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Mental health in the virtual world:Challenges and opportunities in the metaverse era

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World Journal of Clinical Cases 2024年第17期12卷 2939-2945页

作者： Yolanda López del Hoyo Matilde Elices javier garcia-campayo Department of Psychology and Sociology University of ZaragozaZaragoza 50009Spain Mental Health Research Group Hospital del Mar Medical Research InstituteBarcelona 08003Spain Department of Psychiatry Miguel Servet HospitalAragon Institute for Health ResearchUniversity of ZaragozaZaragoza 50009Spain

Current rates of mental illness are *** illness mainly affects females and younger age *** use of the internet to deliver mental health care has been growing since 2020 and includes the implementation of novel mental health treatments using virtual reality,augmented reality,and artificial intelligence.A new three dimensional digital environment,known as the metaverse,has emerged as the next version of the *** intelligence,augmented reality,and virtual reality will create fully immersive,experiential,and interactive online environments in the *** will use a unique avatar to do anything they do in their“real”lives,including seeking and receiving mental health *** this opinion review,we reflect on how the metaverse could reshape how we deliver mental health treatment,its opportunities,and its challenges.

关键词： Metaverse Virtual world Artificial intelligence Mental health Virtual reality Augmented reality Technology

Astrocytes, reactive astrogliosis, and glial scar formation in traumatic brain injury

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Neural Regeneration Research 2025年第4期20卷 973-989页

作者： María Belén Cieri Alberto javier Ramos Laboratorio de Neuropatología Molecular IBCN UBA-CONICETFacultad de MedicinaUniversidad de Buenos AiresBuenos AiresArgentina

Traumatic brain injury is a global health crisis,causing significant death and disability *** that follows traumatic brain injury has serious consequences for neuronal survival and cognitive impairments,with astrocytes involved in this *** traumatic brain injury,astrocytes rapidly become reactive,and astrogliosis propagates from the injury core to distant brain *** astroglial proteins are downregulated near the traumatic brain injury core,while pro-inflammatory astroglial genes are *** altered gene expression is considered a pathological remodeling of astrocytes that produces serious consequences for neuronal survival and cognitive *** addition,glial scar formed by reactive astrocytes is initially necessary to limit immune cell infiltration,but in the long term impedes axonal reconnection and functional *** therapeutic strategies for traumatic brain injury are focused on preventing acute ***,cannabinoids,progesterone,beta-blockers,and cerebrolysin demonstrate neuroprotective benefits but most of them have not been studied in the context of *** this review,we discuss the cell signaling pathways activated in reactive astrocytes following traumatic brain injury and we discuss some of the potential new strategies aimed to modulate astroglial responses in traumatic brain injury,especially using cell-targeted strategies with miRNAs or lncRNA,viral vectors,and repurposed drugs.

关键词： astrocyte glial scar innate immunity neuroinflammation stab injury Toll-like receptors

Beyond neurodegeneration:engineering amyloids for biocatalysis

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Neural Regeneration Research 2025年第10期20卷 2915-2916页

作者： Andrea Bartolomé-Nafría javier García-Pardo Salvador Ventura Institut de Biotecnologia i de Biomedicina(IBB)and Departament de Bioquímica i Biologia Molecular Universitat Autònoma de BarcelonaBellaterraBarcelonaSpain Hospital Universitari Parc Taulí Institut d’Investigaciói InnovacióParc Taulí(I3PT-CERCA)Universitat Autònoma de BarcelonaSabadellSpain

Amyloid fibrils are highly organized protein or peptide aggregates,often characterized by a distinctive supramolecular cross-β-sheet *** formation and accumulation of these structures have been traditionally associated with neural or systemic human diseases,such as Alzheimer’s disease,Parkinson’s disease,type-2 diabetes,or amyotrophic lateral sclerosis(Wei et al.,2017;Wittung-Stafshede,2023).

关键词： structure amyloid

Lie Symmetries of Quasihomogeneous Polynomial Planar Vector Fields and Certain Perturbations

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Acta Mathematica Sinica,English Series 2005年第1期21卷 185-192页

作者： javier CHAVARRIGA Isaac A.garcia Departament de Matemdtica Universitat de LleidaAvda.Jaume II6925001LleidaSpain

In this work we study Lie symmetries of planar quasihomogeneous polynomialvector fields from different points of view, showing its integrability. Additionally, we show thatcertain perturbations of such vector fields w... 详细信息

关键词： Lie symmetries Quasi-homogeneous systems Planar vector fields

Atrial fibrillation in the elderly： predisposing factors and management

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Journal of Geriatric Cardiology 2017年第3期14卷 185-194页

作者： Juan Lacalzada-Almeida javier garcia-Niebla Department of Cardiology Hospztal Umversitarlo de Canarias Tenerife Spain Servicios Sanitarios del Area de Salud de El Hierro Valle del Golfo Health Center El Hierro Spain

In the last twenty years, new imaging techniques to assess atrial function and to predict the risk of recurrence of atrial fibrillation after treatment have been developed. The present review deals with the role of these techniques in the detection of structural and functional changes of the atrium and diagnosis of atrial remodeling, particularly atrial fibrosis. Echocardiography allows the detection of anatomical, functional changes and deformation of the atrial wall during the phases of the cardiac cycle. For this, adequate acquisition of atrial images is necessary using speckle tracking imaging and interpretation of the resulting strain and strain rate curves. This allows to predict new-onset atrial fibrillation and recurrences. Its main limitations are inter-observer variability, the existence of different software manufacturers, and the fact that the software used were originally developed for the evaluation of the ventricular function and are now applied to the atria. Cardiac magnetic resonance, using contrast enhancement with gadolinium, plays a key role in the visualization and quantification of atrial fibrosis. This is the established method for in vivo visualization of myocardial fibrotic tissue. The non-invasive evaluation of atrial fibrosis is associ- ated with the risk of recurrence of atrial fibrillation and with electro-anatomical endocardial mapping. We discuss the limitations of these techniques, derived from the difficulty of demonstrating the correlation between fibrosis imaging and histology, and poor intra- and inter- observer reproducibility. The sources of discordance are described, mainly due to image acquisition and processing, and the challenges ahead in an attempt to eliminate differences between operators.

关键词： Atrial fibrillation Atrial fibrosis Cardiac magnetic resonance imaging Speckle tracking echocardiography Strain

Human condition monitoring in hazardous locations using pervasive RFID sensor tags and energy-efficient wireless networks

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Journal of Zhejiang University-Science C(Computers and Electronics) 2012年第9期13卷 674-688页

作者： javier G.ESCRIBANO Andrés garcia Autolog Group Industrial Engineering SchoolUniversity of Castilla-La ManchaAvda.Camilo José Cela s/n13071 Ciudad RealSpain

Tracking persons in dangerous situations as well as monitoring their physical condition, is often crucial for their safety. The systems commonly used for this purpose do not include individual monitoring or are too expensive and intrusive to be deployed in common situations. In this project, a mobile system based on energy-efficient wireless sensor networks (WSNs) and active radio frequency identification (RFID) has been developed to achieve ubiquitous positioning and monitoring of people in hazardous situations. The system designed can identify each individual, locate him/her, send data regarding their physical situation, and ascertain whether they are located in a confined space. A new algorithm called time division double beacon scheduling (TDDBS) has been implemented to increase operation time and data transmission rate of the nodes in the system. The results show that the use of this system allows us to find the location and state of a person, as well as to provide an analysis of the potential risks at each moment, in real time and in an energy-efficient way. In an emergency, the system also allows for quicker intervention, as it not only provides the location and causes of the event, but also informs about the physical condition of the individual at that moment.

关键词： Active RFID Wireless sensor networks (WSNs) ZigBee Human monitoring Time division double beacon sched-uling (TDDBS)

Data model extension for security event notification with dynamic risk assessment purpose

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Science China(Information Sciences) 2013年第11期56卷 36-44页

作者： David LOPEZ Oscar PASTOR Luis javier garcia VILLALBA Group of Analysis Security and Systems (GASS) Department of Software Engineering and Artificial Intelligence (DISIA) School of Computer Science Universidad Complutense Madrid 28040 Spain

Dynamic risk assessment refers to a risk management framework where frequent updates of risk evaluation information are used to evaluate risk exposure,as close as possible to *** this paper,we present the incident object description exchange format extended model for dynamic risk *** format attempts to overcome the absence of integration and real-time communication between security systems and risk assessment *** model is based on the incident object definition exchange format,which is commonly used in the computer security incident response teams *** data model aims to facilitate a global vision of information systems risk by supplying real-time security events data to risk assessment tools based on renowned *** present a proof-of-concept scenario to demonstrate the usefulness of this integration and the proposed data model,and discuss the expected improvements.

关键词： dynamic risk assessment risk management DRA IODEF-DRA IODEF.

Thermo-electro-mechanical microstructural interdependences in conductive thermoplastics

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npj Computational Materials 2023年第1期9卷 955-965页

作者： javier Crespo-Miguel Sergio Lucarini Angel Arias Daniel garcia-Gonzalez Department of Continuum Mechanics and Structural Analysis Universidad Carlos III de MadridAvda.de la Universidad 3028911 LeganésMadridSpain Department of Civil and Environmental Engineering Imperial College of LondonSouth Kensington CampusLondon SW72AZUK

Additive manufacturing has enabled the design of thermoplastic components that provide structural support,electrical conductivity and heat generation modulated by mechanical *** mechanisms and interplays that govern the material response at the microstructural level remain,however,***,we develop an experimental method to characterise conductive filaments from a combined mechanical,electrical and thermal *** approach is used to unravel exciting material interplays of conductive polylactic *** overcome experimental limitations that prevent a complete microstructural analysis of the problem,we develop a full-field homogenisation framework and implement it for finite *** framework accounts for viscoplasticity,electrical and thermal conduction,convection and heat generation via Joule effect,as well as for the interdependences between *** experimental validation,the framework is applied to virtually optimise fabrication requirements to obtain desired properties in final products,i.e.,stiffer products,filaments with higher conductivities or with better sensing capabilities.

关键词： conductive electrical overcome

Assessment of Technical and Economic Impacts of EV User Behavior on EV Aggregator Smart Charging

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Journal of Modern Power Systems and Clean Energy 2020年第2期8卷 356-366页

作者： Jean-Michel Clairand javier Rodriguez-garcia Carlosalvarez-Bel the Facultad de Ingenieria y Ciencias Agropecuarias Universidad de las Americas-Ecuador170122 QuitoEcuador the Institute for Energy Engineering Universitat Politecnica de Valencia46022 ValenciaSpain

The increase in global electricity consumption has made energy efficiency a priority for ***,there has been a focus on the efficient integration of a massive penetration of electric vehicles(EVs)into energy *** study presents an assessment of various strategies for EV *** this analysis,the smart charging methodology proposed in a previous study is *** smart charging technique employs charging power rate modulation and considers user *** adopt several strategies,this study simulates the effect of these actions in a case study of a distribution system from the city of Quito,*** actions are simulated,and the EV aggregator costs and technical conditions are evaluated.

关键词： Electric vehicle(EV) smart grid aggregator smart charging charging power modulation charging strategies