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Antiurolithiatic activity of Aavarai Bhavanai Chooranam a Siddha polyherbal formulation on ethylene glycol-induced urolithiasis in Wister albino rats

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Drug Combination Therapy 2022年第4期4卷 25-29页

作者： Harishanbuselvan Venkatesan Arthi Gurumurthy rathinam jayaraj Lakshmanakumar Venkatachalam Resident Medical Officer National Institute of SiddhaChennai 600047Tamil NaduIndia Sai Siddha Clinic Salem 636354Tamil NaduIndia Govt upgraded Primary Health Centre EriayamangalamNamakkal 637210Tamil NaduIndia All India Institute of Medical Sciences(AIIMS) Raipur 492099ChattishgarhIndia

Background:Aavarai Bhavanai Chooranam(ABC)is a Siddha polyherbal formulation containing ten medicinal plants that have been used in the Siddha system of medicine,practiced in the Southern part of Tamil Nadu,India for the management of ***:The study is carried out to scientifically validate the traditional formulation and to study the mechanism of ***:In the present study,the antiurolithiatic activity of ABC was evaluated in Wister albino rats by using ethylene glycol through drinking *** I acted as the standard control group and was given unlimited access to conventional rat food and *** II-V was given ethylene glycol(0.75%)in water to induce renal calculi for 28 *** III got the typical anti-urolithiatic medication,Cystone(750 mg/kg),from the 15th day to the 28th day,whereas Group II functioned as the lithiatic control group and received the *** Bhavanai Chooranam(200 mg/kg)was administered to Group IV from the 15th to the 28th day as a curative *** the first day to the 28th day,Group V received Aavarai Bhavanai Chooranam(200 mg/kg),which was administered as a preventative *** groups'urine samples were taken,and using accepted techniques,their calcium,magnesium,oxalate,inorganic phosphate,protein,and creatinine levels were *** treatment promotes diuresis which leads to flushing of the renal stones and maintains the alkaline condition in the urinary system which probably mediates the antilithiatic ***:ABC provides structural and functional protection to the kidneys by enhancing its physiological function against stone formation and validates its clinical use.

关键词： Aavarai Bhavanai Chooranam ethylene glycol kalladaippu Siddha drug urolithiasis

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Molecular docking analysis to validate the efficacy of phytocompounds of traditional Siddha herb Glycyrrhiza glabra against enzyme tyrosinase for the treatment of vitiligo

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TMR Integrative Medicine 2022年第32期6卷 1-7页

作者： Gurumurthy Arthi Venkatachalam Lakshmanakumar jayaraj rathinam Dhanasekaran Sivaraman Sai Siddha Clinic SalemTamil Nadu 636354India Department of Siddha All India Institute of Medical Sciences RaipurChhattisgarh 492099India GUPHC EriyamangalamNamakkalTamil Nadu 637210India Department of Biotechnology Pandit Deenadayal Energy UniversityKnowledge CorridorRaisan VillagePDPU RoadGandhi NagarGujarat 382426India

Background: Siddha system is one of the ancient medical systems which originated in Indiamore than 4000 years ago had given many formularies and treatment methods for variousdiseases especially skin diseases and autoimmune diseases. One of the most well-knownmembers of the Fabaceae family and a popular medicinal plant is Athimathuram(Glycyrrhiza glabra). Glycyrrhiza glabra root powder (Athimathuram chooranam) fromSiddha herbal formulation mentioned in the texts to treat vitiligo. The study is aimed toexecute the In Silico computational studies of phytoconstituents of Siddha herbAthimathuram chooranam (Glycyrrhiza glabra) against Tyrosinase enzyme for the treatmentof vitiligo. Method: Making use of Auto Dock 4, docking calculations were *** partial charges were applied to the ligand atoms. In order to simulate docking, theSolis & Wets local search approach and the Lamarckian genetic algorithm were *** ligand molecules’ initial locations, orientations, and torsion angles were determined atrandom. During docking, all rotatable torsions were freed. Results: By interacting withamino acids located on the active site of the tyrosinase enzyme, bioactive substances likeGlycyrrhizin, Liquirtin, Glabridin, Umbelliferone, and Glabrene included in the Siddhaformulation exhibit substantial binding activity against the target protein. Conclusion: Itwas concluded that these compounds might exert promising anti-vitiligo properties.

关键词： Glycyrrhiza glabra Athimathuram chooranam vitiligo molecular docking Siddha

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Molecular docking analysis to validate the efficacy of traditional Siddha polyherbal Formulation Aavarai Bhavanai Chooranam(ABC)against enzyme alpha-glucosidase for Type II Diabetes Mellitus

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TMR Integrative Medicine 2023年第1期7卷 1-11页

作者： Venkatachalam Lakshmanakumar Gurumurthy Arthi jayaraj rathinam Venkatesan Harishanbuselvan Dhanasekaran Sivaraman AIIMS Raipur Chhattisgarh 492099India Sai Siddha Clinic SalemTamil Nadu 636354India GUPHC EriyamangalamNamakkal 637210Tamil NaduIndia National Institute of Siddha ChennaiTamil Nadu 600047India Department of Biotechnology Pandit Deenadayal Energy UniversityKnowledge CorridorRaisan VillagePDPU RoadGandhi NagarGujarat 382426India

Background:The Siddha system of traditional medicine has historically been utilized to treat a wide range of illnesses,including noncommunicable *** more than 62 million people in India already living with diabetes,the disease is quickly gaining the status of a possible *** has been demonstrated that this medical theory contains anti-diabetic *** goal of this work is to assess in silico computational investigations of the phytoconstituents in the traditional Siddha polyherbal preparation ABC,which is frequently used to treat ***:Alpha-Glucosidase was used as the target enzyme in docking calculations for recovered *** the help of Auto Dock tools,necessary hydrogen atoms,Kollman unified atom type charges,and solvation parameters were *** Lamarckian genetic algorithm and the Solis and Wets local search approach were used to simulate ***:A total of 13 bioactive lead compounds were identified from the Siddha Formulation *** to the herb’s stated data,the target enzyme Alpha-Glucosidase can interact with the phytochemicals Beta-Sitosterol,Amyrin,Lupeol,Arjunic acid,Arjungenin,Tinosporide,and Tembetarine up to four or five *** second-placed substances,which had a maximum of two to three interactions with the target enzyme Alpha-Glucosidase,were betulonic acid,kaempferol,gallic acid,and ***:The implementation of these formulations in future preclinical and clinical studies could result in the effective management of Type II Diabetes Mellitus.

关键词： Aavarai Bhavanai Chooranam molecular docking polyherbal diabetes traditional siddha

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