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Arabidopsis photoperiodic regulator CONSTANS feeds back to control the circadian clock

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Molecular Plant 2024年第9期17卷 1338-1340页

作者： Abril San martin Marcelo javier Yanovsky Instituto de Investigaciones Bioquimicas de Buenos Aires(Fundacion Instituto Leloir-CONICET) Av.Patricias Argentinas 435Buenos Aires C1405BWEAraentina

Human beings live in a world defined by daily cycles of light and darkness caused by the Earth’s rotation around its ***,like most living organisms,have evolved internal circadian clocks that time biological processes in anticipation of these daily environmental changes(Young and Kay,2001).The plant clock relies on core genes encoding transcription factors(TFs),which regulate each other’s expression through intricate networks of interlocking transcriptional-translational feedback loops(Nohales and Kay,2016).These loops ultimately control the expression of thousands of genes,allowing plants to adapt to daily fluctuations in light,temperature,and humidity(Covington et al.,2008).In addition to daily rhythms,the Earth experiences yearly seasonal cycles marked by longer,warmer days in spring and summer,followed by shorter,cooler days in autumn and *** changes in day length and temperature intensify with distance from the ***,the ability of plants to adjust their growth and development in anticipation of seasonal changes determines their latitudinal distribution(McMillan,1960).

关键词： circadian seasonal Arabidopsis

Elutriation, attrition and segregation in a conical spouted bed with a fountain confiner

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Particuology 2020年第4期18卷 35-44页

作者： Aitor Pablos Roberto Aguado Jorge Vicente Mikel Tellabide javier Bilbao martin Olazar Department of Chemical Engineering University of the Basque Country UPV/EHUP.O.Box 644E48080 BilbaoSpain Novattia Desarrollos Ltd.Scientific and Technologic Park of BizkaiaAstondo BideaBuilding 612E48160 DerioSpain

This study examined elutriation,attrition,and segregation in a conical spouted bed with a fountain confiner and incorporating an open sided draft *** silica sand with a wide particle size distribution was employed as a model material,operating in both the batch and continuous *** use of a fountain confiner is crucial when operating with fine particles,because otherwise the bed rapidly exhibits significant *** extent of attrition was quantified using a tracing technique based on differently-coloured sand fractions as well as monitoring size distributions by *** breakage was found to be the primary attrition mechanism,and the fountain confiner was determined to limit the elutriation of fine particles resulting from ***,only a small fraction of the finest particles were entrained from the *** incorporation of a confiner increased operational stability while reducing segregation,especially in the upper half of the bed where the majority of segregation typically ***,the bed was perfectly mixed apart from very minimal segregation close to the wall and at the bottom of the *** results provide a basis for the design and operation of larger scale equipment for the continuous drying of materials.

关键词： Spouted bed Fine sand Elutriation Attrition Segregation Fountain confinement device

Infrared phononic nanoantennas:Localized surface phonon polaritons in SiC disks

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Chinese Science Bulletin 2010年第24期55卷 2625-2628页

作者： AMEEN Mohamed GARCIA-ETXARRI Aitzol SCHNELL martin HILLENBRAND Rainer AIZPURUA javier Department of Materials Physics University of the Basque Country UPV/EHU Centro Mixto de Física de Materiales CSIC-UPV/EHU and Donostia International Physics Centre Nanooptics Group CIC Nanogune Consolider Ikerbasque

The electromagnetic interaction of light with polar materials shows a sharp and well defined electromagnetic response in the infrared(IR)region that consists mainly of excitation of optical *** to surface plasmons in the visible region,surface phonons can couple efficiently to infrared light in micron-sized antennas made of polar *** applied the boundary element method to calculating the infrared electromagnetic response of single SiC disks acting as effective infrared antennas as a function of different parameters such as disk size and *** also analyzed the effect of locating a probing metallic tip near the SiC disk to scatter light in the proximity of the SiC disk,thereby obtaining new spectral peaks connected with localized modes between the tip and the SiC *** then further investigated their application in IR scanning probe microscopy.A near-field map of the phononic resonances enhances the understanding of the nature of the IR extinction peaks.

关键词：表面声子碳化硅光磁盘红外线极化激元扫描探针显微技术电磁相互作用电磁响应

HEART RATE VARIABILITY DURING HIGH-INTENSITY EXERCISE

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Journal of Systems Science & Complexity 2013年第1期26卷 104-116页

作者： SARMIENTO Samuel GARCIA-MANSO Juan Manuel martin-GONZALEZ Juan Manuel VA-AMONDE Diana CALDERóN javier DA SILVA-GRIGOLETTO Marzo Edir Department of Physical Education University of Las Palmas de Gran Canaria Spain. Physics Department University of Las Palmas de Gran Canaria Spain. Department of Morphological Sciences School of Medicine University of Cdrdoba Spain. Physical Activity Sciences Faculty Polytechnic University of Madrid Spain. Andalusian Centre of Sports Medicine Cdrdoba Spain.

The aim of this paper is to describe and analyse the behaviour of heart rate variability(HRV)during constant-load,high-intensity exercise using a time frequency analysis(Wavelet Transform).Eleven elite cyclists took part in the study(age:18.6±3.0 years;VO_(2max):4.88±0.61 litres·min^(-1)).Initially,all subjects performed an incremental cycloergometer test to determine load power in a constant load-test(379.55±36.02 W;89.0%).HRV declined dramatically from the start of testing(p<0.05).The behaviour of power spectral density within the LF band mirrored that of total energy,recording a significant decrease from the outset LF peaks fell rapidly thereafter,remaining stable until the end of the ***-VHF fell sharply in the first 20 to 30 *** relative weighting(%) of HF-VHF was inverted with the onset of fatigue,[1.6%at the start,7.1(p<0.05) at the end of the first phase,and 43.1%(p<0.05) at the end of the test].HF-VHF_(peak) displayed three phases:a moderate initial increase,followed by a slight fall,thereafter increasing to the end of the *** LF/HF-VHF ratio increased at the start,later falling progressively until the end of the first phase and remaining around minimal values until the end of the test.

关键词： Cycling heart rate variability wavelet.

Potential strategies offered by animals to implement in buildings' energy performance: Theory and practice

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Frontiers of Architectural Research 2019年第1期8卷 17-31页

作者： Cesar martin-Gomez Amaia Zuazua-Ros javier Bermejo-Busto Enrique Baquero Rafael Miranda Cristina Sanz Department of Building Construction Building Services and Structures Universidad de Navarra Pamplona 31009 Spain School of Sciences Department of Environmental Biology Universidad de Navarra Pamplona 31080 Spain

The strategies for thermal regulation and envir on mental control found in nature are countless. In this article, a parallelism between animals and building energy systems is defined in order to identJfy and emphasize the immediate opportunities that biomimicry offers for future research. The motivation was the need to find alternative solutions to tackle problems mainly in the efficiency of heating, ventilation and cooling systems. Due to the wide range of possibilities offered by animals, this study is largely limited to the strategies that cold-blooded animals have developed through evolutionary adaptation to the environment. The method used for the an a lysis is based on a soluti on-based approach. Firstly, differe nt animal thermoregulation strategies are defined (biological domain). Then the strategy is an a lyzed and classified into three categories. This classification is esse ntial in order to formulate the parallelism with building systems (transfer phase). The final step is to identify the potential implementation (technological domain).This approach has been seen to be useful in creating new research opportunities based on biomimicry. In addition, suitable solutions arising from multidisciplinary team research are presented as promising answers to the challenges that building energy systems face no wadays.

关键词： Biomimicry Building services Energy systems Passive design Multidisciplinary

Kinetic behaviour of commercial catalysts for methane reforming in ethanol steam reforming process

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Journal of Energy Chemistry 2014年第5期23卷 639-644页

作者： Jorge Vicente javier Erea martin Olazar Pedro L.Benito javier Bilbao Ana G.Gayubo Departamento de Ingeniería Química Universidad del País Vasco UPV/EHU Apartado 644 48080 Bilbao Spain Departamento de Ingeniería Minera y Metalúrgica y Ciencia de los Materiales Universidad del País Vasco UPV/EHUNieves Cano 12 01006 Vitoria-Gasteiz Spain

Ethanol steam reforming has been studied in a fluidized bed （in order to ensure bed isothermicity） on commercial catalysts for methane reforming. The results allow analyzing the effect of temperature （in 300-700℃ range）, and both metal and support nature on the reaction indices （ethanol conversion, yields and selectivities to H2 and byproducts （CO2, CO, CH4 and C2H4O））. Special attention has been paid to catalysts＇ stability by comparing the evolution of the reaction indices with time on stream at 500°C （minimum CO formation） and 700℃ （minimum deactivation by coke deposition）. Although they provide a slightly lower H2 yield, the results evidence a good behaviour of Ni based catalysts, indicating that they are an interesting alternative of more expensive Rh based ones.

关键词： ethanol steam reforming hydrogen commercial catalyst selectivity deactivation

Auricular embryonal rhabdomyosarcoma

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World Journal of Pediatrics 2022年第5期18卷 358-360页

作者： javier Arredondo Montero Monica Bronte Anaut Sara Hernandez-martin Juan Carlos Lopez-Gutierrez Pediatric Surgery Department Complejo Hospitalario de NavarraCalle Irunlarrea 331008 PamplonaNavarraSpain Pathology Department Complejo Hospitalario de NavarraPamplonaSpain Pediatric Surgery Department Hospital Universitario La PazMadridSpain

A 13-month-old girl presented with a red-violaceous tumor of 13 mm in diameter on the inner side of the root of the right helix,with increased temperature and cystic consistency(Fig.1).No pulse was palpable in the *** ultrasonography was performed,showing a 1.6 cm rounded lesion with well-defined margins,hypoechogenic and homogeneous,compatible with *** treatment with oral propranolol was started without improve-ment.

关键词： sarcoma ultrasonography showing

Diagnostic performance of serum interleukin-6 in pediatric acute appendicitis:a systematic review

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World Journal of Pediatrics 2022年第2期18卷 91-99页

作者： javier Arredondo Montero Carlos Bardaji Pascual Monica Bronte Anaut Natalia Lopez-Andres Giuseppa Antona Nerea martin-Calvo Pediatric Surgery Department Complejo Hospitalario de NavarraCalle Irunlarrea 331008 PamplonaNavarraSpain Pathology Department Complejo Hospitalario de NavarraPamplonaSpain Cardiovascular Translational Research Navarrabiomed(Miguel Servet Foundation)Complejo Hospitalario de Navarra(CHN)Universidad Publica de Navarra(UPNA)IdiSNAPamplonaSpain Department of Preventive Medicine and Public Health Instituto de Investigacion Sanitaria de Navarra(IdiSNA).University of Navarra.PamplonaSpain CIBER Fisiopatologia de la Obesidad y Nutricion(CIBERobn) Health Institute CarlosⅢMadridSpain

Background Despite the radiological and analytical advances of the last decades,there is still a significant rate of diagnostic error in pediatric acute *** recent years,multiple biomarkers have emerged as potential diagnostic *** study aimed to examine the diagnostic performance of serum interleukin-6 in pediatric acute *** We conducted a systematic review of the literature that involved an extensive search in the main databases of medical bibliography(Medline,PubMed,Web of Science and SciELO).Two independent reviewers selected the relevant articles based on the previously defined inclusion and exclusion *** quality of the selected article was rated using the QUADAS2 *** extraction was performed by two independent *** The research in the medical bibliography databases resulted in 68 *** removed 26 *** the remaining 42 articles,we excluded 33 following the inclusion and exclusion *** the final 9 studies included in this review,8 provided measured serum interleukin-6 values,and all of them reported significant differences between groups,but inconsistent results regarding sensitivity and *** The diagnostic performance of interleukine-6 alone for the diagnosis of acute appendicitis in children is *** sensitivity and specificity of interleukine-6 for the diagnosis of non-complicated acute appendicitis in the pediatric population are moderate but increased in complicated *** seems to be a direct relationship between serum level of interleukin-6 and the hours of evolution of abdominal pain in children with acute *** increasingly widespread use of non-operative management of acute appendicitis warrants further exploration of the classificatory potential of this marker between complicated and uncomplicated *** consider that this may be an avenue of research to explore in the future.

关键词： Acute appendicitis Children Interleukin-6 Pediatric Sensitivity Specificity Systematic review

Phase Ⅱ trial of CDK4/6 inhibitor palbociclib in advanced sarcoma based on mRNA expression of CDK4/CDKN2A

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Signal Transduction and Targeted Therapy 2023年第11期8卷 5518-5527页

作者： javier martin-Broto Jeronimo martinez-Garcia David SMoura Andres Redondo Antonio Gutierrez Antonio Lopez-Pousa javier martinez-Trufero Isabel Sevilla Roberto Diaz-Beveridge Maria Pilar Solis-Hernandez Amancio Carnero Marco Perez David Marcilla Jesus Garcia-Foncillas Pablo Romero javier Fernandez-Jara Daniel Lopez-Lopez Ivan Arribas Nadia Hindi Health Research Institute-Fundación Jiménez Díaz University Hospital Universidad Autónoma de Madrid(IIS-FJDUAM)28040MadridSpain Medical Oncology Department Fundación Jimenez Diaz University Hospital28040MadridSpain General de Villalba University Hospital 28400MadridSpain Medical Oncology Department University Hospital Virgen de la Arrixaca30120MurciaSpain Department of Medical Oncology Hospital Universitario La Paz-IdiPAZP.Castellana26128046MadridSpain Hematology Department University Hospital Son Espases07120MallorcaSpain Medical Oncology Department Sant Pau Hospital08025BarcelonaSpain Medical Oncology Department University Hospital Miguel Servet50009ZaragozaSpain Investigación Clínica y Traslacional en Cáncer/Instituto de Investigaciones Biomédicas de Malaga(IBIMA)/Hospitales Universitarios Regional y Virgen de la Victoria de Malaga MalagaSpain Medical Oncology Department Hospital Universitari i Politècnic La Fe46026ValenciaSpain Medical Oncology Department Central University Hospital of Asturias33011OviedoSpain Instituto de Biomedicina de Sevilla(IBiS HUVRCSICUS)41013SevillaSpain Pathology Department Virgen del Rocio University Hospital41013SevillaSpain Radiology Department Fundación Jimenez Diaz University Hospital28040MadridSpain Computational Medicine Platform Fundación progreso y salud(FPS)Hospital Virgen del Rocío41013SevilleSpain Bioinformatics in Rare Diseases(BiER).Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER) FPSHospital Virgen del RocioSevillaSpain Universitat de València-ERI-CES 46010ValenciaSpain

Cyclin-dependent kinases 4 and 6(CDK4/6)inhibitors demonstrated activity in terms of progression-free survival(PFS)in advanced dedifferentiated liposarcoma(DD-LPS),a sarcoma with CDK4 ***4 overexpression is by far more common than amplification in sarcomas and it might be a rational target for CDK *** investigators of this study found that CDK4 overexpression,while not of CDKN2A,was the most consistent predictive factor for palbociclib efficacy in *** adult-type soft-tissue sarcoma,excluding DD-LPS,or bone sarcoma patients,progressing after at least one systemic line,whose tumors overexpressed CDK4,but not CDKN2A at baseline biopsy,were accrued in this single-arm phase II trial(EudraCT number:2016-004039-19).With the main endpoint of a 6-month PFS rate,40%was considered promising in this *** was administered orally at 125 mg/day for 21 days in 28-day cycles.A total of 214 patients with 236 CDK4/CDKN2A determinations were assessed for prescreening,archival material(141),and screening,baseline biopsy(95).There were 28(29%)with favorable mRNA profiles from 95 screened patients at *** 23 enrolled patients,21 evaluable,the 6-month PFS rate was 29%(95%CI 9–48),and there were 6 patients out of 21 with a PFS longer than 6 *** median PFS and overall survival were 4.2(95%CI 3.6–4.8)and 12(95%CI 8.7–15.4)months,*** research showed a significant correlation between CDK4 mRNA and protein *** was active in a variety of sarcoma subtypes,selected by CDK4/CDKN2A,and deserves further investigation in the sarcoma context.

关键词： CDKN2A sarcoma CDK4