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significant association between ABO blood group and pancreatic cancer

World Journal of Gastroenterology 2010年第44期16卷 5588-5591页

作者： Julia B Greer Mark H Yazer jay s raval M Michael Barmada Randall E Brand David C Whitcomb Department of Medicine Division of GastroenterologyHepatology and NutritionUniversity of Pittsburgh School of Medicine Department of Pathology University of Pittsburgh School of Medicine The Institute for Transfusion Medicine Department of Human Genetics Graduate School of Public HealthUniversity of Pittsburgh University of Pittsburgh Cancer Institute

AIM:To evaluate whether the ABO blood group is related to pancreatic cancer risk in the general population of the United ***:Using the University of Pittsburgh's clinicalpancreatic cancer registry,the blood donor database from our local blood bank (Central Blood Bank),and the blood product recipient database from the regional transfusion service (Centralized Transfusion service) in Pittsburgh,Pennsylvania,we identified 274 pancreatic cancer patients with previously determined serological ABO blood group *** ABO blood group frequency was compared between these patients and 708842 individual,community-based blood donors who had made donations to Pittsburgh's Central Blood Bank between 1979 and ***:The frequency of blood group A was statistically significantly higher amongst pancreatic cancer patients compared to its frequency amongst the regional blood donors [47.63% vs 39.10%,odds ratio (OR)=1.43,P=0.004].Conversely,the frequency of blood group O was significantly lower amongst pancreatic cancer patients relative to the community blood donors (32.12% vs 43.99%,OR=0.60,P=0.00007).There were limited blood group B (n=38) and AB (n=17) pancreatic cancer patients;the overall P trend value comparing patient to donor blood groups was ***:The ABO blood group is associated with pancreatic cancer *** studies should examine the mechanism linking pancreatic cancer risk to ABO blood group.

关键词： ABO blood group Pancreatic adenocarcinoma surveillance Risk reduction Epidemiology

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Microglial dysfunction and genetic risk for neurodegenerative disease

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Neural Regeneration Research 2025年第5期20卷 1401-1402页

作者： Debra s.MacDonald jay Penney Department of Biomedical sciences AVCUniversity of Prince Edward IslandCharlottetownPECanada

Neurodegenerative disorders such as Alzheimer's and Parkinson's diseases a re increasing in prevalence as world populations *** tremendous progress has been made,our understanding of the mechanisms that underlie the development of these diseases remains far from com *** troubling,despite the growing emotional and financial toll being to ken by neurodegenerative disorders,existing treatment options are limited almost exclusively to those that help manage symptoms but that lack the ability to alter the progression of the disease(Liu et al.,2022).

关键词： degenerative diseases

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Mapping sensitive Vegetation Communities in Mining Eco-space using UAV-LiDAR

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International Journal of Coal science & Technology 2022年第3期9卷 185-200页

作者： Bikram Pratap Banerjee simit raval Agriculture Victoria Grains Innovation Park110 Natimuk Road3400 HorshamVICAustralia school of Minerals and Energy Resources Engineering University of New South Wales2052 SydneyNSWAustralia

Near earth sensing from uncrewed aerial vehicles or UAVs has emerged as a potential approach for fne-scale environmental *** systems provide a cost-efective and repeatable means to acquire remotely sensed images in unprecedented spatial detail and a high signal-to-noise *** is increasingly possible to obtain both physiochemical and structural insights into the environment using state-of-art light detection and ranging(LiDAR)sensors integrated onto *** sensitive environments,such as swamp vegetation in longwall mining areas,is essential yet challenging due to their inherent *** practices for monitoring these remote and challenging environments are primarily *** is partly due to an absent framework and challenges of using UAV-based sensor systems in monitoring such sensitive *** research addresses the related challenges in developing a LiDAR system,including a workfow for mapping and potentially monitoring highly heterogeneous and complex *** involves amalgamating several design components,including hardware integration,calibration of sensors,mission planning,and developing a processing chain to generate usable *** also includes the creation of new methodologies and processing routines to establish a pipeline for efcient data retrieval and generation of usable *** designed systems and methods were applied to a peat swamp environment to obtain an accurate geo-spatialised LiDAR point *** of the LiDAR data was tested against ground-based measurements on various aspects,including visual assessment for generation LiDAR metrices maps,canopy height model,and fne-scale mapping.

关键词： Upland swamps Mine surveying Monitoring Environment sustainability Drones and laser scanning

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A robust approach to identify roof bolts in 3D point cloud data captured from a mobile laser scanner

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International Journal of Mining science and Technology 2021年第2期31卷 303-312页

作者： sarvesh Kumar singh simit raval Bikram Banerjee school of Minerals and Energy Resources Engineering University of New South WalesSydneyNSW 2052Australia Agriculture Victoria HorshamVIC 3400Australia

Roof bolts such as rock bolts and cable bolts provide structural support in underground *** assessment of these support structures is critical to maintain roof stability and minimise safety risks in underground *** study proposes a robust workflow to classify roof bolts in 3 D point cloud data and to generate maps of roof bolt density and *** workflow was evaluated for identifying roof bolts in an underground coal mine with suboptimal lighting and global navigation satellite system(GNss)signals not *** approach is based on supervised classification using the multi-scale Canupo classifier coupled with a random sample consensus(RANsAC)shape detection algorithm to provide robust roof bolt *** issue of sparseness in point cloud data has been addressed through upsampling by using a moving least squares *** accuracy of roof bolt identification was measured by correct identification of roof bolts(true positives),unidentified roof bolts(false negatives),and falsely identified roof bolts(false positives)using correctness,completeness,and quality *** proposed workflow achieved correct identification of 89.27%of the roof bolts present in the test ***,considering the false positives and false negatives,the overall quality metric was reduced to 78.54%.

关键词： Mobile laser scanning Roof bolts support system planning Roof monitoring Change detection Underground roadways

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A review of laser scanning for geological and geotechnical applications in underground mining

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International Journal of Mining science and Technology 2023年第2期33卷 133-154页

作者： sarvesh Kumar singh Bikram Pratap Banerjee simit raval school of Minerals and Energy Resources Engineering University of New South WalesSydneyNSW 2052Australia Agriculture Victoria Grains Innovation ParkHorshamVIC 3400Australia

Laser scanning can provide timely assessments of mine sites despite adverse challenges in the operational *** there are several published articles on laser scanning,there is a need to review them in the context of underground mining *** this end,a holistic review of laser scanning is presented including progress in 3D scanning systems,data capture/processing techniques and primary applications in underground *** scanning technology has advanced significantly in terms of mobility and mapping,but there are constraints in coherent and consistent data collection at certain mines due to feature deficiency,dynamics,and environmental influences such as dust and *** suggest that laser scanning has matured over the years for change detection,clearance measurements and structure mapping ***,there is scope for improvements in lithology identification,surface parameter measurements,logistic tracking and autonomous *** scanning has the potential to provide real-time solutions but the lack of infrastructure in underground mines for data transfer,geodetic networking and processing capacity remain limiting ***,laser scanners are becoming an integral part of mine automation thanks to their affordability,accuracy and mobility,which should support their widespread usage in years to come.

关键词： Mine automation Point cloud Rock mass characterisation Change detection Data registration Georeferencing

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Broadband 200-nm second-harmonic generation in silicon in the telecom band

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Light(science & Applications) 2020年第1期9卷 1844-1850页

作者： Neetesh singh Manan raval Alfonso Ruocco Michael R.Watts Research Laboratory of Electronics Massachusetts Institute of Technology77 Massachusetts AvenueCambridgeMA 02139USA

silicon is well known for its strong third-order optical nonlinearity,exhibiting efficient supercontinuum and four-wave mixing processes.A strong second-order effect that is naturally inhibited in silicon can also be observed,for example,by electrically breaking the inversion symmetry and quasi-phase matching the pump and the *** generate an efficient broadband second-harmonic signal,however,the most promising technique requires matching the group velocities of the pump and the *** this work,we utilize dispersion engineering of a silicon waveguide to achieve group velocity matching between the pump and the signal,along with an additional degree of freedom to broaden the second harmonic through the strong third-order *** demonstrate that the strong self-phase modulation and cross-phase modulation in silicon help broaden the second harmonic by 200 nm in the ***,we show a waveguide design that can be used to generate a second-harmonic signal in the entire nearinfrared *** work paves the way for various applications,such as efficient and broadband complementarymetal oxide semiconductor based on-chip frequency synthesizers,entangled photon pair generators,and optical parametric oscillators.

关键词： waveguide synthesizer harmonic

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study of locust bean gum reinforced cyst-chitosan and oxidized dextran based semi-IPN cryogel dressing for hemostatic application

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Bioactive Materials 2018年第3期3卷 370-384页

作者： Lalit Kumar Meena Pavani raval Dhaval Kedaria Rajesh Vasita school of Life sciences Central University of GujaratSector-30Gandhinagar 382030India Government Engineering College Sector-28Gandhinagar 382028India

severe blood loss due to traumatic injuries remains one of the leading causes of death in emergency *** continues to be the candidate material for hemostatic applications due to its inherent hemostatic ***,available chitosan-based dressings have been reported to have an acidic odor at the wound site due to the incorporation of acid based solvents for their fabrication and deformation under compression owing to low mechanical strength limiting its *** the present study semi-IPN cryogel was fabricated via schiff's base cross-linking between the polyaldehyde groups of oxidized dextran and thiolated chitosan in presence of locust bean gum(LBG)known for its *** at12C yielded macroporous semi-IPN cryogels with an average pore size of 124.57±20.31 mm and 85.46%*** hydrophobicity index of LBG reinforced semi-IPN cryogel was reduced 2.42 times whereas the swelling ratio was increased by 156.08%compare to control *** increased hydrophilicity and swelling ratio inflated the compressive modulus from 28.1 kPa to 33.85 for LBG reinforced semi-IPN *** structural stability and constant degradation medium pH were also recorded over a period of 12 *** cryogels demonstrated lower adsorption affinity towards *** cytotoxicity assays(direct,indirect)with 3T3-L1 fibroblast cells confirmed the cytocompatibility of the *** hemolysis assay showedsis confirming blood compatibility of the fabricated cryogel,while whole blood clotting and platelet adhesion assays confirmed the hemostatic potential of semi-IPN cryogel.

关键词： Chitosan Oxidized dextran Locust bean gum Cryogel Hemostasis

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Design and development of a machine vision system using artificial neural network-based algorithm for automated coal characterization

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International Journal of Coal science & Technology 2021年第4期8卷 737-755页

作者： Amit Kumar Gorai simit raval Ashok Kumar Patel snehamoy Chatterjee Tarini Gautam Department of Mining Engineering National Institute of TechnologyRourkela 769008India school of Minerals and Energy Resources Engineering University of New South WalesSydneyNSW 2052Australia Department of Computer science&Engineering C.V.Raman Global UniversityBhubaneswarOdisha 752054India Department of Geological and Mining Engineering and science Michigan Technological UniversityHoughtonMI 49931USA

Coal is heterogeneous in nature,and thus the characterization of coal is essential before its use for a specific ***,the current study aims to develop a machine vision system for automated coal *** model was calibrated using 80 image samples that are captured for different coal samples in different *** the images were captured in RGB color space and converted into five other color spaces(HsI,CMYK,Lab,xyz,Gray)for feature *** intensity component image of HsI color space was further transformed into four frequency components(discrete cosine transform,discrete wavelet transform,discrete Fourier transform,and Gabor filter)for the texture features extraction.A total of 280 image features was extracted and optimized using a step-wise linear regression-based algorithm for model *** datasets of the optimized features were used as an input for the model,and their respective coal characteristics(analyzed in the laboratory)were used as outputs of the *** R-squared values were found to be 0.89,0.92,0.92,and 0.84,respectively,for fixed carbon,ash content,volatile matter,and moisture *** performance of the proposed artificial neural network model was also compared with the performances of performances of Gaussian process regression,support vector regression,and radial basis neural network *** study demonstrates the potential of the machine vision system in automated coal characterization.

关键词： Coal characterization Machine vision system Artificial neural network Gaussian process regression

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Effect of El Nino southern Oscillations on the incidence of enteric fever in Ahmedabad,India from 1985 to 2017

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Asian Pacific Journal of Tropical Medicine 2019年第12期12卷 552-558页

作者： Veena Iyer susanna Abraham Cottagiri Ayushi sharma Divya Nair Mehul s.raval Bhavin solanki Dileep Mavalankar Indian Institute of Public Health Gandhinagar Opposite Air Force HQNear Lekavada Bus StopCRPF P.O.Gandhinagar 382042GujaratIndia ICT Department School of TechnologyPandit Deendayal Petroleum UniversityGandhinagarIndia Medical Officer of Health Ahmedabad Municipal CorporationAhmedabadGujaratIndia

Objective:To explore the relationship between climate variables and enteric fever in the city of Ahmedabad and report preliminary findings regarding the influence of El Nino southern Oscillations and Indian Ocean Dipole over enteric fever ***:A total of 29808 Widal positive enteric fever cases reported by the Ahmedabad Municipal Corporation and local climate data in 1985-2017 from Ahmedabad Meteorology Department were *** Nino,La Nina,neutral and Indian Ocean Dipole years as reported by the National Oceanic and Atmospheric Administration for the same period were compared for the incidence of enteric ***:Population-normalized average monthly enteric fever case rates were the highest for El Nino years(25.5),lower for La Nina years(20.5)and lowest for neutral years(17.6).A repeated measures ANOVA analysis showed no significant difference in case rates during the three yearly El Nino southern Oscillations ***,visual profile plot of estimated marginal monthly means showed two distinct characteristics:an early rise and peaking of cases in the El Nino and La Nina years,and a much more restrained rise without conspicuous peaks in neutral *** analysis based on monthly El Nino southern Oscillations categories was conducted to detect differences in median monthly case *** case rates in strong and moderate El Nino months and strong La Nina months were significantly dissimilar from that during neutral months(Psions:El Nino southern Oscillations events influence the incidence of enteric fever cases in Ahmedabad,and further investigation from more cities and towns is required.

关键词： Enteric fever and climate El Nino,La Nina and Enteric fever El Nino southern Oscillations Typhoid Indian Ocean Dipole salmonella and climate

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Crohn’s disease:Evidence for involvement of unregulated transcytosis in disease etio-pathogenesis

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World Journal of Gastroenterology 2011年第11期17卷 1416-1426页

作者： jay Pravda Inflammatory Disease Research Centre PO Box 32632 West Palm BeachFloridaFL 33420United States

Crohn’s disease(CD)is a chronic inflammatory bowel *** has identified genetic predisposition and environmental factors as key elements in the development of the ***,the precise mechanism that initiates immune activation remains *** pathway for luminal antigenic molecules to enter the sterile lamina propria and activate an immune response is via ***,although tightly regulated by the cell,has the potential for transepithelial transport of bacteria and highly antigenic luminal molecules whose uncontrolled translocation into the lamina propria can be the source of immune *** as a whole,the evidence suggests that unregulated intestinal epithelial transcytosis is involved in the inappropriate presentation of immunogenic luminal macromolecules to the intestinal lamina *** fulfilling the role of an early pre-morbid mechanism that can result in antigenic overload of the lamina propria and initiate an immune response culminating in chronic inflammation characteristic of this *** is the aim of this paper to present evidence implicating enterocyte transcytosis in the early etio-pathogenesis of CD.

关键词： Crohn’s Transcytosis Endocytosis

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