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Comparative susceptibility and immune responses of Asian and European honey bees to the American foulbrood pathogen, Paenibacillus larvae

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Insect Science 2019年第5期26卷 831-842页

作者： Sasiprapa Krongdang jay D.Evans Yanping Chen Wannapha Mookhploy Panuwan Chantawannakul 1Bee Protection Laboratory Department of BiologyFaculty of ScienceChiang Mai UniversityChiang MaiThailand Interdisciplinary Program in Biotechnology Graduate SchoolChiang Mai UniversityChiang MaiThailand USDA-ARS Bee Research LaboratoryBeltsvilleMarylandUSA Environmental Science Research Center Faculty of ScienceChiang Mai UniversityChiang MaiThailand

American foulbrood (AFB) disease is caused by Paenibacillus larvae. Currently, this pathogen is widespread in the European honey bee— Apis mellifera. However, little is known about infectivity and pathogenicity of P. lan'ae in the Asiatic cavity-nesting honey bees, Apis cerana. Moreover, comparative knowledge of P. larvae infectivity and pathogenicity between both honey bee species is scarce. In this study, we examined susceptibility, larval mortality, survival rate and expression of genes encoding antimicrobial peptides (AMPs) including defensin, apidaecin, abaecin, and hymenoptaecin in A. mellifera and A. cerana when infected with P. larvae. Our results showed similar effects of P. larvae on the survival rate and patterns of AMP gene expression in both honey bee species when bee larvae are infected with spores at the median lethal concentration (LC5 0 ) for A. mellifera. All AMPs of infected bee larvae showed significant upregulation compared with noninfected bee larvae in both honey bee species. However, larvae of A. cerana were more susceptible than A. mellifera when the same larval ages and spore concentration of P. larvae were used. It also appears that A. cerana showed higher levels of AMP expression than A. mellifera. This research provides the first evidence of survival rate, LC50 and immune response profiles of Asian honey bees, A. cerana, when infected by P. larvae in comparison with the European honey bee, A. mellifera.

关键词： Apis cerana Apis mellifera honey bee immune gene Paenibacillus larvae susceptibility

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Calculation of Robust and Optimal Fractional PID Controllers for Time Delay Systems with Gain Margin and Phase Margin Specifications 36

Calculation of Robust and Optimal Fractional PID Controllers...

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第36届中国控制会议

作者： Yuan-jay Wang Shao-Tang Huang Kun-Han You Department of Electrical Engineering Tungnan University

ISBN: (纸本)9781538629185

This paper proposes a novel method to graphically compute all feasible gain and phase margin specifications-oriented robust and optimal fractional PID controllers to stabilize time delay processes（TD） of any order. The gain-phase margin tester method is utilized to guarantee the concerned systems certain robust safety margins and test the constant gain margin boundary, constant phase margin boundary, and stability boundary in the parameter plane. The overlapping region of these plotted boundaries, which represents all feasible robust stabilizing PID controllers and allows the considered TD processes to retain pre-specified safety margins, is graphically determined as the gain and phase margin specifications-oriented region（GPMSOR）. The variations of the GPMSOR and the stability region with respect to the variations of the noninteger orders of the integral and derivative terms have been investigated. According this, it is possible to slightly enlarge the GPMSOR by altering the noninterger order of the integral and derivative terms. This modifications in GPMSOR through altering the noninteger orders of the integral and derivative terms allows us to find the robust and optimal PID controller gain set for the considered TD systems. In other words, the selected fractional order PID controllers from the GPMSOR not only retain the prescribed GM and PM specifications but minimize the integral of the absolute error（IAE） or the integral of the squared error（ISE） performance criterion. Finally, an illustrative example cited from the literature with computer simulations is provided to demonstrate the effectiveness and confirm the validity of the proposed methodology.

关键词： Fractional order stability equation IAE ISE time delay robust PID controller gain margin phase margin

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Surgical considerations in diabetic vitrectomy

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Annals of Eye Science 2018年第1期3卷 365-368页

作者： Ajay Singh jay M.Stewart Department of Ophthalmology University of Kansas School of MedicinePrairie VillageKSUSA Discover Vision Centers LeawoodKSUSA Kansas City VA Medical Center Kansas CityMOUSA Department of Ophthalmology University of California San FranciscoSan FranciscoCAUSA

High speed and small gauge vitrectomy systems have made surgical intervention in complications of diabetic retinopathy(DR)*** availability of anti-vascular endothelial growth factor(anti-VEGF)compounds for use in DR has significantly improved intraoperative and postoperative *** review discusses the indications for surgical intervention in *** role of anti-VEGF compounds is discussed as surgical adjuvants with an emphasis on timing of treatment before surgery.

关键词： Vitrectomy vitreous hemorrhage(VH) diabetic macular edema(DME) taut posterior hyaloid tractional retinal detachment(TRD) bevacizumab

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Thermal and environmental stability of poly(4-ethynyl-p-xylylene-co-p-xylylene) thin films

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Chinese Chemical Letters 2015年第4期26卷 459-463页

作者： Yu Liang Xiaopei Deng jay J.Senkevich Hao Ding Joerg Lahann Department of Material Science and Engineering China University of Geosciences (Beijing) Department of Chemical Engineering University of Michigan Massachusetts Institute of Technology Institute for Soldier Nanotechnologies

The aim of this paper was to test the thermal and environmental stability of poly（4-ethynyl-p-xylylene- co-p-xylylene） thin films prepared by chemical vapor deposition （CVD） and to optimize the reaction conditions of the polymer. Fourier transformed infrared spectroscopy （FTIR）, thermogravimetric analysis （TGA） and fluorescence microscopy were employed to investigate the stability of the reactive polymer coatings in various environmental conditions. Chemical reactivity of the thin films were then tested by Huisgen 1,3-dipolar cycloaddition reaction （＂click＂ reaction）. The alkyne functional groups on poly（4- ethynyl-p-xylylene-co-p-xylylene） thin films were found to be stable under ambient storage conditions and thermally stable up to 100 ℃ when annealed at 0.08 Torr in argon. We also optimized the click reaction conditions of azide-functionalized molecules with poly（4-ethynyl-p-xylylene-co-p-xylylene）. The best reaction result was achieved, when copper concentration was 0.5 retool/L, sodium ascorbate concentration to copper concentration was 5：1. In contrast, the azide concentration and temperature had no obvious effect on the surface reaction.

关键词： Chemical vapor depositionPoly( 4-ethynyl-p- xylylene-co-p-xylylene )Thermal stabilityEnvironmental stabilityClick reaction

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Formation of fine crystalline dolomites in lacustrine carbonates of the Eocene Sikou Depression, Bohai Bay Basin, East China

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Petroleum Science 2016年第4期13卷 642-656页

作者： Yong-Qiang Yang Long-Wei Qiu jay Gregg Zheng Shi Kuan-Hong Yu School of Geosciences China University of Petroleum Department of Geology Oklahoma State University

The genesis of the fine crystalline dolomites that exhibit good to excellent reservoir properties in the upper fourth member of the Eocene Shahejie Formation（Es4s）around the Sikou Sag, Bohai Bay Basin, is uncertain. This paper investigates the formation mechanisms of this fine crystalline dolomite using XRD, SEM, thin section analysis and geochemical data. The stratigraphy of the Sikou lacustrine carbonate is dominated by the repetition of metre-scale, high-frequency deposition cycles, and the amount of dolomite within a cycle increases upward from the cycle bottom. These dolomite crystals are 2–30 μm in length, subhedral to anhedral in shape and typically replace both grains and matrix. They also occur as rim cement and have thin lamellae within ooid cortices. Textural relations indicate that the dolomite predates equant sparry calcite cement and coarse calcite cement. The Sr concentrations of dolomites range from 900 to 1200 ppm. Dolomite δ18O values（-11.3 to-8.2 ‰ PDB） are depleted relative to calcite mudstone（-8.3 to-5.4 ‰ PDB） that precipitated from lake water, while δ13C values（0.06–1.74 ‰ PDB） are within the normal range of calcite mudstone values（-2.13 to 1.99 ‰ PDB）. High87Sr/86Sr values（0.710210–0.710844） indicate that amounts of Ca2＋ and Mg2＋have been derived from the chemical weathering of Palaeozoic carbonate bedrocks. The high strontium concentration indicates that hypersaline conditions were maintainedduring the formation of the dolomites and that the dolomites were formed by the replacement of precursor calcite or by direct precipitation.

关键词： Dolomite Lacustrine carbonate Eocene Sikou Sag Bohai Bay Basin

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Significant methodologic variations in calculating renal function changes following kidney tumor surgery:A quality reporting issue?

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World Journal of Clinical Oncology 2015年第5期6卷 89-91页

作者： Ruth D Blum jay D Raman Division of Urology Penn State Milton S.Hershey Medical Center

Renal tumor surgery places patients at increased risk for chronic kidney disease(CKD). Accurate quantification of kidney function changes before and after surgery is essential to determine the magnitude of decline attributable to an index procedure. Current literature, however, highlights heterogeneity and inconsistencies in measurement techniques thereby contributing to ambiguity amongst studies. Further efforts are necessary to standardize reporting of kidney function outcomes related to renal surgery.

关键词： Radical nephrectomy Partial nephrectomy Nephroureterectomy Glomerular filtration rate Chronic kidney disease

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Soluble Graphene Through Edge-Selective Functionalization

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Nano Research 2010年第2期3卷 117-125页

作者： Zhengzong Sun Shin-ichiro Kohama Zengxing Zhang jay RLomeda James M.Tour Department of Chemistry and Mechanical Engineering and Materials Science and the Smalley Institute for Nanoscale Science and Technology Rice UniversityMS 2226100 Main StreetHoustonTexas 77005USA

Thermally expanded graphite was functionalized with 4-bromophenyl addends using the in situ diazonium formation procedure,and after mild sonication treatment in N,N’-dimethylformamide,thin graphene layers were exfoliated from the bulk *** chemically-assisted exfoliated graphene(CEG)sheets had higher solubility than pristine graphene without any stabilizer *** than 70%of these soluble flakes had less than 5 *** filtered transmission electron microscopy(EFTEM)elemental mapping provided evidence of the edge-selective diazonium functionalization with graphene.A majority of the Br signals came from the edges of the CEG indicating that the basal planes were not highly *** CEG was also characterized by X-ray photoelectron spectroscopy,atomic force microscopy,Raman spectroscopy,and transmission electron microscopy.

关键词： Edge-selective functionalization graphene energy filtered transmission electron microscopy(EFTEM) chemically-assisted exfoliation

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Survival strategies for family-run homestays: analyzing user reviews through text mining

Data Science and Management

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Data Science and Management 2024年第3期7卷 228-237页

作者： jay Krishnan Biplab Bhattacharjee Maheshwar Pratap Janardan Krishna Yadav Moinak Maiti Amrita School of Business Amrita Vishwa VidyapeethamCoimbatore641112India Jindal Global Business School O.P.Jindal Global UniversitySonipat131001India Department of Finance School of Economics and FinanceUniversity of the WitwatersrandJohannesburg2050South Africa

Online booking of homestays through e-travel portals is based on the virtual brand and perception,which are largely affected by user-generated electronic word-of-mouth(eWOM).With the objective of mining actionable insights from eWOM,this study conducted opinion mining for homestays located in four thematic areas of ***,various techniques have been deployed,such as sentiment and emotional analyses,topic modeling,and clustering *** themes revealed from topic modeling were breakfast,facilities provided,ambience,bathroom,cleanliness,hospitality exhibited,and satisfaction with the host.A lasso logistic regression-based predictive binary text classification model(with 97.6%accuracy)for homestay recommendations was *** findings and predictive model have implications for managers and homestay owners in devising appropriate marketing strategies and improving their overall guest experience.

关键词： Text miningTourismHomestaysTopic modelingPredictive modeling

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Thickness Effect of Nanocrystalline Layer on the Deformation Mechanism of Amorphous/Crystalline Multilayered Structure

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Computer Modeling in Engineering & Sciences 2019年第8期120卷 293-304页

作者： Wen-jay Lee Yu-Chien Lo Anchen Yang Kuanpeng Chen Nan-Yow Chen National Center for High-Performance Computing No.22Keyuan Rd.Central Taiwan Science ParkTaichung City 40763Taiwan Department of Materials Science and Engineering National Chiao Tung UniversityNo.1001 University Rd.Hsinchu 30010Taiwan National Center for High-Performance Computing No.7R&D 6th Rd.Hsinchu Science ParkHsinchu City 30076Taiwan

Different thickness of amorphous/nanocrystalline multi-layered structure can be used to modulate the strength and ductility of the composite *** this work,molecular dynamics simulations were conducted to study the thickness effect of nanocrystalline layer on mechanical properties and deformation behavior of the Cu64Zr36/Cu multi-layer *** stress-strain relationship,local stress,local strain,and deformation mechanism are *** results reveal that the change of thickness of the crystalline layer significantly affects the mechanical properties and deformation *** the strain at the elastic region,the amorphous Cu64Zr36 layer dominates the mechanical behavior,leading the fact that Young’s modulus,first yielding stress,and first yielding strain are close to that of Cu64Zr36 *** the strain at the plastic region,the contribution of the crystalline layer on the mechanical behavior becomes more and more significant with increasing the thickness of the crystalline *** the thickness ratio(amorphous/crystalline)of 4,the shear band deformation of amorphous layer dominates the mechanical *** the thickness ratio is 1,the glide dislocation of the crystalline layer dominates the stress-strain behavior.

关键词： Molecular dynamics Cu64Zr36 bulk metallic glass Cu64Zr36/Cu layered structure shear band mechanical property deformation

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External drainage for exudative retinal detachment secondary to central serous chorioretinopathy

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Eye Science 2015年第4期30卷 204-208页

作者： Sailaja Bondalapati Avinash Pathengay jay Chhablani University of North Carolina School of Medicine GMRV Campus L V Prasad Eye Institute L V Prasad Eye Institute Kallam Anji Reddy Campus

Background: To report the outcomes of external drainage of subretinal fluid(SRF) in exudative retinal detachment secondary to central serous chorioretinopathy(CSCR).Methods: Retrospective observational analysis of six eyes with exudative retinal detachment secondary to CSCR who underwent external drainage of SRF between 2004 and 2014 was performed. Collected data included demographics, steroid usage, surgical details, and visual acuity preoperatively and postoperative visual acuity and clinical examination data were collected. Results: Six eyes of six subjects were included with mean age of 45 years(range, 32 to 61 years). All subjects were male. Mean duration of symptoms was 4.6 months(range, 3 to 8 months). The pre-operative bestcorrected visual acuity(BCVA) ranged from perception of light to 20/60. Four eyes were treated with conventional external drainage and two underwent Chandelier-assisted external drainage. Three cases had laser treatment before drainage and one case underwent photodynamic therapy(PDT) after drainage. The BCVA at last follow-up ranged from 20/2,000(counting fingers at 2 feet) to 20/20. No recurrences were noted in any of the cases till the last follow-up. Mean duration of follow-up was 38 months. Conclusions: Our study demonstrates successful management of exudative retinal detachment secondary to CSCR with external SRF drainage without any complications.

关键词：视网膜继发性渗出性脉络膜浆液性引流中心性平均年龄

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