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A reciprocal inhibitory module for Pi and iron signaling

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Molecular Plant 2022年第1期15卷 138-150页

作者： Meina Guo Wenyuan Ruan Yibo Zhang Yuxin Zhang Xueqing Wang Zhenhui Guo Long Wang Tian Zhou javier paz-ares Keke Yi Key Laboratory of Plant Nutrition and Fertilizer Ministry of AgricultureInstitute of Agricultural Resources and Regional PlanningChinese Academy of Agricultural SciencesBeijing 100081China Department of Plant Molecular Genetics Centro Nacional de Biotecnología-Consejo Superior de Investigaciones Cientificas28049 MadridSpain

Phosphorous(P)and iron(Fe),two essential nutrients for plant growth and development,are highly abundant elements in the earth's crust but often display low availability to *** to the ability to form insoluble complexes,the antagonistic interaction between P and Fe nutrition in plants has been noticed for ***,the underlying molecular mechanism modulating the signaling and homeostasis between them re-mains ***,we show that the possible iron sensors HRZs,the iron deficiency-induced E3 ligases,could interact with the central regulator of phosphate(Pi)signaling,PHR2,and prompt its ubiquitination at lysine residues K319 and K328,leading to its degradation in *** with this,the hrzs mutants dis-played a high Pi accumulation ***,we found that iron deficiency could attenuate Pi star-vation signaling by inducing the expression of HRZs,which in turn trigger PHR2 protein ***-estingly,on the other hand,rice PHRs could negatively regulate the expression of HRZs to modulate iron deficiency ***,PHR2 and HRZs form a reciprocal inhibitory module to coordinate Pi and iron signaling and homeostasis in *** together,our results uncover a molecular link between Pi and iron master regulators,which fine-tunes plant adaptation to Pi and iron availability in rice.

关键词： Phosphate(Pi) Iron(Fe) PHRs HRZs Pi/Fe signaling and homeostasis

Plant adaptation to low phosphorus availability:Core signaling,crosstalks,and applied implications

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Molecular Plant 2022年第1期15卷 104-124页

作者： javier paz-ares Maria Isabel Puga Monica Rojas-Triana Iris Martinez-Hevia Sergio Diaz Cesar Poza-Carrión Miguel Mi(n)ambres Antonio Leyva Department of Plant Molecular Genetics Centro Nacional de Biotecnología(CNB-CSIC)Darwin 3Campus Universidad Autónoma28049 MadridSpain Institute of Plant Biochemistry Institute of Synthetic Biology and CEPLASUniversity of Düsseldorf40225 DüsseldorfGermany

Phosphorus(P)is an essential nutrient for plant growth and *** preferentially absorb P as orthophosphate(Pi),an ion that displays low solubility and that is readily fixed in the soil,making P limita-tion a condition common to many soils and Pi fertilization an inefficient *** cope with Pi limitation,plants have evolved a series of developmental and physiological responses,collectively known as the Pi starvation rescue system(PSR),aimed to improve Pi acquisition and use efficiency(PUE)and protect from Pi-starvation-induced *** research has been carried out during the last 20 years to un-ravel the mechanisms underlying the control of the PSR in *** we review the results of this research effort that have led to the identification and characterization of several core Pi starvation signaling components,including sensors,transcription factors,microRNAs(miRNAs)and miRNA inhibitors,kinases,phosphatases,and components of the proteostasis *** also refer to recent results revealing the existence of intricate signaling interplays between Pi and other nutrients and antagonists,N,Fe,Zn,and As,that have changed the initial single-nutrient-centric view to a more integrated view of nutrient ***,we discuss advances toward improving PUE and future research priorities.

关键词： inositol pyrophosphate plant nutrient PHR1 transcription factor PUE(phosphorus acquisition and use efficiency) SPX sensor and STOP1 transcription factor

Arsenite provides a selective signal that coordinates arsenate uptake and detoxification through the regulation of PHR1 stability in Arabidopsis

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Molecular Plant 2021年第9期14卷 1489-1507页

作者： Cristina Navarro Cristian Mateo-Elizalde Thotegowdanapalya C.Mohan Eduardo Sanchez-Bermejo Oscar Urrutia Maria Nieves Fernandez-Muniz Jose M.Garcia-Mina Riansares Munoz javier paz-ares Gabriel Castrillo Antonio Leyva Department of Plant Molecular Genetics Centro Nacional de Biotecnología-Consejo Superior de Investigaciones CientíficasMadrid 28049Spain Department of Environmental Biology Sciences SchoolUniversity of NavarraPamplona 31008Spain Department of Analytical Chemistry School of Chemical SciencesUniversidad Complutense de MadridMadrid 28040Spain Present address:Department of Biotechnology and Bioinformatics Faculty of Life SciencesJSS Academy of Higher Education and ResearchMysuruKarnataka 570015India Present address:S&A Fresh Produce.Brook Farm MardenHereford HR13ETUK Future Food Beacon of Excellence&School of Biosciences University of NottinghamNottingham LE125RDUK

In nature,plants acquire nutrients from soils to sustain growth,and at the same time,they need to avoid the uptake of toxic compounds and/or possess tolerance systems to cope with *** is particularly challenging when the toxic compound and the nutrient are chemically similar,as in the case of phosphate and *** this study,we demonstrated that regulatory elements of the phosphate starvation response(PSR)coordinate the arsenate detoxification machinery in the *** showed that arsenate repression of the phosphate transporter PHT1;1 is associated with the degradation of the PSR master regulator *** arsenic is sequestered into the vacuole,PHR1 stability is restored and PHT1;1 expression is ***,we identified an arsenite responsive SKP1-like protein and a PHR1 interactor F-box(PHIF1)as constituents of the SCF complex responsible for PHR1 *** found that arsenite,the form to which arsenate is reduced for compartmentalization in vacuoles,represses PHT1;1 expression,providing a highly selective signal versus phosphate to control PHT1;1 expression in response to ***,our results provide molecular insights into a sensing mechanism that regulates arsenate/phosphate uptake depending on the plant’s detoxification capacity.

关键词： arsenic signaling F-box protein arsenate uptake arsenic detoxification phosphate starvation phytoremediation

Arsenite provides a selective signal that coordinates arsenate uptake and detoxification through the regulation of PHR1 stability in Arabidopsis

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Molecular Plant 2022年第11期15卷 1826-1826页

作者： Cristina Navarro Cristian Mateo-Elizalde Thotegowdanapalya CMohan Eduardo Sánchez-Bermejo Oscar Urrutia María Nieves Fernández-Muñiz JoséMGarcía-Mina Riansares Muñoz javier paz-ares Gabriel Castrillo Antonio Leyva 不详

(Molecular Plant 14,1489-1507;September 6,2021)In the“Accession numbers”section in the originally published version of our manuscript,we mistakenly listed At5g44570 as the Arabidopsis Genome Initiative locus identif... 详细信息

关键词： Arabidopsis identifier stability

An analysis of key process parameters for hybrid manufacturing by material extrusion and CNC machining

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Bio-Design and Manufacturing 2018年第4期1卷 237-244页

作者： Ruben paz javier Santamarta Mario D.Monzon Joshua Garcfa Eujin Pei Departamento de Ingenierfa Mecainica Universidad de Las Palmas de Gran CanariaLas Palmas de Gran Canaria 35017 Spain Institute of Materials and Manufacturing Brunel University LondonKingston LaneUxbridge UB83PHUK

Hybrid Manufacturing combines the advantages of Additive Manufacturing (AM)and Subtractive Manufacturing on a single *** previous research has provided a good background of the manufacturing parameters,the analysis is often carried out separately and there is a lack of combined *** purpose of this research is to examine the influence of the main manufacturing parameters involved in AM and subtracfive processes using different ***,the study is focused on the Material Extrusion process concerning the layer height,fill angle and fill density;as well as two factors related to machining,including stepover and pass *** parameters that were examined include the dimension,hardness, flatness,weight and roughness.A mulfifactofial Design of Experiments was proposed with a total of 64 ***,a statistical analysis was carried out to assess the influence of the different groups on the response ***,a decision table presented and facilitated the selection of parameters depending on the desired objectives,leading to a framework that was applied to a case study for *** decision guide could enable designers and engineers to select the best strategy for a specific application,leading to a more efficient approach for manufacturing.

关键词： Hybrid manufacturing Material extrusion Additive manufacturing Subtractive manufacturing ~Machining Statistical analysis

Splanchnic-aortic inflammatory axis in experimental portal hypertension

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World Journal of Gastroenterology 2013年第44期19卷 7992-7999页

作者： Maria-Angeles Aller Natalia de las Heras Maria-paz Nava javier Regadera Jaime Arias Vicente Lahera Surgery Department School of Medicine Complutense University of Madrid 28040 MadridSpain Department of Physiology School of Medicine Complutense University of Madrid28040 Madrid Spain Animal Physiology II School of BiologyComplutense University of Madrid 28040 Madrid Spain Department of Histology and Neuroscience School of Medicine Universidad Autonoma Madrid 28046Spain

Splanchnic and systemic low-grade inflammation has been proposed to be a consequence of long-term prehepatic portal *** experimental model causes minimal alternations in the liver,thus making a more selective study possible for the pathological changes characteristic of prehepatic portal ***-grade splanchnic inflammation after longterm triple partial portal vein ligation could be associated with liver steatosis and portal hypertensive intestinal *** fact,we have previously shown that prehepatic portal hypertension in the rat induces liver steatosis and changes in lipid and carbohydrate metabolism similar to those produced in chronic inflammatory conditions described in metabolic syndrome in *** and bacterial translocation in this experimental model suggest the existence of a portal hypertensive intestinal microbiome implicated in both the splanchnic and systemic alterations related to prehepatic portal *** the systemic impairments,aortopathy characterized by oxidative stress,increased levels of proinflammatory cytokines and profibrogenic mediators stand *** this experimental model of long-term triple portal vein ligated-rats,the abdominal aortic proinflammatory response could be attributed to oxidative ***,the increased aortic reduced-nicotinamide-adenine dinucleotide phosphate[NAD(P)H]oxidase activity could be associated with reactive oxygen species production and promote aortic ***,oxidative stress mediated by NAD(P)H oxidase has been associated with risk factors for inflammation and *** splanchnic and systemic pathology that is produced in the long term after triple partial portal vein ligation in the rat reinforces the validity of this experimental model to study the chronic low-grade inflammatory response induced by prehepatic portal hypertension.

关键词： Portal hypertension Inflammation Aortopathy Hepatic steatosis

Performance analysis of visual markers for indoor navigation systems

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Frontiers of Information Technology & Electronic Engineering 2016年第8期17卷 730-740页

作者： Gaetano C.LA DELFA Salvatore MONTELEONE Vincenzo CATANIA Juan F.DE paz javier BAJO Department of Electrical Electronics and Computer Engineering (DIEEI) University of Catania Catania 95125 Italy BISITE Research Group Faculty of Science University of Salamanca Salamanca 37007 Spain Department of Artificial Intelligence Polytechnic University of Madrid Madrid 28660 Spain

The massive diffusion of smartphones, the growing interest in wearable devices and the Internet of Things, and the exponential rise of location based services（LBSs） have made the problem of localization and navigation inside buildings one of the most important technological challenges of recent years. Indoor positioning systems have a huge market in the retail sector and contextual advertising; in addition, they can be fundamental to increasing the quality of life for citizens if deployed inside public buildings such as hospitals, airports, and ***, in emergency situations, they can make the difference between life and death. Various approaches have been proposed in the literature. Recently, thanks to the high performance of smartphones＇ cameras, marker-less and marker-based computer vision approaches have been investigated. In a previous paper, we proposed a technique for indoor localization and navigation using both Bluetooth low energy（BLE） and a 2D visual marker system deployed into the floor. In this paper, we presented a qualitative performance evaluation of three 2D visual markers, Vuforia,Ar Uco marker, and AprilT ag, which are suitable for real-time applications. Our analysis focused on specific case study of visual markers placed onto the tiles, to improve the efficiency of our indoor localization and navigation approach by choosing the best visual marker system.

关键词： Indoor localization Visual markers Computer vision

Alcoholic liver disease:Utility of animal models

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World Journal of Gastroenterology 2018年第45期24卷 5063-5075页

作者： Arantza Lamas-paz Fengjie Hao Leonard J Nelson Maria Teresa Vázquez Santiago Canals Manuel Gómez del Moral Eduardo Martínez-Naves Yulia A Nevzorova Francisco javier Cubero Department of Immunology Ophthalmology and ORLComplutense University School of MedicineMadrid 28040Spain 12 de Octubre Health Research Institute(imas12) Madrid 28041Spain Institute for Bioengineering(IBioE) School of EngineeringFaraday BuildingThe University of EdinburghEdinburgh EH9 3 JLScotlandUnited Kingdom Department of Human Anatomy and Embryology Complutense University School of MedicineMadrid 28040Spain Instituto de Neurociencias Consejo Superior de Investigaciones CientíficasUniversidad Miguel HernándezSan Juan de Alicante 03550Spain Department of Cell Biology Complutense University School of MedicineMadrid 28040Spain Department of Genetics Physiology and MicrobiologyFaculty of BiologyUniversidad ComplutenseMadrid 28040Spain Department of Internal Medicine Ⅲ University Hospital RWTH AachenAachen 52062Germany

Alcoholic liver disease(ALD) is a major cause of acute and chronic liver injury. Extensive evidence has been accumulated on the pathological process of ALD during the past decades. However, effective treatment options for ALD are very limited due to the lack of suitable in vivo models that recapitulate the full spectrum of ALD. Experimental animal models of ALD, particularly rodents, have been used extensively to mimic human ALD. An ideal animal model should recapitulate all aspects of the ALD process, including significant steatosis, hepatic neutrophil infiltration, and liver injury. A better strategy against ALD depends on clear diagnostic biomarkers, accurate predictor(s) of its progression and new therapeutic approaches to modulate stop or even reverse the disease. Numerous models employing rodent animals have been established in the last decades to investigate the effects of acute and chronic alcohol exposure on the initiation and progression of ALD. Although significant progress has been made in gaining better knowledge on the mechanisms and pathology of ALD, many features of ALD are unknown, and require further investigation, ideally with improved animal models that more effectively mimic human ALD. Although differences in the degree and stages of alcoholic liver injury inevitably exist between animal models and human ALD, the acquisition and translational relevance will be greatly enhanced with the development of new and improved animal models of ALD.

关键词： Steatohepatitis Cirrhosis Hepatocellular carcinoma Alcoholic liver disease Reactive oxygen species

The Social Determinants of Health in Relation to Sexually Transmitted Infections in Maricopa County Arizona

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Advances in Infectious Diseases 2022年第2期12卷 328-336页

作者： Benjamin Picciano Andrea Vizcaino Rosa Angelica Hernandez Francisco javier Vizcaino Carla Segura Coutino Alonso Trevino IV javier paz International University of the Health Sciences Basseterre Saint Kitts and Nevis School of Medicine Universidad Autónoma de Guadalajara Guadalajara Mexico

Based on the information that was collected on the County Health Rankings website [1], one of the top health concerns for Maricopa County was sexually transmitted infections or STIs. A big concern with STIs is this is not a common subject explored in educational settings or addressed socially. There are many organizations, including the CDC, that have access to materials, there is limited distribution of the educational content. Therefore, the public is not well informed and lacks the information to make educated decisions. The areas with insufficiencies are knowledge of the disease processes, prevention, and treatment.

关键词： STI Infectious Disease Maricopa Arizona Sexually Transmitted Infections Public Health Disease Prevention Sexual Health Sexual Health Education