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西班牙马德里立体构成别墅

设计 2017年第4期30卷 30-31页

作者： Jacob javier callejas sevilla

这栋位于马德里的纯白色住宅与晴朗的蓝天形成了鲜明的对比。它建于西班牙山脉西侧的一个山坡上,可俯瞰到一览无余的美景。在设计阶段,建筑师采用计算法来构成建筑的角度。他们需要在一块12米×12米的正方形场地上工作,建筑被分成了四块... 详细信息

这栋位于马德里的纯白色住宅与晴朗的蓝天形成了鲜明的对比。它建于西班牙山脉西侧的一个山坡上,可俯瞰到一览无余的美景。在设计阶段,建筑师采用计算法来构成建筑的角度。他们需要在一块12米×12米的正方形场地上工作,建筑被分成了四块6米×6米的正方形。根据这个图案,地面层被升高,还有一个简单的螺旋状移动。

关键词：马德里西班牙立体构成别墅建筑师设计阶段正方形计算法

Phase Ⅱ trial of CDK4/6 inhibitor palbociclib in advanced sarcoma based on mRNA expression of CDK4/CDKN2A

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Signal Transduction and Targeted Therapy 2023年第11期8卷 5518-5527页

作者： javier Martin-Broto Jeronimo Martinez-Garcia David SMoura Andres Redondo Antonio Gutierrez Antonio Lopez-Pousa javier Martinez-Trufero Isabel sevilla Roberto Diaz-Beveridge Maria Pilar Solis-Hernandez Amancio Carnero Marco Perez David Marcilla Jesus Garcia-Foncillas Pablo Romero javier Fernandez-Jara Daniel Lopez-Lopez Ivan Arribas Nadia Hindi Health Research Institute-Fundación Jiménez Díaz University Hospital Universidad Autónoma de Madrid(IIS-FJDUAM)28040MadridSpain Medical Oncology Department Fundación Jimenez Diaz University Hospital28040MadridSpain General de Villalba University Hospital 28400MadridSpain Medical Oncology Department University Hospital Virgen de la Arrixaca30120MurciaSpain Department of Medical Oncology Hospital Universitario La Paz-IdiPAZP.Castellana26128046MadridSpain Hematology Department University Hospital Son Espases07120MallorcaSpain Medical Oncology Department Sant Pau Hospital08025BarcelonaSpain Medical Oncology Department University Hospital Miguel Servet50009ZaragozaSpain Investigación Clínica y Traslacional en Cáncer/Instituto de Investigaciones Biomédicas de Malaga(IBIMA)/Hospitales Universitarios Regional y Virgen de la Victoria de Malaga MalagaSpain Medical Oncology Department Hospital Universitari i Politècnic La Fe46026ValenciaSpain Medical Oncology Department Central University Hospital of Asturias33011OviedoSpain Instituto de Biomedicina de sevilla(IBiS HUVRCSICUS)41013SevillaSpain Pathology Department Virgen del Rocio University Hospital41013SevillaSpain Radiology Department Fundación Jimenez Diaz University Hospital28040MadridSpain Computational Medicine Platform Fundación progreso y salud(FPS)Hospital Virgen del Rocío41013SevilleSpain Bioinformatics in Rare Diseases(BiER).Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER) FPSHospital Virgen del RocioSevillaSpain Universitat de València-ERI-CES 46010ValenciaSpain

Cyclin-dependent kinases 4 and 6(CDK4/6)inhibitors demonstrated activity in terms of progression-free survival(PFS)in advanced dedifferentiated liposarcoma(DD-LPS),a sarcoma with CDK4 amplification.CDK4 overexpression is by far more common than amplification in sarcomas and it might be a rational target for CDK inhibitors.Preclinical investigators of this study found that CDK4 overexpression,while not of CDKN2A,was the most consistent predictive factor for palbociclib efficacy in sarcomas.Advanced adult-type soft-tissue sarcoma,excluding DD-LPS,or bone sarcoma patients,progressing after at least one systemic line,whose tumors overexpressed CDK4,but not CDKN2A at baseline biopsy,were accrued in this single-arm phase II trial(EudraCT number:2016-004039-19).With the main endpoint of a 6-month PFS rate,40%was considered promising in this population.Palbociclib was administered orally at 125 mg/day for 21 days in 28-day cycles.A total of 214 patients with 236 CDK4/CDKN2A determinations were assessed for prescreening,archival material(141),and screening,baseline biopsy(95).There were 28(29%)with favorable mRNA profiles from 95 screened patients at baseline.From 23 enrolled patients,21 evaluable,the 6-month PFS rate was 29%(95%CI 9–48),and there were 6 patients out of 21 with a PFS longer than 6 months.The median PFS and overall survival were 4.2(95%CI 3.6–4.8)and 12(95%CI 8.7–15.4)months,respectively.Translational research showed a significant correlation between CDK4 mRNA and protein expression.Palbociclib was active in a variety of sarcoma subtypes,selected by CDK4/CDKN2A,and deserves further investigation in the sarcoma context.

关键词： CDKN2A sarcoma CDK4

Projecting the distribution and abundance of Mediterranean tree species under climate change:a demographic approach

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Journal of Plant Ecology 2017年第5期10卷 731-743页

作者： David García-callejas Roberto Molowny-Horas javier Retana CREAF Universitat Autònoma de Barcelona(Edifici C)Cerdanyola del Vallès 08193Spain Departament de Biologia Animal de Biologia Vegetal i d'EcologiaUniversitat Autònoma de Barcelona(Edifici C)Cerdanyola del Vallès 08193Spain

Distribution and abundance patterns of species arise from the spatiotemporal dynamics of demographic processes.Population rates of birth,death,growth and patterns of dispersal are,in turn,influenced by environmental conditions and biotic interactions.However,current approaches for modelling large-scale geographical patterns often bypass these simple premises.centred in the mainland territory of Spain and using Pinus halepensis as a case study,our goal was to gain insight into the main driv-ers affecting local demographic processes,and how large-scale distribution and abundance patterns are shaped by these local variations in vital rates.Methods We applied the integral projection methodology to develop a spa-tially explicit demographic model of tree species in mainland Spain,using individual-level data from a national forest inventory.In our integral projection model,environmental conditions and competi-tive interactions influence the survival,growth and reproduction of trees,and we model explicitly the dynamic colonization of new patches.With this framework,the projected distribution and abun-dance patterns of P.halepensis up to 2090 were evaluated under two different climate scenarios.Important Findings When environmental conditions were kept constant,popula-tions tended to decrease in net number of adults and to increase in net basal area,thus consisting in fewer and bigger individuals.Accounting for climate change in our simulations exacerbated the trend in mortality,causing widespread losses in number of trees,and few locations maintained populations of>100 adult individu-als per hectare.the expected increase in mortality under climate change,on the other hand,prompted a higher degree of regeneration via the release of niche space,although not enough to maintain current abundance levels.colonization spatial patterns did not vary significantly with climatic conditions,but the species was able to increase its distribution under climate change more than in a constant climate scenario.Our approach yields relevant

关键词： climate change demographic model Pinus halepensis Mediterranean population dynamics

Deep convolutional neural network for damaged vegetation segmentation from RGB images based on virtual NIR-channel estimation

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Artificial Intelligence in Agriculture 2022年第1期6卷 199-210页

作者： Artzai Picon Arantza Bereciartua-Perez Itziar Eguskiza javier Romero-Rodriguez Carlos javier Jimenez-Ruiz Till Eggers Christian Klukas Ramon Navarra-Mestre TECNALIA Basque Research and Technology Alliance(BRTA)Parque Tecnológico de BizkaiaC/Geldo.Edificio 700E-48160 Derio-BizkaiaSpain University of the Basque Country Plaza Torres Quevedo48013 BilbaoSpain BASF Espanola S.L.Carretera A376 41710 Utrera SevillaSpain BASF SE Speyererstrasse 267117 LimburgerhofGermany

Performing accurate and automated semantic segmentation of vegetation is a first algorithmic step towards more complex models that can extract accurate biological information on crop health,weed presence and phenological state,among others.Traditionally,models based on normalized difference vegetation index(NDVI),near infrared channel(NIR)or RGB have been a good indicator of vegetation presence.However,these methods are not suitable for accurately segmenting vegetation showing damage,which precludes their use for downstream phenotyping algorithms.In this paper,we propose a comprehensive method for robust vegetation segmentation in RGB images that can cope with damaged vegetation.The method consists of a first regression convolutional neural network to estimate a virtual NIR channel from an RGB image.Second,we compute two newly proposed vegetation indices from this estimated virtual NIR:the infrared-dark channel subtraction(IDCS)and infrared-dark channel ratio(IDCR)indices.Finally,both the RGB image and the estimated indices are fed into a semantic segmentation deep convolutional neural network to train a model to segment vegetation regardless of damage or condition.The model was tested on 84 plots containing thirteen vegetation species showing different degrees of damage and acquired over 28 days.The results show that the best segmentation is obtained when the input image is augmented with the proposed virtual NIR channel(F1=0:94)and with the proposed IDCR and IDCS vegetation indices(F1=0:95)derived from the estimated NIR channel,while the use of only the image or RGB indices lead to inferior performance(RGB(F1=0:90)NIR(F1=0:82)or NDVI(F1=0:89)channel).The proposed method provides an end-to-end land cover map segmentation method directly from simple RGB images and has been successfully validated in real field conditions.

关键词： Vegetation indices estimation Vegetation coverage map Near infrared estimation Convolutional neural network Deep learning

Wing morphology covaries with migration distance in a highly aerial insectivorous songbird

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Current Zoology 2023年第3期69卷 255-263页

作者： Piotr Matyjasiak Cosme Lopez-Calderon Roberto Ambrosini javier Balbontin Alessandra Costanzo Yosef Kiat Andrea Romano Diego Rubolini Museum and Institute of Zoology Polish Academy of Sciences Wilcza 64PL-00-679 WarsawPoland Departamento de Zoologia Facultad de BiologiaEdificio VerdeAvda.de Reina Mercedes s/nE-41012 SevillaSpain Dipartimento di Scienze e Politiche Ambientali Universita degli Studi di Milanovia Celoria 26I-20133 MilanItaly Israeli Bird Ringing Center(IBRC) Israel Ornithological CenterSociety for the Protection of Nature in IsraelHanegev 2Tel-AvivIsrael Istituto di Ricerca sulle Acque IRSA-CNRVia del Mulino 19I-20861 Brugherio(MB)Italy Institute of Biological Sciences Cardinal Stefan Wyszynski University in WarsawWoycickiego 1/3PL-01-815 Warsaw Department of Wetland Ecology Estacion Biologica de Donana CsiCAmerico Vespucio s/nE-41092 SevilleSpain

According to classical prediction of aerodynamic theory,birds and other powered fliers that migrate over long distances should have longer and more pointed wings than those that migrate less.However,the association between wing morphology and migratory behavior can be masked by contrasting selective pressures related to foraging behavior,habitat selection and predator avoidance,possibly at the cost of lower flight energetic efficiency.We studied the handwing morphology of Eurasian barn swallows Hirundo rustica from four populations representing a migration distance gradient.This species is an aerial insectivore,so it flies extensively while foraging,and may migrate during the day using a‘fly-and-forage’migration strategy.Prolonged foraging flights may reinforce the effects of migration distance on flight morphology.We found that two wings’aerodynamic properties—isometric handwing length and pointedness,both favoring energetically efficient flight,were more pronounced in barn swallows from populations undertaking longer seasonal migrations compared to less migratory populations.Our result contrast with two recent interspecific comparative studies that either reported no relationship or reported a negative relationship between pointedness and the degree of migratory behavior in hirundines.Our results may thus contribute to confirming the universality of the rule that longer migrations are associated with more pointed wings.

关键词： flight morphology geographical differences Hirundo rustica migration syndrome population wing shape

Fungal diversity and community composition responses to the reintroduction of fire in a non-managed Mediterranean shrubland ecosystem

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Forest Ecosystems 2023年第2期10卷 268-278页

作者： Juncal Espinosa Tatek Dejene Mercedes Guijarro Xim Cerdá javier Madrigal Pablo Martín-Pinto Centre for the Research and Technology of Agro-Environmental and Biological Sciences University of Trás-os-Montes e Alto DouroVila RealPortugal Sustainable Forest Management Research Institute University of ValladolidPalenciaSpain Ethiopian Forestry Development Addis AbabaEthiopia Instituto de Ciencias Forestales(ICIFOR-INIA) CSICMadridSpain Estaciógica de Doñana CSICSevillaSpain University Polytechnic of Madrid ETSI MontesForestal y Medio NaturalMadridSpain

Background:More than a decade of fire suppression has changed the structure of fire-adapted shrubland ecosystems in Spain’s National Parks,which are now at extreme risk of uncontrolled wildfires.Prescribed burning can mitigate the risk of wildfires by reducing the fuel load but prescribed burning may also alter the soil properties and reduce microbial and fungal activity,causing changes in the availability of nutrients deep in the soil layer.Although fungal communities are a vital part of post-fire restoration,some fire effects remain unclear.To examine the short-term effects of prescribed burning on soil fungal communities in Doñana Biological Reserve(SW Spain),we collected soil samples pre-burn and 1 day,6 and 12 months post-burn from burned plots to perform physicochemical and metabarcode DNA analyses.Results:Prescribed burning had no significant effect on the total fungal operational taxonomic unit richness and abundance.However,changes in soil pH,nitrogen and potassium content post-burn affected fungal community composition.Small non-significant changes in pH and phosphorous affected the composition of ectomycorrhizal fungi.Conclusions:The ectomycorrhizal fungal community appears to be resilient to the effects of low-to moderate-intensity fires and saprotrophic taxa may benefit from this kind of fire.This finding revealed that prescribed burning is a potentially valuable management tool for reducing fire hazards in shrublands that has little effect on the total richness and abundance of fungal communities.

关键词： Doñana National Park Ectomycorrhizal fungi Fire ecology Forest management Global change Prescribed burning Wildfire Saprotrophic fungi

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安大路西亚纪念博物馆

世界建筑导报 2015年第3期30卷 64-69页

作者： javier callejas

传递理念我们希望让格拉纳达的安大路西亚纪念博物馆（MA）成为＂最美丽的建筑＂。这座博物馆用来呈现安大路西亚的全部历史。早在罗马时代,斯特拉博就把安大路西亚居民称为＂以诗立法的、最有修养的伊比利亚人。＂我们的MA项目是一座与... 详细信息

传递理念我们希望让格拉纳达的安大路西亚纪念博物馆（MA）成为＂最美丽的建筑＂。这座博物馆用来呈现安大路西亚的全部历史。早在罗马时代,斯特拉博就把安大路西亚居民称为＂以诗立法的、最有修养的伊比利亚人。＂我们的MA项目是一座与2001年完工的卡哈格拉纳达储蓄银行总部风格一致的建筑。我们建议建造一座60x120 m的三层裙楼,使其顶层与格拉纳达储蓄银行总部主楼的裙楼保持一致。其立面也一样。所有元素均围绕呈椭圆形的中庭布置,通过圆形渐变连接三个楼层,形成一种非常有趣的空间张力。椭圆中庭的尺寸取自阿尔罕布拉的查理五世宫中庭。

关键词：纪念博物馆格拉纳达伊比利亚人储蓄银行斯特拉博罗马时代查理阿尔 architect elliptical

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无际住宅

世界建筑导报 2015年第3期30卷 102-107页

作者： javier callejas

面向无边海洋的无际平面这是我们创作过的最激进的住宅作品——一个面向无边海洋的无际平面。这座面向大西洋的住宅位于加的斯一个海滩上,宛如人间天堂,而古罗马人也曾经居住在附近的波隆尼亚。我们用罗马洞石建造了一座宏伟裙楼,它的... 详细信息

面向无边海洋的无际平面这是我们创作过的最激进的住宅作品——一个面向无边海洋的无际平面。这座面向大西洋的住宅位于加的斯一个海滩上,宛如人间天堂,而古罗马人也曾经居住在附近的波隆尼亚。我们用罗马洞石建造了一座宏伟裙楼,它的上部水平面成为了空间的主角。在裙楼内,平台下方是住宅,就像＂神圣围地＂一样。在石质平台上方和后方,建有防风石墙。

关键词：罗马洞石古罗马人人间天堂尼亚空间的石质围地 looking powerful architect

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建造一个家

建筑实践 2015年第12期 64-69页

作者：李莹 javier callejas Urko Sanchez Architects

SOS儿童村是一个国际性的民间慈善组织,起源于第二次世界大战时期的奥地利,其特色在于采用家庭模式管理、抚养、教育孩子们,让他们重新享有母爱和家庭温暖,可以说,家庭是儿童村的核心。坐落于非洲之角的吉布提市,阿法尔语意为"沸腾的蒸... 详细信息

SOS儿童村是一个国际性的民间慈善组织,起源于第二次世界大战时期的奥地利,其特色在于采用家庭模式管理、抚养、教育孩子们,让他们重新享有母爱和家庭温暖,可以说,家庭是儿童村的核心。坐落于非洲之角的吉布提市,阿法尔语意为"沸腾的蒸锅",可想而知,这里常年干旱,资源严重匮乏。Urko Sanchez Architects受国际慈善组织SOS儿童村委托,在此修建一座可容纳15户家庭的村落社区,以支持当地的家庭强固项目。

关键词：自然通风 SOS 儿童村村落社区私人空间聚居区建筑师肯尼亚