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Ubiquitous Computing and Its Applications in the Disease Management in a Ubiquitous City

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Journal of Computer and Communications 2018年第3期6卷 19-42页

作者： javier Cabo Salvador Jose Miguel Ramirez Uceda Veronica Cabo Muinos javier Ramos Lopez Carlos de Castro Cátedra de Telemedicina Universidad Internacional de AndalucíaSevilleSpain CITEC Centro de Investigaciones Tecnológicas Universidad de CórdobaCórdobaSpain Cátedra de Gestión Sanitaria y Ciencias de la Salud UDIMAMadridSpain IHM-Medical Technology MadridSpain Fundación de Ingeniería Biomédica MadridSpain Escuela Técnica Superior de Ingenieros de Telecomunicación Universidad Rey Juan CarlosMadridSpain departamento Cardiovascular Hospital Vithas NISA Pardo de Aravaca MadridSpain

The actual challenge in health is to manage patients with chronic diseases from a holistic approach where technology around the patient and at the city enhances their wellness. This paper deepens in the relations between health, devices, and models of technological cities and how these can be modeled to provide a more cost efficient solution while less invasive and more natural to the end users. In light of this, usable and accessible software and a wide range of devices, ranging from PC, smartphone, tablet and SmartTV have been tested. This manuscript will give good comprehension on how technology and disease management care models interact with the patient.

关键词： U-Health Ubiquitous Computing Internet of Things Spimes

Projecting the distribution and abundance of Mediterranean tree species under climate change:a demographic approach

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Journal of Plant Ecology 2017年第5期10卷 731-743页

作者： David García-Callejas Roberto Molowny-Horas javier Retana CREAF Universitat Autònoma de Barcelona(Edifici C)Cerdanyola del Vallès 08193Spain departament de Biologia Animal de Biologia Vegetal i d'EcologiaUniversitat Autònoma de Barcelona(Edifici C)Cerdanyola del Vallès 08193Spain

Distribution and abundance patterns of species arise from the spatiotemporal dynamics of demographic *** rates of birth,death,growth and patterns of dispersal are,in turn,influenced by environmental conditions and biotic ***,current approaches for modelling large-scale geographical patterns often bypass these simple *** in the mainland territory of Spain and using Pinus halepensis as a case study,our goal was to gain insight into the main driv-ers affecting local demographic processes,and how large-scale distribution and abundance patterns are shaped by these local variations in vital *** We applied the integral projection methodology to develop a spa-tially explicit demographic model of tree species in mainland Spain,using individual-level data from a national forest *** our integral projection model,environmental conditions and competi-tive interactions influence the survival,growth and reproduction of trees,and we model explicitly the dynamic colonization of new *** this framework,the projected distribution and abun-dance patterns of *** up to 2090 were evaluated under two different climate *** Findings When environmental conditions were kept constant,popula-tions tended to decrease in net number of adults and to increase in net basal area,thus consisting in fewer and bigger *** for climate change in our simulations exacerbated the trend in mortality,causing widespread losses in number of trees,and few locations maintained populations of>100 adult individu-als per *** expected increase in mortality under climate change,on the other hand,prompted a higher degree of regeneration via the release of niche space,although not enough to maintain current abundance *** spatial patterns did not vary significantly with climatic conditions,but the species was able to increase its distribution under climate change more than in a consta

关键词： climate change demographic model Pinus halepensis Mediterranean population dynamics

Platelet Endothelial Cell Adhesion Molecule (PECAM-1) Expression in Malignant Human Tumours and their Metastases

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Journal of Cancer Therapy 2010年第2期1卷 66-70页

作者： Juan R de la Haba Rodríguez Ignacio Porras Quintela Gema Pulido Cortijo Concepción Lucena Martínez javier García Corbacho Enrique Aranda Aguilar 1Medical Oncology and Pathology departments Reina Sofía University Hospital Córdoba Spain department of Cell Biology Physiology and Immunology University of Cordoba Córdoba Spain department of Cell Biology Physiology and Immunology University of Cordoba Córdoba Spain. Medical Oncology and Pathology departments Reina Sofía University Hospital Córdoba Spain

PECAM-1 is an adhesion molecule that plays an important role in the process of tumour disease dissemination since a function in transendothelial migration, angiogenesis and immune response has been shown for this membrane protein. Nevertheless the expression of PECAM-1 protein in solid tumours is a controversial matter and it has not been clarified so far. Thus, the aim of our study was to investigate PECAM-1 expression by immunohistochemistry in primary carci-nomas from colon, breast, bladder, ovary and kidney, and in their metastases. In addition an example of primary and metastatic melanoma was also investigated. We found that PECAM-1 is expressed in the metastases of all primary car-cinomas that express PECAM-1 (colorectal, breast and urothelial bladder). By the contrary metastases from primary carcinomas non-expressing PECAM-1 are also negative for expression. In conclusion, our findings support a possible role of this molecule in metastatic development of a subset of malignant human epithelial tumours.

关键词： PECAM-1 CD31 Angiogenesis Neoplasms Immunohistochemistry

Leishmaniasis in the knee area

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Asian Pacific Journal of Tropical Medicine 2010年第4期3卷 330-331页

作者： Bava Amadeo javier Rossi Maria laura Seley Celeste Troncoso Alcides department of Micology La Plata University department of Microbiology Parasitology and Infectious DiseasesSchool of MedicineBuenos Aires University

Leishmaniasis is a parasitic infection caused by species leishmaniae,which can produce two types of manifestations:visceral and *** south America cutaneous leishmaniasis is more common than visceral leishmaniasis.A case of primary cutaneous leishmaniasis from Bolivia is presented for its *** patient of our case showed an ulcerated lesion of the knee. Montenegro’s intradermal test was ***-stained touch preparation of the skin biopsy revealed amastigotes inside macrophages,consistent with *** patient was treated with meglumine antimoniate intramuscular(20 mg of Sb+/kg/day) three weeks,with complete cicatrization of the lesion.

关键词： Cutaneous leishmaniasis Skin ulcers Leishmania

Adipokines,cytokines and body fat stores in hepatitis Cvirus liver steatosis

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World Journal of Hepatology 2016年第1期8卷 74-82页

作者： emilio gonzález-reimers javier lópez-prieto geraldine quintero-platt ricardo pelazas-gonzález m remedios alemán-valls onán pérez-hernández m joséde-la-vega-prieto m angeles gómez-rodríguez candelaria martín-gonzález francisco santolaria-fernández Servicio de Medicina Interna Hospital Universitario de CanariasUniversidad de La Laguna38320 Canary IslandsSpain

AIM: To identify patients with or without liver steatosis and its severity in treatment-na?ve patients affected by hepatitis C virus(HCV) ***: We included 56 HCV infected patients, and assessed the amount of liver fat by histomorphometry, and its relationships with fat and lean mass at different parts of the body(by densitometry), hormones [insulin, homeostatic model assessment(HOMA)], adipokines(resistin, adiponectin, leptin), and cytokines(tumor necrosis factor α, interleukin-6).RESULTS: Although the intensity of liver steatosis is related to trunk fat mass and HOMA, 33% of patients showed no liver steatosis, and this finding was not related to body mass index or genotype. Besides trunkfat mass, no other factor was related to the presence or not of liver steatosis, or to the intensity of it, by multivariate analysis. Lean mass was not related to liver steatosis. Adiponectin levels were lower among patients. No differences were observed in leptin and ***: Steatosis in HCV infection is common(67.2%), and closely related to trunk fat, and insulin resistance, but not with leg fat mass or adipokines.

关键词： Resistin Adiponectin Insulin resistance Proinflammatory cytokines Leptin Hepatitis C virus Liver steatosis

“Rescue” regimens after Helicobacter pylori treatment failure

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World Journal of Gastroenterology 2008年第35期14卷 5385-5402页

作者： javier P Gisbert Gastroenterology Unit Hospital Universitario de la Princesa and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y DigestivasMadridSpain

Helicobacter pylori (H pylori) infection is the main cause of gastritis, gastroduodenal ulcer disease, and gastric cancer. After more than 20 years of experience in H pylori treatment, in my opinion, the ideal regimen to treat this infection is still to be found. Currently, apart from having to know first-line eradication regimens well, we must also be prepared to face treatment failures. Therefore, in designing a treatment strategy we should not focus on the results of primary therapy alone, but also on the final (overall) eradication rate. The choice of a "rescue" treatment depends on which treatment is used initially. If a clarithromycin- based regimen was used initially, a subsequent metronidazole-based treatment (quadruple therapy) may be used afterwards, and then a levofloxacin- based combination would be a third "rescue" option. Alternatively, it has recently been suggested that levofloxacin-based rescue therapy constitutes an encouraging second-line strategy, representing an alternative to quadruple therapy in patients with previous PPI-clarithromycin-amoxicillin failure, with the advantage of efficacy, simplicity and safety. In this case, a quadruple regimen may be reserved as a third-line rescue option. Finally, rifabutin-based rescue therapy constitutes an encouraging empirical fourth- line strategy after multiple previous eradication failures with key antibiotics such as amoxicillin, clarithromycin, metronidazole, tetracycline, and levofloxacin. Even after two consecutive failures, several studies have demonstrated that H pylori eradication can finally be achieved in almost all patients if several rescue therapies are consecutively given. Therefore, the attitude in H pylori eradication therapy failure, evenafter two or more unsuccessful attempts, should be to fight and not to surrender.

关键词： Helicobacter pylori Rescue Salvage Rifabutin Levofloxacin

Chromoblastomycosis as a problem of the tropics

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Asian Pacific Journal of Tropical Medicine 2009年第3期2卷 79-80页

作者： Bava Amadeo javier Rodriguez Rios Elizabeth Troncoso Alcides department of Micology La Plata National UniversityBuenos Aires State department of Microbiology Parasitology and Infectious DiseasesSchool of MedicineBuenos Aires University

Chromoblastomycosis can also cause severe but usually superficial lesions on the *** other deep mycosis, this chronic and disabling condition is seen in many tropical regions,including Argentina,where this man was ***... 详细信息

关键词： Chromoblastomycosis Verrucous Lesiones

A Hybrid Statistical-Dynamical Downscaling of Air Temperature over Scandinavia Using the WRF Model

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Advances in Atmospheric Sciences 2020年第1期37卷 57-74页

作者： Jianfeng WANG Ricardo M.FONSECA Kendall RUTLEDGE javier MARTÍN-TORRES Jun YU department of Mathematics and Mathematical Statistics UmeåUniversitySE 90187UmeåSweden Group of Atmospheric Science Division of Space TechnologyDepartment of Computer ScienceElectrical and Space EngineeringLuleåUniversity of TechnologySE 97187 LuleåSweden Novia University of Applied Sciences PO BOX 6FI-65201 VaasaFinland Instituto Andaluz de Ciencias de la Tierra 18100 GranadaSpain The Pheasant Memorial laboratory for Geochemistry and Cosmochemistry Institute for Planetary MaterialsOkayama University at MisasaTottori 682-0193Japan

An accurate simulation of air temperature at local scales is crucial for the vast majority of weather and climate *** this work,a hybrid statistical–dynamical downscaling method and a high-resolution dynamical-only downscaling method are applied to daily mean,minimum and maximum air temperatures to investigate the quality of localscale estimates produced by *** two downscaling approaches are evaluated using station observation data obtained from the Finnish Meteorological Institute over a near-coastal region of western *** dynamical downscaling is performed with the Weather Research and Forecasting(WRF)model,and the statistical downscaling method implemented is the Cumulative Distribution Function-transform(CDF-t).The CDF-t is trained using 20 years of WRF-downscaled Climate Forecast System Reanalysis data over the region at a 3-km spatial resolution for the central month of each *** performance of the two methods is assessed qualitatively,by inspection of quantile-quantile plots,and quantitatively,through the Cramer-von Mises,mean absolute error,and root-mean-square error *** hybrid approach is found to provide significantly more skillful forecasts of the observed daily mean and maximum air temperatures than those of the dynamical-only downscaling(for all seasons).The hybrid method proves to be less computationally expensive,and also to give more skillful temperature forecasts(at least for the Finnish near-coastal region).

关键词： WRF air temperature Cumulative Distribution Function-transform hybrid statistical–dynamical downscaling,model evaluation Scandinavian Peninsula

FNDC4 and FNDC5 reduce SARS-CoV-2 entry points and spike glycoprotein S1-induced pyroptosis, apoptosis, and necroptosis in human adipocytes

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Cellular & Molecular Immunology 2021年第10期18卷 2457-2459页

作者： Gema Frühbeck Victoria Catalán Víctor Valentí Rafael Moncada javier Gómez-Ambrosi Sara Becerril Camilo Silva Piero Portincasa javier Escalada Amaia Rodríguez Metabolic Research laboratory Clínica Universidad de NavarraPamplonaSpain CIBER Fisiopatología de la Obesidad y Nutrición(CIBEROBN) Instituto de Salud Carlos IIIMadridSpain Obesity and Adipobiology Group Instituto de Investigación Sanitaria de Navarra(IdiSNA)PamplonaSpain department of Endocrinology and Nutrition Clínica Universidad de NavarraPamplonaSpain department of Surgery Clínica Universidad de NavarraPamplonaSpain department of Anesthesia Clínica Universidad de NavarraPamplonaSpain department of Biomedical Sciences and Human Oncology Clinica Medica“A.Murri”University of Bari Medical SchoolPoliclinico HospitalBariItaly.

A sedentary lifestyle and obesity are important risk factors for severe COVID-19 complications and death[1,2].Excessive adipose tissue(AT)might contribute to more extensive viral spread with increased shedding,immune activation,and cytokine amplification[3].Several factors secreted by contracting muscle,termed myokines,mediate the beneficial effects of exercise in a wide range of diseases,including obesity[4].Thus,we conducted a study to explore the potential role of myokines of the fibronectin type III domain-containing family,FNDC4 and FNDC5,in mechanisms underlying the increased susceptibility to COVID-19 complications in obesity.

关键词： FNDC5 obesity FND