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A reciprocal inhibitory module for Pi and iron signaling

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Molecular Plant 2022年第1期15卷 138-150页

作者： Meina Guo Wenyuan Ruan Yibo Zhang Yuxin Zhang Xueqing Wang Zhenhui Guo Long Wang Tian Zhou javier paz-Ares Keke Yi Key Laboratory of Plant Nutrition and Fertilizer Ministry of AgricultureInstitute of Agricultural Resources and Regional PlanningChinese Academy of Agricultural SciencesBeijing 100081China Department of Plant Molecular Genetics Centro Nacional de Biotecnología-Consejo Superior de Investigaciones Cientificas28049 MadridSpain

Phosphorous(P)and iron(Fe),two essential nutrients for plant growth and development,are highly abundant elements in the earth's crust but often display low availability to *** to the ability to form insoluble complexes,the antagonistic interaction between P and Fe nutrition in plants has been noticed for ***,the underlying molecular mechanism modulating the signaling and homeostasis between them re-mains ***,we show that the possible iron sensors HRZs,the iron deficiency-induced E3 ligases,could interact with the central regulator of phosphate(Pi)signaling,PHR2,and prompt its ubiquitination at lysine residues K319 and K328,leading to its degradation in *** with this,the hrzs mutants dis-played a high Pi accumulation ***,we found that iron deficiency could attenuate Pi star-vation signaling by inducing the expression of HRZs,which in turn trigger PHR2 protein ***-estingly,on the other hand,rice PHRs could negatively regulate the expression of HRZs to modulate iron deficiency ***,PHR2 and HRZs form a reciprocal inhibitory module to coordinate Pi and iron signaling and homeostasis in *** together,our results uncover a molecular link between Pi and iron master regulators,which fine-tunes plant adaptation to Pi and iron availability in rice.

关键词： Phosphate(Pi) Iron(Fe) PHRs HRZs Pi/Fe signaling and homeostasis

Plant adaptation to low phosphorus availability:Core signaling,crosstalks,and applied implications

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Molecular Plant 2022年第1期15卷 104-124页

作者： javier paz-Ares Maria Isabel Puga Monica Rojas-Triana Iris Martinez-Hevia Sergio Diaz Cesar Poza-Carrión Miguel Mi(n)ambres Antonio Leyva Department of Plant Molecular Genetics Centro Nacional de Biotecnología(CNB-CSIC)Darwin 3Campus Universidad Autónoma28049 MadridSpain Institute of Plant Biochemistry Institute of Synthetic Biology and CEPLASUniversity of Düsseldorf40225 DüsseldorfGermany

Phosphorus(P)is an essential nutrient for plant growth and *** preferentially absorb P as orthophosphate(Pi),an ion that displays low solubility and that is readily fixed in the soil,making P limita-tion a condition common to many soils and Pi fertilization an inefficient *** cope with Pi limitation,plants have evolved a series of developmental and physiological responses,collectively known as the Pi starvation rescue system(PSR),aimed to improve Pi acquisition and use efficiency(PUE)and protect from Pi-starvation-induced *** research has been carried out during the last 20 years to un-ravel the mechanisms underlying the control of the PSR in *** we review the results of this research effort that have led to the identification and characterization of several core Pi starvation signaling components,including sensors,transcription factors,microRNAs(miRNAs)and miRNA inhibitors,kinases,phosphatases,and components of the proteostasis *** also refer to recent results revealing the existence of intricate signaling interplays between Pi and other nutrients and antagonists,N,Fe,Zn,and As,that have changed the initial single-nutrient-centric view to a more integrated view of nutrient ***,we discuss advances toward improving PUE and future research priorities.

关键词： inositol pyrophosphate plant nutrient PHR1 transcription factor PUE(phosphorus acquisition and use efficiency) SPX sensor and STOP1 transcription factor

Arsenite provides a selective signal that coordinates arsenate uptake and detoxification through the regulation of PHR1 stability in Arabidopsis

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Molecular Plant 2021年第9期14卷 1489-1507页

作者： Cristina Navarro Cristian Mateo-Elizalde Thotegowdanapalya C.Mohan Eduardo Sanchez-Bermejo Oscar Urrutia Maria Nieves Fernandez-Muniz Jose M.Garcia-Mina Riansares Munoz javier paz-Ares Gabriel Castrillo Antonio Leyva Department of Plant Molecular Genetics Centro Nacional de Biotecnología-Consejo Superior de Investigaciones CientíficasMadrid 28049Spain Department of Environmental Biology Sciences SchoolUniversity of NavarraPamplona 31008Spain Department of Analytical Chemistry School of Chemical SciencesUniversidad Complutense de MadridMadrid 28040Spain Present address:Department of Biotechnology and Bioinformatics Faculty of Life SciencesJSS Academy of Higher Education and ResearchMysuruKarnataka 570015India Present address:S&A Fresh Produce.Brook Farm MardenHereford HR13ETUK Future Food Beacon of Excellence&School of Biosciences University of NottinghamNottingham LE125RDUK

In nature,plants acquire nutrients from soils to sustain growth,and at the same time,they need to avoid the uptake of toxic compounds and/or possess tolerance systems to cope with *** is particularly challenging when the toxic compound and the nutrient are chemically similar,as in the case of phosphate and *** this study,we demonstrated that regulatory elements of the phosphate starvation response(PSR)coordinate the arsenate detoxification machinery in the *** showed that arsenate repression of the phosphate transporter PHT1;1 is associated with the degradation of the PSR master regulator *** arsenic is sequestered into the vacuole,PHR1 stability is restored and PHT1;1 expression is ***,we identified an arsenite responsive SKP1-like protein and a PHR1 interactor F-box(PHIF1)as constituents of the SCF complex responsible for PHR1 *** found that arsenite,the form to which arsenate is reduced for compartmentalization in vacuoles,represses PHT1;1 expression,providing a highly selective signal versus phosphate to control PHT1;1 expression in response to ***,our results provide molecular insights into a sensing mechanism that regulates arsenate/phosphate uptake depending on the plant’s detoxification capacity.

关键词： arsenic signaling F-box protein arsenate uptake arsenic detoxification phosphate starvation phytoremediation

The Social Determinants of Health in Relation to Sexually Transmitted Infections in Maricopa County Arizona

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Advances in Infectious Diseases 2022年第2期12卷 328-336页

作者： Benjamin Picciano Andrea Vizcaino Rosa Angelica Hernandez Francisco javier Vizcaino Carla Segura Coutino Alonso Trevino IV javier paz International University of the Health Sciences Basseterre Saint Kitts and Nevis School of Medicine Universidad Autónoma de Guadalajara Guadalajara Mexico

Based on the information that was collected on the County Health Rankings website [1], one of the top health concerns for Maricopa County was sexually transmitted infections or STIs. A big concern with STIs is this is not a common subject explored in educational settings or addressed socially. There are many organizations, including the CDC, that have access to materials, there is limited distribution of the educational content. Therefore, the public is not well informed and lacks the information to make educated decisions. The areas with insufficiencies are knowledge of the disease processes, prevention, and treatment.

关键词： STI Infectious Disease Maricopa Arizona Sexually Transmitted Infections Public Health Disease Prevention Sexual Health Sexual Health Education

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西班牙青年活动中心

现代装饰 2011年第4期 120-123页

作者： Manuel Collado Nacho Martin javier de paz 肖俊 Mi5 Arquitectos

Mi5 Arquitectos新近改造完成了西班牙青年活动中心的室内设计，该项目位于西班牙郊外的Fuenlabrada地区，其原址是一栋老旧的市政厅建筑。改造该项目的第一步就是将Fuenlabrada市政厅内原有的装饰元素全部清除．在室内形成视野开阔的... 详细信息

Mi5 Arquitectos新近改造完成了西班牙青年活动中心的室内设计，该项目位于西班牙郊外的Fuenlabrada地区，其原址是一栋老旧的市政厅建筑。改造该项目的第一步就是将Fuenlabrada市政厅内原有的装饰元素全部清除．在室内形成视野开阔的活动空间。

关键词：活动中心西班牙室内设计活动空间装饰元素市政厅改造建筑

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市场大厦改建——西班牙TERUEL-ZILLA青年活动中心

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现代装饰 2012年第8期 76-85页

作者： Manuel Collado Nacho Martin Miguel de Guzman javier de paz 何文君 Mi5建筑事务所

1987年,阿拉贡龙（Aragosaurus ischiaticus）骨骼化石被挖掘了出来并被一组来自加尔韦城（Galve）的研究小组（由Sanz、Buscalioni、Cassanovas和Santafe组成）收录在册。这是特鲁埃尔省首只在伊比利亚半岛被发现的恐龙。

关键词：活动中心西班牙改建大厦市场骨骼化石

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西班牙阿尔卡萨尔德圣胡安旅游办公室

现代装饰 2015年第11期 62-67页

作者： David Pérez Rocio Pina Carmelo Rodriguez Enrique Espinosa javier de paz Garcia 姜敏华 PKMN Architectures

传统的旅游办公厅往往张贴着一些具有当地特色的景点海报,或是摆放极具特色的纪念品,而本案则是一间外表看似如同店铺的旅游办公室。项目位于西班牙阿尔卡萨尔德圣胡安,由PKMN建筑事务所设计。乍一看,这似乎是一个除了几把＂座椅＂,连... 详细信息

传统的旅游办公厅往往张贴着一些具有当地特色的景点海报,或是摆放极具特色的纪念品,而本案则是一间外表看似如同店铺的旅游办公室。项目位于西班牙阿尔卡萨尔德圣胡安,由PKMN建筑事务所设计。乍一看,这似乎是一个除了几把＂座椅＂,连个像样的家具都没有的空间,身处其中,却能深切地感受到轻松惬意的氛围。

关键词：圣胡安卡萨阿尔建筑事务所雕刻艺术品动态效果几何造型陶壶工作区堂吉诃德

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Arsenite provides a selective signal that coordinates arsenate uptake and detoxification through the regulation of PHR1 stability in Arabidopsis

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Molecular Plant 2022年第11期15卷 1826-1826页

作者： Cristina Navarro Cristian Mateo-Elizalde Thotegowdanapalya CMohan Eduardo Sánchez-Bermejo Oscar Urrutia María Nieves Fernández-Muñiz JoséMGarcía-Mina Riansares Muñoz javier paz-Ares Gabriel Castrillo Antonio Leyva 不详

(Molecular Plant 14,1489-1507;September 6,2021)In the“Accession numbers”section in the originally published version of our manuscript,we mistakenly listed At5g44570 as the Arabidopsis Genome Initiative locus identif... 详细信息

关键词： Arabidopsis identifier stability

From liver to hormones:The endocrine consequences of cirrhosis

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World Journal of Gastroenterology 2024年第9期30卷 1073-1095页

作者： Juan Eduardo Quiroz-Aldave Elman Rolando Gamarra-Osorio María del Carmen Durand-Vásquez Luciana del Pilar Rafael-Robles Jhean Gabriel Gonzáles-Yovera María Alejandra Quispe-Flores Luis Alberto Concepción-Urteaga Alejandro Román-González José paz-Ibarra Marcio José Concepción-Zavaleta Non-communicable Diseases Endocrinology Research LineHospital de Apoyo ChepénChepén 13871Peru Department of Endocrinology Hospital Víctor Lazarte EchegarayTrujillo 13006Peru Department of Endocrinology Clínica Javier PradoLima 15046Peru Department of Gastroenterology Hospital Nacional Guillermo Almenara IrigoyénLima 15018Peru Department of Endocrinology Hospital de Emergencias GrauLima 15001Peru Internal Medicine Hospital Regional Docente de TrujilloTrujillo 13011Peru Department of Endocrinology Hospital Universitario de San Vicente FundaciónMedellin 050010Colombia Internal Medicine Universidad de AntioquiaMedellín 050010Colombia School of Medicine Universidad Nacional Mayor de San MarcosLima 15081Peru Department of Endocrinology Hospital Nacional Edgardo Rebagliati MartinsLima 15072Peru Carrera de Medicina Humana Universidad Científica del SurLima 15067Peru

Hepatocrinology explores the intricate relationship between liver function and the endocrine *** liver diseases such as liver cirrhosis can cause endocrine disorders due to toxin accumulation and protein synthesis *** its importance,assessing endocrine issues in cirrhotic patients is frequently *** article provides a comprehensive review of the epidemiology,pathophysiology,diagnosis,and treatment of endocrine disturbances in liver *** review was conducted using the PubMed/Medline,EMBASE,and Scielo databases,encompassing 172 *** cirrhosis is associated with endocrine disturbances,including diabetes,hypoglycemia,sarcopenia,thyroid dysfunction,hypogonadotropic hypogonadism,bone disease,adrenal insufficiency,growth hormone dysfunction,and secondary *** optimal tools for diagnosing diabetes and detecting hypoglycemia are the oral glucose tolerance test and continuous glucose monitoring system,*** can be assessed through imaging and functional tests,while other endocrine disorders are evaluated using hormonal assays and imaging *** options include metformin,glucagon-like peptide-1 analogs,sodium-glucose co-transporter-2 inhibitors,and insulin,which are effective and safe for diabetes *** standards are followed for managing hypoglycemia,and hormone replacement therapy is often necessary for other endocrine *** transplantation can address some of these problems.

关键词： Diabetes mellitus Hypoglycemia Thyroid diseases Hypogonadism Metabolic bone diseases Liver cirrhosis