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Protein phosphatases and chromatin modifying complexes in the inflammatory cascade in acute pancreatitis

World Journal of Gastrointestinal Pharmacology and Therapeutics 2010年第3期1卷 75-80页

作者： javier escobar javier Pereda Alessandro Arduini Juan Sastre Juan Sandoval Luis Aparisi Gerardo López-Rodas Luis Sabater Department of Physiology University of Valencia 46100 Burjasot (Valencia) Spain Department of Biochemistry & Molecular Biology University of Valencia 46100 Burjasot (Valencia) Spain Laboratory of Pancreatic Function University Clinic Hospital 46010 Valencia Spain Department of Surgery University Clinic Hospital 46010 Valencia Spain

Acute pancreatitis is an inflammation of the pancreas that may lead to systemic inflammatory response syndrome and death due to multiple organ failure. Acinar cells, together with leukocytes, trigger the inflammatory cascade in response to local damage of the pancreas. Amplification of the inflammatory cascade requires up-regulation of proinflammatory cytokines and this process is mediated not only by nuclear factor κB but also by chromatinmodifying complexes and chromatin remodeling. Among the different families of histone acetyltransferases, the p300/CBP family seems to be particularly associated with the inflammatory process. cAMP activates gene expression via the cAMP-responsive element (CRE) and the transcription factor CRE-binding protein (CREB). CREB can be phosphorylated and activated by different kinases, such as protein kinase A and MAPK, and then it recruits the histone acetyltransferase co-activator CREB-binding protein (CBP) and its homologue p300. The recruitment of CBP/p300 and changes in the level of histone acetylation are required for transcription activation. Transcriptional repression is also a dynamic and essential mechanism of down-regulation of genes for resolution of inflammation, which seems to be mediated mainly by protein phosphatases (PP1, PP2A and MKP1) and histone deacetylases(HDACs) .Class HDACs are key transcriptional regulators whose activities are controlled via phosphorylationdependent nucleo/cytoplasmic shuttling. PP2A is responsible for dephosphorylation of class HDACs, triggeringnuclear localization and repression of target genes, whereas phosphorylation triggers cytoplasmic localization leading to activation of target genes. The potential benefit from treatment with phosphodiesterase inhibitors and histone deacetylase inhibitors is discussed.

关键词： Dual specificity protein phosphatases Acute pancreatitis Phosphodiesterase inhibitors Cytokines Histone acetylation Pentoxifylline PP2A Serine/threonine protein phosphatases

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Model of Mediating Determinants of Time Differences in INDYCAR

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Journalism and Mass Communication 2024年第4期14卷 232-240页

作者： Wilfrido Isidro Aldana Balderas Héctor Daniel Molina Ruiz Enrique Martínez Muñoz Eleazar Villegas González Tirso javier Hernández Gracia Arturo Sánchez Sánchez Cruz García Lirios Alfredo Barrera escobar University of México HuehuetocaMèxico University of Hidalgo PachucaMèxico University of Tlaxcala Mèxico University of CDMX Mexico University of FV Mexico

The IndyCar series distinguishes itself by providing the same design and operation of the single-seater to its *** difference in times is then attributable to the skills of the drivers,but considering the data from the races could test this *** objective of this work was to establish a trajectory model to predict race times.A cross-sectional,correlational,and explanatory work was carried out with a sample of 18,474 records in the period from 2020 to 2023 of the IndyCar *** results show that the time span predicts the time *** relation to the studies of acceptance of the technology,the adjustment of this to human capacities to explain the time differences in the series of racing cars is discussed.

关键词： time differences ranking differences ranking race time laps completed

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How Learning from Trauma Benefits the Obstetric Population?Damage Control Surgery

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Maternal-Fetal Medicine 2023年第4期5卷 248-252页

作者： María Fernanda escobar Vidarte Daniela Nasner Albaro José Nieto-Calvache María Paula Echavarría javier Andrés Carvajal Department of Obstetrics and Gynecology High Complexity Obstetric UnitFundación Valle del LiliCali 760032Colombia Department of Obstetrics and Gynecology School of MedicineUniversidad IcesiCali 760032Colombia Clinical Research Center Fundación Valle del LiliCali 760032Colombia

The recent implementation of trauma-validated damage control strategies in severe postpartum hemorrhage proves the importance of interdisciplinary management in the obstetric *** hemorrhage control techniques and damage control surgery are clear examples of how learning from trauma can benefit the obstetric ***,most obstetric programs do not include training in this type of ***,it has been shown that these interventions are useful in the management of severe postpartum *** aim of this article is to introduce the application of damage control surgery principles in the management of massive obstetric *** propose to include appropriate training and the implementation of damage control surgery in obstetric management *** prompt application of damage control principles can be considered in patients with persistent hemodynamic instability despite control of the source of bleeding.

关键词： Postpartum hemorrhage Damage control Obstetric hemorrhage Critical care Maternal mortality

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Exhaust Ventilation through a Solar Chimney： A Response to High Hermeticity in Welfare Housing

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Journal of Civil Engineering and Architecture 2015年第7期9卷 767-774页

作者： Marcos Eduardo Gonzalez-Trevizo Adolfo Gomez-Amador Anibal Luna-Leon Carlos escobar-Del POZO Carlos javier Esparza Lopez Facultad de Arquitectura (Faculty of Architecture) Universidad Michoacana de San Nicoldls de Hidalgo (Michoacan Universityof Saint Nicholas of Hidalgo) Morelia MN 58030 Mexico Facultad de Arquitectura y DiseFzo (Faculty of Architecture and Design) Universidad de Colima (University of Colima) ColimaCL 28400 Mexico Facultad de Arquitectura y Diseho (Faculty of Architecture and Design) Universidad Aut6noma de Baja California (BajaCalifornia Autonomous University) Mexieali BC 21280 Mexico Facultad de Ingenieria Mecnica y Elctrica (Faculty of Mechanical and Electrical Engineering) Universidad de ColimaColima CL 28400 Mexico

This research reports on potentiality in the solar chimney as an exhaust ventilation device through a hypothetical statement that convenient weather conditions exist on sub-humid warm climate to enhance the performance ofa SC （solar chimney）, in order to increase ventilation to dissipate metabolic heat from inhabitants of airtight buildings. The methodology used in this research integrates the use of simplified mathematical models that predict in a semi-empirical way a potential volume flow through estimation of kinetic power generation, by natural circulation and stack effect in a typical covered-plate air solar collector. The study was carried out during the warm month of April, an important warm season for Colima, where the prevailing wind is about 6.8 m/s, the average temperature of maximums and minimums oscillates between 15.4℃and 34.4 ℃ with average relative humidity of 65% according to national weather service. A scale model of the SC was installed on environmental chambers. The results showed that this device is capable of generating ventilation conditions around light breeze parameters near between 0.6 m/s and 1.5 m/s width, a better performance at day in 45% approximately than the night values, making ventilation rates up 0.24 ACH （air changes per hour） as average air change rate.

关键词： Exhaust ventilation solar chimney air solar collector welfare housing.

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Application of the Modified Early Obstetric Warning System in Three Patients with Obstetric Sepsis Through a Telemedicine System

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Maternal-Fetal Medicine 2020年第2期2卷 110-114页

作者： María Fernanda escobar-Vidarte Juan Pablo Suso María Paula Echavarría María Antonia Hincapié Daniela Nasner javier Andrés Carvajal Department of Obstetrics and Gynecology High Complexity Obstetric UnitFundación Valle del LiliCali 760032Colombia Department of Clinical Postgraduate Programs Universidad IcesiCali 760032Colombia Department of Health Sciences Obstetrics and Gynecology ProgramUniversidad IcesiCali 760032Colombia Department of Health Sciences Faculty Medicine ProgramUniversidad IcesiCali 760032Colombia Clinic Research Center Department of Obstetrics and GynecologyFundación Valle del LiliCali 760032Colombia

To editor:Maternal sepsis represents the third cause of maternal mortality worldwide and the diagnosis delay portrays a great contribution due to its high *** Modified Early Obstetric Warning System is an early detect... 详细信息

关键词： Telemedicine Early warning system Maternal care patterns Maternal early recognition criteria Maternal early warning trigger Maternal morbidity

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Diagnosis and treatment of hepatocellular carcinoma: An update

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World Journal of Hepatology 2015年第3期7卷 362-376页

作者： javier Tejeda-Maldonado Ignacio García-Juárez Jonathan Aguirre-Valadez Adrián González-Aguirre Mario Vilatobá-Chapa Alejandra Armengol-Alonso Francisco escobar-Penagos Aldo Torre Juan Francisco Sánchez-ávila Diego Luis Carrillo-Pérez Department of Internal Medicine Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Department of Gastroenterology Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Department of Interventional Radiology Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Department of Transplantation Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Department of Hematology and Oncology Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

Hepatocellular carcinoma(HCC) is one of the most common malignancies leading to high mortality rates in the general population; in cirrhotic patients, it is the primary cause of death. The diagnosis is usually delayed in spite of at-risk population screening recommendations, i.e., patients infected with hepatitis B or C virus. Hepatocarcinogenesis hinges on a great number of genetic and molecular abnormalities that lead to tumor angiogenesis and foster their dissemination potential. The diagnosis is mainly based on imaging studies such as computed tomography and magnetic resonance, in which lesions present a characteristic classical pattern of early arterial enhancement followed by contrast medium "washout" in late venous phase. On occasion, when imaging studies are not conclusive, biopsy of the lesion must be performed to establish the diagnosis. The Barcelona Clinic Liver Cancer staging method is the most frequently used worldwide and recommended by the international guidelines of HCC management. Currently available treatments include tumor resection, liver transplant, sorafenib and locoregional therapies(alcoholization, radiofrequency ablation, chemoembolization). The prognosis of hepatocarcinoma is determined according to the lesion's stage and in cirrhotic patients, on residual liver function. Curative treatments, such as liver transplant, are sought in patients diagnosed in early stages; patients in more advanced stages, were not greatly benefitted by chemotherapy in terms of survival until the advent of target molecules such as sorafenib.

关键词： Hepatocellular carcinoma Surveillance Liver transplant Sorafenib Catheter ablation

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