检索结果-南通市图书馆

NLRP3 inflammasome blockade reduces adipose tissue inflammation and extracellular matrix remodeling

Cellular & Molecular Immunology 2021年第4期18卷 1045-1057页

作者： Xabier Unamuno javier Gomez-Ambrosi Beatriz Ramirez Amaia Rodriguez Sara Becerril Victor Valenti Rafael Moncada Camilo Silva javier Salvador Gema Fruhbeck Victoria Catalan Metabolic Research Laboratory Clfnica Universidad de NavarraPamplonaSpain CIber Fisiopatologfa de la Obesidad y Nutricion(CIberOBN) Instituto de Salud Carlos ⅢPamplonaSpain Obesity and Adipobiology Group Instituto de Investigaci6n Sanitaria de Navarra(IdiSNA)PamplonaSpain Department of Surgery Clinica Universidad de NavarraPamplonaSpain Department of Anesthesia Clinica Universidad de NavarraPamplonaSpain Department of Endocrinology&Nutrition Clfnica Universidad de NavarraPamplonaSpain

The NLRP3-IL-1β pathway plays an important role in adipose tissue(AT)-induced inflammation and the development of obesityassociated *** aimed to determine the impact of NLRP3 on obesity and its associated metabolic alterations as well as its role in adipocyte inflammation and extracellular matrix(ECM)*** obtained from 98 subjects were used in a case-control *** expression of different components of the inflammasome as well as their main effectors and inflammation-and ECM remodeling-related genes were *** impact of blocking NLRP3 using siRNA in lipopolysaccharide(LPS)-mediated inflammation and ECM remodeling signaling pathways was *** demonstrated that obesity(P<0.01),obesity-associated T2D(P<0.01)and NAFLD(P<0.05)increased the expression of different com ponents of the inflammasome as well as the expression and release of IL-1β and IL-18 in *** also found that obese patients with T2D exhibited increased(P<0.05)hepatic gene expression levels of NLRP3,IL1B and *** showed that NLRP3,but not NLRP1,is regulated by inflammation and hypoxia in visceral *** revealed that the inhibition of NLRP3 in human visceral adipocytes significantly blocked(P<0.01)LPS-induced inflammation by downregulating the mRNA levels of CCL2,IL1B,IL6,IL8,S100A8,S100A9,TLR4 and TNF as well as inhibiting(P<0.01)the secretion of IL1-β into the culture ***,blocking NLRP3 attenuated(P<0.01)the LPS-induced expression of important molecules involved in AT fibrosis(COL1A1,COL4A3,COL6A3 and MMP2).These novel findings provide evidence that blocking the expression of NLRP3 reduces AT inflammation with significant fibrosis attenuation.

关键词： NLRP3 Inflammasone Inflammation Obesity Type 2 diabetes Nonalcoholic fatty liver disease

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food supplementation by an invasive fleshy-fruited shrub sustains body condition of a native frugivorous bird during winter

引用

Integrative Zoology 2019年第3期14卷 259-269页

作者： Tobias Nicolas ROJAS David Lautaro VERGARA-TABARES Diego javier VALDEZ Marina Flavia PONZIO Susana Inés PELUC Institute of Diversity and Animal Eology(IDEA-CONICET) National University of CórdobaCórdobaArgentina Institute of Health Science Research(INICSA-CONICET) Faculty of Medical SciencesNational University of CórdobaCórdobaArgentina Faculty of Exacts Physics and Nature SciencesNational University of CórdobaCórdobaArgentina Instituto de Ecología Regional(IER-CONICET) National University of TucumánTucumánArgentina.

Birds tend to adjust their behavior and physiology to changes in food availability in their ***al fluctuation of food resources may act as an energetic challenge,augmenting hypothalamus-pituitary-adrenal axis(HPA axis)activity,leading to an increase in corticosterone concentrations and promoting the metabolism of energy *** invasions may alter seasonal food fluctuations by providing a food supply during scarce *** could attenuate the energetic challenge,reducing HPA axis activity and the metabolism of *** a system with seasonal fluctuation in food availability,we tested if fruit supplementation by the invasive fleshy-fruited Pyracantha angustifolia during the season of native fruit scarcity decreases the consumption of energy stores through activity attenuation of the HPA *** measured changes in body condition and circulating corticosterone(CORT)concentration in Turdus chiguanco occurring at sites both invaded and not invaded by *** over 3 time periods that correspond to the periods prior to,during and after highest fruit production of the *** scarcity in the ecosystem appears as an energetic challenge for ***co,given that body mass,fat score and residuals of body mass/tarsus length decreased during winter in a site not invaded by the exotic ***,the presence of the invasive plant seemed to attenuate the metabolism of energetic reserves,as we did not record changes in body condition in birds inhabiting the invaded ***,plasma CORT concentration did not vary between sites or *** evaluation is required to elucidate how enhanced body condition,resulting from the consumption of a fleshy-fruited invasive plant,affects survivorship and reproductive performance in ***.

关键词： biological invasion energetic reserves food fluctuation frugivory plasma corticosterone

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ketamine anesthesia reduces intestinal ischemia/reperfusion injury in rats

引用

World Journal of Gastroenterology 2008年第33期14卷 5192-5196页

作者： Carlos Rodrigo Cámara Francisco javier Guzmán Ernesto Alexis Barrera Andrés Jesús Cabello Armando Garcia Nancy Esthela Fernández Eloy Caballero Jesus Ancer Department of Physiology Universidad Autonoma de Nuevo Leon School of MedicineMonterrey Nuevo Leon 64460 Mexico Department of Pathology Universidad Autonoma de Nuevo Leon School of MedicineMonterrey Nuevo Leon 64460 Mexico

AIM: To investigate the effects of ketamine anesthesia on the motility alterations and tissue injury caused by ischemia/reperfusion in rats. METHODS: Thirty male Wistar rats weighing 200-250 g were used. Ischemia was induced by ob-structing blood flow in 25% of the total small intesti-nal length (ileum) with a vascular clamp for 45 min, after which either 60 min or 24 h of reperfusion was allowed. Rats were either anesthetized with pento-barbital sodium (50 mg/kg) or ketamine (100 mg/kg). Control groups received sham surgery. After 60 min of reperfusion, the intestine was examined for mor-phological alterations, and after 24 h intestinal basic electrical rhythm (ber) frequency was calculated, and intestinal transit determined in all groups. RESULTS: The intestinal mucosa in rats that were anesthetized with ketamine showed moderate altera-tions such as epithelial lifting, while ulceration and hemorrhage was observed in rats that received pento-barbital sodium after 60 min of reperfusion. Quantita-tive analysis of structural damage using the Chiu scaleshowed significantly less injury in rats that received ketamine than in rats that did not (2.35 ± 1.14 vs 4.58 ± 0.50, P ber was not statistically different between groups. CONCLUSION: Our results show that ketamine anesthesia is associated with diminished intestinal injury and abolishes the intestinal transit delay induced by ischemia/reperfusion.

关键词： Ischemia/Reperfusion Ketamine N-methyl-D-aspartate Intestinal motility Tissue damage

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：