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Influence of Angiotensin II on α₁-Adrenergic receptors Function in rat Aorta and Expression in Vascular Smooth Muscle Cells

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Journal of Biosciences and Medicines 2024年第4期12卷 123-134页

作者： Itzell Alejandrina Gallardo-Ortíz Juan pablo de Jesús Benítez-Garrido Santiago C. Sigrist-Flores Juan javier López-Guerrero Enrique Hong rafael Villalobos-Molina Unidad de Biomedicina Facultad de Estudios Superiores Iztacala Universidad Nacional Aut&#243noma de M&#233xico Tlalnepantla M&#233xico Carrera de Enfermerí a Facultad de Estudios Superiores Iztacala Universidad Nacional Aut&#243noma de M&#233xico Tlalnepantla M&#233xico Departamento de Farmacobiologí a Centro de Investigaci&#243n and de Estudios Avanzados-IPN Ciudad de M&#233xico M&#233xico Carrera de Mé dico Cirujano Facultad de Estudios Superiores Iztacala Universidad Nacional Aut&#243noma de M&#233xico Tlalnepantla M&#233xico

Angiotensin II (Ang II) is the main mediator of the renin-Angiotensin-System acting on AT1 and other AT receptors. It is regarded as a pleiotropic agent that induces many actions, including functioning as a growth factor, and as a contractile hormone, among others. The aim of this work was to examine the impact of Ang II on the expression and function of α1-adrenergic receptors (α1-Ars) in cultured rat aorta, and aorta-derived smooth muscle cells. Isolated Wistar rat aorta was incubated for 24 h in DMEM at 37˚C, then subjected to isometric tension and to the action of added norepinephrine, in concentration-response curves. Ang II was added (1 × 10p>−5p> M), and in some experiments, 5-Methylurapidil (α1A-Ar antagonist), AH11110A (α1B-Ar antagonist), or BMY-7378 (α1D-Ar antagonist), were used to identify the α1-Ar involved in the response. Desensitization of the contractile response to norepinephrine was observed due to incubation time, and by the Ang II action. α1D-Ar was protected from desensitization by BMY-7378;while rS-100329 and pr.zosin partially mitigated desensitization. In another set of experiments, isolated aorta-derived smooth muscle cells were exposed to Ang II and α1-Ars proteins were evaluated. α1D-Ar increased at 30 and 60 min post Ang II exposure, the α1A-Ar diminished from 1 to 4 h, while α1B-Ar remained unchanged over 24 h of Ang II exposure. Ang II induced an increase of α1D-Ar at short times, and BMY-7378 protected α1D-Ar from desensitization.

关键词： Angiotensin II α1D-Ar α1-Ar Expression rat aorta Smooth Muscle Cells

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Hepatitis C virus NS5A region mutation in chronic hepatitis C genotype 1 patients who are non-responders to two or more treatments and its relationship with response to a new treatment

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World Journal of Gastroenterology 2017年第25期23卷 4538-4547页

作者： paloma Munoz de rueda José Manuel Fuentes rodríguezrosa Quiles pér.z Ana Gila Medina Ana Belén Martínálvar.z Jorge Casado ruíz ángeles ruíz Extremera javier Salmerón research Support Unit San Cecilio University Hospital of Granada Instituto de Investigación Biosanitaria CIBErehd Instituto de Salud Carlos III Unit for Clinical Management of Digestive Diseases San Cecilio University Hospital of Granada Granada University

To determine the number of mutations in the NS5A region of the hepatitis C virus (HCV) and its relationship to the response to antiviral therapy in patients with chronic hepatitis C genotype 1 who are non-responders to two or more treatments. METHODSSequences within HCV NS5A [pKr binding domain (pKrBD) and the interferon-sensitivity-determining region (ISDr)] were analysed via direct sequencing in a selected cohort of 72 patients, with a total of 201 treatments [interferon-alpha (IFN-α), n = 49; IFN-α + ribavirin (rBV), n = 75; pegylated (peg) IFN-α + rBV, n = 47; first-generation direct-acting antivirals (DAAs), n = 13; and second-generation DAAs, n = 17]. Of these, 48/201 achieved a sustained virological response (SVr) and 153/201 achieved no virological response (NVr). rESULTSFor both regions, treatments resulting in SVr were associated with more baseline mutations than were treatments resulting in NVr (SVr vs NVr; pKrBD: 5.82 ± 3 vs 4.86 ± 2 mutations, p = 0.045; ISDr: 2.65 ± 2 vs 1.51 ± 1.7 mutations, p = 0.005). A decrease or no change in the number of mutations over time between treatments in the pKrBD or ISDr, as shown by sequencing, was associated with patients who usually failed to respond to treatment (pKrBD, p = 0.02; ISDr, p = 0.001). Moreover, patients showing a post-treatment baseline viral load > 600000 IU/mL and increased ISDr mutations with respect to the previous treatment were 9.21 times more likely to achieve SVr (p = 0.001). CONCLUSIONThe obtained results show that among patients who have shown no response to two or more antiviral treatments, the likelihood of achieving SVr increases with the genetic variability in the ISDr region (≥ 2 mutations or number of substitutions from the HCV-J and HCV-1 prototype), especially when the viral load is greater than 600000 IU/mL.

关键词： Interferon-based therapy Interferon-free therapy Chronic hepatitis C NS5A region Sustained virological response Number of mutations

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Mapping aboveground biomass by integrating geospatial and forest inventory data through a k-nearest neighbor strategy in North Central Mexico

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Journal of Arid Land 2014年第1期6卷 80-96页

作者： Carlos A AGUIrrE-SALADO Eduardo J TrEVIO-GArzA Oscar A AGUIrrE-CALDEróN javier JIMNEz-pr.z Marco A GONzLEz-TAGLE José r VALDz-LAzALDE Guillermo SNCHEz-DíAz reija HAApANEN Alejandro I AGUIrrE-SALADO Liliana MIrANDA-ArAGóN Faculty of Forest Sciences Autonomous University of Nuevo Leon Faculty of Engineering Autonomous University of San Luis Potosi Forestry program Postgraduate College Haapanen Forest Consulting Faculty of Agronomy and Veterinary Autonomous University of San Luis Potosí

As climate change negotiations progress,monitoring biomass and carbon stocks is becoming an important part of the current forest ***,national governments are interested in developing forest-monitoring strategies using geospatial *** statistical methods for mapping biomass,there is a nonparametric approach called k-nearest neighbor(kNN).We compared four variations of distance metrics of the kNN for the spatially-explicit estimation of aboveground biomass in a portion of the Mexican north border of the intertropical *** derived,climatic,and topographic predictor variables were combined with the Mexican National Forest Inventory(NFI)data to accomplish the *** of distance metrics applied into the kNN algorithm was evaluated using a cross validation leave-one-out *** results indicate that the Most Similar Neighbor(MSN)approach maximizes the correlation between predictor and response variables(r=0.9).Our results are in agreement with those reported in the *** findings confirm the predictive potential of the MSN approach for mapping forest variables at pixel level under the policy of reducing Emission from Deforestation and Forest Degradation(rEDD+).

关键词： k-nearest neighbor Mahalanobis most similar neighbor MODIS BrDF-adjusted reflectance forest inventory the policy of reducing Emission from Deforestation and Forest Degradation

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Metadoxine improves the three- and six-month survival rates in patients with severe alcoholic hepatitis

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World Journal of Gastroenterology 2015年第16期21卷 4975-4985页

作者： Fátima Higuera-de la Tijera Alfredo I Servín-Caamano Aurora E Serralde-zúniga javier Cr.z-Herrera Eduardo pér.z-Torres Juan M Abdo-francis francisco Salas-Gordillo JoséL pér.z-Hernández Liver Clinic Gastroenterology DepartmentHospital General de MéxicoDr.Eduardo LiceagaMexico City 06720Mexico Internal Medicine Department Hospital General de MéxicoDr.Eduardo LiceagaMexico City 06720Mexico Fundación Mexicana para la Salud A.C Mexico City 06720Mexico

AIM:To evaluate the impact of metadoxine(MTD) on the 3- and 6-mo survival of patients with severe alcoholic hepatitis(AH).METHODS:This study was an open-label clinical trial,performed at the"Hospital General de México,*** Liceaga".We randomized 135 patients who met the criteria for severe AH into the following groups:35 patients received prednisone(pDN)40 mg/d,35patients received pDN+MTD 500 mg three times daily,33 patients received pentoxifylline(pTX)400 mg three times daily,and 32 patients received pTX+MTD 500 mg three times *** duration of the treatment for all of the groups was 30 ***:In the groups treated with the MTD,thesurvival rate was higher at 3 mo(pTX+MTD 59.4%vs pTX 33.3%,p=0.04;pDN+MTD 68.6%vs pDN20%,p=0.0001)and at 6 mo(pTX+MTD 50%vs pTX18.2%,p=0.01;pDN+MTD 48.6%vs pDN 20%,p=0.003)than in the groups not treated with MTD.A relapse in alcohol intake was the primary independent factor predicting mortality at 6 *** patients receiving MTD maintained greater abstinence than those who did not receive it(74.5%vs 59.4%,p=0.02).CONCLUSION:MTD improves the 3-and 6-mo survival rates in patients with severe *** abstinence is a key factor for survival in these *** patients who received the combination therapy with MTD were more likely to maintain abstinence than those who received monotherapy with either pDN or pTX.

关键词： Alcoholic hepatitis Metadoxine Survival Alcohol abstinence

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Mediation role of cardiorespiratory fitness on the association between fatness and cardiometabolic risk in European adolescents: The HELENA study

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Journal of Sport and Health Science 2021年第3期10卷 360-367页

作者： Carlos Cristi-Montero javier Courel-Ibanez francisco B.Ortega Jose Castro-pinero Alba Santaliestra-pasias Angela polito Jeremy Vanhelst Ascension Marcos Luis M.Moreno Jonatan r.ruiz IryS Group Physical Education SchoolPontificia Universidad Catolicade ValparaisoValparaisso 2530388Chile Department of physical Activity and Sport Faculty of Sport SciencesUniversity of MurciaMurcia 30071Spain prOmoting FITness and Health through physical Activity research Group(prOFITH) Department of Physical Education and SportsFaculty of Sport SciencesUniversity of GranadaGranada 18001Spain Department of physical Education Faculty of Education SciencesUniversity of CadizPuerto Real 11003Spain Department of Health and Human performance School of Health SciencesUniversity of ZaragozaZaragoza 50001Spain Growth ExerciseNutrition and Development(GENUD)Research GroupZaragoza 50001Spain National Institute for Food and Nutrition research Rome 80070Italy Lille Inflammation research International Center University of LilleLille 59000France Immunonutrition research Group Department Metabolism and NutritionInstitute of Food Science and Technology and Nutrition(ICTAN)Spanish National Research Council(CSIC)Madrid E-28040 Spain

purpose:This study was aimed to analyze the mediation role of cardiorespiratory fitness(CrF)on the association between fatness and cardiometabolic risk scores(CMrs)in European ***:A cross-sectional study was conducted in adolescents(n=525;46%boys;14.1±1.1 years old,mean ±SD)from 10 European cities involved in the Healthy Lifestyle in Europe by Nutrition in Adolescence *** was measured by means of the shuttle run test,while fatness measures included body mass index(BMI),waist to height ratio,and fat mass index estimated from skinfold thicknesses.A clustered CMrs was computed by summing the standardized values of homeostasis model assessment,systolic blood pressure,triglycerides,total cholesterol/highdensity lipoprotein cholesterol ratio,and ***:Linear regression models indicated that CrF acted as an important and partial mediator in the association between fatness and CMrs in 1217-year-old adolescents(for BMI:coefficients of the indirect role b=0.058(95%confidence interval(95%CI):0.023-0.101),Sobel test z=3.11(10.0%mediation);for waist to height ratio:b=4.279(95%CI:2.242-7.059),z=3.86(11.5%mediation);and for fat mass index:b=0.060(95%CI:0.020-0.106),z=2.85(9.4%mediation);all prs could be partially decreased with improvements to fitness levels;therefore,CrF contribution both in the clinical field and public health could be important to consider and promote in adolescents independently of their fatness levels.

关键词： Cardiovascular disease Children Fat mass Fitness Health physical activity

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z-line examination by the pillCam^(TM) SB:prospective comparison of three ingestion protocols

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World Journal of Gastroenterology 2010年第1期16卷 63-68页

作者： Ignacio Fernandez-Urien Erika Borobio Inmaculada Elizalde rebeca Irisarri Juan Jose Vila Jesus Maria Urman javier Jimenez Department of Gastroenterology Hospital of Navarra

AIM:To evaluate the z-line visualization by the pillCamTM SB2 using three different ingestion protocols. METHODS:Ninety consecutive patients undergoing small bowel capsule endoscopy(SBCE)between January and May 2008 were included in the study. They swallowed the capsule in the standing(Group A= 30),supine(Group B=30)and right supine positions (Group C=30).Baseline patient characteristics, difficulties in capsule ingestion,esophageal transit times(ETT)and z-line visualization were noted. rESULTS:No significant differences were found between the groups with regard to baseline patient characteristics,ingestion difficulties and complete SB examinations(p>0.05).At least 1 frame of the z-line was detected in 15.8%,46.7%and 90%of patients in groups A,B and C,respectively(prage number of z-line images was 0.21±0.53,3.23 ±6.59 and 5.53±7.55 and the mean%of the z-linedetected was 71.3,25.1 and 8.3,in groups A,B and C, respectively(both pre longer in the supine group followed by the right supine and the standing groups(median of 237 s vs 64 s and 39 s, respectively;pz-line visualization in patients undergoing SBCE can be accurately achieved in most cases when the capsule is swallowed in the right supine position.

关键词： Barrett Capsule endoscopy Esophagus Gastroesophageal reflux disease Ingestion Varices z-line

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Effects of dielectric stoichiometry on the photoluminescence properties of encapsulated WSe2 monolayers

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Nano research 2018年第3期11卷 1399-1414页

作者： javier Martfn-Sanchez Antonio Mariscal Marta De Luca Aitana Tar.zaga Martin-Luengo Georg Gramse Alma Halilovic rosalia Serna Alberta Bonanni Ilaria zardo rinaldo Trotta Armando rastelli Institute of Semiconductor and Solid State physics Johannes Kepler University Linz Altenbergerstrasse 69 A-4040 Linz Austria Laser processing Group Instituto de Optica CSIC C/Serrano 121 28006 Madrid Spain Department of physics University of Basel Klingelbergstrasse 82 4056 Basel Switzerland Institute for Biophysics Johannes Kepler University Linz Gruberstrasse 40 A-4020 Linz Austria

Two-dimensional transition metal dichalcogenide semiconductors have emerged as promising candidates for optoelectronic devices with unprecedented properties and ultra-compact footprints. However, the high sensitivity of atomically thin materials to the surrounding dielectric media imposes severe limitations on their practical applicability. Hence, to enable the effective integration of these materials in devices, the development of reliable encapsulation procedures that preserve their physical properties is required. Here, the excitonic photoluminescence （at room temperature and 10 K） is assessed on mechanically exfoliated WSe2 monolayer flakes encapsulated with SiOx and AlxOy layers by means of chemical and physical deposition techniques. Conformal coating on untreated and non- functionalized flakes is successfully achieved by all the techniques examined, with the exception of atomic layer deposition, for which a cluster-like oxide coating is formed. No significant compositional or strain state changes in the flakes are detected upon encapsulation, independently of the technique adopted. remarkably, our results show that the optical emission of the flakes is strongly influenced by the stoichiometry quality of the encapsulating oxide. When the encapsulation is carried out with slightly sub-stoichiometric oxides, two remarkable phenomena are observed. First, dominant trion （charged exciton） photoluminescence is detected at room temperature, revealing a clear electrical doping of the monolayers. Second, a strong decrease in the optical emission of the monolayers is observed, and attributed to non-radiative recombination processes and/or carrier transfer from the flake to the oxide. power- and temperature-dependent photoluminescence measurements further confirm that stoichiometric oxides obtained by physical deposition lead to a successful encapsulation, opening a promising route for the development of integrated two-dimensional devices.

关键词： two dimensional (2D)materials dielectric encapsulation transition metaldichalcogenides semiconductors photoluminescence WSe2

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Endogenous Norepinephrine Desensitizes α_1D-Adrenoceptors in Cultured rat Aorta

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Journal of Biosciences and Medicines 2023年第10期11卷 168-180页

作者： Itzell Alejandrina Gallardo-Ortíz Jesús David Gómez-rodríguez Juan javier López-Guerrero Santiago C. Sigrist-Flores rafael Villalobos-Molina Unidad de Biomedicina Facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de México Tlalnepantla México Carrera de Enfermería Facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de México Tlalnepantla México Ciencias de la Salud Unidad Xochimilco Universidad Autónoma Metropolitana Ciudad de México México Carrera de Médico Cirujano Facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de México Tlalnepantla México

Desensitization is a process character.zed by the loss of cellular response to an agonist when this is present for a long time. α1D-adrenergic receptor (α1D-Ar) desensitization is important since this receptor is involved in the contraction of large caliber arteries, such as the aorta. The aim of this research was to evaluate the desensitization of α1D-Ar due to the endogenous release of norepinephrine in cultured rat aorta. Wistar rat aorta was incubated for 2 h or 24 h in DMEM at 37°C, and then subjected to isometric tension and the action of added norepinephrine, in concentration-response curve (CrC). In some experiments, BMY-7378 (α1D-Ar antagonist) or 5-methylurapidil (α1A-Ar antagonist) was used to identify the α1-Ar involved in the response, or BMY-7378 to protect the α1D-Ar from desensitization. results showed that α1D-Ar was desensitized when the aorta was incubated for 24 h, since the CrC to exogenous norepinephrine showed lower maximal contraction and the curve was displaced to the right, indicating that the receptor involved in contraction was not the α1D-Ar, as compared to the aorta incubated 2 h. The receptor stimulated by norepinephrine at 24 h was neither the α1A-Ar, as shown by the lack of displacement of the curve by 5-methylurapidil, but rather it seems that α1B-Ar is inducing contraction. When the aorta was incubated with BMY-7378 for 24 h, the α1D-Ar antagonist protected the receptor from desensitization. Endogenous norepinephrine desensitizes α1D-Ar in the cultured aorta, and the α1D-Ar is protected by BMY-7378.

关键词： Desensitization Norepinephrine α1D-Adrenergic receptor BMY-7378 rat Aorta

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Neurocognitive outcomes in pediatric brain tumors after treatment with proton versus photon radiation:a systematic review and meta-analysis

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世界儿科杂志:英文版 2023年第8期19卷 727-740页

作者： Álvaro Lassaletta javier S.Morales pedro L.Valenzuela Borja Esteso Lisa S.Kahalley Donald J.Mabbott Soumya Unnikrishnan Elena panizo Felipe Calvo radiation Oncology Department Clínica Universidad de NavarraCalle Marquesado de Santa Marta 128027 MadridSpain pediatric Neuro-Oncology Unit Hospital Infantil Universitario Niño JesúsMadridSpain MOVE-IT research Group Department of Physical EducationFaculty of Education SciencesUniversity of CadizCádizSpain Biomedical research and Innovation Institute of Cádiz(INiBICA)research Unit Puerta del Mar University HospitalUniversity of CádizCádizSpain physical Activity and Health research Group(paHerg) Research Institute of the Hospital 12 de Octubre(‘imas12’)MadridSpain Systems Biology Department University of AlcaláMadridSpain Clinical Neuropsychology Unit Psychiatry and Clinical Psychology DepartmentHospital Infantil Universitario Niño JesúsMadridSpain Baylor College of Medicine HoustonTXUSA Texas Children’s Hospital HoustonTXUSA The Hospital for Sick Children TorontoONCanada The University of Toronto TorontoONCanada University of California School of Medicine San DiegoLa JollaCAUSA

Background Advances in cancer treatments,particularly the development of radiation therapy,have led to improvements in survival outcomes in children with brain ***,radiation therapy is associated with significant long-term neurocognitive *** present systematic review and meta-analysis aimed to compare the neurocognitive outcomes of children and adolescents with brain tumors treated with photon radiation(XrT)or proton therapy(pBrT).Methods A systematic search was conducted(pubMed,Embase,Cochrane,and Web of Science from inception until 02/01/2022)for studies comparing the neurocognitive outcomes of children and adolescents with brain tumors treated with XrT *** pooled mean differences(expressed as z scores)were calculated using a random effects method for those endpoints analyzed by a minimum of three *** Totally 10 studies(n=630 patients,average age range:1–20 years)met the inclusion *** who had received pBrT achieved significantly higher scores(difference in z scores ranging from 0.29–0.75,all pr treatment than those who had received XrT for most analyzed neurocognitive outcomes(i.e.,intelligence quotient,verbal comprehension and perceptual reasoning indices,visual motor integration,and verbal memory).No robust significant differences(p>0.05 in main analyses or sensitivity analyses)were found for nonverbal memory,verbal working memory and working memory index,processing speed index,or focused *** pediatric brain tumor patients who receive pBrT achieve significantly higher scores on most neurocognitive outcomes than those who receive *** studies with long-term follow-ups are needed to confirm these results.

关键词： Brain health Childhood cancer Intelligence quotient radiotherapy

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Assembly of JAz–JAz and JAz–NINJA complexes in jasmonate signaling

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plant Communications 2023年第6期4卷 296-312页

作者： X.Edward zhou Yaguang zhang Jian Yao Jie zheng Yuxin zhou Qing He javier Moreno Vinh QLam Xiaoman Cao Koichi Sugimoto Leidy Vanegas-Cano Leena Kariapper Kelly Suino-powell Yuanye zhu Scott Novick patrick r.Griffin Feng zhang Gregg A.Howe Karsten Melcher Department of Structural Biology Van Andel InstituteGrand RapidsMI 49503USA Key Laboratory of pesticide College of Plant ProtectionNanjing Agricultural UniversityNanjingChina MSU-DOE plant research Laboratory Michigan State UniversityEast LansingMI 48824USA Department of Molecular Medicine UF Scripps Biomedical ResearchJupiterFL 33458USA plant resilience Institute Michigan State UniversityEast LansingMI 48824USA Department of Biochemistry and Molecular Biology Michigan State UniversityEast LansingMI 48824USA present address:Institute of Botany Jiangsu Province and Chinese Academy of SciencesNanjing 210014China present address:Tsukuba-plant Innovation research Center University of TsukubaTsukubaIbaraki 305-8572Japan

Jasmonates(JAs)are plant hormones with crucial roles in development and stress *** activate MYC transcription factors by mediating the proteolysis of MYC inhibitors called JAz *** the absence of JA,JAz proteins bind and inhibit MYC through the assembly of MYC–JAz–Novel Interactor of JAz(NINJA)–TpL repressor ***,JAz and NINJA are predicted to be largely intrinsically unstructured,which has precluded their experimental structure *** a combination of biochemical,mutational,and biophysical analyses and AlphaFold-derived ColabFold modeling,we character.zed JAz–JAz and JAz–NINJA interactions and generated models with detailed,high-confidence domain *** demonstrate that JAz,NINJA,and MYC interface domains are dynamic in isolation and become stabilized in a stepwise order upon complex *** contrast,most JAz and NINJA regions outside of the interfaces remain highly dynamic and cannot be modeled in a single *** data indicate that the small JAz zinc finger expressed in Inflorescence Meristem(zIM)motif mediates JAz–JAz and JAz–NINJA interactions through separate surfaces,and our data further suggest that NINJA modulates JAz *** study advances our understanding of JA signaling by providing insights into the dynamics,interactions,and structure of the JAz–NINJA core of the JA repressor complex.

关键词： JAz protein NINJA AlphaFold ColabFold MYC hydrogen-deuterium exchange

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