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The lncRNA APOLO interacts with the transcription factor WRKY42 to trigger root hair cell expansion in response to cold

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molecular Plant 2021年第6期14卷 937-948页

作者： michael moison Javier m.rtinez Pacheco Leandro Lucero Camille Fonouni-Farde Johan Rodriguez-melo Natanael mansilla Aurelie Christ Jeremie Bazin moussa Benhamed Fernando Ibanez martin Crespi Jose m.Estevez Federico Ariel Instituto de Agrobiotecnología del Litoral Universidad Nacional del LitoralCONICETFBCB/FHUCCentro Científico Tecnológico CONICET Santa FeColectora Ruta Nacional No 168 km.0Paraje El PozoSanta Fe 3000Argentina Fundación Instituto Leloir and IIBBA-CONICET Av.Patricias Argentinas 435Buenos Aires CP C1405BWEArgentina Instituto de Investigaciones Agrobiotecnológicas CONICETUniversidad Nacional de Río CuartoRío Cuarto 5800Argentina Institute of Plant Sciences Paris-Saclay(IPS2) CNRSINRAUniversity Paris-Saclay and University of Paris Bâtiment 63091192 Gif sur YvetteFrance Centro de Biotecnología Vegetal(CBV) Facultad de Ciencias de la Vida(FCsV)Universidad Andres BelloSantiagoChile and Millennium Institute for Integrative Biology(iBio)SantiagoChile

Plant long noncoding RNAs(lncRNAs)have emerged as important regulators of chromatin dynamics,impacting on transcriptional programs leading to different developmental outputs.The lncRNA AUXIN-REGULATED PROmOTER LOOP(APOLO)directly recognizes multiple independent loci across the Arabidopsis genome and modulates their three-dimensional chromatin conformation,leading to transcriptional shifts.Here,we show that APOLO recognizes the locus encoding the root hair(RH)master regulator ROOT HAIR DEFECTIVE 6(RHD6)and controls RHD6 transcriptional activity,leading to cold-enhanced RH elongation through the consequent activation of the transcription factor gene RHD6-like RSL4.Furthermore,we demonstrate that APOLO interacts with the transcription factor WRKY42 and modulates its binding to the RHD6 promoter.WRKY42 is required for the activation of RHD6 by low temperatures and WRKY42 deregulation impairs cold-induced RH expansion.Collectively,our results indicate that a novel ribonucleoprotein complex with APOLO and WRKY42 forms a regulatory hub to activate RHD6 by shaping its epigenetic environment and integrate signals governing RH growth and development.

关键词： root hairs long noncoding RNAs APOLO RHD6 WRKY42 cold temperature

Renormings concerning exposed points and non-smoothness

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Science China mathematics 2009年第9期52卷 1844-1848页

作者： GARCíA-pacheco Francisco javier Department of mathematics Texas A&M UniversityCollege Station

Intuitively, non-smooth points might look like exposed points. However, in this paper we show that real Banach spaces having dimension greater than or equal to three can be equivalently renormed to obtain non-smooth p... 详细信息

关键词： exposed point smooth point rotund point

The RALF1-FERONIA Complex Phosphorylates eIF4E1 to Promote Protein Synthesis and Polar Root Hair Growth

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molecular Plant 2020年第5期13卷 698-716页

作者： Sirui Zhu Jose manuel Estevez Hongdong Liao Yonghua Zhu Tao Yang Chiyu Li Yichuan Wang Lan Li Xuanming Liu Javier m.rtinez Pacheco Hongwei Guo Feng Yu State Key Laboratory of Chemo/Biosensing and Chemometrics College of Biologyand Hunan Key Laboratory of Plant Functional Genomics and Developmental RegulationHunan UniversityChangsha 410082P.R.China Fundacion Instituto Leloir Buenos Aires C1405BWEArgentina and IIBBA-CONICETBuenos Aires C1405BWEArgentina Centro de Biotecnologfa Vegetal Facultad de Ciencias de la VidaUniversidad Andres BelloSantiago RM 8370146Chile National Engineering Laboratory for Rice and Byproduct Deep Processing Central South University of Forestry and TechnologyChangsha 410004P.R.China Institute of Plant and Food Science Department of BiologySouthern University of Science and TechnologyShenzhenGuangdong 518055P.R.China State Key Laboratory of Hybrid Rice Hunan Hybrid Rice Research CenterChangsha 410125P.R.China

The molecular links between extracellular signals and the regulation of localized protein synthesis in plant cells are poorly understood.Here,we show that in Arabidopsis thaliana,the extracellular peptide RALF1 and its receptor,the FERONIA receptor kinase,promote root hair(RH)tip growth by modulating protein synthesis.We found that RALF1 promotes FERONIA-mediated phosphorylation of elF4E1,a eukaryotic translation initiation factor that plays a crucial role in the control of mRNA translation rate.Phosphorylated elF4E1 increases mRNA affinity and modulates mRNA translation and,thus,protein synthesis.The mRNAs targeted by the RALF1-FERONIA-elF4E1 module include ROP2 and RSL4,which are important regulators of RH cell polarity and growth.RALF1 and FERONIA are expressed in a polar manner in RHs,which facilitate elF4E1 polar丨ocalization and thus may control local f?OP2 translation.moreover,we demonstrated that high-level accumulation of RSL4 exerts negative-feedback regulation of RALF1 expression by directly binding the RALF1 gene promoter,determining the final RH size.Our study reveals that the link between RALF1-FERONIA signaling and protein synthesis constitutes a novel component regulating cell expansion in these polar growing cells.

关键词： elF4E1 FER polar cell growth RALF1 root hairs RSL4

Systemic Inflammation Response Index and weight loss as prognostic factors in metastatic pancreatic cancer: A concept study from the PANTHEIA-SEOm trial

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 386-397页

作者： Vilma pacheco-Barcia Sara Custodio-Cabello Fatima Carrasco-Valero magda Palka-Kotlowska Axel mariño-mendez Alberto Carmona-Bayonas javier Gallego A J muñoz martín Paula Jimenez-Fonseca Luis Cabezon-Gutierrez Department of medical Oncology Hospital Universitario de TorrejonMadrid 28850Spain Department of Internal medicine Hospital Universitario de TorrejonMadrid 28850Spain Department of medical Oncology Hospital Universitario Central de AsturiasOviedo 33011Spain Department of medical Oncology Hospital Universitario Morales MeseguerUniversity of MurciaMurcia 30001Spain Department of medical Oncology Hospital General Universitario de ElcheElche 03202Spain Department of medical Oncology Hospital General Universitario Gregorio MarañónUniversidad Complutense MadridMadrid 28007Spain Universidad Francisco de Vitoria Madrid 28223Spain

BACKGROUND The prognostic value of the Systemic Inflammation Response Index(SIRI)in advanced pancreatic cancer is recognized,but its correlation with patients´nutritional status and outcomes remains unexplored.AIm To study the prognostic significance of SIRI and weight loss in metastatic pancreatic cancer.mETHODS The PANTHEIA-Spanish Society of medical Oncology(SEOm)study is a multicentric(16 Spanish hospitals),observational,longitudinal,non-interventional initiative,promoted by the SEOm Real World-Evidence work group.This pilot study sought to analyze the association between weight loss and inflammatory status as defined by SIRI.The cohort stems from a proof-of-concept pilot study conducted at one of the coordinating centers.Patients with pathologically confirmed metastatic pancreatic adenocarcinoma,treated from January 2020 to January 2023,were included.The index was calculated using the product of neutrophil and monocyte counts,divided by lymphocyte counts,obtained within 15 days before initiation chemotherapy.This study evaluated associations between overall survival(OS),SIRI and weight loss.RESULTS A total of 50 patients were included.66%of these patients were male and the median age was 66 years.metastasis sites:36%liver,12%peritoneal carcinomatosis,10%lung,and 42%multiple locations.Regarding the first line palliative chemotherapy treatments:50%received gemcitabine plus nab-paclitaxel;28%,modified fluorouracil,leucovorin,irinotecan and oxaliplatin,and 16%were administered gemcitabine.42%had a weight loss>5%in the three months(mo)preceding diagnosis.21 patients with a SIRI≥2.3×10^(3)/L exhibited a trend towards a lower median OS compared to those with a SIRImo;Pmong 21 patients with>5%weight loss before diagnosis,the median OS was 6 mo,in contrast to 19 mo for those who did not experience such weight loss(P=0.003).Patients with a weight loss>5%showed higher SIRI levels.This difference was statistically significant(P<0.000).For patients with a SIRI<2.3×10^(3)/L,those who did not

关键词： Pancreatic cancer Nutrition Prognostic factor Inflammation Advanced cancer Systemic inflammatory response index Weight loss

Turbo-taxonomy to assemble a megadiverse lichen genus:seventy new species of Cora(Basidiomycota:Agaricales:Hygrophoraceae),honouring David Leslie Hawksworth’s seventieth birthday

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Fungal Diversity 2017年第3期84卷 139-207页

作者： Robert Lücking manuela Dal Forno Bibiana moncada Luis Fernando Coca Leidy Yasmín Vargas-mendoza André Aptroot Laura Juliana Arias Betty Besal Frank Bungartz Diego mauricio Cabrera-Amaya marcela E.S.Cáceres José Luis Chaves Sionara Eliasaro martha Cecilia Gutiérrez Jesús E.Hernández marin maría de los Ángeles Herrera-Campos maría E.Holgado-Rojas Harald Jonitz martin Kukwa Fabiane Lucheta Santiago madriñán marcelo Pinto marcelli Suzana maria de Azevedo martins Joel A.mercado-Díaz Jorge Alberto molina Eduardo A.morales Peter R.Nelson Freddy Nugra Francisco Ortega Telma Paredes Ayda Lucía Patiño Rouchi Nadine Peláez-Pulido Rosa Emilia Pérez Pérez Gary B.Perlmutter Eimy Rivas-Plata javier Robayo Camilo Rodríguez Diego Fernando Simijaca Edier Soto-medina Adriano Afonso Spielmann Alejandra Suárez-Corredor Jean-marc Torres Carlos Alberto Vargas Alba Yánez-Ayabaca Gothamie Weerakoon Karina Wilk marcela Celis pacheco mauricio Diazgranados Grischa Brokamp Thomas Borsch Patrick m.Gillevet masoumeh Sikaroodi James D.Lawrey Botanical Garden and Botanical museum Berlin KöniginLuise-Straße 6-814195 BerlinGermany Science Education The Field Museum1400 South Lake ShoreChicagoIL 60605USA Department of Botany Smithsonian InstitutionNational Museum of Natural History10th St Constitution Ave NWWashingtonDC 20560USA Department of Environmental Science and Policy George Mason UniversityFairfaxVA 22030-4444USA Licenciatura en Biologı´a Universidad Distrital Francisco Jose´de CaldasCra.4 No.26D-54Torre de LaboratoriosHerbarioBogota´D.C.Colombia Herbario Universidad de Caldas(FAUC) Edificio BicentenarioCalle 65No.26-10ManizalesA.A.275CaldasColombia ABL Herbarium G.v.d.Veenstraat 1073762 XK SoestThe Netherlands Biologı´a Universidad del Quindı´oCarrera 15 Calle 12 NorteArmeniaQuindı´oColombia 120 Chavis Avenue LexingtonVA 24450USA Charles Darwin Foundation Puerto AyoraSanta Cruz IslandGala´pagosEcuador Schedestraße 8 53113 BonnGermany Jardı´n Bota´nico de Bogota´Jose´Celestino mutis Avenida Calle 63 No.68-95Bogota´D.C.Colombia Departamento de Biocieˆncias Universidade Federal de SergipeAvenida Vereador Olı´mpio Grandes/n.ItabaianaCEP:49.500-000 SergipeBrazil Laboratorio de Hongos Instituto Nacional de Biodiversidad(INBio)Apdo.22-3100Santo Domingo de HerediaCosta Rica Departamento de Botaˆnica Universidade Federal do Parana´Campus Polite´cnicoSetor de Cieˆncias Biolo´gicasAv.Cel.Francisco H.dos Santoss/nJardim das Ame´ricas81531-980 CuritibaPRBrazil Ingenierı´a Ambiental Universidad Distrital Francisco Jose´de CaldasCarrera 5 Este No.15-82Av.CircumvalarBogota´D.C.Colombia Instituto Experimental Jardı´n Bota´nico Dr.Tobı´as Lasser Centro de Investigacio´n y DesarrolloUniversidad Central de VenezuelaAve.Salvador AllendeJardı´n Bota´nico de CaracasApartado#2156Caracas 1010-AVenezuela Departamento de Bota´nica Instituto de Biologı´aUniversidad Nacional Auto´noma de Me´xicoApartado Postal 70-36704510 Ciudad De Me´xicoMexico Facultad de Ciencias Escuela Profesional de Biologı´aUniv

Following a large-scale phylogenetic study of the lichenized genus Cora(Basidiomycota:Agaricales:Hygrophoraceae),we formally describe 70 new species,honouring the seventieth birthday of David Leslie Hawksworth,one of the preeminent figures in mycology and lichenology in the past 50 years.Based on an updated phylogeny using the ITS fungal barcoding locus,we now recognize 189 taxa in a genus that until recently was considered to represent a single species;including this contribution,92 of these are formally recognized,including five taxa based on historical names or collections that have not been sequenced.Species of Cora can be recognized by a combination of morphological(size,colour,lobe configuration,surface hairs,hymenophore size and shape),anatomical(thallus thickness,cortex structure,photobiont type,hyphal papillae),and ecogeographical features(substrate,habitat,distribution),and a keytable allowing the identification of all accepted taxa is provided.The new species are:Cora accipiter moncada,madrin˜a´n&Lücking spec.nov.,C.applanata moncada,Soto-medina&Lücking spec.nov.,C.arachnodavidea moncada,Dal Forno&Lücking spec.nov.,C.arborescens Dal Forno,Chaves&Lücking spec.nov.,C.arcabucana moncada,C.Rodrı´guez&Lücking spec.nov.,C.aturucoa Lücking,moncada&C.Vargas spec.nov.,C.auriculeslia moncada,Ya´nez-Ayabaca&Lücking spec.nov.,C.barbifera moncada,Patin˜o&Lücking spec.nov.,C.boleslia Lücking,E.morales&Dal Forno spec.nov.,C.caliginosa Holgado,Rivas Plata&Perlmutter spec.nov.,C.campestris Dal Forno,Eliasaro&Spielmann spec.nov.,C.canari Nugra,Dal Forno&Lücking spec.nov.,C.caraana Lücking,martins&Lucheta spec.nov.,C.casasolana moncada,R.-E.Pe´rez&Lücking spec.nov.,C.caucensis moncada,m.Gut.&Lücking spec.nov.,C.celestinoa moncada,CabreraAmaya&Lücking spec.nov.,C.comaltepeca moncada,R.-E.Pe´rez&Herrera-Camp.***.nov.,C.corani Lücking,E.morales&Dal Forno spec.nov.,C.corelleslia moncada,A.Sua´rez-Corredor&Lücking spec.nov.,C.crispoleslia moncada,J.molina&Lücking spec.nov.,C.cuzcoensis Holgado,Rivas Plata&Perlmutter spec.nov

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