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APEX2- tagging of Sigma 1-receptor indicates subcellular protein topology with cytosolic N-terminus and ER luminal C-terminus

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Protein & Cell 2018年第8期9卷 733-737页

作者： Timur Mavylutov Xi Chen Lianwang Guo jay yang Department of Anesthesiology University of Wisconsin SMPH Madison Wl 53705 USA Department of Surgery and Physiology & Cell Biology Ohio State University Columbus OH 43210 USA

Dear Editor, Deciphering the role of any protein in a cell requires knowl- edge of the structure, subcellular localization, and the topological orientation of the protein within the relevant cells. The Sigma-1 receptor （S1R） largely localized to the endo- plasmic reticulum （ER） serves as a pluripotent intracellular signaling molecule with diverse roles in the cell including ion channel modulation, stress signaling, and transcriptional regulation （reviewed in Suet al., 2016）, however, the basic topology of this protein within a cell remains controversial.

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Forecasting cyberattacks with incomplete,imbalanced,and insignificant data

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Cybersecurity 2018年第1期1卷 263-278页

作者： Ahmet Okutan Gordon Werner Shanchieh jay yang Katie McConky Computer Engineering Rochester Institute of TechnologyRochesterNYUSA Industrial&Systems Engineering Rochester Institute of TechnologyRochesterNYUSA

Having the ability to forecast cyberattacks before they happen will unquestionably change the landscape of cyber warfare and cyber *** work predicts specific types of attacks on a potential victim network before the actual malicious actions take *** challenge to forecasting cyberattacks is to extract relevant and reliable signals to treat sporadic and seemingly random acts of *** paper builds on multi-faceted machine learning solutions and develops an integrated system to transform large volumes of public data to aggregate signals with imputation that are relevant and predictive of cyber incidents.A comprehensive analysis of the individual parts and the integrated whole demonstrates the effectiveness and trade-offs of the proposed *** 16-months of reported cyber incidents by an anonymized victim organization,the integrated approach achieves up to 87%,90%,and 96% AUC for forecasting endpoint-malware,malicious-destination,and malicious-email attacks,*** assessed month-by-month,the proposed approach shows robustness to perform consistently well,achieving F-Measure between 0.6 and *** framework also enables an examination of which unconventional signals are meaningful for cyberattack forecasting.

关键词： Cyber security Forecasting Unconventional signals

Targeting multiple signaling pathways:the new approach to acute myeloid leukemia therapy

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Signal Transduction and Targeted Therapy 2021年第1期6卷 41-69页

作者： Jenna LCarter Katie Hege jay yang Hasini AKalpage Yongwei Su Holly Edwards Maik Hüttemann Jeffrey WTaub Yubin Ge Cancer Biology Graduate Program Wayne State University School of MedicineDetroitMIUSA MD/PhD Program Wayne State University School of MedicineDetroitMIUSA Department of Oncology Wayne State University School of MedicineDetroitMIUSA Molecular Therapeutics Program Barbara Ann Karmanos Cancer InstituteWayne State University School of MedicineDetroitMIUSA Center for Molecular Medicine and Genetics Wayne State University School of MedicineDetroitMIUSA National Engineering Laboratory for AIDS Vaccine Key Laboratory for Molecular Enzymology and EngineeringThe Ministry of EducationSchool of Life SciencesJilin UniversityChangchunChina Division of Pediatric Hematology/Oncology Children’s Hospital of MichiganDetroitMIUSA Department of Pediatrics Wayne State University School of MedicineDetroitMIUSA

Acute myeloid leukemia(AML)is the most common form of acute leukemia in adults and the second most common form of acute leukemia in *** this,very little improvement in survival rates has been achieved over the past few *** is partially due to the heterogeneity of AML and the need for more targeted therapeutics than the traditional cytotoxic chemotherapies that have been a mainstay in therapy for the past 50 *** the past 20 years,research has been diversifying the approach to treating AML by investigating molecular pathways uniquely relevant to AML cell proliferation and *** we review the development of novel therapeutics in targeting apoptosis,receptor tyrosine kinase(RTK)signaling,hedgehog(HH)pathway,mitochondrial function,DNA repair,and c-Myc *** has been an impressive effort into better understanding the diversity of AML cell characteristics and here we highlight important preclinical studies that have supported therapeutic development and continue to promote new ways to target AML *** addition,we describe clinical investigations that have led to FDA approval of new targeted AML therapies and ongoing clinical trials of novel therapies targeting AML survival *** also describe the complexity of targeting leukemia stem cells(LSCs)as an approach to addressing relapse and remission in AML and targetable pathways that are unique to LSC *** comprehensive review details what we currently understand about the signaling pathways that support AML cell survival and the exceptional ways in which we disrupt them.

关键词： myeloid approach approval

Genome-wide high-throughput screening in yeast for functional analysis and drug target discovery

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Genome-wide high-throughput screening in yeast for functiona...

Microglial dysfunction and genetic risk for neurodegenerative disease

2014年第七届中国模式真菌研讨会

作者： jay yang Singer Instrument Co Ltd

Yeast is an ideal model organism for high-throughput phenotypic screening because of its experimental tractability and the availability of Yeast Knockout Collection and other powerful genetic *** such as synthetic genetic array analysis(SGA),yeast two-hybrid screening(Y2H),haploid insufficiency profiling/homozygous deletion profiling(HIP/HOP),and multicopy suppression profiling(MSP)have been developed for the systematic and unbiased mapping of genetic and physical interactions and drug-target ***,I will present

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Neural Regeneration Research 2025年第5期20卷 1401-1402页

作者： Debra S.MacDonald jay Penney Department of Biomedical Sciences AVCUniversity of Prince Edward IslandCharlottetownPECanada

Neurodegenerative disorders such as Alzheimer's and Parkinson's diseases a re increasing in prevalence as world populations *** tremendous progress has been made,our understanding of the mechanisms that underlie the development of these diseases remains far from com *** troubling,despite the growing emotional and financial toll being to ken by neurodegenerative disorders,existing treatment options are limited almost exclusively to those that help manage symptoms but that lack the ability to alter the progression of the disease(Liu et al.,2022).

关键词： degenerative diseases

Maximizing biomass utilization: An integrated strategy for coproducing multiple chemicals

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Journal of Energy Chemistry 2025年第1期100卷 180-191页

作者： Byeongchan Ahn Sua Jo Jonggeol Na J.jay Liu Young-Ju Kim Wangyun Won Department of Chemical and Biological Engineering Korea University Department of Chemical Engineering (Integrated process) Kyung Hee University Department of Chemical Engineering and Materials Science Ewha Womans University Department of Chemical Engineering Pukyong National University Resources Engineering Plant Research Department Korea Institute of Geoscience and Mineral Resources

Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol（1,6-HDO） with tetrahydrofuran and adipic acid from biomass, referred to as Strategy A. To compare the impacts of lignin upgrading and feedstock, Strategy B, which co-produces tetrahydrofuran alone, and Strategy C, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in Strategy A. The market competitiveness of Strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments（LCAs）.Strategy A was found to be the most favorable both economically（USRDSCHARDOLLAR3,402/ton） and environmentally（-26.9 kg CO2eq.）. This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.

关键词： Carbon capture and utilization

Efficient degradation of tetracycline by singlet oxygen-dominated peroxymonosulfate activation with magnetic nitrogen-doped porous carbon

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Journal of Environmental Sciences 2022年第5期34卷 330-340页

作者： Shaohua Wu Chunping yang Yan Lin jay J.Cheng Guangdong Provincial Key Laboratory of Petrochemcial Pollution Processes and Control School of Environmental Science and EngineeringGuangdong University of Petrochemical TechnologyMaomingGuangdong 525000China College of Environmental Science and Engineering Hunan University and Key Laboratory of Environmental Biology and Pollution Control(Hunan University)Ministry of EducationChangshaHunan 410082China Maoming Engineering Research Center for Organic Pollution Control Academy of Environmental and Resource SciencesGuangdong University of Petrochemical TechnologyMaomingGuangdong 525000China Hunan Provincial Environmental Protection Engineering Center for Organic Pollution Control of Urban Water and Wastewater ChangshaHunan 410001China Department of Biological and Agricultural Engineering North Carolina State UniversityRaleighNC 27695USA

Nonradical reaction driven by peroxymonosulfate(PMS)based advanced oxidation pro-cesses has drawn widespread attention in water treatment due to their inherent advantages,but the degradation behavior and mechanism of organic pollutants are still *** this study,the performance,intermediates,mechanism and toxicity of tetracycline(TC)degra-dation were thoroughly examined in the constructed magnetic nitrogen-doped porous car-bon/peroxymonosulfate(Co-N/C-PMS)*** results showed that 85.4%of TC could be removed within 15 min when Co-N/C and PMS was simultaneously added and the degra-dation rate was enhanced by 3.4 and 14.7 folds compared with Co-N/C or PMS alone,***,the performance of Co-N/C was superior to that of most previously reported *** lines of evidence indicated that Co-N/C-PMS system was a singlet oxygen-dominated nonradical reaction,which was less interfered by pH and water compo-nents,and displayed high adaptability to actual water ***,the degrada-tion process was elaborated on the basis of three-dimensional excitation-emission matrix spectra and liquid chromatography-mass *** last,the toxicity of treated TC was greatly reduced by using microalgae Coelastrella *** ecological *** study provides a promising approach based on singlet oxygen-dominated nonradical reaction for eliminating TC in water treatment.

关键词： Tetracycline Peroxymonosulfate Activation Singlet oxygen Toxicity

Degradation of Wetlands on the Qinghai-Tibet Plateau:A Comparison of the Effectiveness of Three Indicators

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Journal of Mountain Science 2013年第4期10卷 658-667页

作者： GAO jay LI Xi-lai CHEUNG Alan yang Yuan-wu School of Environment University of Auckland Private Bag 92019Auckland New Zealand College of Agriculture and Animal Husbandry Qinghai University College of Agriculture and Animal Husbandry Qinghai UniversityXining 810016 China

The Qinghai-Tibet Plateau encompasses a large quantity of wetlands, some of which have been degraded to varying severity levels. In the literature, a number of degradation indicators have been proposed to evaluate ecological health of wetlands, but their effectiveness in the plateau environment remains unknown. In this study, we assessed the effectiveness of three degradation indicators, soil moisture content at lo em deep, vegetative cover, and density of pika burrows. The degradation severity of wetlands in Maduo County on the Qinghai-Tibet Plateau is enumerated at four levels, intact, slight, moderate and severe. Analysis of xo6 samples collected in the field demonstrates that the density of pika burrows is the least reliable indicator. By comparison, vegetative cover and underlying soil moisture content are more reliable, even though neither is a perfect indicator as the difference among adjacent levels of severity as revealed by t-test is not always statistically significant. The imperfection of vegetative cover as an indicator is due to its variation among different types of wetlands. The limitation of moisture content is attributed to its non-linear relationship with wetland degradation. Above the threshold of about 50% in moisture content wetlands are unlikely to be degraded. It is recommended that moisture be measured at the point near the surface and vegetative cover be further differentiated by species in order to improve their effectiveness.

关键词： Wetland degradation Grass cover Soilmoisture Pika damage Qinghai-Tibet Plateau

Geomorphic-centered Classification of Wetlands on the Qinghai-Tibet Plateau, Western China

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Journal of Mountain Science 2013年第4期10卷 632-642页

作者： GAO jay LI Xi-lai Gary BRIERLEY Alan CHEUNG yang Yuan-wu School of Environment University of Auckland Private Bag 92019Auckland New Zealand College of Agriculture and Animal Husbandry Qinghai University

In this paper a geomorphic-centered system was proposed for classifying the wetlands on the Qinghai-Tibet Plateau in western China, where the flora comprises primarily grasses. Although the geomorphic properties (e.g., elevation and morphology) of wetlands form the primary criteria of classification, this system also takes hydrological processes into implicit consideration. It represents an improvement over the hydrogeomorphic perspective as the relative importance of the two components (wetness and landform) of wetlands is clearly differentiated. This geomorphic-centered perspective yields insights into the hydrogeomorphic dynamics of plateau wetlands while indicates their vulnerability to change and degradation indirectly. According to this geomorphic-centered perspective, all plateau wetlands fall into one of the seven types of alpine, piedmont, valley, terrace, floodplain, lacustrine, and riverine in three elevational categories of upland, midland, and lowland. Upland (alpine and piedmont) wetlands with the steepest topography are the most sensitive to change whereas midland (floodplain, terrace and valley) wetlands are less vulnerable to degradation owing to a high water reserve except terrace wetlands. They have a dry surface caused by infrequent hydrological replenishment owing to their higher elevation than the channel. Low lying (lacustrine and riverine) wetlands are the most resilient. The geomorphic-centered perspective developed in this paper provides a framework for improving recognition and management of wetlands on the Plateau. Resilient wetlands can be grazed more intensively without the risk of degradation. Fragile and vulnerable wetlands require careful managementto avoid degradation.

关键词： Plateau wetlands Geomorphieclassification Wetland vulnerability Qinghai-TibetPlateau