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Generating native user interfaces for multiple devices by means of model transformation

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Frontiers of Information Technology & Electronic Engineering 2015年第12期16卷 995-1017页

作者： Ignacio MARIN Francisco ORTIN German PEDROSA javier RODRIGUEZ Department of Research and Development CTIC Foundation Department of Computer Science University of Oviedo

In the last years, the types of devices used to access information systems have notably increased using different operating systems, screen sizes, interaction mechanisms, and software features. This device fragmentation is an important issue to tackle when developing native mobile service front-end applications. To address this issue,we propose the generation of native user interfaces(UIs) by means of model transformations, following the modelbased user interface(MBUI) paradigm. The resulting MBUI framework, called LIZARD, generates applications for multiple target platforms. LIZARD allows the definition of applications at a high level of abstraction, and applies model transformations to generate the target native UI considering the specific features of target platforms. The generated applications follow the UI design guidelines and the architectural and design patterns specified by the corresponding operating system manufacturer. The objective is not to generate generic applications following the lowest-common-denominator approach, but to follow the particular guidelines specified for each target device. We present an example application modeled in LIZARD, generating different UIs for Windows Phone and two types of Android devices(smartphones and tablets).

关键词： Model-to-model transformation Native user interfaces Model-based user interfaces Model-driven engineering

Do Rules and Patterns Affect Design Maintainability?

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Journal of Computer Science & Technology 2009年第2期24卷 262-272页

作者： javier Garzás Félix García Mario Piattini Kybele Consulting Madrid Spain Department of Information Technologies and Systems-Escuela Superior de Informáica University of Castilla-La Mancha Alarcos Research Group-Institute of Information Technologies and Systems Department of Information Technologies and Systems-Escuela Superior de Informáica University of Castilla-La Mancha

At the present time, best rules and patterns have reached a zenith in popularity and diffusion, thanks to the software community＇s efforts to discover, classify and spread knowledge concerning all types of rules and patterns. Rules and patterns are useful elements, but many features remain to be studied if we wish to apply them in a rational manner. The improvement in quality that rules and patterns can inject into design is a key issue to be analyzed, so a complete body of empirical knowledge dealing with this is therefore necessary. This paper tackles the question of whether design rules and patterns can help to improve the extent to which designs are easy to understand and modify. An empirical study, composed of one experiment and a replica, was conducted with the aim of validating our conjecture. The results suggest that the use of rules and patterns affect the understandability and modifiability of the design, as the diagrams with rules and patterns are more difficult to understand than non-rule/pattern versions and more effort is required to carry out modifications to designs with rules and patterns.

关键词： design patterns and rules maintainability software quality object-oriented design

Ophiolite hosted chromitite formed by supra-subduction zone peridotite–plume interaction

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Geoscience Frontiers 2020年第6期11卷 2083-2102页

作者： Júlia Farré-de-Pablo Joaquín A.Proenza JoséMaría González-Jiménez Thomas Aiglsperger Antonio garcia-Casco javier Escuder-Viruete Vanessa Colás Francisco Longo Departament de Mineralogia Petrologia i Geologia AplicadaUniversitat de BarcelonaC/Martíi Franquess/n08028BarcelonaSpain Departamento de Mineraloga y Petrologa Universidad de GranadaFacultad de CienciasFuentenueva s/n18002GranadaSpain Department of Civil Engineering and Natural Resources LuleåUniversity of TechnologySE 97187LuleåSweden Instituto Andaluz de Ciencias de la Tierra(CSIC-UGR) Avda.de las Palmeras 4E-18100ArmillaGranadaSpain Instituto Geologico y Minero de Espana C/La Calera 1Tres Cantos28760MadridSpain Instituto de Geología Universidad Nacional Autonoma de MéxicoCiudad Universitaria04510Ciudad de MéxicoMexico Facultad de Ingeniería Universidad Catòlica de CibaoLa VegaDominican Republic

Chromitite bodies hosted in peridotites typical of suboceanic mantle(***)are found in the northern and central part of the Loma Caribe peridotite,in the Cordillera Central of the Dominican *** chromitites are massive pods of small size(less than a few meters across)and veins that intrude both dunite and ***,they are high-Cr chromitites[Cr#=Cr/(Cr+Al)atomic ratio=0.71-0.83]singularly enriched in TiO2(up to 1.25 wt.%),Fe2 O3(2.77-9.16 wt.%)as well as some trace elements(Ga,V,Co,Mn,and Zn)and PGE(up to 4548 ppb in whole-rock).This geochemical signature is unknown for chromitites hosted in oceanic upper mantle but akin to those chromites crystallized from mantle plume derived ***,the melt estimated to be in equilibrium with such chromite from the Loma Caribe chromitites is similar to basalts derived from different source regions of a heterogeneous Caribbean mantle *** mantle plume is responsible for the formation of the Caribbean Large Igneous Province(CLIP).Dolerite dykes with back-arc basin basalt(BABB)and enriched mid-ocean ridge basalt(E-MORB)affinities commonly intrude the Loma Caribe peridotite,and are interpreted as evidence of the impact that the Caribbean plume had in the off-axis magmatism of the back-arc basin,developed after the Caribbean island-arc extension in the Late *** propose a model in which chromitites were formed in the shallow portion of the back-arc mantle as a result of the metasomatic reaction between the supra-subduction zone(SSZ)peridotites and upwelling plume-related melts.

关键词： Chromitite Ophiolite Plume Mantle Back-arc basin Dominican Republic

Ketamine anesthesia reduces intestinal ischemia/reperfusion injury in rats

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World Journal of Gastroenterology 2008年第33期14卷 5192-5196页

作者： Carlos Rodrigo Cámara Francisco javier Guzmán Ernesto Alexis Barrera Andrés Jesús Cabello Armando garcia Nancy Esthela Fernández Eloy Caballero Jesus Ancer Department of Physiology Universidad Autonoma de Nuevo Leon School of MedicineMonterrey Nuevo Leon 64460 Mexico Department of Pathology Universidad Autonoma de Nuevo Leon School of MedicineMonterrey Nuevo Leon 64460 Mexico

AIM: To investigate the effects of ketamine anesthesia on the motility alterations and tissue injury caused by ischemia/reperfusion in rats. METHODS: Thirty male Wistar rats weighing 200-250 g were used. Ischemia was induced by ob-structing blood flow in 25% of the total small intesti-nal length (ileum) with a vascular clamp for 45 min, after which either 60 min or 24 h of reperfusion was allowed. Rats were either anesthetized with pento-barbital sodium (50 mg/kg) or ketamine (100 mg/kg). Control groups received sham surgery. After 60 min of reperfusion, the intestine was examined for mor-phological alterations, and after 24 h intestinal basic electrical rhythm (BER) frequency was calculated, and intestinal transit determined in all groups. RESULTS: The intestinal mucosa in rats that were anesthetized with ketamine showed moderate altera-tions such as epithelial lifting, while ulceration and hemorrhage was observed in rats that received pento-barbital sodium after 60 min of reperfusion. Quantita-tive analysis of structural damage using the Chiu scaleshowed significantly less injury in rats that received ketamine than in rats that did not (2.35 ± 1.14 vs 4.58 ± 0.50, P < 0.0001). The distance traveled by a mark-er, expressed as percentage of total intestinal length, in rats that received pentobarbital sodium was 20% ± 2% in comparison with 25.9% ± 1.64% in rats that re-ceived ketamine (P = 0.017). BER was not statistically different between groups. CONCLUSION: Our results show that ketamine anesthesia is associated with diminished intestinal injury and abolishes the intestinal transit delay induced by ischemia/reperfusion.

关键词： Ischemia/Reperfusion Ketamine N-methyl-D-aspartate Intestinal motility Tissue damage

Renormings concerning exposed points and non-smoothness

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Science China Mathematics 2009年第9期52卷 1844-1848页

作者： GARCíA-PACHECO Francisco javier Department of Mathematics Texas A&M UniversityCollege Station

Intuitively, non-smooth points might look like exposed points. However, in this paper we show that real Banach spaces having dimension greater than or equal to three can be equivalently renormed to obtain non-smooth p... 详细信息

关键词： exposed point smooth point rotund point Primary 46B20, 46B03 Secondary 46B07

Gold Nanozymes:From Concept to Biomedical Applications

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Nano-Micro Letters 2021年第1期13卷 138-173页

作者： javier Lou‑Franco Bhaskar Das Christopher Elliott Cuong Cao Institute for Global Food Security School of Biological SciencesQueen’s University of Belfast19 Chlorine GardensBelfast BT95DLUK Present Address:Department of Biotechnology and Medical Engineering National Institute of Technology RourkelaRourkelaIndia

In recent years,gold nanoparticles have demonstrated excellent enzyme-mimicking activities which resemble those of peroxidase,oxidase,catalase,superoxide dismutase or ***,merged with their ease of synthesis,tunability,biocompatibility and low cost,makes them excellent candidates when compared with biological enzymes for applications in biomedicine or biochemical ***,over 200 research papers have been systematically reviewed to present the recent progress on the fundamentals of gold nanozymes and their potential *** review reveals that the morphology and surface chemistry of the nanoparticles play an important role in their catalytic properties,as well as external parameters such as pH or ***,real applications often require specific biorecognition elements to be immobilized onto the nanozymes,leading to unexpected positive or negative effects on their ***,rational design of efficient nanozymes remains a challenge of paramount *** implementation paths have already been explored,including the application of peroxidase-like nanozymes for the development of clinical diagnostics or the regulation of oxidative stress within cells via their catalase and superoxide dismutase *** review also indicates that it is essential to understand how external parameters may boost or inhibit each of these activities,as more than one of them could ***,further toxicity studies are required to ensure the applicability of gold nanozymes in *** challenges and future prospects of gold nanozymes are discussed in this review,whose significance can be anticipated in a diverse range of fields beyond biomedicine,such as food safety,environmental analyses or the chemical industry.

关键词： Gold nanoparticles Catalysis Nanozymes Diagnosis Nanomedicine

New determinants of prognosis in bacterial infections in cirrhosis

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World Journal of Gastroenterology 2014年第23期20卷 7252-7259页

作者： Juan Acevedo javier Fernández Department of Gastroenterology and Hepatology Hospital of Calella08370 BarcelonaCatalunyaSpain Liver Unit Hospital ClínicUniversity of Barcelona08150 BarcelonaCatalunyaSpain Institut d’Investigacions Biomèdiques August-Pi-Sunyer (IDIBAPS) 08036 BarcelonaSpain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHED) 08150 BarcelonaSpain

Despite major advances in the knowledge and management of liver diseases achieved in recent decades,decompensation of cirrhosis still carries a high burden of morbidity and *** infections are one of the main causes of *** is very important for clinical management to be aware of the population with the highest risk of poor *** review deals with the new determinants of prognosis in patients with cirrhosis and bacterial infections reported *** of multiresistant bacteria has led to an increasing failure rate of the standard empirical antibiotic therapy recommended by international ***,it has been recently reported that endothelial dysfunction is associated with the degree of liver dysfunction and,in infected patients,with the degree of *** has also been reported that relative adrenal insufficiency is frequent in the non-critically ill cirrhotic population and it is associated with a higher risk of developing infection,severe sepsis,hepatorenal syndrome and *** advise a change in the standard empirical antibiotic therapy in patients with high risk for multiresistant infections and also to take into account endothelial and adrenal dysfunction in prognostic models in hospitalized patients with decompensated cirrhosis.

关键词： Bacterial infections Liver cirrhosis Drug resistance Bacterial Endothelial dysfunction Relative adrenal insufficiency

Anemia and digestive diseases: An update for the clinician

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World Journal of Gastroenterology 2009年第37期15卷 4615-4616页

作者： Fernando Gomollón javier P Gisbert Digestive Diseases Service Clinical University Hospital CIBEREHD IACS Avenida San Juan Bosco 15 Zaragoza 50009 Spain Digestive Diseases Service University Hospital "La Princesa" CIBEREHD C/ Diego León 62 Madrid 28006 Spain

Anemia and iron deficiency are so common in digestive diseases that often are underestimated and undertreated. Our goal is to review from classif ication to treatment of the diverse types of anemias in different digestive diseases to update our knowledge on diagnosis and treatment. With the goal of improving the prognosis and quality of life of digestive diseases patients, we will review current transfusion, intravenous iron, and erythropoietin roles in the treatment of anemia.

关键词： Anemia Iron deficiency Inflammatory bowel disease Crohn's disease Ulcerative colitis

Gone with the wind： Seasonal trends in foraging movement directions for a central-place forager

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Current Zoology 2014年第5期60卷 604-615页

作者： Jesus HERNANDEZ-PLIEGO Carlos RODRIGUEZ javier BUSTAMANTE Department of Wetland Ecology Estacion Biologica de Dofiana CSIC c/Amorico Vespucio s/n 41092 Seville Spain Department of Conservation Biology Estacion Biologica de Dofiana C SIC c/Amorico Vespucio s/n 41092 Seville Spain

Lesser kestrels Falco naumanni are migratory central-place foragers that breed in dynamic arable landscapes. After arriving from migration, kestrels have no knowledge of the distribution of crops, and consequently prey, around their colony. The energy demand of pairs increases as breeding season progresses, but at the same time prey abundance, and their knowledge on prey distribution, also increases. Wind can have a strong influence on flight cost and kestrels should try to reduce energy expendi- ture when possible. When prey abundance is low, kestrels have little knowledge of prey distribution, and pairs have no chicks, they could reduce foraging flight cost by leaving the colony with tailwinds. When prey is abundant, knowledge on prey distribu- tion has increased, and chick demand is high, kestrels should fly to the most favorable foraging patches. We analyzed foraging trips directions in a lesser kestrel colony along the breeding season and in relation to wind speed and direction. We recorded 664 foraging trips from 19 individuals using GPS-dataloggers. We found that outward flights direction changed from uniform to a concentrated distribution along the season, as prey abundance and individual experience increased. We also found a temporal trend in the angular difference between outward flights and wind directions, with low values early in the season and then increa- sing as expected, but again low values at the end, contrary to expectation. Results suggest changes in kestrels foraging strategy along the season in relation to wind. Kestrels depart more with tailwinds in exploratory flights early in the season, while there is a spurious coincidence in direction to preferred foraging patches and dominant wind direction at the end [Current Zoology 60 （5）： 604-615, 2014].

关键词： Falco naumanni Movement ecology Foraging behavior Wind effect GPS-dataloggers