative counselling Operating room setting

Linkage between precipitation isotopes and water vapor sources in the monsoon margin:Evidence from arid areas of Northwest China

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Journal of Arid Land 2024年第3期16卷 355-372页

作者： CHEN Fenli ZHANG Qiuyan WANG Shengjie CHEN Jufan GAO Minyan Mohd Aadil bhat College of Geography and Environmental Science Northwest Normal UniversityLanzhou 730000China Key Laboratory of Resource Environment and Sustainable Development of Oasis of Gansu Province Northwest Normal UniversityLanzhou 730000China School of Ocean and Earth Science Tongji UniversityShanghai 200092China

The isotope composition in precipitation has been widely considered as a tracer of monsoon *** with the coastal region,the monsoon margin usually has limited precipitation with large fluctuation and is usually sensitive to climate *** water resource management in the monsoon margin should be better planned by understanding the composition of precipitation isotope and its influencing *** this study,the precipitation samples were collected at five sampling sites(Baiyin City,Kongtong District,Maqu County,Wudu District,and Yinchuan City)of the monsoon margin in the northwest of China in 2022 to analyze the characteristics of stable hydrogen(δD)and oxygen(δ18O)*** analyzed the impact of meteorological factors(temperature,precipitation,and relative humidity)on the composition of precipitation isotope at daily level by regression analysis,utilized the Hybrid Single-Particle Lagrangian Integrated Trajectory(HYSPLIT)-based backward trajectory model to simulate the air mass trajectory of precipitation events,and adopted the potential source contribution function(PSCF)and concentration weighted trajectory(CWT)to analyze the water vapor *** results showed that compared with the global meteoric water line(GMWL),the slope of the local meteoric water line(LMWL;δD=7.34δ^(18)O-1.16)was lower,indicating the existence of strong regional evaporation in the study *** significantly contributed toδ18O value,while relative humidity had a significant negative effect onδ18O *** the backward trajectory analysis,we found eight primary locations that were responsible for the water vapor sources of precipitation in the study area,of which moisture from the Indian Ocean to South China Sea(ITSC)and the western continental(CW)had the greatest influence on precipitation in the study *** hydrogen and oxygen isotopes in precipitation are significantly influenced by the sources and transportation paths of air *** addition,the r

关键词： water vapor monsoon margin stable water isotope transport trajectory air mass d-excess δ18O δD

Implications of electrode modifications in aqueous organic redox flow batteries

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Journal of Energy Chemistry 2024年第8期95卷 499-510,I0011页

作者： Zahid Manzoor bhat Mohammad Furquan Muhammad Aurang Zeb Gul Sial Umair Alam Atif Saeed Alzahrani Mohammad Qamar Interdisciplinary Research Center for Hydrogen Technologies and Carbon Management(IRC-HTCM) King Fahd University of Petroleum&Minerals(KFUPM)Dhahran 31261Saudi Arabia Department of Materials Science and Engineering King Fahd University of Petroleum and MineralsDhahran 31261Saudi Arabia Interdisciplinary Research Center for Sustainable Energy Systems(IRC-SES) King Fahd University of Petroleum and MineralsDhahran 31261Saudi Arabia

Aqueous organic redox flow batteries(RFBs)exhibit favorable characteristics,such as tunability,multielectron transfer capability,and stability of the redox active molecules utilized as anolytes and catholytes,making them very viable contenders for large-scale grid storage *** attention has been paid on the development of efficient redox-active molecules and their performance optimization through chemical substitutions at various places on the backbone as part of the pursuit for high-performance *** the fact that electrodes are vital to optimal performance,they have not garnered significant *** research has been conducted on the effects of electrode modifications to improve the performance of *** primary emphasis has been given on the impact of electrode engineering to augment the efficiency of aqueous organic *** overview of electron transfer at the electrode-electrolyte interface is *** implications of electrode modification on the performance of redox flow batteries,with a particular focus on the anodic and cathodic half-cells separately,are then *** each section,significant discrepancies surrounding the effects of electrode engineering are thoroughly examined and ***,we have presented a comprehensive assessment along with our perspectives on the future trajectory.

关键词： Redox flow batteries Electrode modification Organic redox molecules Outer sphere and inner sphere

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森林砍伐、气候变化与农业可持续性:综述

Journal of Resources and Ecology 2024年第1期15卷 140-150页

作者： Gayatri KUNTE Varadurga bhat 基督大学经济学系印度卡纳塔克邦班加罗尔市560029

本研究通过总结相关文献探讨了森林砍伐与农业之间的关系,并评估了气候变化对其潜在影响。选择具有重要生态意义的西高止山区作为研究对象,通过整理各个研究主题下的相关结果,我们详细探讨了包括森林砍伐的根本原因,森林土地转化为农业... 详细信息

本研究通过总结相关文献探讨了森林砍伐与农业之间的关系,并评估了气候变化对其潜在影响。选择具有重要生态意义的西高止山区作为研究对象,通过整理各个研究主题下的相关结果,我们详细探讨了包括森林砍伐的根本原因,森林土地转化为农业用途,农业、森林砍伐与气候变化之间的关系,气候驱动的农业脆弱性以及如何在保护森林与发展农业之间取得平衡。研究发现,农业的转变已经成为引发森林砍伐的主要原因;气候变化对农业的主要影响体现在作物产量的下降。印度的干旱和亚热带地区对气候变化的敏感性较高,这很可能是由于印度的热带森林遭受了较严重的砍伐。西高止山区联合森林规划和管理区域的树木密度较高,这为剩余土地用于非森林用途(如农业)创造了潜在的机会。

关键词：农业敏感性农林复合种植气候变化适应性气候变化暴露森林砍伐可持续性

Mechanistic insights toward identification and interaction of plant parasitic nematodes:A review

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Soil Ecology Letters 2024年第1期6卷 11-27页

作者： Bisma Jan Ali Haider Shah Mudasir Ahmad bhat Arif Tasleem Jan Ishfaq Ahmad Wani Ali Asghar Shah Section of Microbiology Baba Ghulam Shah Badshah UniversityRajouriJ&K185234India Department of Biotechnology Baba Ghulam Shah Badshah University RajouriJ&K185234India Department of Botany Baba Ghulam Shah Badshah University RajouriJ&K185234India Department of Zoology School of Biosciences and BiotechnologyBaba Ghulam Shah Badshah University RajouriJ&K185234India

Nematode identification serves as an important param-eter to study their behaviour,importance and *** of classical morphometric based identifica-tion methods prove to be lacking due to insufficient knowledge on morphological variations among closely related *** approaches such as DNA and protein-based information,microarray,probing,sequence-based methods and others have been used to supplement morphology-based methods for nematode *** and certain protein-based nematode-associated molecular patterns(NAMPs),can be perceived by the host plants,and can initiate a signalling *** review primarily emphasizes on an updated account of different classical and modern tools used for the identification of *** we also summa-rize the mechanism of some important signalling pathways which are involved in the different plant nematode *** constitute most diverse and least studied group of soil inhabiting *** are ecologically and physiologically important,however,wide range of nematodes show harmful impact on the individuals that live within their *** parasitic nematodes(PPNs)are transparent,pseudocoelomate,free living or parasitic *** lack morphometric identification methods due to insufficient knowl-edge on morphological variations among closely related *** such,molecular approaches such as DNA and protein-based information,microarray,probing,sequence-based methods and others have been used to supplement morphology-based methods for their *** invade the defense response of different plant species,parasitic nematodes have evolved different molecular *** and certain protein-based nematode-associated molecular patterns(NAMPs),can be perceived by the host plants,and can initiate a signaling *** overcome the host confrontation and develop certain nematode feeding sites,some members can inject effectors into

关键词： nematode identification plant nematode interaction DNA fingerprinting nematode-associated molecular patterns signaling path-ways

Antibiotics Misuse and Antimicrobial Resistance Development in Agriculture:A Global Challenge

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Environment & Health 2024年第9期2卷 618-622页

作者： Baljit Singh Abhijnan bhat Kamna Ravi MiCRA Biodiagnostics Technology Gateway Technological University Dublin(TU Dublin)Dublin D24 FKT9Ireland Health Engineering&Materials Science(HEMS)Research HubTechnological University Dublin(TU Dublin)Dublin D24 FKT9Ireland

INTRODUCTION Antibiotics or antimicrobials are medications that are used to treat infections in animals or people by either killing or inhibiting the growth of microorganisms that cause *** are composed of medications such as antibiotics,antifungals,antivirals,anthelmintics,etc.,all of which are critical in safeguarding human and animal health and *** of the most widely known and important breakthroughs in the history of medicine was the discovery of antibiotics.

关键词： medication inhibiting breakthrough

Construction of a broad-host-range Anderson promoter series and particulate methane monooxygenase promoter variants expand the methanotroph genetic toolbox

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Synthetic and Systems Biotechnology 2024年第2期9卷 250-258页

作者： Etash H.bhat Jessica M.Henard Spencer A.Lee Dustin McHalffey Mahith S.Ravulapati Elle V.Rogers Logan Yu David Skiles Calvin A.Henard Department of Biological Sciences and BioDiscovery Institute University of North TexasDentonTXUSA

Methanotrophic bacteria are currently used industrially for the bioconversion of methane-rich natural gas and anaerobic digestion-derived biogas to valuable *** bacteria may also serve to mitigate the negative effects of climate change by capturing atmospheric greenhouse *** genetic tools have previously been developed for genetic and metabolic engineering of ***,the available tools for use in methanotrophs are significantly underdeveloped compared to many other industrially relevant bacteria,which hinders genetic and metabolic engineering of these *** such,expansion of the methanotroph genetic toolbox is needed to further our understanding of methanotrophy and develop biotechnologies that leverage these unique microbes for mitigation and conversion of methane to valuable ***,we determined the copy number of three broad-host-range plasmids in Methylococcus capsulatus Bath and Methylosinus trichosporium OB3b,representing phylogenetically diverse Gammaproteobacterial and Alphaproteobacterial methanotrophs,***,we show that the commonly used synthetic Anderson series promoters are functional and exhibit similar relative activity in *** and *** OB3b,but the synthetic series had limited ***,we mutagenized the native *** particulate methane monooxygenase promoter and identified variants with activity that expand the activity range of synthetic,constitutive promoters functional not only in ***,but also in Escherichia ***,the tools developed here advance the methanotroph genetic engineering toolbox and represent additional synthetic genetic parts that may have broad applicability in Pseudomonadota bacteria.

关键词： Methanotroph Methane monooxygenase Promoter Metabolic engineering Synthetic biology