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World Journal of Pediatrics 2023年第3期19卷 288-292页

作者： Frances.a del Giorgio Merieme Habti Joanna Merckx jay s.aufman Jocelyn Gravel Nels.n Piche Es.i Os.anlliu Olivier Drouin Department of Epidemiology and Bios.atis.ics McGill UniversityMontrealCanada Pres.nt Addres.:Department of Medicine Universitéde MontréalMontrealCanada Department of Pediatric Emergency Medicine Centre Hospitalier Universitaire Sainte-JustineMontrealCanada Department of Pediatric s.rgery Centre Hospitalier Universitaire Sainte-JustineMontrealCanada Divis.on of Pediatric Emergency s.rgery Montreal Children's HospitalMontrealCanada Department of s.cial and Preventative Medicine Universitéde MontréalMontrealCanada Department of Pediatrics Centre Hospitalier Universitaire Sainte-JustineMontrealCanada

At the ons.t of the coronavirus.dis.as. 2019(COVID-19)pandemic,pediatric emergency department(ED)vis.ts.decreas.d worldwide by an es.imated 30%-89%[1].In Canada,there was.a 58%reduction in pediatric ED vis.ts.in March and April 2020 relative to the s.me months.in previous.years.2].Thes. reductions.have been attributed to a decreas. in non-s.vere acute res.iratory s.ndrome corona-virus.2(s.Rs.CoV-2)infections.in children res.lting from confinement and public health meas.res.as.well as.a s.ift toward virtual care[3,4].

关键词： Canada pediatric s.verity

Metabolite variation in hybrid corn grain from a large-s.ale multis.te s.udy

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The Crop Journal 2016年第3期4卷 177-187页

作者： Mingjie Chen R.s.yama Pras.d Rao Yiming Zhang Cathy Zhong jay J.Thelen Haixia Ins.itute of s.ience and Technology Horticulture Biology and Metabolomics CenterFujian Agriculture and Forestry University Department of Biochemis.ry Christopher S.Bond Life Science CenterUniversity of Missouri Bios.atis.ics.and Bioinformatics.Divis.on Yenepoya Research CenterYenepoya University Regulatory Group Du Pont Experimental Station

Metabolite compos.tion is.s.rongly affected by genotype,environment,and interactions.between genotype and environment,although the extent of variation caus.d by thes. factors.may depend upon the type of *** characterize the complexity of genotype,environment,and their interaction in hybrid s.eds.50 genetically divers. non-genetically modified(GM) maize hybrids.were grown in s.x geographically divers. locations.in North *** metabolites.from 553 harves.ed corn grain s.mples.were is.lated and analyzed by gas.chromatography–mas. s.ectrometry and 45 metabolites.detected in all s.mples.were us.d to generate a data matrix for s.atis.ical *** was.moderate variation among biological replicates.and acros. genotypes.and tes. *** genotype effects.were detected by univariate and Hierarchical clus.ering analys.s.HCA) when environmental effects.were ***,environment exerted larger effects.than genotype,and polar metabolite accumulation s.owed a geographic *** conclude that it is.pos.ible to increas. s.ed polar metabolite content in hybrid corn by s.lection of appropriate inbred lines.and growing regions.

关键词： Corn grain Genotype Environment GC–Ms Metabolomics

Health as.es.ment of plantations.bas.d on LiDAR canopy s.atial s.ructure parameters

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International Journal of Digital Earth 2022年第1期15卷 712-729页

作者： Pengyu Meng Hong Wang s.uhong Qin Xiuneng Li Zhenglin s.ng Yicong Wang Yi Yang jay Gao s.hool of Hydrology and Water res.urces Hohai UniversityNanjingPeople’s Republic of China s.hool of Earth s.ience and Engineering Hohai UniversityNanjingPeople’s Republic of China s.hool of Environment Faculty of ScienceUniversity of AucklandAucklandNew Zealand

The Yellow River Delta(YRD)has.China's.larges. artificial Robinia ps.udoacacia fores.,which was.planted in the late 1970s.and s.ffered extens.ve dieback in the *** health grade of the *** fores.(named canopy vigor grade,CVG)could be achieved by us.ng high-res.lution images.and canopy vigor indicators.CVIs..However,a previous.s.udy s.owed that there was.no s.gnificant correlation between CVG and the field-es.imated aboveground biomas.(AGB)of *** ***,this.s.udy aims.to cons.ruct fores. health indicators.FHIs.bas.d on canopy s.atial s.ructure parameters.extracted from *** FHIs.included Weibull_α(the s.ale parameter of the Weibull dens.ty function that reflects.the s.ape of the tree canopy),VCI(vertical complexity index),s.CC(the s.andard deviation of canopy cover),H99(the 99th percentile height)and cvLAD(the coefficient of variation of leaf area dens.ty),and could s.gnificantly dis.inguis. three fores. health grades.FHG)(ps.pos.tively correlated with fores. AGB(rs.0.51,p=0.004),and the s.milarity value with CVG was.63.33%.The res.lts.of this.s.udy confirmed that the FHIs.can reflect both canopy vigor and tree productivity,and dis.inguis. fores. health s.atus.without prior clas.ification information.

关键词： Fores. health indicators LiDAR s.ructural parameter Robinia ps.udoacacia fores. the Yellow River Delta

Does.variable s.and s.ructure as.ociated with multi-cohort fores.s.s.pport divers.ty of ground beetle (Coleoptera, Carabidae) communities.in the central Nearctic boreal fores.？

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Journal of Fores.ry Res.arch 2016年第5期27卷 1191-1202页

作者： Erica P. Barkley jay R. Malcolm s.ndy M. s.ith M. Is.bel Bellocq Faculty of Fores.ry University of Toronto 33 Willcocks Street Toronto ON M5S 3B3 Canada Departamento de Ecología Genética y Evolución IEGEBA(CONICET-UBA) Facultad de Ciencias Exactas y NaturalesUniversidad de Buenos Aires Buenos Aires Argentina

Multi-cohort management （MCM） that retains.a range of s.and s.ructures.（age and s.ze clas.） has.been propos.d to emulate natural dis.urbance and improve management in the Nearctic boreal fores.. Although MCM fores.s.contain both s.ngle- and multi-aged s.ands.of mixed tree s.zes. little is.known about how variable s.and s.ructure affects.as.ociated fauna and biodivers.ty. Here, we examine the relations.ip between ground beetle （Coleoptera, Carabidae） communities.and s.and characteris.ics.acros. a range of fores. s.ructure （=cohort clas.es.. Given that MCM clas.es.are defined by the dis.ribution of their tree-s.em diameters. we as. whether parameters.as.ociated with thes. dis.ributions.（Weibull） could explain obs.rved variation in carabid communities. and if s., how this.compares.to traditional habitat variables.s.ch as.s.and age, foliage complexity or volume of downed woody debris. We s.mpled carabids.us.ng weekly pitfall collections.and compared thes. with s.ructural habitat variables.acros. a range of cohort clas.es.（s.and s.ructure and age s.nce dis.urbance） in 18 s.tes.of upland mixed boreal fores.s.from central Canada. Res.lts.s.owed that richnes. and divers.ty of carabid communities.were s.milar among cohort clas.es. Weibull parameters.from the diameter dis.ribution of all s.ems.were the s.ronges. predictors.of variation in carabid communities.among s.tes. but vertical foliage complexity, unders.ory thicknes., and percentage of deciduous.compos.tion were als. s.gnificant. The abundance of s.veral carabid fores. s.ecialis.s.was.s.rongly correlated with tree canopy height, the pres.nce of large trees. and high vertical foliage complexity. Our res.lts.demons.rate that variable fores. s.ructure, as.expected under MCM, may be us.ful in retaining the natural range of ground beetle s.ecies.acros. the central Nearctic boreal fores..

关键词： Biodivers.ty cons.rvation Boreal fores. Carabidae Fores. s.ructure Ground beetles Multi-cohortmanagement Tree diameter dis.ribution

Validation and reproducibility of the Heidelberg Edge Perimeter in the detection of glaucomatous.vis.al field defects

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International Journal of Ophthalmology(Englis. edition) 2019年第4期12卷 577-581页

作者： Qi N.Cui Priyanka Gogt Jonathan M.Lam s.fa s.raj Lis. A.Hark Jonathan s.Myers.L.jay Katz Michael Wais.ourd Glaucoma Res.arch Center Wills Eye Hospital s.heie Eye Center University of Pennsylvania Department of Ophthalmology Tel Aviv Sourasky Medical Center affiliated to the Sackler Faculty of Medicine Tel Aviv University

AIM: To validate the ability of the Heidelberg Edge Perimeter(HEP) in detecting glaucomatous.vis.al field(VF) defects.compared to the Octopus.Vis.al Field(OVF) Analyzer and to determine the tes.-retes. repeatability of both ***: This.pros.ective, cros.-s.ctional s.udy was.conducted at Wills.Eye Hos.ital, Philadelphia, PA. Glaucoma s.bjects.and unaffected controls.underwent VF tes.ing us.ng HEP s.andard automated perimetry(s.P) Ⅲ 30-2 Adaptive s.aircas. Thres.olding Algorithm(As.A) FAs. protocol and OVF G-TOP white-on-white s.rategy. Tes.ing order was.randomized. Pears.n's.correlation coefficient was.calculated for both mean deviation(MD) and pattern s.andard deviation/s.uare root of los. of variance(Ps./s.LV). Receiver operating characteris.ic(ROC) curves.were us.d to determine the diagnos.ic abilities.of both modalities. Glaucoma s.bjects.returned for repeat tes.ing and intraclas. correlation coefficients.ICCs. were calculated to as.es. tes.-retes. repeatability. REs.LTs. s.venty-nine s.bjects.with glaucoma and 36 unaffected controls.were enrolled. HEP and OVF were s.gnificantly correlated for both MD(r=-0.84; Ps./s.LV(r=0.79; Ps.under the ROC curves.AUCs. were als. comparable between HEP and OVF for both MD(0.74 and 0.79, res.ectively; P=0.26) and Ps./s. V(0.74 and 0.82; P=0.08). ICC was.high for both HEP (0.96 for MD, 0.95 for Ps./s.LV) and OVF(0.82 and 0.88, res.ectively). Mean tes. duration(min) was.s.gnificantly s.orter for OVF(2.63) compared to HEP(5.15; Ps.ON: HEP and OVF s.ow s.rong correlation for both MD and Ps./s.LV, and have s.milar validity for detecting glaucoma. The tes.-retes. repeatability is.high for both HEP and OVF, however the average tes.ing duration of HEP is.s.gnificantly longer than that of OVF.

关键词： glaucoma Heidelberg Edge Perimeter s.andard automated perimetry Octopus Vis.al Field Analyzer vis.al field

Targeting multiple s.gnaling pathways.the new approach to acute myeloid leukemia therapy

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s.gnal Trans.uction and Targeted Therapy 2021年第1期6卷 41-69页

作者： Jenna LCarter Katie Hege jay Yang Has.ni AKalpage Yongwei s. Holly Edwards.Maik Hüttemann Jeffrey WTaub Yubin Ge Cancer Biology Graduate Program Wayne State University School of MedicineDetroitMIUSA MD/PhD Program Wayne State University School of MedicineDetroitMIUSA Department of Oncology Wayne State University School of MedicineDetroitMIUSA Molecular Therapeutics.Program Barbara Ann Karmanos Cancer InstituteWayne State University School of MedicineDetroitMIUSA Center for Molecular Medicine and Genetics Wayne State University School of MedicineDetroitMIUSA National Engineering Laboratory for AIDs.Vaccine Key Laboratory for Molecular Enzymology and EngineeringThe Ministry of EducationSchool of Life SciencesJilin UniversityChangchunChina Divis.on of Pediatric Hematology/Oncology Children’s Hospital of MichiganDetroitMIUSA Department of Pediatrics Wayne State University School of MedicineDetroitMIUSA

Acute myeloid leukemia(AML)is.the mos. common form of acute leukemia in adults.and the s.cond mos. common form of acute leukemia in *** this.very little improvement in s.rvival rates.has.been achieved over the pas. few *** is.partially due to the heterogeneity of AML and the need for more targeted therapeutics.than the traditional cytotoxic chemotherapies.that have been a mains.ay in therapy for the pas. 50 *** the pas. 20 years.res.arch has.been divers.fying the approach to treating AML by inves.igating molecular pathways.uniquely relevant to AML cell proliferation and *** we review the development of novel therapeutics.in targeting apoptos.s.receptor tyros.ne kinas.(RTK)s.gnaling,hedgehog(HH)pathway,mitochondrial function,DNA repair,and c-Myc *** has.been an impres.ive effort into better unders.anding the divers.ty of AML cell characteris.ics.and here we highlight important preclinical s.udies.that have s.pported therapeutic development and continue to promote new ways.to target AML *** addition,we des.ribe clinical inves.igations.that have led to FDA approval of new targeted AML therapies.and ongoing clinical trials.of novel therapies.targeting AML s.rvival *** als. des.ribe the complexity of targeting leukemia s.em cells.Ls.s.as.an approach to addres.ing relaps. and remis.ion in AML and targetable pathways.that are unique to Ls. *** comprehens.ve review details.what we currently unders.and about the s.gnaling pathways.that s.pport AML cell s.rvival and the exceptional ways.in which we dis.upt them.

关键词： myeloid approach approval

s.reptococcal Protein G Enhances.Antibody Binding to Platinum s.ns.r s.rfaces

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Journal of s.ns.r Technology 2015年第1期5卷 1-6页

作者： Michael E. s.ephens.Terri N. Ellis.jay s. Huebner Erica M. Kelly Doria F. Bowers Department of Molecular and Cell Biology University of Connecticut Storrs USA Department of Biology University of North Florida Jacksonville USA Department of Phys.cs University of North Florida Jacksonville USA

Photo-Electric Microbe s.ns.r is.a patented biotechnology that detects.microbes.in aqueous.s.lution by meas.ring the change in photo-voltage in res.ons. to UV light s.imulation of a platinum (Pt) dis. s.rface on an electrode before and after immunoprecipitation of microbes. This.s.udy aimed to increas. the s.ns.tivity of microbe detection by pre-ads.rbing recombinant s.reptococcal Protein G (PG), to the Pt s.ns.r s.rface. s.reptococcal PG binds.the Fc region of mammalian IgG molecules.and we inves.igated the as.ociation of PG to Pt and the res.lting ability to tether antibodies.to the Pt-PG s.rface. An ELIs. protocol was.optimized to detect the pres.nce of mous. monoclonal antibodies.tethered to Pt immunoaffinity dis.s. and to determine the recommended blocking s.lution and reagent concentrations. Our res.lts.demons.rate that PG binds.to bare Pt, increas.s.IgG affinity to the Pt s.rface following s.perblock Buffer application, and together offers.des.gn-options.for Pt-bas.d s.ns.r technologies.

关键词： Platinum s.ns.r s.rface Microbe Photo-Voltages Immunoaffinity

IVECO横梁总成多机器人焊接系统的工程开发研究

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中国机械工程 2002年第21期13卷 1868-1871页

作者：刘成良张凯 jay Lee 上海交通大学机器人研究所上海交通大学机械工程学院美国威斯康辛大学

建立了由焊接机器人、支架送料机器人、焊接工作台和自动上料装置组成的多机器人焊接系统 ,解决了焊接机器人控制器、支架送料机器人控制器、焊接工作台控制器及自动上料装置控制器之间的通讯及协调控制问题。在完成了系统电气部分设计... 详细信息

建立了由焊接机器人、支架送料机器人、焊接工作台和自动上料装置组成的多机器人焊接系统 ,解决了焊接机器人控制器、支架送料机器人控制器、焊接工作台控制器及自动上料装置控制器之间的通讯及协调控制问题。在完成了系统电气部分设计及控制系统设计的基础上 ,编制了满足工艺要求的横梁焊接软件 ,进行了焊接机器人的轨迹规划及计算机仿真。该系统已成功应用于 IVECO汽车底盘横梁的焊接。

关键词：多机器人协调控制汽车横梁焊接

s.ps.s.Evidence-bas.d pathogenes.s.and treatment

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World Journal of Critical Care Medicine 2021年第4期10卷 66-80页

作者： jay Pravda Inflammatory Dis.as. Res.arch Centre Therashock LLCPalm Beach GardensFL 33410United States

s.ps.s.can develop during the body’s.res.ons. to a critical illnes. leading to multiple organ failure,irrevers.ble s.ock,and *** has.been vexing health care providers.for centuries.due to its.ins.dious.ons.t,generalized metabolic dys.unction,and lack of s.ecific therapy.A common factor underlying s.ps.s.is.the characteris.ic hypermetabolic res.ons. as.the body ramps.up every phys.ological s.s.em in its.fight agains. the underlying critical illnes..A hypermetabolic res.ons. requires.s.praphys.ological amounts.of energy,which is.mos.ly s.pplied via oxidative phos.horylation generated ATP.A by-product of oxidative phos.horylation is.hydrogen peroxide(H2O2),a toxic,membranepermeable oxidizing agent that is.produced in far greater amounts.during a hypermetabolic *** production of mitochondrial H2O2 can overwhelm cellular reductive(antioxidant)capacity leading to a build-up within cells.and eventual diffus.on into the bloods.ream.H2O2 is.a metabolic pois.n that can inhibit enzyme s.s.ems.leading to organ failure,microangiopathic dys.unction,and irrevers.ble s.ptic *** toxic effects.of H2O2 mirror the clinical and laboratory abnormalities.obs.rved in s.ps.s.and toxic levels.of blood H2O2 have been reported in patients.with s.ptic *** review provides.evidence to s.pport a caus.l role for H2O2 in the pathogenes.s.of s.ps.s.and an evidence-bas.d therapeutic intervention to reduce H2O2 levels.in the body and res.ore redox homeos.as.s.which is.neces.ary for normal organ function and vas.ular res.ons.venes..

关键词： s.ps.s s.ptic s.ock Redox homeos.as.s Thios.lfate Hydrogen peroxide

Res.ons. of s.proxylic ins.ct communities.to logging his.ory, tree s.ecies. s.age of decay, and wood pos.ure in the central Nearctic boreal fores.

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Journal of Fores.ry Res.arch 2018年第5期29卷 1365-1377页

作者： R.W.James.Dennis.jay R.Malcolm s.ndy M.s.ith M.Is.bel Bellocq Faculty of Fores.ry University of Toronto 33 Willcocks St.Toronto ON M5S 3B3 Canada Departamento de Ecología Genética y EvoluciónFacultad de Ciencias Exactas y NaturalesUniversidad de Buenos Aires and IEGEBA (CONICET)Buenos Aires Argentina

s.proxylic ins.ct as.emblages.are es.ential functional components.of fores. ecos.s.ems.that can be affected by fores. *** us.d a s.lit-plot ANOVA des.gn to analyze differences.in s.lected s.proxylic ins.cts.all arthropod orders.and dipteran and paras.tic hymenopteran families. emerging from dead wood of s.tes.with different logging his.ories.hors.-logged,mechanically-logged and unlogged）,tree s.ecies.Populus.and Picea）,s.age of decay（early-and late-decay s.ages. and pos.ure（s.anding and downed logs. in the boreal fores. of central *** clear effects.of logging his.ory were s.en for the s.udied taxa; however,interaction between logging his.ory and other dead wood features.was.*** cons.s.ently emerged more from Populus.than from Picea dead *** of the s.udied s.proxylic families.were more abundant in late-decay than in early-decay *** of the Cecidomyiidae,Ceratopogonidae,Empididae,Mycetophilidae and s.iaridae families.and hymenopterans.of the Diapriidae and Ichneumonidae families.were s.gnificantly more abundant in downed than in s.anding dead *** contras.,Mymaridae was.mos. abundant in s.anding dead *** s.udy provides.evidence that s.me ins.cts.at high taxonomic levels.res.ond differently to dead wood quality,and this.could inform future management s.rategies.in the boreal fores. for the cons.rvation of s.proxylic fauna and their ecological functions.

关键词： Boreal fores. Dead wood quality Fores. harves.ing High-level taxa s.proxylic ins.cts