检索结果-南通市图书馆

Umbilical cord as a mesenchymal stem cell source for treating joint pathologies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Orthopedics 2011年第6期2卷 43-50页

作者： María Carmen Arufe Alexandre de la.fuente Isaac fuentes Francisco javier de Toro Francisco javier Blanco department of Medicine Area of Anatomy and Human EmbryologyCampus Oza s/nFac.of Health ScienceUniversity of A Coruna15006 A CorunaSpain Osteoarticular and Aging Research lab Cellular Therapy UnitINIBIC-CH Universitario A Coruna15006 A CorunaSpain Rheumatology Division INIBIC-CH Universitario A Coruna15006 A CorunaSpain Cathedra Bioiberica Universidad de A Coruna15006 A CorunaSpain CIBER-BBN-Instituto de Salud Carlos III 15006 A CorunaSpain Centro de Investigacion Biomedica Hospital Universitario A CorunaC/Xubias 8415006 A CorunaSpain

Articular cartilage disorders and injuries often result in life-long chronic pain and compromised quality of ***,the regeneration of articular cartilage is a continuing challenge for biomedical *** of the most promising therapeutic approaches is cellbased tissue engineering,which provides a healthy population of cells to the injured site but requires differentiated chondrocytes from an uninjured *** use of healthy chondrocytes has been found to have limitations.A promising alternative cell population is mesenchymal stem cells(MSCs),known to possess excellent proliferation potential and proven capability for differentiation into ***“immunosuppressive”property of human MSCs makes them an important candidate for allogeneic cell *** use of allogeneic MSCs to repair large defects may prove to be an alternative to current autologous and allogeneic tissue-grafting *** allogeneic cell-based approach would enable MSCs to be isolated from any donor,expanded and cryopreserved in allogeneic MSC banks,providing a readily available source of progenitors for cell replacement *** possibilities have spawned the current exponential growth in stem cell research in pharmaceutical and biotechnology *** objective in this review is to summarize the knowledge about MSCs from umbilical cord stroma and focus mainly on their applications for joint pathologies.

关键词： Human Mesenchymal stem cell Umbilical cord Cartilage degeneration

Binary Fruit Fly Swarm Algorithms for the Set Covering Problem

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2022年第6期71卷 4295-4318页

作者： Broderick Crawford Ricardo Soto Hanns de la.fuente Mella Claudio Elortegui Wenceslao Palma Claudio Torres-Rojas Claudia Vasconcellos-Gaete Marcelo Becerra javier Pena Sanjay Misra Pontificia Universidad Católica de Valparaíso Valparaíso2362807Chile LERIA Universitéd’AngersAngers49000France department of Computer Science and Communication Ostfold University CollegeHaldenNorway

Currently,the industry is experiencing an exponential increase in dealing with binary-based combinatorial *** this sense,metaheuristics have been a common trend in the field in order to design approaches to solve them ***,a well-known strategy consists in the use of algorithms based on discrete swarms transformed to perform in binary *** the No Free Lunch theorem,we are interested in testing the performance of the Fruit Fly Algorithm,this is a bio-inspired metaheuristic for deducing global optimization in continuous spaces,based on the foraging behavior of the fruit fly,which usually has much better sensory perception of smell and vision than any other *** the other hand,the Set Coverage Problem is a well-known NP-hard problem with many practical applications,including production line balancing,utility installation,and crew scheduling in railroad and mass transit *** this paper,we propose different binarization methods for the Fruit Fly Algorithm,using Sshaped and V-shaped transfer functions and various discretization methods to make the algorithm work in a binary search *** are motivated with this approach,because in this way we can deliver to future researchers interested in this area,a way to be able to work with continuous metaheuristics in binary *** new approach was tested on benchmark instances of the Set Coverage Problem and the computational results show that the proposed algorithm is robust enough to produce good results with low computational cost.

关键词： Set covering problem fruit fly swarm algorithm metaheuristics binarization methods combinatorial optimization problem

Gene expression changes in spleens of the wildlife reservoir species,Eurasian wild boar(Sus scrofa),naturally infected with Brucella suis biovar 2

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2010年第11期37卷 725-736页

作者： Ruth C.Galindo Pilar M.Muoz María J.de Miguel Clara M.Marin javier labairu Miguel Revilla José M.Blasco Christian Gortazar José de la.fuente Instituto de Investigación en Recursos Cinegéticos IREC(CSIC-UCLM-JCCM) Unidad de Sanidad Animal Centro de Investigación y Tecnología Agroalimentaria(CITA) ITG Ganadero Avda. Serapio Huici 2231610 VillabaNavarraSpain departamento de Patología Animal Facultad de VeterinariaUniversity of Zaragoza department of Veterinary Pathobiology Center for Veterinary Health SciencesOklahoma State University

Brucella suis is responsible for swine brucellosis worldwide. Of the five different B. suis biovars （by.）, bv. 2 appears restricted to Europe where it is frequently isolated from wild boar and hares, can infect pigs and can cause human brucellosis. In this study, the differ- ential gene expression profile was characterized in spleens of Eurasian wild boar naturally infected with B. suis bv. 2. Of the 20,201 genes analyzed in the microarray, 633 and 1,373 were significantly （fold change 〉 1.8; P 〈 0.01） upregulated and downregulated, respectively, in infected wild boar. The analysis was focused on genes that were over represented after conditional test for biological process gene ontology. Upregulated genes suggested that B. suis bv. 2 infection induced cell maturation, migration and/or proliferation in infected animals. The genes downregulated in infected wild boar impaired the activity of several important cellular metabolic pathways such as metabolism, cytoskeleton organization and biogenesis, immune response and lysosomal function and vesicle-mediated transport. In addition, the response to stress, sperm fertility, muscle development and apoptosis seemed to be also impaired in infected animals. These results suggested that B. suis bv. 2 may use strategies similar to other smooth brucellae to facilitate intracellular multiplication and the development of chronic infections. To our knowledge, this is the first report of the analysis of gene expression profile in hosts infected with B. suis bv. 2, which is important to understand the molecular mechanisms at the host-pathogen interface in the main reservoir species with possible implications in the zoonotic cycle of the pathogen.

关键词： Brucella suis boar genomics microarray systems biology

Pathogenesis of occult chronic hepatitis B virus infection

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2011年第12期17卷 1543-1548页

作者： Rocio Aller de la.fuente María L Gutiérrez javier Garcia-Samaniego Conrado Fernández-Rodriguez Jose Luis Lledó Gregorio Castellano Gastroenterology Hospital Clinico Universitario Valladolid Institute of endocrinology and Nutrition Medical SchoolUniversity of Valladolid47003 ValladolidSpain Service of Gastroenterology Hospital Universitario Fundación AlcorcónAv Budapest-128922 AlcorcónMadridSpain Gastroenterology department Hospital Carlos IIIc/Sinesio Delgado28029 MadridSpain Hospital Universitario 12 de Octubre Av de Andalucia 2804128039 MadridSpain

Occult hepatitis B infection(OBI) is characterized by hepatitis B virus(HBV) DNA in serum in the absence of hepatitis B surface antigen(HBsAg) presenting HBsAg-negative and anti-HBc positive serological *** HBV status is associated in some cases with mutant viruses undetectable by HBsAg assays;but more frequently it is due to a strong suppression of viral replication and gene *** is an entity with world-wide *** failure to detect HBsAg,despite the persistence of the viral DNA,is due in most cases to the strong suppression of viral replication and gene expression that characterizes this"occult"HBV infection;although the mechanisms responsible for suppression of HBV are not well *** majority of OBI cases are secondary to overt HBV infection and represent a residual low viremia level suppressed by a strong immune response together with histological derangements which occurred during acute or chronic HBV *** evidence suggests that it can favour the progression of liver fibrosis and the development of hepatocellular carcinoma.

关键词： Occult hepatitis B virus infection Hepatitis B virus-DNA Anti-HBc alone Hepatitis B virus Hepadnaviral hepatitis Occult viral persistence Primary occult infection Secondary occult infection Virus reactivation

Identification and Characterization of Métiers in Multi-Species Artisanal Fisheries. A Case Study in Northwest Spain

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Natural Resources 2016年第6期7卷 295-314页

作者： javier González-Álvarez laura García-de-la.fuente Lucía García-Flórez Mª del Pino Fernández-Rueda Jorge Luis Alcázar-Álvarez INDUROT (Instituto de Recursos Naturales y Ordenación del Territorio) University of Oviedo Mieres Spain CEP (Centro de Experimentación Pesquera) Regional Ministry of Rural Development and Natural Resources of the Principality of Asturias Gijón Spain

Artisanal fisheries are characterized by using a vast array of different fishing gears and target species. Such heterogeneity has traditionally complicated their management and the availability of accurate data on fishing effort and incomes. This study identifies and characterizes the métiers currently used by an artisanal fishing fleet based in a coastal Atlantic region in South-Europe (Asturias, Northwest Spain), by applying an integrated method of analysis which combines administrative data on fishing licenses, daily sales statistics and information from surveys. As a result, 21 artisanal fishing métiers have been identified, with special relevance of the trammel net (targeting Lophius spp.), the Merluccius longline and the Merluccius gillnet métiers. Spatio-temporal patterns of fishing effort have been also described, and outputs and inputs demands per métier have been quantified. It has been also found a high degree of alternation between different métiers during the fishing season and significant differences in terms of technical aspects and workforce. Finally, fishermen’s short- and long-term strategies (métier choice) are discussed, different comparisons are made on the basis of other South-European studies and main findings are linked to artisanal fisheries management.

关键词： Métier Artisanal Fisheries Multi-Species Fleet Management Bioeconomic Sustainability North West Spain

deep diving in the PACIFIC:Practical issues in stage III non-small cell lung cancer to avoid shipwreck

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2020年第11期11卷 898-917,I0003页

作者： Xabier Mielgo-Rubio Federico Rojo laura Mezquita-Pérez Francesc Casas Amadeo Wals Manel Juan Carlos aguado javier Garde-Noguera David Vicente Felipe Couñago department of Medical Oncology Hospital Universitario Fundación AlcorcónMadrid 28922Spain department of Pathology IIS-Jiménez Díaz-CIBERONC FoundationMadrid 28040Spain department of Medical Oncology Hospital ClinicLaboratory of Translational Genomics and Targeted Therapeutics in Solid TumorsIDIBAPSBarcelona 08036Spain department of Radiation Oncology Hospital ClinicBarcelona 08036Spain department of Radiation Oncology Hospital Universitario Virgen MacarenaSevilla 41009Spain department of Immunology Service Hospital ClínicUniversitat de BarcelonaBarcelona 08036Spain department of Medical Oncology Hospital Universitario Clínico San CarlosMadrid 28040Spain department of Medical Oncology Hospital Universitario Virgen MacarenaSevilla 49001Spain department of Radiation Oncology Hospital Universitario Quirónsalud MadridHospital La LuzUniversidad Europea de MadridMadrid 28028Spain

After publication of the PACIFIC trial results,immune checkpoint inhibitor-based immunotherapy was included in the treatment algorithm of locally advanced non-small cell lung cancer(NSCLC).The PACIFIC trial demonstrated that 12 mo of durvalumab consolidation therapy after radical-intent platinum doublet chemotherapy with concomitant radiotherapy improved both progression-free survival and overall survival in patients with unresectable stage III *** is the first treatment in decades to successfully improve survival in this clinical setting,with manageable toxicity and without deterioration in quality of *** integration of durvalumab in the management of locally advanced NSCLC accentuates the need for multidisciplinary,coordinated decision-making among lung cancer specialists,bringing new challenges and controversies as well as important changes in clinical work *** aim of the present article is to review—from a practical,multidisciplinary perspective—the findings and implications of the PACIFIC *** evaluate the immunobiological basis of durvalumab as well as practical aspects related to programmed cell death ligand 1 *** addition,we comprehensively assess the efficacy and toxicity data from the PACIFIC trial and discuss the controversies and practical aspects of incorporating durvalumab into routine clinical ***,we discuss unresolved questions and future *** short,the present document aims to provide clinicians with a practical guide for the application of the PACIFIC regimen in routine clinical practice.

关键词： Durvalumab Non-small cell lung cancer PACIFIC Immunotherapy Immune checkpoint inhibitors Anti-programmed cell death ligand 1 Consolidation therapy Unresectable stage III lung cancer