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Update in lean metabolic dysfunction-associated steatotic liver disease

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World Journal of Hepatology 2024年第3期16卷 452-464页

作者： Karina Sato-Espinoza Perapa Chotiprasidhi Mariella R Huaman javier Díaz-Ferrer Division of Gastroenterology and Hepatology Department of MedicineMayo ClinicRochesterMN 55902United States Obesity and Metabolic Center for Obesity and Metabolic HealthLima 02002LimaPeru Hepatology Service Department of Digestive DiseasesHospital Nacional Edgardo Rebagliati MartinsLima 02002LimaPeru Medicine Faculty Universidad San Martin de PorresLima 02002LimaPeru Gastroenterology Service Clinica InternacionalLima 02002LimaPeru

BACKGROUND A new nomenclature consensus has emerged for liver diseases that were previously known as non-alcoholic fatty liver disease(NAFLD)and metabolic dysfunction-associated fatty liver disease(MAFLD).They are now defined as metabolic dysfunction-associated steatotic liver disease(MASLD),which includes cardiometabolic criteria in *** condition,extensively studied in obese or overweight patients,constitutes around 30%of the population,with a steady increase *** patients account for approximately 10%-15%of the MASLD ***,the pathogenesis is complex and is not well *** To systematically review the literature on the diagnosis,pathogenesis,characteristics,and prognosis in lean MASLD patients and provide an interpretation of these new *** We conducted a comprehensive database search on PubMed and Google Scholar between January 2012 and September 2023,specifically focusing on lean NAFLD,MAFLD,or MASLD *** include original articles with patients aged 18 years or older,with a lean body mass index categorized according to the World Health Organization criteria,using a cutoff of 25 kg/m2 for the general population and 23 kg/m2 for the Asian *** We include 85 studies in our *** findings revealed that,for lean NAFLD patients,the prevalence rate varied widely,ranging from 3.8%to 34.1%.The precise pathogenesis mechanism remained elusive,with associations found in genetic variants,epigenetic modifications,and adaptative metabolic *** risk factors included metabolic syndrome,hypertension,and type 2 diabetes mellitus,but their prevalence varied based on the comparison group involving lean *** non-invasive tools,Fibrosis-4 index outperformed the NAFLD fibrosis score in lean *** modifications aided in reducing hepatic steatosis and improving cardiometabolic profiles,with some medications showing efficacy to a lesser ***,lean NAFLD patients ex

关键词： Lean Non-obese Non-alcoholic fatty liver disease Metabolic dysfunction-associated fatty liver disease Metabolic dysfunction-associated steatotic liver disease Guidelines Diagnosis Management Pathogenesis Treatment

Feeding Calcium Salts of Linseed Oil on Metabolic Status and Reproductive Traits in Grazing Dairy Cows

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Open Journal of Animal Sciences 2024年第3期14卷 219-233页

作者： Jesica Daniela Iorio Yaliska Moreno González Maria Florencia Olmeda Dino Curletto Daniel Edgardo Scandolo martin Guillermo Maciel Rafael Alejandro Palladino Mauricio javier Giuliodori Eloy Eduardo Salado School of Agriculture of the University of Buenos Aires (FAUBA) Buenos Aires Argentina Faculty of Agricultural Sciences National University of Lomas de Zamora (UNLZ) Lomas de Zamora Argentina Rafaela Agricultural Experiment Station National Institute of Agricultural Technology (INTA) Rafaela Argentina Faculty of Veterinary Science La Plata National University (FCV) La Plata Argentina

This experiment aimed to evaluate the effect of calcium salts of linseed oil (rich in alpha-linolenic acid (ALA, C18:3n-3) on metabolic and reproductive traits in high-producing dairy cows under grazing. Thirty-six Holstein dairy cows were randomly assigned, in a complete block design, to receive ALA supplementation (0.85 kg∙day−1 of calcium salts of linseed oil) or to remain as untreated control (CON). The concentrate was formulated to offer the same amount of energy across treatments (CON cows received an extra kg of corn to compensate for the higher energy density of ALA treatment). A PMR + Alfalfa pasture was offered to all cows at the same time. A fixed time artiﬁcial insemination (FTAI) at 80 DIM, preceded by a Presynch plus Ovsynch protocol was implemented for the first service and later, on return to estrus, heat detection and artiﬁcial insemination (AI) were performed. Pregnancy diagnosis was checked at 30, 42, 60, and 90 d after AI. Blood and milk samples were taken biweekly. Treatment affected plasma cholesterol concentration (160.36 vs. 186.70 mg∙dl−1, p = 0.03, for ALA and CON, respectively) and on size of corpus luteum (CL, 17.6 vs. 13.7 mm, p = 0.02, for ALA and CON, respectively). Supplementation tended (p = 0.136) to increase conception rate by 200 DIM (81.69% vs. 55.43% in ALA and CON cows, respectively). However, treatment had no effect (p > 0.05) on body weight (BW), body condition score (BCS), and circulating levels of beta-hydroxybutyrate (BHBA), glucose, insulin, growth hormone (GH) and insulin-like growth factor (IGF-I). Our results suggest that supplementation with calcium salts of linseed oil could enhance ovarian function without affecting energy metabolism in early lactation dairy cows.

关键词： α-Linolenic Acid Supplementation Reproduction Grazing Dairy Cows

欧洲儿科胃肠病学、肝病学和营养协会儿童及青少年炎症性肠病诊断的改良波尔图标准(2014年版)

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中华儿科杂志 2016年第10期54卷 728-732页

作者： Arie Levine Sibylle Koletzko Dan Turner Johanna C.Escher Salvatore Cucchiara Lissy de Ridder Kaija-Leena Kolho Gabor Veres Richard K.Russell Anders Paerregaard Stephan Buderus Mary-Louise C.Greer Jorge A.Dias Gigi Veereman-Wauters Paolo Lionetti Malgorzata Sladek javier martin de carpi Annamaria Staiano Frank M.Ruemmele David C.Wilson 罗优优陈洁 Pediatric Gastroenterology and Nutrition Unit Wolfson Medical CenterSackler School of MedicineTel-Aviv University the Dr von Hauner Children's Hospital Ludwig Maximilians University the Pediatric Gastroenterology Unit Shaare Zedek Medical CenterThe Hebrew University of Jerusalem the Pediatric Gastroenterology Department of PediatricsErasmus MC-Sophia Children's Hospital 5. the Pediatric Gastroenterology and Liver UnitSapienza University of Rome 6. the Children's HospitalUniversity of Helsinki 7. the Semmelweis University 8. the Department of Paediatric Gastroenterology and NutritionYorkhill Children's Hospital 9. the Department of PaediatricsHvidovre University Hospital 10. the St.Marien-HospitalDepartment of Pediatrics 11. the Department of Diagnostic ImagingThe Hospital for Sick Childrenthe Department of Medical ImagingUniversity of Toronto 12. the Hospital S.Joao 13. the-Pediatric Gastroenterology and Nutrition 14. the Departement NeurofarbaUniversity of FlorenceMeyer Children Hospital 15. the Department of PediatricsGastroenterology and NutritionJagiellonian University Medical College 16. the Department of Pediatric GastroenterologyHepatology and NutritionHospital Sant Joan de De'u 17. the Department of Translational Medical SciencesSection of PediatricsUniversit

炎症性肠病(IBD)包括克罗恩病(CD)、溃疡性结肠炎(UC)和未分型IBD(IBDU)。IBD的确切诊断需综合病史、体检、实验室检查、内镜以及影像学的检查,并严格排除肠道感染、过敏性疾病或原发性免疫缺陷病(PID)。近年对儿童期起病的IBD(PIBD)的... 详细信息

炎症性肠病(IBD)包括克罗恩病(CD)、溃疡性结肠炎(UC)和未分型IBD(IBDU)。IBD的确切诊断需综合病史、体检、实验室检查、内镜以及影像学的检查,并严格排除肠道感染、过敏性疾病或原发性免疫缺陷病(PID)。近年对儿童期起病的IBD(PIBD)的研究高度提示3种PIBD的亚型均存在不典型的表型。本标准对2005年波尔图标准进行改良,利用循证方法,整合最新证据,包括诊断方法、以巴黎分型为基础的PIBD亚型的定义以及诊断误区,为新一代的PIBD提供优质的个体化管理以及可靠的诊断、评估和预后。

关键词：体检实验室检查内镜

Auricular embryonal rhabdomyosarcoma

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World Journal of Pediatrics 2022年第5期18卷 358-360页

作者： javier Arredondo Montero Monica Bronte Anaut Sara Hernandez-martin Juan Carlos Lopez-Gutierrez Pediatric Surgery department Complejo Hospitalario de NavarraCalle Irunlarrea 331008 PamplonaNavarraSpain Pathology department Complejo Hospitalario de NavarraPamplonaSpain Pediatric Surgery department Hospital Universitario La PazMadridSpain

A 13-month-old girl presented with a red-violaceous tumor of 13 mm in diameter on the inner side of the root of the right helix,with increased temperature and cystic consistency(Fig.1).No pulse was palpable in the *** ultrasonography was performed,showing a 1.6 cm rounded lesion with well-defined margins,hypoechogenic and homogeneous,compatible with *** treatment with oral propranolol was started without improve-ment.

关键词： sarcoma ultrasonography showing

Diagnostic performance of serum interleukin-6 in pediatric acute appendicitis:a systematic review

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World Journal of Pediatrics 2022年第2期18卷 91-99页

作者： javier Arredondo Montero Carlos Bardaji Pascual Monica Bronte Anaut Natalia Lopez-Andres Giuseppa Antona Nerea martin-Calvo Pediatric Surgery department Complejo Hospitalario de NavarraCalle Irunlarrea 331008 PamplonaNavarraSpain Pathology department Complejo Hospitalario de NavarraPamplonaSpain Cardiovascular Translational Research Navarrabiomed(Miguel Servet Foundation)Complejo Hospitalario de Navarra(CHN)Universidad Publica de Navarra(UPNA)IdiSNAPamplonaSpain department of Preventive Medicine and Public Health Instituto de Investigacion Sanitaria de Navarra(IdiSNA).University of Navarra.PamplonaSpain CIBER Fisiopatologia de la Obesidad y Nutricion(CIBERobn) Health Institute CarlosⅢMadridSpain

Background despite the radiological and analytical advances of the last decades,there is still a significant rate of diagnostic error in pediatric acute *** recent years,multiple biomarkers have emerged as potential diagnostic *** study aimed to examine the diagnostic performance of serum interleukin-6 in pediatric acute *** We conducted a systematic review of the literature that involved an extensive search in the main databases of medical bibliography(Medline,PubMed,Web of Science and SciELO).Two independent reviewers selected the relevant articles based on the previously defined inclusion and exclusion *** quality of the selected article was rated using the QUADAS2 *** extraction was performed by two independent *** The research in the medical bibliography databases resulted in 68 *** removed 26 *** the remaining 42 articles,we excluded 33 following the inclusion and exclusion *** the final 9 studies included in this review,8 provided measured serum interleukin-6 values,and all of them reported significant differences between groups,but inconsistent results regarding sensitivity and *** The diagnostic performance of interleukine-6 alone for the diagnosis of acute appendicitis in children is *** sensitivity and specificity of interleukine-6 for the diagnosis of non-complicated acute appendicitis in the pediatric population are moderate but increased in complicated *** seems to be a direct relationship between serum level of interleukin-6 and the hours of evolution of abdominal pain in children with acute *** increasingly widespread use of non-operative management of acute appendicitis warrants further exploration of the classificatory potential of this marker between complicated and uncomplicated *** consider that this may be an avenue of research to explore in the future.

关键词： Acute appendicitis Children Interleukin-6 Pediatric Sensitivity Specificity Systematic review

Phase Ⅱ trial of CDK4/6 inhibitor palbociclib in advanced sarcoma based on mRNA expression of CDK4/CDKN2A

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Signal Transduction and Targeted Therapy 2023年第11期8卷 5518-5527页

作者： javier martin-Broto Jeronimo martinez-Garcia David SMoura Andres Redondo Antonio Gutierrez Antonio Lopez-Pousa javier martinez-Trufero Isabel Sevilla Roberto Diaz-Beveridge Maria Pilar Solis-Hernandez Amancio Carnero Marco Perez David Marcilla Jesus Garcia-Foncillas Pablo Romero javier Fernandez-Jara Daniel Lopez-Lopez Ivan Arribas Nadia Hindi Health Research Institute-Fundación Jiménez Díaz University Hospital Universidad Autónoma de Madrid(IIS-FJDUAM)28040MadridSpain Medical Oncology department Fundación Jimenez Diaz University Hospital28040MadridSpain General de Villalba University Hospital 28400MadridSpain Medical Oncology department University Hospital Virgen de la Arrixaca30120MurciaSpain department of Medical Oncology Hospital Universitario La Paz-IdiPAZP.Castellana26128046MadridSpain Hematology department University Hospital Son Espases07120MallorcaSpain Medical Oncology department Sant Pau Hospital08025BarcelonaSpain Medical Oncology department University Hospital Miguel Servet50009ZaragozaSpain Investigación Clínica y Traslacional en Cáncer/Instituto de Investigaciones Biomédicas de Malaga(IBIMA)/Hospitales Universitarios Regional y Virgen de la Victoria de Malaga MalagaSpain Medical Oncology department Hospital Universitari i Politècnic La Fe46026ValenciaSpain Medical Oncology department Central University Hospital of Asturias33011OviedoSpain Instituto de Biomedicina de Sevilla(IBiS HUVRCSICUS)41013SevillaSpain Pathology department Virgen del Rocio University Hospital41013SevillaSpain Radiology department Fundación Jimenez Diaz University Hospital28040MadridSpain Computational Medicine Platform Fundación progreso y salud(FPS)Hospital Virgen del Rocío41013SevilleSpain Bioinformatics in Rare Diseases(BiER).Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER) FPSHospital Virgen del RocioSevillaSpain Universitat de València-ERI-CES 46010ValenciaSpain

Cyclin-dependent kinases 4 and 6(CDK4/6)inhibitors demonstrated activity in terms of progression-free survival(PFS)in advanced dedifferentiated liposarcoma(DD-LPS),a sarcoma with CDK4 ***4 overexpression is by far more common than amplification in sarcomas and it might be a rational target for CDK *** investigators of this study found that CDK4 overexpression,while not of CDKN2A,was the most consistent predictive factor for palbociclib efficacy in *** adult-type soft-tissue sarcoma,excluding DD-LPS,or bone sarcoma patients,progressing after at least one systemic line,whose tumors overexpressed CDK4,but not CDKN2A at baseline biopsy,were accrued in this single-arm phase II trial(EudraCT number:2016-004039-19).With the main endpoint of a 6-month PFS rate,40%was considered promising in this *** was administered orally at 125 mg/day for 21 days in 28-day cycles.A total of 214 patients with 236 CDK4/CDKN2A determinations were assessed for prescreening,archival material(141),and screening,baseline biopsy(95).There were 28(29%)with favorable mRNA profiles from 95 screened patients at *** 23 enrolled patients,21 evaluable,the 6-month PFS rate was 29%(95%CI 9–48),and there were 6 patients out of 21 with a PFS longer than 6 *** median PFS and overall survival were 4.2(95%CI 3.6–4.8)and 12(95%CI 8.7–15.4)months,*** research showed a significant correlation between CDK4 mRNA and protein *** was active in a variety of sarcoma subtypes,selected by CDK4/CDKN2A,and deserves further investigation in the sarcoma context.

关键词： CDKN2A sarcoma CDK4

Kinetic behaviour of commercial catalysts for methane reforming in ethanol steam reforming process

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Journal of Energy Chemistry 2014年第5期23卷 639-644页

作者： Jorge Vicente javier Erea martin Olazar Pedro L.Benito javier Bilbao Ana G.Gayubo departamento de Ingeniería Química Universidad del País Vasco UPV/EHU Apartado 644 48080 Bilbao Spain departamento de Ingeniería Minera y Metalúrgica y Ciencia de los Materiales Universidad del País Vasco UPV/EHUNieves Cano 12 01006 Vitoria-Gasteiz Spain

Ethanol steam reforming has been studied in a fluidized bed （in order to ensure bed isothermicity） on commercial catalysts for methane reforming. The results allow analyzing the effect of temperature （in 300-700℃ range）, and both metal and support nature on the reaction indices （ethanol conversion, yields and selectivities to H2 and byproducts （CO2, CO, CH4 and C2H4O））. Special attention has been paid to catalysts＇ stability by comparing the evolution of the reaction indices with time on stream at 500°C （minimum CO formation） and 700℃ （minimum deactivation by coke deposition）. Although they provide a slightly lower H2 yield, the results evidence a good behaviour of Ni based catalysts, indicating that they are an interesting alternative of more expensive Rh based ones.

关键词： ethanol steam reforming hydrogen commercial catalyst selectivity deactivation

Elutriation, attrition and segregation in a conical spouted bed with a fountain confiner

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Particuology 2020年第4期18卷 35-44页

作者： Aitor Pablos Roberto Aguado Jorge Vicente Mikel Tellabide javier Bilbao martin Olazar department of Chemical Engineering University of the Basque Country UPV/EHUP.O.Box 644E48080 BilbaoSpain Novattia desarrollos Ltd.Scientific and Technologic Park of BizkaiaAstondo BideaBuilding 612E48160 DerioSpain

This study examined elutriation,attrition,and segregation in a conical spouted bed with a fountain confiner and incorporating an open sided draft *** silica sand with a wide particle size distribution was employed as a model material,operating in both the batch and continuous *** use of a fountain confiner is crucial when operating with fine particles,because otherwise the bed rapidly exhibits significant *** extent of attrition was quantified using a tracing technique based on differently-coloured sand fractions as well as monitoring size distributions by *** breakage was found to be the primary attrition mechanism,and the fountain confiner was determined to limit the elutriation of fine particles resulting from ***,only a small fraction of the finest particles were entrained from the *** incorporation of a confiner increased operational stability while reducing segregation,especially in the upper half of the bed where the majority of segregation typically ***,the bed was perfectly mixed apart from very minimal segregation close to the wall and at the bottom of the *** results provide a basis for the design and operation of larger scale equipment for the continuous drying of materials.

关键词： Spouted bed Fine sand Elutriation Attrition Segregation Fountain confinement device

不同固定床位置生物质热解挥发物蒸汽催化重整反应中焦炭的形成和演化

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Chinese Journal of Catalysis 2023年第5期48卷 101-116页

作者： Enara Fernandez Laura Santamaria Irati García Maider Amutio Maite Artetxe Gartzen Lopez javier Bilbao martin Olazar 巴斯克大学化工系西班牙巴斯克科学基金会西班牙

对生物质热解挥发物蒸汽重整反应过程中催化剂的失活过程和主要机理进行了研究.在圆锥形喷动床反应器中于500℃进行生物质热解,随后在固定床反应器中于600℃进行重整反应;同时在不同轴向位置分析了催化剂位置对重整反应器的影响.采用N_... 详细信息

对生物质热解挥发物蒸汽重整反应过程中催化剂的失活过程和主要机理进行了研究.在圆锥形喷动床反应器中于500℃进行生物质热解,随后在固定床反应器中于600℃进行重整反应;同时在不同轴向位置分析了催化剂位置对重整反应器的影响.采用N_(2)吸附-脱附、X射线衍射、扫描电镜、透射电镜、程序升温氧化、拉曼光谱和傅里叶变换红外光谱对失活样品进行表征.结果表明,焦炭沉积是初始催化剂活性衰减的主要原因,且没有观察到镍位点的烧结或氧化.随着反应的进行,沿着重整催化床观察到失活情况,焦炭沉积于催化剂内,其性质和组成取决于到达床中每个轴向位置的挥发物组成.在催化床的入口部分,焦炭沉积在Ni位点上,并且具有一定的含氧量.在更深的轴向床位置,催化剂与挥发性物质接触,该挥发性物质的组成已经明显改变,从而形成具有石墨化程度更高的焦炭,并且形成更多的缩合聚芳烃化合物.此外,沉积在所有失活样品上的焦炭没有呈现任何特定的形态,这也表明,无论所处的催化床位置和反应时间,焦炭均呈现无定形结构.

关键词：生物质热解蒸汽重整失活积碳氢气生物油